2.0 2015-09-08 17:50:05 -0600 2015-09-14 16:46:34 -0600 ECMDB24209 M2MDB006326 aldehydo-D-allose 6-phosphate Aldehydo-D-allose 6-phosphate is an intermediate in D-allose degradation pathway in E.coli. It is a substrate for the enzymes allose-6-phosphate isomerase / ribose-5-phosphate isomerase B which catalyze the reaction aldehydo-D-allose 6-phosphate -> D-allulose 6-phosphate. It is also a product for enzyme D-allose kinase which catalyzes reaction D-allopyranose + ATP -> aldehydo-D-allose 6-phosphate + ADP + H+ (BioCyc compound: D-ALLOSE-6-PHOSPHATE). aldehydo-D-Allose 6-phosphoric acid C6H11O9P 258.12 258.015166092 2,3,4,5-tetrahydroxy-6-(phosphonatooxy)hexanal 2,3,4,5-tetrahydroxy-6-(phosphonatooxy)hexanal OC(COP([O-])([O-])=O)C(O)C(O)C(O)C=O InChI=1S/C6H13O9P/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14/h1,3-6,8-11H,2H2,(H2,12,13,14)/p-2 VFRROHXSMXFLSN-UHFFFAOYSA-L logp -1.95 ALOGPS logs -0.69 ALOGPS solubility 5.97e+01 g/l ALOGPS logp -3.7 ChemAxon pka_strongest_acidic 1.49 ChemAxon pka_strongest_basic -3.5 ChemAxon iupac 2,3,4,5-tetrahydroxy-6-(phosphonatooxy)hexanal ChemAxon average_mass 258.12 ChemAxon mono_mass 258.015166092 ChemAxon smiles OC(COP([O-])([O-])=O)C(O)C(O)C(O)C=O ChemAxon formula C6H11O9P ChemAxon inchi InChI=1S/C6H13O9P/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14/h1,3-6,8-11H,2H2,(H2,12,13,14)/p-2 ChemAxon inchikey VFRROHXSMXFLSN-UHFFFAOYSA-L ChemAxon polar_surface_area 170.41 ChemAxon refractivity 45.98 ChemAxon polarizability 20.05 ChemAxon rotatable_bond_count 7 ChemAxon acceptor_count 8 ChemAxon donor_count 4 ChemAxon physiological_charge -2 ChemAxon formal_charge -2 ChemAxon D-allulose degradation E. coli can utilize D-allose as the sole source of carbon for growth. D-allose is transported into the cell in unphosphorylated form via the D-allose ABC transporter. AlsK, the D-allose kinase which phosphorylates D-allose, is not essential for this pathway. Allose-6-phosphate isomerase and allulose-6-phosphate 3-epimerase catalyze the remaining reactions resulting in D-allulose 6 phosphate and Beta-D-fructofuranose 6-phosphate respectively. Once Beta D fructofuranose 6-phosphate is synthesized, it goes into the glycolysis and pyruvatedehydrogenase pathway. PW000825 Metabolic Specdb::MsMs 24086 Specdb::MsMs 24087 Specdb::MsMs 24088 Specdb::MsMs 30884 Specdb::MsMs 30885 Specdb::MsMs 30886 D-allose kinase P32718 ALSK_ECOLI alsK http://ecmdb.ca/proteins/P32718.xml Ribose-5-phosphate isomerase B P37351 RPIB_ECOLI rpiB http://ecmdb.ca/proteins/P37351.xml D-allopyranose + Adenosine triphosphate > Adenosine diphosphate + Hydrogen ion + aldehydo-D-allose 6-phosphate + ADP + aldehydo-D-allose 6-phosphate PW_R002964 aldehydo-D-allose 6-phosphate + aldehydo-D-allose 6-phosphate > D-allulose 6-phosphate + D-Allulose-6-phosphate PW_R002965