2.0 2015-06-08 15:34:32 -0600 2015-08-05 16:22:05 -0600 ECMDB23871 M2MDB005537 Orthophosphoric monoester An organic phosphate that is phosphoric acid in which one of the hydrogens is replaced by an organyl group 2-Hydroxycyclohexanone Adipoin C6H10O2 114.144 114.068079562 2-hydroxycyclohexan-1-one 2-hydroxycyclohexanone OC1CCCCC1=O InChI=1S/C6H10O2/c7-5-3-1-2-4-6(5)8/h5,7H,1-4H2 ODZTXUXIYGJLMC-UHFFFAOYSA-N logp -0.08 ALOGPS logs 0.25 ALOGPS solubility 2.01e+02 g/l ALOGPS logp 0.62 ChemAxon pka_strongest_acidic 13.41 ChemAxon pka_strongest_basic -3.5 ChemAxon iupac 2-hydroxycyclohexan-1-one ChemAxon average_mass 114.144 ChemAxon mono_mass 114.068079562 ChemAxon smiles OC1CCCCC1=O ChemAxon formula C6H10O2 ChemAxon inchi InChI=1S/C6H10O2/c7-5-3-1-2-4-6(5)8/h5,7H,1-4H2 ChemAxon inchikey ODZTXUXIYGJLMC-UHFFFAOYSA-N ChemAxon polar_surface_area 37.3 ChemAxon refractivity 29.74 ChemAxon polarizability 12.01 ChemAxon rotatable_bond_count 0 ChemAxon acceptor_count 2 ChemAxon donor_count 1 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon gamma-Hexachlorocyclohexane degradation ec00361 Folate biosynthesis The biosynthesis of folic acid begins with a product of purine nucleotides de novo biosynthesis pathway, GTP. This compound is involved in a reaction with water through a GTP cyclohydrolase 1 protein complex, resulting in a hydrogen ion, formic acid and 7,8-dihydroneopterin 3-triphosphate. The latter compound is dephosphatased through a dihydroneopterin triphosphate pyrophosphohydrolase resulting in the release of a pyrophosphate, hydrogen ion and 7,8-dihydroneopterin 3-phosphate. The latter compound reacts with water spontaneously resulting in the release of a phosphate and a 7,8 -dihydroneopterin. This compound reacts with a dihydroneopterin aldolase, releasing a glycoaldehyde and 6-hydroxymethyl-7,9-dihydropterin. The latter compound is phosphorylated with a ATP-driven 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase resulting in a (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate. Chorismate is metabolized by reacting with L-glutamine through a 4-amino-4-deoxychorismate synthase resulting in L-glutamic acid and 4-amino-4-deoxychorismate. The latter compound then reacts through an aminodeoxychorismate lyase resulting in pyruvic acid,hydrogen ion and p-aminobenzoic acid. (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate and p-aminobenzoic acid react through a dihydropteroate synthase resulting in pyrophosphate and 7,8-dihydropteroic acid. This compound reacts with L-glutamic acid through an ATP driven bifunctional folylpolyglutamate synthetase / dihydrofolate synthetase resulting in a 7,8-dihydrofolate monoglutamate. This compound is reduced through an NADPH mediated dihydrofolate reductase resulting in a tetrahydrofate. This product goes on to a one carbon pool by folate pathway. PW000908 ec00790 Metabolic Inositol phosphate metabolism ec00562 Riboflavin metabolism ec00740 1,4-Dichlorobenzene degradation ec00627 Microbial metabolism in diverse environments ec01120 Metabolic pathways eco01100 Specdb::CMs 1085195 Specdb::MsMs 29402 Specdb::MsMs 29403 Specdb::MsMs 29404 Specdb::MsMs 35960 Specdb::MsMs 35961 Specdb::MsMs 35962 C01153 Orthophosphoric monoester + Water <> Alcohol + Phosphate R00626