2.0 2015-06-04 15:17:12 -0600 2015-08-05 16:22:04 -0600 ECMDB23788 M2MDB004318 Selenate A divalent inorganic anion obtained by removal of both protons from selenic acid H2SEO4 Selenate Selenic acid [SeO2(OH)2] H2O4Se 144.97 145.91183038 selenic acid selenic acid 7783-08-6 O[Se](O)(=O)=O InChI=1S/H2O4Se/c1-5(2,3)4/h(H2,1,2,3,4) QYHFIVBSNOWOCQ-UHFFFAOYSA-N logp -1.6 ChemAxon pka_strongest_acidic -3.8 ChemAxon iupac selenic acid ChemAxon average_mass 144.97 ChemAxon mono_mass 145.91183038 ChemAxon smiles O[Se](O)(=O)=O ChemAxon formula H2O4Se ChemAxon inchi InChI=1S/H2O4Se/c1-5(2,3)4/h(H2,1,2,3,4) ChemAxon inchikey QYHFIVBSNOWOCQ-UHFFFAOYSA-N ChemAxon polar_surface_area 74.6 ChemAxon refractivity 21.13 ChemAxon polarizability 6.65 ChemAxon rotatable_bond_count 0 ChemAxon acceptor_count 5 ChemAxon donor_count 2 ChemAxon physiological_charge -2 ChemAxon formal_charge 0 ChemAxon Selenoamino acid metabolism ec00450 Selenium metabolism The selenium metabolism begins with the introduction of selenate and selenite to the cytosol through a sulphate permease system. Once in the cell, selenate can be reduced to selenite through nitrate reductases A and Z. Selenite then interacts with glutathione and 2 hydrogen ions resulting in the release of 2 water molecules, a hydroxide molecule, a glutathione disulfide and a selenodiglutathione. The latter compound then reacts with NADPH+H resulting in the release of a NADP, a glutathione and a glutathioselenol. Glutathiolselenol can then be oxidize resulting in a a glutathiolselenol ion which can then interact with a water molecule resulting in a release of glutathion and selenium Glutathiolselenol can also react with NADPH and hydrogen ion resulting in a release of glutathione, NADP, a hydroxide molecule and a hydrogen selenide. This compound can react in a reversible reaction by being oxidized resulting in a hydrogen selenide ion . This compound can then be phosphorylated by interacting with an ATP and releasing a AMP, a phosphate and a selenophosphate. PW001894 Metabolic inner membrane transport list of inner membrane transport complexes, transporting compounds from the periplasmic space to the cytosol This pathway should be updated regularly with the new inner membrae transports added PW000786 Metabolic Specdb::CMs 35605 Specdb::CMs 155323 Specdb::MsMs 29315 Specdb::MsMs 29316 Specdb::MsMs 29317 Specdb::MsMs 35873 Specdb::MsMs 35874 Specdb::MsMs 35875 Specdb::MsMs 2754319 Specdb::MsMs 2754320 Specdb::MsMs 2754321 Specdb::MsMs 2951412 Specdb::MsMs 2951413 Specdb::MsMs 2951414 C05697 Respiratory nitrate reductase 1 alpha chain P09152 NARG_ECOLI narG http://ecmdb.ca/proteins/P09152.xml Respiratory nitrate reductase 2 gamma chain P0AF32 NARV_ECOLI narV http://ecmdb.ca/proteins/P0AF32.xml Respiratory nitrate reductase 1 beta chain P11349 NARH_ECOLI narH http://ecmdb.ca/proteins/P11349.xml Respiratory nitrate reductase 1 gamma chain P11350 NARI_ECOLI narI http://ecmdb.ca/proteins/P11350.xml Probable nitrate reductase molybdenum cofactor assembly chaperone NarW P19317 NARW_ECOLI narW http://ecmdb.ca/proteins/P19317.xml Respiratory nitrate reductase 2 beta chain P19318 NARY_ECOLI narY http://ecmdb.ca/proteins/P19318.xml Respiratory nitrate reductase 2 alpha chain P19319 NARZ_ECOLI narZ http://ecmdb.ca/proteins/P19319.xml Sulfate adenylyltransferase subunit 2 P21156 CYSD_ECOLI cysD http://ecmdb.ca/proteins/P21156.xml Sulfate adenylyltransferase subunit 1 P23845 CYSN_ECOLI cysN http://ecmdb.ca/proteins/P23845.xml Periplasmic nitrate reductase P33937 NAPA_ECOLI napA http://ecmdb.ca/proteins/P33937.xml Diheme cytochrome c napB P0ABL3 NAPB_ECOLI napB http://ecmdb.ca/proteins/P0ABL3.xml Nitrate reductase molybdenum cofactor assembly chaperone NarJ P0AF26 NARJ_ECOLI narJ http://ecmdb.ca/proteins/P0AF26.xml Selenite + Water + Acceptor <> Selenate + Reduced acceptor R07229 Selenate + 2 Hydrogen ion + 2 Electron > Selenite + Water PW_R005187