2.02012-10-10 12:23:20 -06002015-06-03 17:26:14 -0600ECMDB23236M2MDB003626molybdenum cofactorMolybdenum cofactor is a cofactor required for the activity of enzymes such as sulfite oxidase, xanthine oxidoreductase, and aldehyde oxidase. It is a coordination complex formed between molybdopterin (which, despite the name, does not contain molybdenum) and an oxide of molybdenum. Molybdenum-containing enzymes catalyze basic metabolic reactions in the nitrogen, sulfur, and carbon cycles. With the exception of the nitrogenase cofactor, molybdenum is incorporated into proteins as the molybdenum cofactor that contains a mononuclear molybdenum atom coordinated to the sulfur atoms of a pterin derivative named molybdopterin. Certain microorganisms can also utilize tungsten in a similar fashion. Molybdenum-cofactor-containing enzymes catalyze the transfer of an oxygen atom, ultimately derived from or incorporated into water, to or from a substrate in a two-electron redox reaction.MCDMoCoMolybdenum enzyme molybdenum cofactorMolybdoenzyme molybdenum-containing cofactorMolybdopterin cytosine dinucleotideMoO2(OH)DTPP-mCDPMoO<sub>2</sub>(OH)Dtpp-mCDPNitrate reductase molybdenum cofactorNitric acid reductase molybdenum cofactorPterin molybdenum cofactorC10H18MoN5O8PS2527.32528.938848315molybdenum(2+) ion ({4-hydroxy-2-imino-6,7-disulfanyl-1H,2H,5H,5aH,8H,9aH,10H-pyrano[3,2-g]pteridin-8-yl}methoxy)phosphonic acid dihydratemolybdenum(2+) ion molybdopterin cofactor dihydrate73508-07-3O.O.[Mo++].OC1=NC(=N)NC2=C1NC1C(N2)OC(COP(O)(O)=O)C(S)=C1SInChI=1S/C10H14N5O6PS2.Mo.2H2O/c11-10-14-7-4(8(16)15-10)12-3-6(24)5(23)2(21-9(3)13-7)1-20-22(17,18)19;;;/h2-3,9,12,23-24H,1H2,(H2,17,18,19)(H4,11,13,14,15,16);;2*1H2/q;+2;;VUKICSJFFDCESC-UHFFFAOYSA-NSolidlogp-5pka_strongest_acidic-4.1pka_strongest_basic15iupacmolybdenum(2+) ion ({4-hydroxy-2-imino-6,7-disulfanyl-1H,2H,5H,5aH,8H,9aH,10H-pyrano[3,2-g]pteridin-8-yl}methoxy)phosphonic acid dihydrateaverage_mass527.32mono_mass528.938848315smilesO.O.[Mo++].OC1=NC(=N)NC2=C1NC1C(N2)OC(COP(O)(O)=O)C(S)=C1SformulaC10H18MoN5O8PS2inchiInChI=1S/C10H14N5O6PS2.Mo.2H2O/c11-10-14-7-4(8(16)15-10)12-3-6(24)5(23)2(21-9(3)13-7)1-20-22(17,18)19;;;/h2-3,9,12,23-24H,1H2,(H2,17,18,19)(H4,11,13,14,15,16);;2*1H2/q;+2;;inchikeyVUKICSJFFDCESC-UHFFFAOYSA-Npolar_surface_area168.52refractivity109.78polarizability34.89rotatable_bond_count3acceptor_count10donor_count9physiological_charge-2formal_charge2GTP degradationGTP, produced in the nucleotide de novo biosyntheis pathway, interacts with a water molecule through a GTP cyclohydrolase resulting in a formate, hydrogen ion and a 7,8-dihydroneopterin 3'-triphosphate. The latter compound interacts with a water molecule through a dihydroneopterin triphosphate pyrophosphohydrolase resulting in the release of a pyrophosphate, a hydrogen ion and a 7,8-dihydroneopterin 3'-phosphate. The latter compound interacts with water spontaneously resulting in the release of a phosphate and a 7,8 dihydroneopterin. The latter compound interacts with a dihydroneopterin aldolase resulting in the release of a glycolaldehyde and a 6-hydroxymethyl-7,8-dihydropterin. This compound then is then diphosphorylated by reacting with a ATP driven 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase resulting in the release of a hydrogen ion, an AMP and 6-hydroxymethyl-7,8-dihydropterin diphosphate.
GTP interacts with a cyclic pyranopterin monophosphate synthase resulting in the release of a diphosphate and a cyclic pyranopterin phosphate. The latter compound interacts with a thiocarboxylated small subunit of molybdopterin synthase (a protein) and a water molecule through a molybdopterin synthase resulting in the release of 4 hydrogen ions, 2 small subunits of molybdopterin synthase and a molybdopterin. The molybdopterin interacts with an ATP and a hydrogen ion through a molybdopterin adenylyltransferase resulting in the release of a diphosphate and a molybdopterin adenine dinucleotide.PW001888MetabolicSpecdb::CMs1083454Specdb::NmrOneD339868Specdb::NmrOneD339869Specdb::NmrOneD339870Specdb::NmrOneD339871Specdb::NmrOneD339872Specdb::NmrOneD339873Specdb::NmrOneD339874Specdb::NmrOneD339875Specdb::NmrOneD339876Specdb::NmrOneD339877Specdb::NmrOneD339878Specdb::NmrOneD339879Specdb::NmrOneD339880Specdb::NmrOneD339881Specdb::NmrOneD339882Specdb::NmrOneD339883Specdb::NmrOneD339884Specdb::NmrOneD339885Specdb::NmrOneD339886Specdb::NmrOneD339887HMDB0220623304237C0592421437CPD0-1882MolybdopterinFDB022906Molybdopterin molybdenumtransferaseP12281MOEA_ECOLImoeAhttp://ecmdb.ca/proteins/P12281.xmlUncharacterized protein ygfJQ46810YGFJ_ECOLIygfJhttp://ecmdb.ca/proteins/Q46810.xmlAdenylyl-molybdopterin + Hydrogen ion + Molybdate > Adenosine monophosphate + Water + molybdenum cofactorPW_R005941molybdenum cofactor + Cytidine triphosphate + Hydrogen ion > Pyrophosphate + Cytidylyl molybdenum cofactorPW_R005992molybdenum cofactor + Cytidine triphosphate + Hydrogen ion > Molybdopterin cytosine dinucleotide + PyrophosphatePW_R006148