2.0 2012-10-10 12:23:20 -0600 2015-06-03 17:26:14 -0600 ECMDB23236 M2MDB003626 molybdenum cofactor Molybdenum cofactor is a cofactor required for the activity of enzymes such as sulfite oxidase, xanthine oxidoreductase, and aldehyde oxidase. It is a coordination complex formed between molybdopterin (which, despite the name, does not contain molybdenum) and an oxide of molybdenum. Molybdenum-containing enzymes catalyze basic metabolic reactions in the nitrogen, sulfur, and carbon cycles. With the exception of the nitrogenase cofactor, molybdenum is incorporated into proteins as the molybdenum cofactor that contains a mononuclear molybdenum atom coordinated to the sulfur atoms of a pterin derivative named molybdopterin. Certain microorganisms can also utilize tungsten in a similar fashion. Molybdenum-cofactor-containing enzymes catalyze the transfer of an oxygen atom, ultimately derived from or incorporated into water, to or from a substrate in a two-electron redox reaction. MCD MoCo Molybdenum enzyme molybdenum cofactor Molybdoenzyme molybdenum-containing cofactor Molybdopterin cytosine dinucleotide MoO2(OH)DTPP-mCDP MoO₂(OH)Dtpp-mCDP Nitrate reductase molybdenum cofactor Nitric acid reductase molybdenum cofactor Pterin molybdenum cofactor C10H18MoN5O8PS2 527.32 528.938848315 molybdenum(2+) ion ({4-hydroxy-2-imino-6,7-disulfanyl-1H,2H,5H,5aH,8H,9aH,10H-pyrano[3,2-g]pteridin-8-yl}methoxy)phosphonic acid dihydrate molybdenum(2+) ion molybdopterin cofactor dihydrate 73508-07-3 O.O.[Mo++].OC1=NC(=N)NC2=C1NC1C(N2)OC(COP(O)(O)=O)C(S)=C1S InChI=1S/C10H14N5O6PS2.Mo.2H2O/c11-10-14-7-4(8(16)15-10)12-3-6(24)5(23)2(21-9(3)13-7)1-20-22(17,18)19;;;/h2-3,9,12,23-24H,1H2,(H2,17,18,19)(H4,11,13,14,15,16);;2*1H2/q;+2;; VUKICSJFFDCESC-UHFFFAOYSA-N Solid logp -5 ChemAxon pka_strongest_acidic -4.1 ChemAxon pka_strongest_basic 15 ChemAxon iupac molybdenum(2+) ion ({4-hydroxy-2-imino-6,7-disulfanyl-1H,2H,5H,5aH,8H,9aH,10H-pyrano[3,2-g]pteridin-8-yl}methoxy)phosphonic acid dihydrate ChemAxon average_mass 527.32 ChemAxon mono_mass 528.938848315 ChemAxon smiles O.O.[Mo++].OC1=NC(=N)NC2=C1NC1C(N2)OC(COP(O)(O)=O)C(S)=C1S ChemAxon formula C10H18MoN5O8PS2 ChemAxon inchi InChI=1S/C10H14N5O6PS2.Mo.2H2O/c11-10-14-7-4(8(16)15-10)12-3-6(24)5(23)2(21-9(3)13-7)1-20-22(17,18)19;;;/h2-3,9,12,23-24H,1H2,(H2,17,18,19)(H4,11,13,14,15,16);;2*1H2/q;+2;; ChemAxon inchikey VUKICSJFFDCESC-UHFFFAOYSA-N ChemAxon polar_surface_area 168.52 ChemAxon refractivity 109.78 ChemAxon polarizability 34.89 ChemAxon rotatable_bond_count 3 ChemAxon acceptor_count 10 ChemAxon donor_count 9 ChemAxon physiological_charge -2 ChemAxon formal_charge 2 ChemAxon GTP degradation GTP, produced in the nucleotide de novo biosyntheis pathway, interacts with a water molecule through a GTP cyclohydrolase resulting in a formate, hydrogen ion and a 7,8-dihydroneopterin 3'-triphosphate. The latter compound interacts with a water molecule through a dihydroneopterin triphosphate pyrophosphohydrolase resulting in the release of a pyrophosphate, a hydrogen ion and a 7,8-dihydroneopterin 3'-phosphate. The latter compound interacts with water spontaneously resulting in the release of a phosphate and a 7,8 dihydroneopterin. The latter compound interacts with a dihydroneopterin aldolase resulting in the release of a glycolaldehyde and a 6-hydroxymethyl-7,8-dihydropterin. This compound then is then diphosphorylated by reacting with a ATP driven 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase resulting in the release of a hydrogen ion, an AMP and 6-hydroxymethyl-7,8-dihydropterin diphosphate. GTP interacts with a cyclic pyranopterin monophosphate synthase resulting in the release of a diphosphate and a cyclic pyranopterin phosphate. The latter compound interacts with a thiocarboxylated small subunit of molybdopterin synthase (a protein) and a water molecule through a molybdopterin synthase resulting in the release of 4 hydrogen ions, 2 small subunits of molybdopterin synthase and a molybdopterin. The molybdopterin interacts with an ATP and a hydrogen ion through a molybdopterin adenylyltransferase resulting in the release of a diphosphate and a molybdopterin adenine dinucleotide. PW001888 Metabolic Specdb::CMs 1083454 Specdb::NmrOneD 339868 Specdb::NmrOneD 339869 Specdb::NmrOneD 339870 Specdb::NmrOneD 339871 Specdb::NmrOneD 339872 Specdb::NmrOneD 339873 Specdb::NmrOneD 339874 Specdb::NmrOneD 339875 Specdb::NmrOneD 339876 Specdb::NmrOneD 339877 Specdb::NmrOneD 339878 Specdb::NmrOneD 339879 Specdb::NmrOneD 339880 Specdb::NmrOneD 339881 Specdb::NmrOneD 339882 Specdb::NmrOneD 339883 Specdb::NmrOneD 339884 Specdb::NmrOneD 339885 Specdb::NmrOneD 339886 Specdb::NmrOneD 339887 HMDB02206 23304237 C05924 21437 CPD0-1882 Molybdopterin FDB022906 Molybdopterin molybdenumtransferase P12281 MOEA_ECOLI moeA http://ecmdb.ca/proteins/P12281.xml Uncharacterized protein ygfJ Q46810 YGFJ_ECOLI ygfJ http://ecmdb.ca/proteins/Q46810.xml Adenylyl-molybdopterin + Hydrogen ion + Molybdate > Adenosine monophosphate + Water + molybdenum cofactor PW_R005941 molybdenum cofactor + Cytidine triphosphate + Hydrogen ion > Pyrophosphate + Cytidylyl molybdenum cofactor PW_R005992 molybdenum cofactor + Cytidine triphosphate + Hydrogen ion > Molybdopterin cytosine dinucleotide + Pyrophosphate PW_R006148