2.0 2012-10-10 12:23:13 -0600 2015-06-03 17:26:14 -0600 ECMDB23234 M2MDB003624 8-oxo-dGMP 8-Oxo-dGMP is a metabolite of 8-oxo-dGTP which is a potent mutagenic substrate for DNA synthesis. 8-Oxo-dGTP is rapidly degraded to 8-oxo-dGMP by cellular 8-oxo-dGTPase activity. (2R,3S,5R)-5-(2-amino-6,8-dioxo-3,7-dihydropurin-9-yl)-3-hydroxyoxolan-2-ylmethyl dihydrogen phosphate (2R,3S,5R)-5-(2-amino-6,8-dioxo-3,7-Dihydropurin-9-yl)-3-hydroxyoxolan-2-ylmethyl dihydrogen phosphoric acid 2'-Deoxy-7,8-dihydro-8-oxo-5'-guanylate 2'-deoxy-7,8-dihydro-8-oxo-5'-guanylic acid 2'-deoxy-7,8-dihydro-8-oxoguanosine 5'-monophosphate 2'-Deoxy-7,8-dihydro-8-oxoguanosine 5'-monophosphoric acid 2'-Deoxy-8-oxo-7,8-dihydroguanosine 5'-(dihydrogen phosphate) 2'-Deoxy-8-oxo-7,8-dihydroguanosine 5'-(dihydrogen phosphoric acid) 8-hydroxydeoxyguanosine 5'-monophosphate 8-Hydroxydeoxyguanosine 5'-monophosphoric acid 8-OH-Dgmp 8-oxo-2'-deoxyguanosine-5'-monophosphate 8-oxo-2'-Deoxyguanosine-5'-monophosphoric acid 8-Oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate 8-oxo-7,8-dihydro-2'-Deoxyguanosine 5'-triphosphoric acid 8-Oxo-dGMP 8OG C10H14N5O8P 363.2206 363.057998961 {[(2R,3S,5R)-5-(6,8-dihydroxy-2-imino-3,9-dihydro-2H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy}phosphonic acid [(2R,3S,5R)-5-(6,8-dihydroxy-2-imino-3H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxyphosphonic acid [H][C@]1(O)C[C@@]([H])(O[C@]1([H])COP(O)(O)=O)N1C(O)=NC2=C1NC(=N)N=C2O InChI=1S/C10H14N5O8P/c11-9-13-7-6(8(17)14-9)12-10(18)15(7)5-1-3(16)4(23-5)2-22-24(19,20)21/h3-5,16H,1-2H2,(H,12,18)(H2,19,20,21)(H3,11,13,14,17)/t3-,4+,5+/m0/s1 AQIVLFLYHYFRKU-VPENINKCSA-N Solid logp -1.77 ALOGPS logs -1.74 ALOGPS solubility 6.61e+00 g/l ALOGPS logp -1.1 ChemAxon pka_strongest_acidic 1.29 ChemAxon pka_strongest_basic 0.33 ChemAxon iupac {[(2R,3S,5R)-5-(6,8-dihydroxy-2-imino-3,9-dihydro-2H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy}phosphonic acid ChemAxon average_mass 363.2206 ChemAxon mono_mass 363.057998961 ChemAxon smiles [H][C@]1(O)C[C@@]([H])(O[C@]1([H])COP(O)(O)=O)N1C(O)=NC2=C1NC(=N)N=C2O ChemAxon formula C10H14N5O8P ChemAxon inchi InChI=1S/C10H14N5O8P/c11-9-13-7-6(8(17)14-9)12-10(18)15(7)5-1-3(16)4(23-5)2-22-24(19,20)21/h3-5,16H,1-2H2,(H,12,18)(H2,19,20,21)(H3,11,13,14,17)/t3-,4+,5+/m0/s1 ChemAxon inchikey AQIVLFLYHYFRKU-VPENINKCSA-N ChemAxon polar_surface_area 202.74 ChemAxon refractivity 86.02 ChemAxon polarizability 30.46 ChemAxon rotatable_bond_count 4 ChemAxon acceptor_count 11 ChemAxon donor_count 7 ChemAxon physiological_charge -2 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 1084495 Specdb::EiMs 4395 Specdb::NmrOneD 334818 Specdb::NmrOneD 334819 Specdb::NmrOneD 334820 Specdb::NmrOneD 334821 Specdb::NmrOneD 334822 Specdb::NmrOneD 334823 Specdb::NmrOneD 334824 Specdb::NmrOneD 334825 Specdb::NmrOneD 334826 Specdb::NmrOneD 334827 Specdb::NmrOneD 334828 Specdb::NmrOneD 334829 Specdb::NmrOneD 334830 Specdb::NmrOneD 334831 Specdb::NmrOneD 334832 Specdb::NmrOneD 334833 Specdb::NmrOneD 334834 Specdb::NmrOneD 334835 Specdb::NmrOneD 334836 Specdb::NmrOneD 334837 Specdb::MsMs 25544 Specdb::MsMs 25545 Specdb::MsMs 25546 Specdb::MsMs 32102 Specdb::MsMs 32103 Specdb::MsMs 32104 HMDB11670 447903 C19968 63223 G42 FDB028359 Mutator mutT protein P08337 MUTT_ECOLI mutT http://ecmdb.ca/proteins/P08337.xml 8-oxo-dGTP + Water > 8-oxo-dGMP + Pyrophosphate 8-oxo-dGTP + Water <> 8-oxo-dGMP + Pyrophosphate R09832