2.0 2012-08-15 08:51:36 -0600 2015-06-03 17:22:02 -0600 ECMDB21661 M2MDB002051 Tetrahydrofolyl-[Glu](2) Tetrahydrofolyl-[Glu](n) is involved in the folate biosynthesis pathway. Tetrahydrofolyl-[Glu](n) can be reversibly converted into Tetrahydrofolyl-[Glu](2) by folylpolyglutamate synthase [EC:6.3.2.17]. Tetrahydrofolyl-[Glu](n) can be irreversibly converted into tetrahydrofolate by gamma-glutamyl hydrolase [EC:3.4.19.9]. N-[(4-{[(2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-g-glutamyl-L-glutamate N-[(4-{[(2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-g-glutamyl-L-glutamic acid N-[(4-{[(2-Amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-gamma-glutamyl-L-glutamate N-[(4-{[(2-Amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-gamma-glutamyl-L-glutamic acid N-[(4-{[(2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-γ-glutamyl-L-glutamate N-[(4-{[(2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-γ-glutamyl-L-glutamic acid Tetrahydrofolyl-[Glu](2) Tetrahydrofolyl-[Glu](N+1) Tetrahydropteroyl-[g-glu]N Tetrahydropteroyl-[g-glu]n+1 Tetrahydropteroyl-[gamma-Glu]N Tetrahydropteroyl-[gamma-Glu]N+1 Tetrahydropteroyl-[γ-glu]N Tetrahydropteroyl-[γ-glu]n+1 THF-L-glutamate THF-L-glutamic acid THF-polyglutamate THF-polyglutamic acid C24H30N8O9 574.5432 574.213574598 2-{4-[(4-{[(2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]-4-carboxybutanamido}pentanedioic acid 2-{4-[(4-{[(2-amino-4-oxo-5,6,7,8-tetrahydro-3H-pteridin-6-yl)methyl]amino}phenyl)formamido]-4-carboxybutanamido}pentanedioic acid NC1=NC2=C(NC(CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)NC(CCC(O)=O)C(O)=O)C(O)=O)CN2)C(=O)N1 InChI=1S/C24H30N8O9/c25-24-31-19-18(21(37)32-24)28-13(10-27-19)9-26-12-3-1-11(2-4-12)20(36)30-15(23(40)41)5-7-16(33)29-14(22(38)39)6-8-17(34)35/h1-4,13-15,26,28H,5-10H2,(H,29,33)(H,30,36)(H,34,35)(H,38,39)(H,40,41)(H4,25,27,31,32,37) ZAOGJXDWOQXFBW-UHFFFAOYSA-N Solid Cytoplasm logp -1.99 ALOGPS logs -3.24 ALOGPS solubility 3.28e-01 g/l ALOGPS logp -4.3 ChemAxon pka_strongest_acidic 2.41 ChemAxon pka_strongest_basic 4.66 ChemAxon iupac 2-{4-[(4-{[(2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]-4-carboxybutanamido}pentanedioic acid ChemAxon average_mass 574.5432 ChemAxon mono_mass 574.213574598 ChemAxon smiles NC1=NC2=C(NC(CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)NC(CCC(O)=O)C(O)=O)C(O)=O)CN2)C(=O)N1 ChemAxon formula C24H30N8O9 ChemAxon inchi InChI=1S/C24H30N8O9/c25-24-31-19-18(21(37)32-24)28-13(10-27-19)9-26-12-3-1-11(2-4-12)20(36)30-15(23(40)41)5-7-16(33)29-14(22(38)39)6-8-17(34)35/h1-4,13-15,26,28H,5-10H2,(H,29,33)(H,30,36)(H,34,35)(H,38,39)(H,40,41)(H4,25,27,31,32,37) ChemAxon inchikey ZAOGJXDWOQXFBW-UHFFFAOYSA-N ChemAxon polar_surface_area 273.67 ChemAxon refractivity 149.67 ChemAxon polarizability 57.11 ChemAxon rotatable_bond_count 14 ChemAxon acceptor_count 14 ChemAxon donor_count 10 ChemAxon physiological_charge -3 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 19505 Specdb::CMs 39106 Specdb::CMs 282408 Specdb::CMs 372794 Specdb::CMs 372795 Specdb::CMs 372796 Specdb::CMs 372797 Specdb::CMs 372798 Specdb::CMs 372799 Specdb::CMs 372800 Specdb::CMs 372801 Specdb::CMs 372802 Specdb::CMs 372803 Specdb::CMs 372804 Specdb::CMs 372805 Specdb::CMs 372806 Specdb::CMs 372807 Specdb::CMs 372808 Specdb::CMs 372809 Specdb::CMs 372810 Specdb::CMs 372811 Specdb::CMs 372812 Specdb::CMs 372813 Specdb::CMs 372814 Specdb::CMs 372815 Specdb::NmrOneD 91792 Specdb::NmrOneD 91793 Specdb::NmrOneD 91794 Specdb::NmrOneD 91795 Specdb::NmrOneD 91796 Specdb::NmrOneD 91797 Specdb::NmrOneD 91798 Specdb::NmrOneD 91799 Specdb::NmrOneD 91800 Specdb::NmrOneD 91801 Specdb::NmrOneD 91802 Specdb::NmrOneD 91803 Specdb::NmrOneD 91804 Specdb::NmrOneD 91805 Specdb::NmrOneD 91806 Specdb::NmrOneD 91807 Specdb::NmrOneD 91808 Specdb::NmrOneD 91809 Specdb::NmrOneD 91810 Specdb::NmrOneD 91811 Specdb::MsMs 26492 Specdb::MsMs 26493 Specdb::MsMs 26494 Specdb::MsMs 33050 Specdb::MsMs 33051 Specdb::MsMs 33052 Specdb::MsMs 2275053 Specdb::MsMs 2275054 Specdb::MsMs 2275055 Specdb::MsMs 3091181 Specdb::MsMs 3091182 Specdb::MsMs 3091183 HMDB06825 442163 390680 C09332 27650 Bifunctional protein folC P08192 FOLC_ECOLI folC http://ecmdb.ca/proteins/P08192.xml Adenosine triphosphate + Tetrahydrofolic acid + L-Glutamate <> ADP + Phosphate + Tetrahydrofolyl-[Glu](2) R00942