Selenophosphate (ECMDB21449) (M2MDB001844)

IdentificationTaxonomyPhysical PropertiesBiological PropertiesSpectraConcentrationsLinksReferencesEnzymes (1)XML
Proteins (1)
Record Information
Version2.0
Creation Date2012-08-09 09:16:17 -0600
Update Date2015-06-03 17:21:31 -0600
Secondary Accession Numbers
  • ECMDB21449
Identification
Name:Selenophosphate
DescriptionSelenophosphate is the universal selenium donor that is required for the formation of selenium dependent enzymes and selenium tRNAs (i.e.: selenocysteyl-tRNA). Selenophosphate is also the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons. Selenophosphate synthetase (EC 2.7.9.3, SPS, product of the E. coli selD gene) produces monoselenophosphate from selenide and ATP. (PMID: 8986768, 10609888)
Structure
Thumb
MOLSDFPDBSMILESInChI
Synonyms:
  • Dihydroxy-oxido-selanylidenephosphorane
  • Phosphorus monoselenide
  • Phosphorus selenide (PSe)
  • Selenidophosphonate
  • Selenidophosphonic acid
  • Selenophosphoric acid
  • Selenoxo-phosphino
  • SePO3
  • SePO3
Chemical Formula:H2O3PSe
Weight:Average: 159.95
Monoisotopic: 160.89067727
InChI Key:JRPHGDYSKGJTKZ-UHFFFAOYSA-M
InChI:InChI=1S/H3O3PSe/c1-4(2,3)5/h(H3,1,2,3,5)/p-1
CAS number:289702-60-9
IUPAC Name:hydroxy(selanylidene)phosphonous acid
Traditional IUPAC Name:selenophosphoric acid
SMILES:OP(O)([O-])=[Se]
Chemical Taxonomy
Description belongs to the class of inorganic compounds known as non-metal selenophosphates. These are inorganic compounds in which the largest oxoanion is selenophosphate, and in which the heaviest atom not in an oxoanion is a non-metal element.
KingdomInorganic compounds
Super ClassMixed metal/non-metal compounds
ClassOther mixed metal/non-metal oxoanionic compounds
Sub ClassNon-metal selenophosphates
Direct ParentNon-metal selenophosphates
Alternative ParentsNot Available
Substituents
  • Non-metal selenophosphate
Molecular FrameworkNot Available
External Descriptors
Physical Properties
State:Solid
Charge:-3
Melting point:Not Available
Experimental Properties:
PropertyValueSource
Predicted Properties
PropertyValueSource
logP-1.1ChemAxon
pKa (Strongest Acidic)-6.3ChemAxon
Physiological Charge-3ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area60.69 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity26.32 m³·mol⁻¹ChemAxon
Polarizability7.23 ųChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Biological Properties
Cellular Locations:Cytoplasm
Reactions:
tRNA containing 5-methylaminomethyl-2-thiouridylate + Selenophosphate > unknown + tRNA containing 5-methylaminomethyl-2-selenouridine
Water + Selenium + Adenosine triphosphate > Phosphate + Selenophosphate + Adenosine monophosphate
SMPDB Pathways:
Selenium metabolismPW001894 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways:Not Available
EcoCyc Pathways:Not Available
Concentrations
Not Available
Spectra
Spectra:
Spectrum TypeDescriptionSplash Key
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positivesplash10-08fr-1900000000-8bbadba0caff6a2e9bfcView in MoNA
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, PositiveNot AvailableView in JSpectraViewer
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, PositiveNot AvailableView in JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-03di-1900000000-7c4cc2e6d42e57db69e1View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-004i-9400000000-26abcaf5c7c97fc49c19View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-03di-3900000000-93b2ddc3ff356009e71cView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-03di-0900000000-7a29d9af6cc1eab8dbe9View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-03di-0900000000-7a29d9af6cc1eab8dbe9View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-03di-0900000000-7a29d9af6cc1eab8dbe9View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-03di-0900000000-1f4443872a69e75b6bdbView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-03di-0900000000-080a642c7d3be639b5e4View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-03di-1900000000-3869630825a1dc7ee071View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-03di-0900000000-dc2cdaa153ba7c67cfd0View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-03di-0900000000-c3c8ecde54e023841cfcView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0006-2900000000-6b17f7962c7285173eb8View in MoNA
References
References:
  • Chung HJ, Yoon SI, Shin SH, Koh YA, Lee SJ, Lee YS, Bae S: p53-Mediated enhancement of radiosensitivity by selenophosphate synthetase 1 overexpression. J Cell Physiol. 2006 Oct;209(1):131-41. Pubmed: 16786570
  • Guimaraes, M. J., Peterson, D., Vicari, A., Cocks, B. G., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Ferrick, D. A., Kastelein, R. A., Bazan, J. F., Zlotnik, A. (1996). "Identification of a novel selD homolog from eukaryotes, bacteria, and archaea: is there an autoregulatory mechanism in selenocysteine metabolism?" Proc Natl Acad Sci U S A 93:15086-15091. Pubmed: 8986768
  • Lacourciere GM: Biosynthesis of selenophosphate. Biofactors. 1999;10(2-3):237-44. Pubmed: 10609888
  • van der Werf, M. J., Overkamp, K. M., Muilwijk, B., Coulier, L., Hankemeier, T. (2007). "Microbial metabolomics: toward a platform with full metabolome coverage." Anal Biochem 370:17-25. Pubmed: 17765195
  • Winder, C. L., Dunn, W. B., Schuler, S., Broadhurst, D., Jarvis, R., Stephens, G. M., Goodacre, R. (2008). "Global metabolic profiling of Escherichia coli cultures: an evaluation of methods for quenching and extraction of intracellular metabolites." Anal Chem 80:2939-2948. Pubmed: 18331064
Synthesis Reference:Not Available
Material Safety Data Sheet (MSDS)Not Available
External Links:
ResourceLink
CHEBI ID16144
HMDB IDHMDB06407
Pubchem Compound ID1092
Kegg IDC05172
ChemSpider ID7822178
Wikipedia IDNot Available
BioCyc IDSEPO3
EcoCyc IDSEPO3

Enzymes

Protein Details
1. tRNA 2-selenouridine synthase
General function:
Involved in transferase activity, transferring selenium-containing groups
Specific function:
Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
Gene Name:
selU
Uniprot ID:
P33667
Molecular weight:
41110
Reactions
5-methylaminomethyl-2-thiouridine + selenophosphate = 5-methylaminomethyl-2-selenouridine + phosphate.