2.0 2012-08-09 09:16:16 -0600 2015-06-03 17:21:31 -0600 ECMDB21445 M2MDB001840 Pectic acid Pectic acid is also known as polygalacturonic acid. (Wikipedia) In E. coli, pectic acid can be produced from pectin in a reaction catalyzed by pectinesterase (EC 3.1.1.11). (KEGG) (1,4-α-D-Galacturonosyl)n 1,4-α-D-galacturonide a Pectate A pectic acid A poly(1,4-α-D-galacturonate) a Poly(1,4-α-D-galacturonic acid) a-delta-Galactopyranuronate a-delta-Galactopyranuronic acid a-delta-Galacturonate a-delta-Galacturonic acid a-delta-Polygalacturonate a-delta-Polygalacturonic acid a-δ-Galactopyranuronate a-δ-Galactopyranuronic acid a-δ-Galacturonate a-δ-Galacturonic acid a-δ-Polygalacturonate a-δ-Polygalacturonic acid alpha-delta-Galactopyranuronate Alpha-delta-galactopyranuronic acid alpha-delta-Galacturonate Alpha-delta-galacturonic acid alpha-delta-Polygalacturonate Alpha-delta-polygalacturonic acid An α-D-polygalacturonate An α-D-polygalacturonic acid Calcium pectate Calcium pectic acid Calcium polygalacturonate Calcium polygalacturonic acid D-galacturonan D-galacturonate D-Galacturonic acid Delta-galacturonan Delta-galacturonate Delta-Galacturonic acid Galacturonan Galacturonate Galacturonic acid Pectate Poly(1,4-α-D-galacturonate)(n) Poly(1,4-α-D-galacturonic acid)(N) Poly(1,4-a-D-galacturonate) Poly(1,4-a-D-galacturonic acid) Poly(1,4-a-delta-galacturonate) Poly(1,4-a-delta-galacturonic acid) Poly(1,4-a-δ-galacturonate) Poly(1,4-a-δ-galacturonic acid) Poly(1,4-alpha-D-galacturonate) Poly(1,4-alpha-D-galacturonic acid) Poly(1,4-alpha-delta-galacturonate) Poly(1,4-alpha-delta-galacturonic acid) Poly(1,4-α-D-galacturonate) Poly(1,4-α-D-galacturonic acid) Poly(1,4-α-δ-galacturonate) Poly(1,4-α-δ-galacturonic acid) Polygalacturonate Polygalacturonic acid Sodium pectate Sodium pectic acid Sulfated polygalacturonate Sulfated polygalacturonic acid Sulphated polygalacturonate Sulphated polygalacturonic acid α-δ-Galactopyranuronate α-δ-Galactopyranuronic acid α-δ-Galacturonate α-δ-Galacturonic acid α-δ-Polygalacturonate α-δ-Polygalacturonic acid δ-Galacturonan δ-Galacturonate δ-Galacturonic acid C6H10O7 194.1394 194.042652674 (2S,3R,4S,5R,6S)-3,4,5,6-tetrahydroxyoxane-2-carboxylic acid α-D-galacturonic acid O[C@H]1O[C@@H]([C@H](O)[C@H](O)[C@H]1O)C(O)=O InChI=1S/C6H10O7/c7-1-2(8)4(5(10)11)13-6(12)3(1)9/h1-4,6-9,12H,(H,10,11)/t1-,2+,3+,4-,6-/m0/s1 AEMOLEFTQBMNLQ-BKBMJHBISA-N Solid logp -2.30 ALOGPS logs 0.18 ALOGPS solubility 2.95e+02 g/l ALOGPS logp -2.6 ChemAxon pka_strongest_acidic 3.21 ChemAxon pka_strongest_basic -3.7 ChemAxon iupac (2S,3R,4S,5R,6S)-3,4,5,6-tetrahydroxyoxane-2-carboxylic acid ChemAxon average_mass 194.1394 ChemAxon mono_mass 194.042652674 ChemAxon smiles O[C@H]1O[C@@H]([C@H](O)[C@H](O)[C@H]1O)C(O)=O ChemAxon formula C6H10O7 ChemAxon inchi InChI=1S/C6H10O7/c7-1-2(8)4(5(10)11)13-6(12)3(1)9/h1-4,6-9,12H,(H,10,11)/t1-,2+,3+,4-,6-/m0/s1 ChemAxon inchikey AEMOLEFTQBMNLQ-BKBMJHBISA-N ChemAxon polar_surface_area 127.45 ChemAxon refractivity 35.79 ChemAxon polarizability 16.27 ChemAxon rotatable_bond_count 1 ChemAxon acceptor_count 7 ChemAxon donor_count 5 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon Starch and sucrose metabolism The metabolism of starch and sucrose begins with D-fructose interacting with a D-glucose in a reversible reaction through a maltodextrin glucosidase resulting in a water molecule and a sucrose. D-fructose is phosphorylated through an ATP driven fructokinase resulting in the release of an ADP, a hydrogen ion and a Beta-D-fructofuranose 6-phosphate. This compound can also be introduced into the cytoplasm through either a mannose PTS permease or a hexose-6-phosphate:phosphate antiporter. The Beta-D-fructofuranose 6-phosphate is isomerized through a phosphoglucose isomerase resulting in a Beta-D-glucose 6-phosphate. This compound can also be incorporated by glucose PTS permease or a hexose-6-phosphate:phosphate antiporter. The beta-D-glucose 6 phosphate can also be produced by a D-glucose being phosphorylated by an ATP-driven glucokinase resulting in a ADP, a hydrogen ion and a Beta-D-glucose 6 phosphate. The beta-D-glucose can produce alpha-D-glucose-1-phosphate by two methods: 1.-Beta-D-glucose is isomerized into an alpha-D-Glucose 6-phosphate and then interacts in a reversible reaction through a phosphoglucomutase-1 resulting in a alpha-D-glucose-1-phosphate. 2.-Beta-D-glucose interacts with a putative beta-phosphoglucomutase resulting in a Beta-D-glucose 1-phosphate. Beta-D-glucose 1-phosphate can be incorporated into the cytoplasm through a glucose PTS permease. This compound is then isomerized into a Alpha-D-glucose-1-phosphate The beta-D-glucose can cycle back into a D-fructose by first interacting with D-fructose in a reversible reaction through a Polypeptide: predicted glucosyltransferase resulting in the release of a phosphate and a sucrose. The sucrose then interacts in a reversible reaction with a water molecule through a maltodextrin glucosidase resulting in a D-glucose and a D-fructose. Alpha-D-glucose-1-phosphate can produce glycogen in by two different sets of reactions: 1.-Alpha-D-glucose-1-phosphate interacts with a hydrogen ion and an ATP through a glucose-1-phosphate adenylyltransferase resulting in a pyrophosphate and an ADP-glucose. The ADP-glucose then interacts with an amylose through a glycogen synthase resulting in the release of an ADP and an Amylose. The amylose then interacts with 1,4-α-glucan branching enzyme resulting in glycogen 2.- Alpha-D-glucose-1-phosphate interacts with amylose through a maltodextrin phosphorylase resulting in a phosphate and a glycogen. Alpha-D-glucose-1-phosphate can also interacts with UDP-galactose through a galactose-1-phosphate uridylyltransferase resulting in a galactose 1-phosphate and a Uridine diphosphate glucose. The UDP-glucose then interacts with an alpha-D-glucose 6-phosphate through a trehalose-6-phosphate synthase resulting in a uridine 5'-diphosphate, a hydrogen ion and a Trehalose 6- phosphate. The latter compound can also be incorporated into the cytoplasm through a trehalose PTS permease. Trehalose interacts with a water molecule through a trehalose-6-phosphate phosphatase resulting in the release of a phosphate and an alpha,alpha-trehalose.The alpha,alpha-trehalose can also be obtained from glycogen being metabolized through a glycogen debranching enzyme resulting in a the alpha, alpha-trehalose. This compound ca then be hydrated through a cytoplasmic trehalase resulting in the release of an alpha-D-glucose and a beta-d-glucose. Glycogen is then metabolized by reacting with a phosphate through a glycogen phosphorylase resulting in a alpha-D-glucose-1-phosphate and a dextrin. The dextrin is then hydrated through a glycogen phosphorylase-limit dextrin α-1,6-glucohydrolase resulting in the release of a debranched limit dextrin and a maltotetraose. This compound can also be incorporated into the cytoplasm through a maltose ABC transporter. The maltotetraose interacts with a phosphate through a maltodextrin phosphorylase releasing a alpha-D-glucose-1-phosphate and a maltotriose. The maltotriose can also be incorporated through a maltose ABC transporter. The maltotriose can then interact with water through a maltodextrin glucosidase resulting in a D-glucose and a D-maltose. D-maltose can also be incorporated through a maltose ABC transporter The D-maltose can then interact with a maltotriose through a amylomaltase resulting in a maltotetraose and a D-glucose. The D-glucose is then phosphorylated through an ATP driven glucokinase resulting in a hydrogen ion, an ADP and a Beta-D-glucose 6-phosphate PW000941 ec00500 Metabolic Pentose and glucuronate interconversions ec00040 Metabolic pathways eco01100 Specdb::CMs 9952 Specdb::CMs 38584 Specdb::CMs 160219 Specdb::NmrOneD 135830 Specdb::NmrOneD 135831 Specdb::NmrOneD 135832 Specdb::NmrOneD 135833 Specdb::NmrOneD 135834 Specdb::NmrOneD 135835 Specdb::NmrOneD 135836 Specdb::NmrOneD 135837 Specdb::NmrOneD 135838 Specdb::NmrOneD 135839 Specdb::NmrOneD 135840 Specdb::NmrOneD 135841 Specdb::NmrOneD 135842 Specdb::NmrOneD 135843 Specdb::NmrOneD 135844 Specdb::NmrOneD 135845 Specdb::NmrOneD 135846 Specdb::NmrOneD 135847 Specdb::NmrOneD 135848 Specdb::NmrOneD 135849 Specdb::MsMs 27911 Specdb::MsMs 27912 Specdb::MsMs 27913 Specdb::MsMs 34469 Specdb::MsMs 34470 Specdb::MsMs 34471 Specdb::MsMs 2737369 Specdb::MsMs 2737370 Specdb::MsMs 2737371 Specdb::MsMs 2968404 Specdb::MsMs 2968405 Specdb::MsMs 2968406 HMDB03363 445929 393411 C00470 62969 PECTATE ADA Pectate van der Werf, M. J., Overkamp, K. M., Muilwijk, B., Coulier, L., Hankemeier, T. (2007). "Microbial metabolomics: toward a platform with full metabolome coverage." Anal Biochem 370:17-25. 17765195 Serban D, Rordorf-Adam C: Binding characteristics of human serum amyloid P component. Scand J Immunol. 1987 Mar;25(3):275-81. 3105045 Nakajima N, Ishihara K, Matsuura Y: Dietary-fiber-degrading enzymes from a human intestinal Clostridium and their application to oligosaccharide production from nonstarchy polysaccharides using immobilized cells. Appl Microbiol Biotechnol. 2002 Jul;59(2-3):182-9. Epub 2002 May 3. 12111144 Putative acyl-CoA thioester hydrolase ybhC P46130 YBHC_ECOLI ybhC http://ecmdb.ca/proteins/P46130.xml L-Lyxose + Water <> Methanol + Pectic acid R02362 Pectin + Water <> Methanol + Pectic acid R02362 R06250