Record Information
Version2.0
Creation Date2012-07-30 14:55:32 -0600
Update Date2015-06-03 17:21:16 -0600
Secondary Accession Numbers
  • ECMDB21380
Identification
Name:Inorganic phosphate
DescriptionPhosphates are important in biochemistry and biogeochemistry or ecology. In ecology, because of its important role in biological systems, phosphate is a highly sought after resource. Once used, it is often a limiting nutrient in environments, and its availability may govern the rate of growth of organisms. In biological systems, phosphorus is found as a free phosphate ion in solution and is called inorganic phosphate, to distinguish it from phosphates bound in various phosphate esters. Inorganic phosphate is generally denoted Pi, and at physiological (neutral) pH primarily consists of a mixture of HPO4(2-) and H2PO4(-) ions. Phosphates in cells are most commonly found in the form of adenosine phosphates (AMP, ADP and ATP) and in DNA and RNA and can be released by the hydrolysis of ATP or ADP. In addition, the addition and removal of phosphate from proteins in all cells (by kinases and phosphatases) is a pivotal strategy in the regulation of metabolic processes. (Wikipedia) Because the addition and removal of phosphates to and from biochemical compounds is so common, inorganic phosphate (Pi) is involved in a huge number of reactions in E. coli. Also, many E. coli enzymes are activated or inhibited by phosphate. (EcoCyc) Some processes that phosphates (Pi) are involved with in E. coli are oxidative phosphorylation, where a phosphate is added to ADP to make ATP, and biosynthesis of peptidoglycan, a component of bacterial cell walls. (KEGG)
Structure
Thumb
Synonyms:
  • HPO4-2
  • HPO42-
  • HPO4-2
  • HPO42-
  • Inorganic phosphate
  • Inorganic phosphoric acid
  • NFB Orthophosphate
  • NFB Orthophosphoric acid
  • O-Phosphate
  • O-Phosphorate
  • O-Phosphoric acid
  • Ortho-phosphate
  • ortho-Phosphoric acid
  • Orthophosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
  • Orthophosphorate
  • Orthophosphoric acid
  • Orthophosphoric acid (PO43-)
  • Orthophosphoric acid(3-)
  • Phosphate
  • Phosphate (NF)
  • Phosphate (PO43-)
  • Phosphate anion(3-)
  • PHOSPHATE ION
  • Phosphate ion (PO43-)
  • Phosphate ion(3-)
  • Phosphate trianion
  • Phosphate(3-)
  • Phosphate-inorganic
  • Phosphorate
  • Phosphorate (NF)
  • Phosphorate ion(3-)
  • Phosphoric acid
  • Phosphoric acid (NF)
  • Phosphoric acid (PO43-)
  • Phosphoric acid anion(3-)
  • PHOSPHoric acid ion
  • Phosphoric acid ion (PO43-)
  • Phosphoric acid ion(3-)
  • Phosphoric acid trianion
  • Phosphoric acid(3-)
  • Phosphoric acid-inorganic
  • Pi
  • PO43
  • PO43-
  • PO43-
  • Tetraoxidophosphate(3)
  • Tetraoxidophosphoric acid(3)
  • Tetraoxophosphate(3)
  • Tetraoxophosphate(5)
  • Tetraoxophosphoric acid(3)
  • Tetraoxophosphoric acid(5)
  • [PO4]3
Chemical Formula:H3O4P
Weight:Average: 97.9952
Monoisotopic: 97.976895096
InChI Key:NBIIXXVUZAFLBC-UHFFFAOYSA-N
InChI:InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)
CAS number:14265-44-2
IUPAC Name:phosphoric acid
Traditional IUPAC Name:phosphoric acid
SMILES:OP(O)(O)=O
Chemical Taxonomy
Description belongs to the class of inorganic compounds known as non-metal phosphates. These are inorganic non-metallic compounds containing a phosphate as its largest oxoanion.
KingdomInorganic compounds
Super ClassHomogeneous non-metal compounds
ClassNon-metal oxoanionic compounds
Sub ClassNon-metal phosphates
Direct ParentNon-metal phosphates
Alternative Parents
Substituents
  • Non-metal phosphate
  • Inorganic oxide
Molecular FrameworkNot Available
External Descriptors
Physical Properties
State:Solid
Charge:-2
Melting point:Not Available
Experimental Properties:
PropertyValueSource
Predicted Properties
PropertyValueSource
logP-1ChemAxon
pKa (Strongest Acidic)1.8ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area77.76 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity14.65 m³·mol⁻¹ChemAxon
Polarizability5.81 ųChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Biological Properties
Cellular Locations:Cytoplasm
Reactions:
Adenosine triphosphate + Acetyl-CoA + Carbonic acid > ADP + Inorganic phosphate + Malonyl-CoA
Adenosine triphosphate + biotin-[carboxyl-carrier-protein] + Carbon dioxide > ADP + Inorganic phosphate + carboxy-biotin-[carboxyl-carrier-protein]
An acylphosphate + Water > a carboxylate + Inorganic phosphate
Alpha-D-glucose 1-phosphate + Water > D-Glucose + Inorganic phosphate
Adenosine triphosphate + Water + monosaccharide(Out) > ADP + Inorganic phosphate + monosaccharide(In)
A phosphate monoester + Water > an alcohol + Inorganic phosphate
N-Acetyl-L-glutamate 5-semialdehyde + NADP + Inorganic phosphate > N-Acetyl-L-glutamyl 5-phosphate + NADPH
Phosphoenolpyruvic acid + Shikimate 3-phosphate > Inorganic phosphate + 5-O-(1-Carboxyvinyl)-3-phosphoshikimate
2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate > 3-Dehydroquinate + Inorganic phosphate
5-O-(1-Carboxyvinyl)-3-phosphoshikimate > Chorismate + Inorganic phosphate
Phosphoenolpyruvic acid + D-Erythrose 4-phosphate + Water > 2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + Inorganic phosphate
Adenosine triphosphate + Water + K(+)(Out) > ADP + Inorganic phosphate + K(+)(In)
Adenosine triphosphate + Water + Mg(2+)(Out) > ADP + Inorganic phosphate + Mg(2+)(In)
Adenosine triphosphate + Water + H(+)(In) > ADP + Inorganic phosphate + H(+)(Out)
Adenosine triphosphate + Water + Cd(2+)(In) > ADP + Inorganic phosphate + Cd(2+)(Out)
Adenosine triphosphate + Water + Zn(2+)(In) > ADP + Inorganic phosphate + Zn(2+)(Out)
Adenosine triphosphate + 7,8-Diaminononanoate + Carbon dioxide > ADP + Inorganic phosphate + Dethiobiotin
Adenosine triphosphate + Water + vitamin B12(Out) > ADP + Inorganic phosphate + vitamin B12(In)
Inorganic phosphate + Oxalacetic acid > Water + Phosphoenolpyruvic acid + Carbonic acid
2 Adenosine triphosphate + L-Glutamine + Carbonic acid + Water >2 ADP + Inorganic phosphate + L-Glutamate + Carbamoylphosphate
Adenosine triphosphate + Water + heme(In) > ADP + Inorganic phosphate + heme(Out)
Adenosylcobalamin + Water > Adenosylcobalamin + Inorganic phosphate
N1-(5-Phospho-a-D-ribosyl)-5,6-dimethylbenzimidazole + Water > alpha-ribazole + Inorganic phosphate
Adenosine triphosphate + Water + Cu(+)(In) > ADP + Inorganic phosphate + Cu(+)(Out)
A 3'-ribonucleotide + Water > a ribonucleoside + Inorganic phosphate
Adenosine triphosphate + Water + sulfate(Out) > ADP + Inorganic phosphate + sulfate(In)
Adenosine 3',5'-diphosphate + Water > Adenosine monophosphate + Inorganic phosphate
Adenosine triphosphate + Water > ADP + Inorganic phosphate
Adenosine triphosphate + 2 D-Alanine > ADP + Inorganic phosphate + D-Alanyl-D-alanine
Purine nucleoside + Inorganic phosphate > Purine + Ribose-1-phosphate
L-Aspartate-semialdehyde + Inorganic phosphate + NADP > L-4-aspartyl phosphate + NADPH
Protein tyrosine phosphate + Water > protein tyrosine + Inorganic phosphate
Fructose 1,6-bisphosphate + Water > Fructose 6-phosphate + Inorganic phosphate
Adenosine triphosphate + Water + Fe(3+)(Out) > ADP + Inorganic phosphate + Fe(3+)(In)
Adenosine triphosphate + Water + iron chelate(Out) > ADP + Inorganic phosphate + iron chelate(In)
Adenosine triphosphate + tetrahydropteroyl-(gamma-Glu)(n) + L-Glutamate > ADP + Inorganic phosphate + tetrahydropteroyl-(gamma-Glu)(n+1)
Adenosine triphosphate + 7,8-Dihydropteroic acid + L-Glutamate > ADP + Inorganic phosphate + Dihydrofolic acid
D-Glyceraldehyde 3-phosphate + Inorganic phosphate + NAD > 3-phospho-D-glyceroyl phosphate + NADH
Adenosine triphosphate + L-Glutamate + Ammonia > ADP + Inorganic phosphate + L-Glutamine
D-Glycero-D-manno-heptose 1,7-bisphosphate + Water > D-glycero-beta-D-manno-heptose 1-phosphate + Inorganic phosphate
Phosphoglycolic acid + Water > Glycolic acid + Inorganic phosphate
Guanosine 3'-diphosphate 5'-triphosphate + Water > Guanosine 3',5'-bis(diphosphate) + Inorganic phosphate
Adenosine triphosphate + L-Glutamate + L-Cysteine > ADP + Inorganic phosphate + gamma-Glutamylcysteine
Adenosine triphosphate + gamma-Glutamylcysteine + Glycine > ADP + Inorganic phosphate + Glutathione
Glutathione + Spermidine + Adenosine triphosphate > Glutathionylspermidine + ADP + Inorganic phosphate
Histidinol phosphate + Water > L-Histidinol + Inorganic phosphate
Pyrophosphate + Water >2 Inorganic phosphate
Phosphoenolpyruvic acid + D-Arabinose 5-phosphate + Water > 3-Deoxy-D-manno-octulosonate 8-phosphate + Inorganic phosphate
3-Deoxy-D-manno-octulosonate 8-phosphate + Water > 3-Deoxy-D-manno-octulosonate + Inorganic phosphate
Guanosine triphosphate + Water > Guanosine diphosphate + Inorganic phosphate
Adenosine triphosphate + Water + D-Maltose > ADP + Inorganic phosphate + D-Maltose
Adenosine triphosphate + Water + xenobiotic(In) > ADP + Inorganic phosphate + xenobiotic(Out)
Adenosine triphosphate + L-Methionine + Water > Inorganic phosphate + Pyrophosphate + S-adenosyl-L-methionine
Dihydroxyacetone phosphate > Pyruvaldehyde + Inorganic phosphate
Adenosine triphosphate + Water + Molybdate > ADP + Inorganic phosphate + Molybdate
2(alpha-D-mannosyl)-3-phosphoglycerate + Water > 2(alpha-D-Mannosyl)-D-glycerate + Inorganic phosphate
Phosphoenolpyruvic acid + Uridine diphosphate-N-acetylglucosamine > Inorganic phosphate + UDP-N-Acetyl-3-(1-carboxyvinyl)-D-glucosamine
Adenosine triphosphate + UDP-N-Acetylmuraminate + L-Alanine > ADP + Inorganic phosphate + UDP-N-Acetylmuramoyl-L-alanine
Adenosine triphosphate + UDP-N-Acetylmuramoyl-L-alanine + DL-Glutamic acid > ADP + Inorganic phosphate + UDP-N-Acetylmuramoyl-L-alanyl-D-glutamate
Adenosine triphosphate + UDP-N-Acetylmuramoyl-L-alanyl-D-glutamate + Meso-2,6-Diaminoheptanedioate > ADP + Inorganic phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelate-D-alanine
Adenosine triphosphate + UDP-N-Acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-Alanyl-D-alanine > ADP + Inorganic phosphate + UDP-N-Acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine
Dihydroxyacetone phosphate + Iminoaspartic acid > Quinolinic acid +2 Water + Inorganic phosphate
A 5'-ribonucleotide + Water > a ribonucleoside + Inorganic phosphate
A nucleoside triphosphate + Water > a nucleoside diphosphate + Inorganic phosphate
Adenosine triphosphate + Water + Ni(2+)(Out) > ADP + Inorganic phosphate + Ni(2+)(In)
Adenosine triphosphate + Water + Nickel > ADP + Inorganic phosphate + Nickel
ADP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide > Adenosine monophosphate + Inorganic phosphate + NADH
Carbamoylphosphate + Ornithine > Inorganic phosphate + Citrulline
Trehalose 6-phosphate + Water > Trehalose + Inorganic phosphate
1-Deoxy-D-xylulose 5-phosphate + 2-Amino-3-phosphonopropionic acid > Pyridoxine 5'-phosphate + Inorganic phosphate +2 Water
Phosphatidylglycerophosphate + Water > phosphatidylglycerol + Inorganic phosphate
1,2-diacyl-sn-glycerol 3-diphosphate + Water > 1,2-diacyl-sn-glycerol 3-phosphate + Inorganic phosphate
A 1,2-diacylglycerol 3-phosphate + Water > a 1,2-diacyl-sn-glycerol + Inorganic phosphate
Undecaprenyl diphosphate + Water > di-trans,octa-cis-undecaprenyl phosphate + Inorganic phosphate
Adenosine triphosphate + Water + phosphonate(Out) > ADP + Inorganic phosphate + phosphonate(In)
(1,4-alpha-D-glucosyl)(n) + Inorganic phosphate > (1,4-alpha-D-glucosyl)(n-1) + Alpha-D-glucose 1-phosphate
Acyl-[acyl-carrier-protein] + Inorganic phosphate > acyl-phosphate + [acyl-carrier-protein]
RNA(n+1) + Inorganic phosphate > RNA(n) + a nucleoside diphosphate
Adenosine triphosphate + Water + polyamine(Out) > ADP + Inorganic phosphate + polyamine(In)
Myo-inositol hexakisphosphate + Water > 1D-myo-inositol 1,2,3,5,6-pentakisphosphate + Inorganic phosphate
Adenosine triphosphate + Pyruvic acid + Water > Adenosine monophosphate + Phosphoenolpyruvic acid + Inorganic phosphate
(Polyphosphate)(n) + Water > (polyphosphate)(n-1) + Inorganic phosphate
L-Glutamic-gamma-semialdehyde + Inorganic phosphate + NADP > L-Glutamic acid 5-phosphate + NADPH
A phosphoprotein + Water > a protein + Inorganic phosphate
[Pyruvate, water dikinase] phosphate + Inorganic phosphate > [pyruvate, water dikinase] + Pyrophosphate
Adenosine triphosphate + Water + phosphate(Out) > ADP + Inorganic phosphate + phosphate(In)
Acetyl-CoA + Inorganic phosphate > CoA + Acetylphosphate
Adenosine triphosphate + 5-Phosphoribosylamine + Glycine > ADP + Inorganic phosphate + 5'-Phospho-ribosylglycinamide
Adenosine triphosphate + 5'-phosphoribosyl-N-formylglycinamide + L-Glutamine + Water > ADP + Inorganic phosphate + 2-(Formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-Glutamate
Adenosine triphosphate + 2-(Formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine > ADP + Inorganic phosphate + 5-Aminoimidazole ribonucleotide
Adenosine triphosphate + 5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-Aspartic acid > ADP + Inorganic phosphate + SAICAR
Guanosine triphosphate + Inosinic acid + L-Aspartic acid > Guanosine diphosphate + Inorganic phosphate + N(6)-(1,2-dicarboxyethyl)AMP
Adenosine triphosphate + 5-Aminoimidazole ribonucleotide + Carbonic acid > ADP + Inorganic phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole
Adenosine triphosphate + L-Glutamate + Putrescine > ADP + Inorganic phosphate + gamma-Glutamyl-L-putrescine
Carbamoylphosphate + L-Aspartic acid > Inorganic phosphate + Ureidosuccinic acid
Adenosine triphosphate + Uridine triphosphate + Ammonia > ADP + Inorganic phosphate + Cytidine triphosphate
7-Deaza-7-carboxyguanine + Ammonia + Adenosine triphosphate > 7-Cyano-7-carbaguanine + ADP + Inorganic phosphate + Water
L-3,4-Dihydroxybutan-2-one 4-phosphate + 5-amino-6-ribitylamino-2,4(1h,3h)-pyrimidinedione > 6,7-dimethyl-8-(D-ribityl)lumazine +2 Water + Inorganic phosphate
tRNA(n+1) + Inorganic phosphate > tRNA(n) + a nucleoside diphosphate
L-seryl-tRNA(Sec) + Phosphoroselenoic acid > L-selenocysteinyl-tRNA(Sec) + Inorganic phosphate
Adenosine triphosphate + Hydrogen selenide + Water > Adenosine monophosphate + Phosphoroselenoic acid + Inorganic phosphate
5-Methylaminomethyl-2-thiouridine + Phosphoroselenoic acid > 5-Methylaminomethyl-2-selenouridine + Inorganic phosphate
O-Phospho-D-serine + Water > L-Serine + Inorganic phosphate
Adenosine triphosphate + Succinic acid + CoA > ADP + Inorganic phosphate + Succinyl-CoA
Sucrose + Inorganic phosphate > D-Fructose + Alpha-D-glucose 1-phosphate
Myo-inositol phosphate + Water > Myoinositol + Inorganic phosphate
Sugar phosphate + Water > Sucrose + Inorganic phosphate
Adenosine triphosphate + Water + Taurine > ADP + Inorganic phosphate + Taurine
O-Phosphohomoserine + Water > L-Threonine + Inorganic phosphate
(Elongator tRNA(Met))-cytidine(34) + Adenosine triphosphate + Acetyl-CoA > (elongator tRNA(Met))-N(4)-acetylcytidine(34) + ADP + Inorganic phosphate + CoA
Thymidine + Inorganic phosphate > Thymine + 2-deoxy-alpha-D-ribose 1-phosphate
Uridine + Inorganic phosphate > Uracil + Ribose-1-phosphate
Adenosine triphosphate + Water + Glycerol 3-phosphate > ADP + Inorganic phosphate + Glycerol 3-phosphate
Pyridoxal 5'-phosphate + Water > Pyridoxal + Inorganic phosphate
2-Deoxy-D-glucose 6-phosphate + Water > 2-Deoxyglucose + Inorganic phosphate
More...

SMPDB Pathways:Not Available
KEGG Pathways:Not Available
EcoCyc Pathways:Not Available
Concentrations
Not Available
Spectra
Spectra:
Spectrum TypeDescriptionSplash Key
GC-MSGC-MS Spectrum - GC-MS (3 TMS)splash10-0002-0794000000-6c866e626b9356994d46View in MoNA
GC-MSGC-MS Spectrum - EI-B (Non-derivatized)splash10-0002-0394000000-3a469377821d88bd699fView in MoNA
GC-MSGC-MS Spectrum - GC-MS (Non-derivatized)splash10-0002-0794000000-6c866e626b9356994d46View in MoNA
GC-MSGC-MS Spectrum - GC-EI-TOF (Non-derivatized)splash10-000t-0972000000-2ddd7182426dbace5342View in MoNA
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positivesplash10-0002-9000000000-1805c2208b5ff15a75b1View in MoNA
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, PositiveNot AvailableView in JSpectraViewer
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, N/A (Annotated)splash10-000t-9000000000-0e85f764ac98e8949759View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, N/A (Annotated)splash10-001i-9000000000-869a362083996a0cec77View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, N/A (Annotated)splash10-03di-9000000000-801101cccfd6c25271d4View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF 10V, positivesplash10-0002-9000000000-6f386712e664a4b37a0fView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF 20V, positivesplash10-0002-9000000000-94c04c712e24776fb333View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF 40V, positivesplash10-0002-9000000000-9cc1283f5af78eb26124View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QFT , negativesplash10-0002-9000000000-c1da993c0996e8d60830View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF 35V, negativesplash10-002b-9000000000-ccb36e7b3439fcc25313View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF 10V, negativesplash10-004i-9000000000-e618cbd5a94aa5860a29View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF 20V, negativesplash10-004i-9000000000-b7f0efd9272b1a27eac4View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF 40V, negativesplash10-004i-9000000000-8cadeed88c84e8c2b6c2View in MoNA
LC-MS/MSLC-MS/MS Spectrum - n/a 6V, negativesplash10-014i-9000000000-093cd2a2a662118d8432View in MoNA
LC-MS/MSLC-MS/MS Spectrum - n/a 6V, negativesplash10-004i-9000000000-46d4cee1b5ac630ba9b8View in MoNA
LC-MS/MSLC-MS/MS Spectrum - QqQ 1V, negativesplash10-0006-0090000000-40333890e636692e7970View in MoNA
LC-MS/MSLC-MS/MS Spectrum - QqQ 2V, negativesplash10-0006-0190000000-52fa21c93ab4c97f8df2View in MoNA
LC-MS/MSLC-MS/MS Spectrum - QqQ 3V, negativesplash10-0006-0490000000-32e316211facaa3d3bb2View in MoNA
LC-MS/MSLC-MS/MS Spectrum - QqQ 4V, negativesplash10-0005-0960000000-bd7aaa47a8ffd82012d3View in MoNA
LC-MS/MSLC-MS/MS Spectrum - QqQ 5V, negativesplash10-0002-0920000000-463d7b1bf72bcc10126fView in MoNA
LC-MS/MSLC-MS/MS Spectrum - QqQ 6V, negativesplash10-0002-0910000000-3c9c666ac95b68e43224View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0002-9000000000-12a5e23d24cd494e99c1View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0002-9000000000-91e06ca38117aabdb14cView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-000t-9000000000-19b1c041aa5e2adcc3e6View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0002-9000000000-e56eecd6724dfbf74160View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-004i-9000000000-0a46ba32971030356ac5View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-004i-9000000000-3a53d27e23b39429d092View in MoNA
References
References:
  • Faiman C, Moorhouse JA: Diurnal variation in the levels of glucose and related substances in healthy and diabetic subjects during starvation. Clin Sci. 1967 Feb;32(1):111-26. Pubmed: 5336272
Synthesis Reference:Not Available
Material Safety Data Sheet (MSDS)Not Available
External Links:
ResourceLink
CHEBI ID18367
HMDB IDHMDB01429
Pubchem Compound ID1061
Kegg IDC00009
ChemSpider ID979
WikipediaPhosphate
BioCyc IDPi
EcoCyc IDPi
Ligand ExpoPO4

Enzymes

General function:
Involved in phosphorylase activity
Specific function:
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
Gene Name:
malP
Uniprot ID:
P00490
Molecular weight:
90522
Reactions
(1,4-alpha-D-glucosyl)(n) + phosphate = (1,4-alpha-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphate.
General function:
Involved in catalytic activity
Specific function:
A phosphate monoester + H(2)O = an alcohol + phosphate
Gene Name:
phoA
Uniprot ID:
P00634
Molecular weight:
49438
Reactions
A phosphate monoester + H(2)O = an alcohol + phosphate.
General function:
Involved in phosphoenolpyruvate carboxylase activity
Specific function:
Through the carboxylation of phosphoenolpyruvate (PEP) it forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Gene Name:
ppc
Uniprot ID:
P00864
Molecular weight:
99062
Reactions
Phosphate + oxaloacetate = H(2)O + phosphoenolpyruvate + HCO(3)(-).
General function:
Involved in catalytic activity
Specific function:
Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Gene Name:
aroH
Uniprot ID:
P00887
Molecular weight:
38735
Reactions
Phosphoenolpyruvate + D-erythrose 4-phosphate + H(2)O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.
General function:
Involved in catalytic activity
Specific function:
Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Gene Name:
aroF
Uniprot ID:
P00888
Molecular weight:
38804
Reactions
Phosphoenolpyruvate + D-erythrose 4-phosphate + H(2)O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.
General function:
Involved in catalytic activity
Specific function:
Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. To a lesser extent, is able to slowly catalyze the deamination of L-threonine into alpha-ketobutyrate and that of L- serine and 3-chloroalanine into pyruvate. Is also able to rapidly convert vinylglycine to threonine, which proves that the pyridoxal p-quinonoid of vinylglycine is an intermediate in the TS reaction
Gene Name:
thrC
Uniprot ID:
P00934
Molecular weight:
47113
Reactions
O-phospho-L-homoserine + H(2)O = L-threonine + phosphate.
General function:
Involved in ATP binding
Specific function:
2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate
Gene Name:
carB
Uniprot ID:
P00968
Molecular weight:
117841
Reactions
2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate.
General function:
Involved in potassium-transporting ATPase activity
Specific function:
One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions
Gene Name:
kdpA
Uniprot ID:
P03959
Molecular weight:
59189
Reactions
ATP + H(2)O + K(+)(Out) = ADP + phosphate + K(+)(In).
General function:
Involved in nucleotide binding
Specific function:
One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions
Gene Name:
kdpB
Uniprot ID:
P03960
Molecular weight:
72198
Reactions
ATP + H(2)O + K(+)(Out) = ADP + phosphate + K(+)(In).
General function:
Involved in potassium-transporting ATPase activity
Specific function:
One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex
Gene Name:
kdpC
Uniprot ID:
P03961
Molecular weight:
20267
Reactions
ATP + H(2)O + K(+)(Out) = ADP + phosphate + K(+)(In).
General function:
Involved in carboxyl- or carbamoyltransferase activity
Specific function:
Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline
Gene Name:
argI
Uniprot ID:
P04391
Molecular weight:
36907
Reactions
Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.
General function:
Involved in ATP binding
Specific function:
ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione
Gene Name:
gshB
Uniprot ID:
P04425
Molecular weight:
35561
Reactions
ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione.
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex RbsABCD involved in ribose import. Responsible for energy coupling to the transport system
Gene Name:
rbsA
Uniprot ID:
P04983
Molecular weight:
55041
Reactions
ATP + H(2)O + monosaccharide(Out) = ADP + phosphate + monosaccharide(In).
General function:
Involved in RNA binding
Specific function:
Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction
Gene Name:
pnp
Uniprot ID:
P05055
Molecular weight:
77100
Reactions
RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
Gene Name:
btuD
Uniprot ID:
P06611
Molecular weight:
27081
Reactions
ATP + H(2)O + vitamin B12(Out) = ADP + phosphate + vitamin B12(In).
General function:
Involved in carboxyl- or carbamoyltransferase activity
Specific function:
Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline
Gene Name:
argF
Uniprot ID:
P06960
Molecular weight:
36827
Reactions
Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.
General function:
Involved in catalytic activity
Specific function:
D-erythro-1-(imidazol-4-yl)glycerol 3- phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O
Gene Name:
hisB
Uniprot ID:
P06987
Molecular weight:
40278
Reactions
D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O.
L-histidinol phosphate + H(2)O = L-histidinol + phosphate.
General function:
Involved in oxidoreductase activity
Specific function:
Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate
Gene Name:
proA
Uniprot ID:
P07004
Molecular weight:
44630
Reactions
L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH.
General function:
Involved in hydrolase activity
Specific function:
Degradation of external UDP-glucose to uridine monophosphate and glucose-1-phosphate, which can then be used by the cell
Gene Name:
ushA
Uniprot ID:
P07024
Molecular weight:
60824
Reactions
UDP-sugar + H(2)O = UMP + alpha-D-aldose 1-phosphate.
A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
General function:
Involved in acid phosphatase activity
Specific function:
A phosphate monoester + H(2)O = an alcohol + phosphate
Gene Name:
appA
Uniprot ID:
P07102
Molecular weight:
47056
Reactions
A phosphate monoester + H(2)O = an alcohol + phosphate.
Myo-inositol hexakisphosphate + H(2)O = 1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate.
General function:
Involved in 3-dehydroquinate synthase activity
Specific function:
3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate
Gene Name:
aroB
Uniprot ID:
P07639
Molecular weight:
38881
Reactions
3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate.
General function:
Involved in transferase activity, transferring glycosyl groups
Specific function:
The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
Gene Name:
deoA
Uniprot ID:
P07650
Molecular weight:
47207
Reactions
Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Responsible for energy coupling to the transport system
Gene Name:
fhuC
Uniprot ID:
P07821
Molecular weight:
28886
Reactions
ATP + H(2)O + iron chelate(Out) = ADP + phosphate + iron chelate(In).
General function:
Involved in ATP binding
Specific function:
Cell wall formation
Gene Name:
ddlB
Uniprot ID:
P07862
Molecular weight:
32839
Reactions
ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.
General function:
Involved in catalytic activity
Specific function:
ATP + 2-(formamido)-N(1)-(5-phospho-D- ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D- ribosyl)imidazole
Gene Name:
purM
Uniprot ID:
P08178
Molecular weight:
36854
Reactions
ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.
General function:
Involved in tetrahydrofolylpolyglutamate synthase activity
Specific function:
Conversion of folates to polyglutamate derivatives
Gene Name:
folC
Uniprot ID:
P08192
Molecular weight:
45405
Reactions
ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate = ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1).
ATP + 7,8-dihydropteroate + L-glutamate = ADP + phosphate + 7,8-dihydropteroylglutamate.
General function:
Involved in hydrolase activity
Specific function:
This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2',3'- cyclic nucleotide to a 3'-nucleotide and then the 3'-nucleotide to the corresponding nucleoside and phosphate
Gene Name:
cpdB
Uniprot ID:
P08331
Molecular weight:
70832
Reactions
Nucleoside 2',3'-cyclic phosphate + H(2)O = nucleoside 3'-phosphate.
A 3'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
General function:
Involved in phosphoribosylaminoimidazole carboxylase activity
Specific function:
Possesses an ATPase activity that is dependent on the presence of AIR (aminoimidazole ribonucleotide). The association of purK and purE produces an enzyme complex capable of converting AIR to CAIR efficiently under physiological condition
Gene Name:
purK
Uniprot ID:
P09029
Molecular weight:
39461
Reactions
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO(3)(-) = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole.
General function:
Involved in transferase activity, transferring alkyl or aryl (other than methyl) groups
Specific function:
Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate
Gene Name:
aroA
Uniprot ID:
P0A6D3
Molecular weight:
46095
Reactions
Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate.
General function:
Involved in magnesium ion binding
Specific function:
ATP + 7,8-diaminononanoate + CO(2) = ADP + phosphate + dethiobiotin
Gene Name:
ynfK
Uniprot ID:
P0A6E9
Molecular weight:
24981
Reactions
ATP + 7,8-diaminononanoate + CO(2) = ADP + phosphate + dethiobiotin.
General function:
Involved in glutamine catabolic process
Specific function:
2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate
Gene Name:
carA
Uniprot ID:
P0A6F1
Molecular weight:
41431
Reactions
2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate.
General function:
Involved in ATP binding
Specific function:
Cell wall formation
Gene Name:
ddlA
Uniprot ID:
P0A6J8
Molecular weight:
39315
Reactions
ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.
General function:
Involved in glutamate-cysteine ligase activity
Specific function:
ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine
Gene Name:
gshA
Uniprot ID:
P0A6W9
Molecular weight:
58269
Reactions
ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine.
General function:
Involved in catalytic activity
Specific function:
Synthesis of KDO 8-P which is required for lipid A maturation and cellular growth
Gene Name:
kdsA
Uniprot ID:
P0A715
Molecular weight:
30833
Reactions
Phosphoenolpyruvate + D-arabinose 5-phosphate + H(2)O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate.
General function:
Involved in methylglyoxal synthase activity
Specific function:
Glycerone phosphate = methylglyoxal + phosphate
Gene Name:
mgsA
Uniprot ID:
P0A731
Molecular weight:
16918
Reactions
Glycerone phosphate = methylglyoxal + phosphate.
General function:
Involved in transferase activity, transferring alkyl or aryl (other than methyl) groups
Specific function:
Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine. Target for the antibiotic phosphomycin
Gene Name:
murA
Uniprot ID:
P0A749
Molecular weight:
44817
Reactions
Phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine.
General function:
Involved in carboxyl- or carbamoyltransferase activity
Specific function:
Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate
Gene Name:
pyrB
Uniprot ID:
P0A786
Molecular weight:
34427
Reactions
Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.
General function:
Involved in catalytic activity
Specific function:
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Gene Name:
pdxJ
Uniprot ID:
P0A794
Molecular weight:
26384
Reactions
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H(2)O.
General function:
Involved in magnesium ion binding
Specific function:
Diphosphate + H(2)O = 2 phosphate
Gene Name:
ppa
Uniprot ID:
P0A7A9
Molecular weight:
19703
Reactions
Diphosphate + H(2)O = 2 phosphate.
General function:
Involved in adenylosuccinate synthase activity
Specific function:
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP
Gene Name:
purA
Uniprot ID:
P0A7D4
Molecular weight:
47345
Reactions
GTP + IMP + L-aspartate = GDP + phosphate + N(6)-(1,2-dicarboxyethyl)-AMP.
General function:
Involved in ATP binding
Specific function:
ATP + 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate
Gene Name:
purC
Uniprot ID:
P0A7D7
Molecular weight:
26995
Reactions
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.
General function:
Involved in CTP synthase activity
Specific function:
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen
Gene Name:
pyrG
Uniprot ID:
P0A7E5
Molecular weight:
60374
Reactions
ATP + UTP + NH(3) = ADP + phosphate + CTP.
General function:
Involved in methionine adenosyltransferase activity
Specific function:
Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. Is essential for growth
Gene Name:
metK
Uniprot ID:
P0A817
Molecular weight:
41951
Reactions
ATP + L-methionine + H(2)O = phosphate + diphosphate + S-adenosyl-L-methionine.
General function:
Involved in catalytic activity
Specific function:
Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. Requires selenophosphate as the selenium-donor molecule
Gene Name:
selA
Uniprot ID:
P0A821
Molecular weight:
50607
Reactions
L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + phosphate.
General function:
Involved in ATP binding
Specific function:
ATP + succinate + CoA = ADP + phosphate + succinyl-CoA
Gene Name:
sucC
Uniprot ID:
P0A836
Molecular weight:
41392
Reactions
ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.
General function:
Involved in hydrolase activity
Specific function:
Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'- monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain- length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. Also plays a significant physiological role in stress-response and is required for the survival of E.coli in stationary growth phase
Gene Name:
surE
Uniprot ID:
P0A840
Molecular weight:
26900
Reactions
A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
A 3'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
(Polyphosphate)(n) + H(2)O = (polyphosphate)(n-1) + phosphate.
General function:
Involved in catalytic activity
Specific function:
Nucleotidase that shows high phosphatase activity toward three nucleoside 5'-monophosphates, UMP, dUMP, and dTMP, and very low activity against TDP, IMP, UDP, GMP, dGMP, AMP, dAMP, and 6- phosphogluconate. Is strictly specific to substrates with 5'- phosphates and shows no activity against nucleoside 2'- or 3'- monophosphates. Might be involved in the pyrimidine nucleotide substrate cycles
Gene Name:
yjjG
Uniprot ID:
P0A8Y1
Molecular weight:
25300
Reactions
A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
General function:
Involved in catalytic activity
Specific function:
Catalyzes the dephosphorylation of the artificial chromogenic substrate p-nitrophenyl phosphate (pNPP) and of the natural substrates erythrose 4-phosphate and mannose 1-phosphate
Gene Name:
yidA
Uniprot ID:
P0A8Y5
Molecular weight:
29721
General function:
Involved in catalytic activity
Specific function:
Hydrolyzes phosphatidylglycerophosphate, phosphatidic acid, and lysophosphatidic acid; the pattern of activities varies according to subcellular location
Gene Name:
pgpB
Uniprot ID:
P0A924
Molecular weight:
29021
Reactions
Phosphatidylglycerophosphate + H(2)O = phosphatidylglycerol + phosphate.
General function:
Involved in phosphoric ester hydrolase activity
Specific function:
D-fructose 1,6-bisphosphate + H(2)O = D- fructose 6-phosphate + phosphate
Gene Name:
fbp
Uniprot ID:
P0A993
Molecular weight:
36834
Reactions
D-fructose 1,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.
General function:
Involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Specific function:
D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH
Gene Name:
gapA
Uniprot ID:
P0A9B2
Molecular weight:
35532
Reactions
D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH.
General function:
Involved in glutamate-ammonia ligase activity
Specific function:
ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine
Gene Name:
glnA
Uniprot ID:
P0A9C5
Molecular weight:
51903
Reactions
ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine.
General function:
Involved in glycerol metabolic process
Specific function:
D-fructose 1,6-bisphosphate + H(2)O = D- fructose 6-phosphate + phosphate
Gene Name:
glpX
Uniprot ID:
P0A9C9
Molecular weight:
35852
Reactions
D-fructose 1,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.
General function:
Involved in phosphate acetyltransferase activity
Specific function:
Acetyl-CoA + phosphate = CoA + acetyl phosphate
Gene Name:
pta
Uniprot ID:
P0A9M8
Molecular weight:
77171
Reactions
Acetyl-CoA + phosphate = CoA + acetyl phosphate.
General function:
Involved in acetyl-CoA carboxylase activity
Specific function:
Controls translation of mRNA for both itself and the alpha-subunit (accA) by binding to a probable hairpin in the 5' of the mRNA. Binding to mRNA inhibits translation; this is partially relieved by acetyl-CoA. Increasing amounts of mRNA also inhibit enzyme activity
Gene Name:
accD
Uniprot ID:
P0A9Q5
Molecular weight:
33322
Reactions
ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA.
General function:
Involved in aspartate-semialdehyde dehydrogenase activity
Specific function:
L-aspartate 4-semialdehyde + phosphate + NADP(+) = L-4-aspartyl phosphate + NADPH
Gene Name:
asd
Uniprot ID:
P0A9Q9
Molecular weight:
40018
Reactions
L-aspartate 4-semialdehyde + phosphate + NADP(+) = L-4-aspartyl phosphate + NADPH.
General function:
Involved in protein tyrosine phosphatase activity
Specific function:
Dephosphorylates wzc. Required for the extracellular polysaccharide colanic acid synthesis. Probably involved in the export of colanic acid from the cell to medium
Gene Name:
wzb
Uniprot ID:
P0AAB2
Molecular weight:
16709
Reactions
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex AraFGH involved in arabinose import. Responsible for energy coupling to the transport system (Probable)
Gene Name:
araG
Uniprot ID:
P0AAF3
Molecular weight:
55018
Reactions
ATP + H(2)O + monosaccharide(Out) = ADP + phosphate + monosaccharide(In).
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system (Probable)
Gene Name:
mglA
Uniprot ID:
P0AAG8
Molecular weight:
56415
Reactions
ATP + H(2)O + monosaccharide(Out) = ADP + phosphate + monosaccharide(In).
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex pstSACB involved in phosphate import. Responsible for energy coupling to the transport system
Gene Name:
pstB
Uniprot ID:
P0AAH0
Molecular weight:
29027
Reactions
ATP + H(2)O + phosphate(Out) = ADP + phosphate + phosphate(In).
General function:
Involved in acylphosphatase activity
Specific function:
An acylphosphate + H(2)O = a carboxylate + phosphate
Gene Name:
yccX
Uniprot ID:
P0AB65
Molecular weight:
10300
Reactions
An acylphosphate + H(2)O = a carboxylate + phosphate.
General function:
Involved in catalytic activity
Specific function:
Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Gene Name:
aroG
Uniprot ID:
P0AB91
Molecular weight:
38009
Reactions
Phosphoenolpyruvate + D-erythrose 4-phosphate + H(2)O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.
General function:
Involved in ATP binding
Specific function:
Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Gene Name:
atpA
Uniprot ID:
P0ABB0
Molecular weight:
55222
Reactions
ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out).
General function:
Involved in nucleotide binding
Specific function:
Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Gene Name:
atpD
Uniprot ID:
P0ABB4
Molecular weight:
50325
Reactions
ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out).
General function:
Involved in hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
Specific function:
Mediates magnesium influx to the cytosol
Gene Name:
mgtA
Uniprot ID:
P0ABB8
Molecular weight:
99466
Reactions
ATP + H(2)O + Mg(2+)(Out) = ADP + phosphate + Mg(2+)(In).
General function:
Involved in acetyl-CoA carboxylase activity
Specific function:
Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
Gene Name:
accA
Uniprot ID:
P0ABD5
Molecular weight:
35241
Reactions
ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA.
General function:
Involved in purine-nucleoside phosphorylase activity
Specific function:
Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules
Gene Name:
deoD
Uniprot ID:
P0ABP8
Molecular weight:
25950
Reactions
Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.
General function:
Involved in 3-deoxy-manno-octulosonate-8-phosphatase activity
Specific function:
Catalyzes the hydrolysis of KDO 8-P to KDO and inorganic phosphate
Gene Name:
kdsC
Uniprot ID:
P0ABZ4
Molecular weight:
19997
Reactions
3-deoxy-D-manno-octulosonate 8-phosphate + H(2)O = 3-deoxy-D-manno-octulosonate + phosphate.
General function:
Involved in phosphorylase activity
Specific function:
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
Gene Name:
glgP
Uniprot ID:
P0AC86
Molecular weight:
93172
Reactions
(1,4-alpha-D-glucosyl)(n) + phosphate = (1,4-alpha-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphate.
General function:
Involved in protein tyrosine phosphatase activity
Specific function:
Dephosphorylates etk
Gene Name:
etp
Uniprot ID:
P0ACZ2
Molecular weight:
16386
Reactions
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
General function:
Involved in phosphatidylinositol phosphorylation
Specific function:
Myo-inositol phosphate + H(2)O = myo-inositol + phosphate
Gene Name:
suhB
Uniprot ID:
P0ADG4
Molecular weight:
29172
Reactions
Myo-inositol phosphate + H(2)O = myo-inositol + phosphate.
General function:
Involved in acid phosphatase activity
Specific function:
Dephosphorylates several organic phosphomonoesters and catalyzes the transfer of low-energy phosphate groups from phosphomonoesters to hydroxyl groups of various organic compounds. Preferentially acts on aryl phosphoesters. Might function as a broad-spectrum dephosphorylating enzyme able to scavenge both 3'- and 5'-nucleotides and also additional organic phosphomonoesters
Gene Name:
aphA
Uniprot ID:
P0AE22
Molecular weight:
26103
Reactions
A phosphate monoester + H(2)O = an alcohol + phosphate.
General function:
Amino acid transport and metabolism
Specific function:
Catalyzes the formation of an amide bond between glutathione and spermidine coupled with hydrolysis of ATP; also catalyzes the hydrolysis of glutathionylspermidine to glutathione and spermidine
Gene Name:
gsp
Uniprot ID:
P0AES0
Molecular weight:
70531
Reactions
Glutathione + spermidine + ATP = glutathionylspermidine + ADP + phosphate.
Glutathionylspermidine + H(2)O = glutathione + spermidine.
General function:
Involved in magnesium ion binding
Specific function:
Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate of circa 500 residues long, while chains of circa 15 residues compete poorly with polyphosphate as substrate
Gene Name:
ppx
Uniprot ID:
P0AFL6
Molecular weight:
58136
Reactions
(Polyphosphate)(n) + H(2)O = (polyphosphate)(n-1) + phosphate.
General function:
Involved in catalytic activity
Specific function:
O-phospho-L(or D)-serine + H(2)O = L(or D)- serine + phosphate
Gene Name:
serB
Uniprot ID:
P0AGB0
Molecular weight:
35042
Reactions
O-phospho-L(or D)-serine + H(2)O = L(or D)-serine + phosphate.
General function:
Involved in catalytic activity
Specific function:
ATP + succinate + CoA = ADP + phosphate + succinyl-CoA
Gene Name:
sucD
Uniprot ID:
P0AGE9
Molecular weight:
29777
Reactions
ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system (Probable). Can also transport glycerophosphoryl diesters
Gene Name:
ugpC
Uniprot ID:
P10907
Molecular weight:
39524
Reactions
ATP + H(2)O + glycerol-3-phosphate(Out) = ADP + phosphate + glycerol-3-phosphate(In).
General function:
Involved in N-acetyl-gamma-glutamyl-phosphate reductase activity
Specific function:
N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = N-acetyl-5-glutamyl phosphate + NADPH
Gene Name:
argC
Uniprot ID:
P11446
Molecular weight:
35952
Reactions
N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = N-acetyl-5-glutamyl phosphate + NADPH.
General function:
Involved in quinolinate synthetase A activity
Specific function:
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Gene Name:
nadA
Uniprot ID:
P11458
Molecular weight:
38240
Reactions
Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H(2)O + phosphate.
General function:
Involved in ATP binding
Specific function:
Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein
Gene Name:
murF
Uniprot ID:
P11880
Molecular weight:
47447
Reactions
ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine.
General function:
Involved in chorismate synthase activity
Specific function:
5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate
Gene Name:
aroC
Uniprot ID:
P12008
Molecular weight:
39137
Reactions
5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate.
General function:
Involved in transferase activity, transferring pentosyl groups
Specific function:
Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
Gene Name:
udp
Uniprot ID:
P12758
Molecular weight:
27159
Reactions
Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.
General function:
Involved in magnesium ion binding
Specific function:
ATP + 7,8-diaminononanoate + CO(2) = ADP + phosphate + dethiobiotin
Gene Name:
bioD
Uniprot ID:
P13000
Molecular weight:
24139
Reactions
ATP + 7,8-diaminononanoate + CO(2) = ADP + phosphate + dethiobiotin.
General function:
Involved in ATP binding
Specific function:
Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Gene Name:
murD
Uniprot ID:
P14900
Molecular weight:
46973
Reactions
ATP + UDP-N-acetylmuramoyl-L-alanine + glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate.
General function:
Involved in catalytic activity
Specific function:
ATP + N(2)-formyl-N(1)-(5-phospho-D- ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2- (formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate
Gene Name:
purL
Uniprot ID:
P15254
Molecular weight:
141402
Reactions
ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate.
General function:
Involved in ATP binding
Specific function:
ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide
Gene Name:
purD
Uniprot ID:
P15640
Molecular weight:
45940
Reactions
ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide.
General function:
Involved in catalytic activity
Specific function:
Synthesizes selenophosphate from selenide and ATP
Gene Name:
selD
Uniprot ID:
P16456
Molecular weight:
36687
Reactions
ATP + selenide + H(2)O = AMP + selenophosphate + phosphate.
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system
Gene Name:
cysA
Uniprot ID:
P16676
Molecular weight:
41059
Reactions
ATP + H(2)O + sulfate(Out) = ADP + phosphate + sulfate(In).
General function:
Involved in ATP binding
Specific function:
Cell wall formation
Gene Name:
murC
Uniprot ID:
P17952
Molecular weight:
53626
Reactions
ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine.
General function:
Involved in phosphatidylglycerophosphatase activity
Specific function:
One of the three phospholipid phosphatases, specifically hydrolyzes phosphatidylglycerophosphate
Gene Name:
pgpA
Uniprot ID:
P18200
Molecular weight:
19418
Reactions
Phosphatidylglycerophosphate + H(2)O = phosphatidylglycerol + phosphate.
General function:
Involved in acid phosphatase activity
Specific function:
Absolutely required for the growth of E.coli in a high- phosphate medium containing G-1-P as the sole carbon source
Gene Name:
agp
Uniprot ID:
P19926
Molecular weight:
45683
Reactions
Alpha-D-glucose 1-phosphate + H(2)O = D-glucose + phosphate.
General function:
Involved in catalytic activity
Specific function:
Catalyzes the dephosphorylation of the artificial chromogenic substrate p-nitrophenyl phosphate (pNPP) and of the natural substrates pyridoxalphosphate and erythrose 4-phosphate
Gene Name:
ybhA
Uniprot ID:
P21829
Molecular weight:
30201
General function:
Involved in ATP binding
Specific function:
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Is also able to use many meso-diaminopimelate analogs as substrates, although much less efficiently, but not L-lysine
Gene Name:
murE
Uniprot ID:
P22188
Molecular weight:
53343
Reactions
ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diamino-heptanedioate.
General function:
Involved in magnesium ion binding
Specific function:
Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP. May also convert adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS). Has 10000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2)
Gene Name:
cysQ
Uniprot ID:
P22255
Molecular weight:
27176
Reactions
Adenosine 3',5'-bisphosphate + H(2)O = adenosine 5'-phosphate + phosphate.
General function:
Involved in catalytic activity
Specific function:
Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate
Gene Name:
ppsA
Uniprot ID:
P23538
Molecular weight:
87434
Reactions
ATP + pyruvate + H(2)O = AMP + phosphoenolpyruvate + phosphate.
General function:
Involved in ligase activity
Specific function:
This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
Gene Name:
accC
Uniprot ID:
P24182
Molecular weight:
49320
Reactions
ATP + biotin-[carboxyl-carrier-protein] + CO(2) = ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].
ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA.
General function:
Involved in guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity
Specific function:
Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities
Gene Name:
gppA
Uniprot ID:
P25552
Molecular weight:
54871
Reactions
Guanosine 5'-triphosphate,3'-diphosphate + H(2)O = guanosine 3',5'-bis(diphosphate) + phosphate.
General function:
Involved in catalytic activity
Specific function:
Removes the phosphate from trehalose 6-phosphate to produce free trehalose
Gene Name:
otsB
Uniprot ID:
P31678
Molecular weight:
29175
Reactions
Trehalose 6-phosphate + H(2)O = trehalose + phosphate.
General function:
Involved in catalytic activity
Specific function:
Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress
Gene Name:
gph
Uniprot ID:
P32662
Molecular weight:
27389
Reactions
2-phosphoglycolate + H(2)O = glycolate + phosphate.
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex AlsBAC involved in D-allose import. Probably responsible for energy coupling to the transport system
Gene Name:
alsA
Uniprot ID:
P32721
Molecular weight:
56744
Reactions
ATP + H(2)O + monosaccharide(Out) = ADP + phosphate + monosaccharide(In).
General function:
Involved in transferase activity, transferring selenium-containing groups
Specific function:
Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
Gene Name:
selU
Uniprot ID:
P33667
Molecular weight:
41110
Reactions
5-methylaminomethyl-2-thiouridine + selenophosphate = 5-methylaminomethyl-2-selenouridine + phosphate.
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system
Gene Name:
ccmA
Uniprot ID:
P33931
Molecular weight:
23053
Reactions
ATP + H(2)O + heme(In) = ADP + phosphate + heme(Out).
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system
Gene Name:
fbpC
Uniprot ID:
P37009
Molecular weight:
39059
Reactions
ATP + H(2)O + Fe(3+)(Out) = ADP + phosphate + Fe(3+)(In).
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex XylFGH involved in xylose import. Responsible for energy coupling to the transport system (Probable). The XylFGH system can also transport ribose in absence of xylose
Gene Name:
xylG
Uniprot ID:
P37388
Molecular weight:
56470
Reactions
ATP + H(2)O + monosaccharide(Out) = ADP + phosphate + monosaccharide(In).
General function:
Involved in nucleotide binding
Specific function:
Involved in export of lead, cadmium, zinc and mercury
Gene Name:
zntA
Uniprot ID:
P37617
Molecular weight:
76839
Reactions
ATP + H(2)O + Cd(2+)(In) = ADP + phosphate + Cd(2+)(Out).
ATP + H(2)O + Zn(2+)(In) = ADP + phosphate + Zn(2+)(Out).
General function:
Involved in catalytic activity
Specific function:
Converts N1-(5-phospho-alpha-D-ribosyl)-5,6- dimethylbenzimidazole into N1-alpha-D-ribosyl-5,6- dimethylbenzimidazole; involved in the assembly of the nucleotide loop of cobalamin
Gene Name:
cobC
Uniprot ID:
P52086
Molecular weight:
23308
Reactions
Adenosylcobalamin 5'-phosphate + H(2)O = coenzyme B12 + phosphate.
Alpha-ribazole 5'-phosphate + H(2)O = alpha-ribazole + phosphate.
General function:
Involved in nucleotide binding
Specific function:
Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum. May be involved in a specialized protein export pathway that proceeds without signal peptide cleavage
Gene Name:
fliI
Uniprot ID:
P52612
Molecular weight:
49315
Reactions
ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out).
General function:
Involved in hydrolase activity
Specific function:
Plays a key role in signaling protein misfolding via the cpxR/CPXA transducing system. It also modulates the phosphorylated status of many phosphoproteins in E.coli, some of which acting as major chaperones. Has been shown, in vitro, to act on Ser, Thr and Tyr-phosphorylated substrates
Gene Name:
pphA
Uniprot ID:
P55798
Molecular weight:
25274
Reactions
A phosphoprotein + H(2)O = a protein + phosphate.
General function:
Involved in hydrolase activity
Specific function:
Has been shown, in vitro, to act on Ser, Thr and Tyr- phosphorylated substrates
Gene Name:
pphB
Uniprot ID:
P55799
Molecular weight:
25098
Reactions
A phosphoprotein + H(2)O = a protein + phosphate.
General function:
Involved in undecaprenyl-diphosphatase activity
Specific function:
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
Gene Name:
uppP
Uniprot ID:
P60932
Molecular weight:
29758
Reactions
Undecaprenyl diphosphate + H(2)O = undecaprenyl phosphate + phosphate.
General function:
Involved in riboflavin biosynthetic process
Specific function:
Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes the condensation of 5-amino-6-(1'-D)-ribityl-amino- 2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4- phosphate yielding 6,7-dimethyl-8-lumazine
Gene Name:
ribH
Uniprot ID:
P61714
Molecular weight:
16156
Reactions
2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Responsible for energy coupling to the transport system
Gene Name:
malK
Uniprot ID:
P68187
Molecular weight:
40990
Reactions
ATP + H(2)O + maltose(Out) = ADP + phosphate + maltose(In).
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system
Gene Name:
potA
Uniprot ID:
P69874
Molecular weight:
43028
Reactions
ATP + H(2)O + polyamine(Out) = ADP + phosphate + polyamine(In).
General function:
Involved in catalytic activity
Specific function:
Catalyzes the hydrolysis of sugar phosphate to sugar and inorganic phosphate. Has a wide substrate specificity catalyzing the hydrolysis of fructose-1-P most efficiently, but it remains uncertain if this is the real substrate in vivo
Gene Name:
supH
Uniprot ID:
P75792
Molecular weight:
30413
Reactions
Sugar phosphate + H(2)O = sugar + phosphate.
General function:
Involved in catalytic activity
Specific function:
Overexpression leads to increased undecaprenyl diphosphatase activity and to increased resistance to bacitracin. May have a preferred substrate other than undecaprenyl diphosphate in vivo
Gene Name:
ybjG
Uniprot ID:
P75806
Molecular weight:
22398
Reactions
Undecaprenyl diphosphate + H(2)O = undecaprenyl phosphate + phosphate.
General function:
Involved in catalytic activity
Specific function:
Sucrose + phosphate = D-fructose + alpha-D- glucose 1-phosphate
Gene Name:
ycjM
Uniprot ID:
P76041
Molecular weight:
64185
Reactions
Sucrose + phosphate = D-fructose + alpha-D-glucose 1-phosphate.
General function:
Involved in catalytic activity
Specific function:
2(alpha-D-mannosyl)-3-phosphoglycerate + H(2)O = 2(alpha-D-mannosyl)-D-glycerate + phosphate
Gene Name:
yedP
Uniprot ID:
P76329
Molecular weight:
30439
Reactions
2(alpha-D-mannosyl)-3-phosphoglycerate + H(2)O = 2(alpha-D-mannosyl)-D-glycerate + phosphate.
General function:
Involved in catalytic activity
Specific function:
Nucleotidase that shows strict specificity toward deoxyribonucleoside 5'-monophosphates and does not dephosphorylate 5'-ribonucleotides or ribonucleoside 3'-monophosphates. Might be involved in the regulation of all dNTP pools in E.coli
Gene Name:
yfbR
Uniprot ID:
P76491
Molecular weight:
22708
Reactions
A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
General function:
Involved in glutamate-ammonia ligase activity
Specific function:
Involved in the breakdown of putrescine via the biosynthesis of gamma-L-glutamylputrescine
Gene Name:
puuA
Uniprot ID:
P78061
Molecular weight:
53177
Reactions
ATP + L-glutamate + putrescine = ADP + phosphate + gamma-L-glutamylputrescine.
General function:
Involved in nucleotide binding
Specific function:
Involved in copper export. May also be involved in silver export
Gene Name:
copA
Uniprot ID:
Q59385
Molecular weight:
87872
Reactions
ATP + H(2)O + Cu(+)(In) = ADP + phosphate + Cu(+)(Out).
General function:
Involved in phosphatase activity
Specific function:
Converts the D-glycero-beta-D-manno-heptose 1,7- bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1- phosphate by removing the phosphate group at the C-7 position
Gene Name:
gmhB
Uniprot ID:
P63228
Molecular weight:
21294
Reactions
D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(2)O = D-glycero-beta-D-manno-heptose 1-phosphate + phosphate.
General function:
Involved in catalytic activity
Specific function:
Specific function unknown
Gene Name:
yigL
Uniprot ID:
P27848
Molecular weight:
29708
Reactions
Pyridoxal 5'-phosphate + H(2)O = pyridoxal + phosphate.
Sugar phosphate + H(2)O = sugar + phosphate.
General function:
Involved in glycerol metabolic process
Specific function:
Specific function unknown
Gene Name:
yggF
Uniprot ID:
P21437
Molecular weight:
34323
Reactions
D-fructose 1,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.
General function:
Involved in catalytic activity
Specific function:
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
Gene Name:
plsX
Uniprot ID:
P27247
Molecular weight:
38214
Reactions
Acyl-[acyl-carrier-protein] + phosphate = acyl-phosphate + [acyl-carrier-protein].
General function:
Involved in nucleoside-triphosphatase activity
Specific function:
Specific function unknown
Gene Name:
yjjX
Uniprot ID:
P39411
Molecular weight:
18213
Reactions
A nucleoside triphosphate + H(2)O = a nucleoside diphosphate + monophosphate.
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system
Gene Name:
nikD
Uniprot ID:
P33593
Molecular weight:
26820
Reactions
ATP + H(2)O + Ni(2+)(Out) = ADP + phosphate + Ni(2+)(In).
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system
Gene Name:
nikE
Uniprot ID:
P33594
Molecular weight:
29721
Reactions
ATP + H(2)O + Ni(2+)(Out) = ADP + phosphate + Ni(2+)(In).
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
Gene Name:
tauB
Uniprot ID:
Q47538
Molecular weight:
28297
Reactions
ATP + H(2)O + taurine(Out) = ADP + phosphate + taurine(In).
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Gene Name:
modC
Uniprot ID:
P09833
Molecular weight:
39102
Reactions
ATP + H(2)O + molybdate(Out) = ADP + phosphate + molybdate(In).
General function:
Involved in argininosuccinate synthase activity
Specific function:
Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Gene Name:
queC
Uniprot ID:
P77756
Molecular weight:
25514
Reactions
7-carboxy-7-carbaguanine + NH(3) + ATP = 7-cyano-7-carbaguanine + ADP + phosphate + H(2)O.
General function:
Not Available
Specific function:
Not Available
Gene Name:
yniC
Uniprot ID:
P77247
Molecular weight:
Not Available
General function:
Not Available
Specific function:
Not Available
Gene Name:
yfbT
Uniprot ID:
P77625
Molecular weight:
Not Available
General function:
Replication, recombination and repair
Specific function:
Has a helix-destabilizing activity, which is not coupled to the ATPase activity. Can unwind the 23S rRNA as well as 16S rRNA. Exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA. Could play a major role in ribosome assembly, specifically in the assembly process of the active center of 50S ribosomal subunits
Gene Name:
dbpA
Uniprot ID:
P21693
Molecular weight:
49187
Reactions
ATP + H(2)O = ADP + phosphate.
General function:
Replication, recombination and repair
Specific function:
Acts in 50S ribosomal subunit biogenesis at low temperatures, acting after srmB. Has a helix-destabilizing activity; however it is unclear whether it requires ATP:according to PubMed:8552679, it does not require ATP, while according to PubMed:15196029 and PubMed:15554978, it requires ATP. Requires a helicase substrate with a single-stranded overhang. Plays a key role in optimal cell growth at low temperature and is required for normal cell division. When overexpressed suppresses cold-sensitive mutants of the rpsB gene (ribosomal protein S2) and of the smbA2 cold-sensitive mutant (pyrH, uridylate kinase). Can replace rhlB, another ATP-dependent RNA helicase, in the RNA degradosome in vitro. Stimulates translation, probably at the level of initiation, of some mRNAs
Gene Name:
deaD
Uniprot ID:
P0A9P6
Molecular weight:
70546
Reactions
ATP + H(2)O = ADP + phosphate.
General function:
Transcription
Specific function:
Probable helicase involved in DNA repair and perhaps also replication
Gene Name:
dinG
Uniprot ID:
P27296
Molecular weight:
81439
Reactions
ATP + H(2)O = ADP + phosphate.
General function:
Replication, recombination and repair
Specific function:
Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with dnaC protein, primase, and other prepriming proteins
Gene Name:
dnaB
Uniprot ID:
P0ACB0
Molecular weight:
52390
Reactions
ATP + H(2)O = ADP + phosphate.
General function:
Replication, recombination and repair
Specific function:
Helicase IV catalyzes the unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand in a reaction that is dependent upon the hydrolysis of ATP
Gene Name:
helD
Uniprot ID:
P15038
Molecular weight:
77976
Reactions
ATP + H(2)O = ADP + phosphate.
General function:
Replication, recombination and repair
Specific function:
Not yet known
Gene Name:
hrpA
Uniprot ID:
P43329
Molecular weight:
149027
Reactions
ATP + H(2)O = ADP + phosphate.
General function:
Replication, recombination and repair
Specific function:
ATP + H(2)O = ADP + phosphate
Gene Name:
hrpB
Uniprot ID:
P37024
Molecular weight:
89147
Reactions
ATP + H(2)O = ADP + phosphate.
General function:
Carbohydrate transport and metabolism
Specific function:
Not Available
Gene Name:
yjeF
Uniprot ID:
P31806
Molecular weight:
54650
Reactions
ADP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide = AMP + phosphate + NADH.
(R)-NADHX = (S)-NADHX.
General function:
Inorganic ion transport and metabolism
Specific function:
Part of the ABC transporter complex PhnCDE involved in phosphonates, phosphate esters, phosphite and phosphate import. Responsible for energy coupling to the transport system
Gene Name:
phnC
Uniprot ID:
P16677
Molecular weight:
29430
Reactions
ATP + H(2)O + phosphonate(Out) = ADP + phosphate + phosphonate(In).
General function:
Replication, recombination and repair
Specific function:
Critical role in recombination and DNA repair. Help process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3' to 5' polarity. recG unwind branched duplex DNA (Y-DNA). Has a role in constitutive stable DNA replication (csdR) and R-loop formation
Gene Name:
recG
Uniprot ID:
P24230
Molecular weight:
76430
Reactions
ATP + H(2)O = ADP + phosphate.
General function:
Replication, recombination and repair
Specific function:
Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase
Gene Name:
recQ
Uniprot ID:
P15043
Molecular weight:
68363
Reactions
ATP + H(2)O = ADP + phosphate.
General function:
Replication, recombination and repair
Specific function:
Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction
Gene Name:
rep
Uniprot ID:
P09980
Molecular weight:
77024
Reactions
ATP + H(2)O = ADP + phosphate.
General function:
Replication, recombination and repair
Specific function:
Can carry out ATP-dependent unwinding of double stranded RNA. Has a role in RNA decay. Involved in the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation
Gene Name:
rhlB
Uniprot ID:
P0A8J8
Molecular weight:
47125
Reactions
ATP + H(2)O = ADP + phosphate.
General function:
Replication, recombination and repair
Specific function:
Acts as an ATP-dependent RNA helicase, able to unwind ds-RNA
Gene Name:
rhlE
Uniprot ID:
P25888
Molecular weight:
49989
Reactions
ATP + H(2)O = ADP + phosphate.
General function:
Replication, recombination and repair
Specific function:
The ruvA-ruvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is an helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of ruvB. Binds both single- and double-stranded DNA (dsDNA). Binds preferentially to supercoiled rather than to relaxed dsDNA
Gene Name:
ruvA
Uniprot ID:
P0A809
Molecular weight:
22086
Reactions
ATP + H(2)O = ADP + phosphate.
General function:
Replication, recombination and repair
Specific function:
The ruvA-ruvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is an helicase that mediates the Holliday junction migration by localized denaturation and reannealing
Gene Name:
ruvB
Uniprot ID:
P0A812
Molecular weight:
37173
Reactions
ATP + H(2)O = ADP + phosphate.
General function:
Replication, recombination and repair
Specific function:
RNA-dependent ATPase activity. Acts in 50S ribosomal subunit biogenesis at low temperatures, acting before deaD/csdA. Suppressor of a mutant defective in 50S ribosomal subunit assembly. Probably interacts with 23S ribosomal RNA
Gene Name:
srmB
Uniprot ID:
P21507
Molecular weight:
49914
Reactions
ATP + H(2)O = ADP + phosphate.
General function:
Involved in tRNA binding
Specific function:
Not Available
Gene Name:
ypfI
Uniprot ID:
P76562
Molecular weight:
74892
Reactions
(Elongator tRNA(Met))-cytidine(34) + ATP + acetyl-CoA = (elongator tRNA(Met))-N(4)-acetylcytidine(34) + ADP + phosphate + CoA.
General function:
Replication, recombination and repair
Specific function:
Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair
Gene Name:
uvrD
Uniprot ID:
P03018
Molecular weight:
81989
Reactions
ATP + H(2)O = ADP + phosphate.
General function:
Translation, ribosomal structure and biogenesis
Specific function:
ATP + H(2)O = ADP + phosphate
Gene Name:
yoaA
Uniprot ID:
P76257
Molecular weight:
70377
Reactions
ATP + H(2)O = ADP + phosphate.

Transporters

General function:
Involved in potassium-transporting ATPase activity
Specific function:
One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions
Gene Name:
kdpA
Uniprot ID:
P03959
Molecular weight:
59189
Reactions
ATP + H(2)O + K(+)(Out) = ADP + phosphate + K(+)(In).
General function:
Involved in nucleotide binding
Specific function:
One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions
Gene Name:
kdpB
Uniprot ID:
P03960
Molecular weight:
72198
Reactions
ATP + H(2)O + K(+)(Out) = ADP + phosphate + K(+)(In).
General function:
Involved in potassium-transporting ATPase activity
Specific function:
One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex
Gene Name:
kdpC
Uniprot ID:
P03961
Molecular weight:
20267
Reactions
ATP + H(2)O + K(+)(Out) = ADP + phosphate + K(+)(In).
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex RbsABCD involved in ribose import. Responsible for energy coupling to the transport system
Gene Name:
rbsA
Uniprot ID:
P04983
Molecular weight:
55041
Reactions
ATP + H(2)O + monosaccharide(Out) = ADP + phosphate + monosaccharide(In).
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
Gene Name:
btuD
Uniprot ID:
P06611
Molecular weight:
27081
Reactions
ATP + H(2)O + vitamin B12(Out) = ADP + phosphate + vitamin B12(In).
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Responsible for energy coupling to the transport system
Gene Name:
fhuC
Uniprot ID:
P07821
Molecular weight:
28886
Reactions
ATP + H(2)O + iron chelate(Out) = ADP + phosphate + iron chelate(In).
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex AraFGH involved in arabinose import. Responsible for energy coupling to the transport system (Probable)
Gene Name:
araG
Uniprot ID:
P0AAF3
Molecular weight:
55018
Reactions
ATP + H(2)O + monosaccharide(Out) = ADP + phosphate + monosaccharide(In).
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system (Probable)
Gene Name:
mglA
Uniprot ID:
P0AAG8
Molecular weight:
56415
Reactions
ATP + H(2)O + monosaccharide(Out) = ADP + phosphate + monosaccharide(In).
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex pstSACB involved in phosphate import. Responsible for energy coupling to the transport system
Gene Name:
pstB
Uniprot ID:
P0AAH0
Molecular weight:
29027
Reactions
ATP + H(2)O + phosphate(Out) = ADP + phosphate + phosphate(In).
General function:
Involved in ATP binding
Specific function:
Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Gene Name:
atpA
Uniprot ID:
P0ABB0
Molecular weight:
55222
Reactions
ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out).
General function:
Involved in nucleotide binding
Specific function:
Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Gene Name:
atpD
Uniprot ID:
P0ABB4
Molecular weight:
50325
Reactions
ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out).
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system (Probable). Can also transport glycerophosphoryl diesters
Gene Name:
ugpC
Uniprot ID:
P10907
Molecular weight:
39524
Reactions
ATP + H(2)O + glycerol-3-phosphate(Out) = ADP + phosphate + glycerol-3-phosphate(In).
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system
Gene Name:
cysA
Uniprot ID:
P16676
Molecular weight:
41059
Reactions
ATP + H(2)O + sulfate(Out) = ADP + phosphate + sulfate(In).
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex AlsBAC involved in D-allose import. Probably responsible for energy coupling to the transport system
Gene Name:
alsA
Uniprot ID:
P32721
Molecular weight:
56744
Reactions
ATP + H(2)O + monosaccharide(Out) = ADP + phosphate + monosaccharide(In).
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system
Gene Name:
fbpC
Uniprot ID:
P37009
Molecular weight:
39059
Reactions
ATP + H(2)O + Fe(3+)(Out) = ADP + phosphate + Fe(3+)(In).
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex XylFGH involved in xylose import. Responsible for energy coupling to the transport system (Probable). The XylFGH system can also transport ribose in absence of xylose
Gene Name:
xylG
Uniprot ID:
P37388
Molecular weight:
56470
Reactions
ATP + H(2)O + monosaccharide(Out) = ADP + phosphate + monosaccharide(In).
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Responsible for energy coupling to the transport system
Gene Name:
malK
Uniprot ID:
P68187
Molecular weight:
40990
Reactions
ATP + H(2)O + maltose(Out) = ADP + phosphate + maltose(In).
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system
Gene Name:
potA
Uniprot ID:
P69874
Molecular weight:
43028
Reactions
ATP + H(2)O + polyamine(Out) = ADP + phosphate + polyamine(In).
General function:
Involved in inorganic phosphate transmembrane transporter activity
Specific function:
Low-affinity inorganic phosphate transport. Can also transport arsenate
Gene Name:
pitA
Uniprot ID:
P0AFJ7
Molecular weight:
53389
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system
Gene Name:
nikD
Uniprot ID:
P33593
Molecular weight:
26820
Reactions
ATP + H(2)O + Ni(2+)(Out) = ADP + phosphate + Ni(2+)(In).
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system
Gene Name:
nikE
Uniprot ID:
P33594
Molecular weight:
29721
Reactions
ATP + H(2)O + Ni(2+)(Out) = ADP + phosphate + Ni(2+)(In).
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
Gene Name:
tauB
Uniprot ID:
Q47538
Molecular weight:
28297
Reactions
ATP + H(2)O + taurine(Out) = ADP + phosphate + taurine(In).
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Gene Name:
modC
Uniprot ID:
P09833
Molecular weight:
39102
Reactions
ATP + H(2)O + molybdate(Out) = ADP + phosphate + molybdate(In).
General function:
Inorganic ion transport and metabolism
Specific function:
Part of the ABC transporter complex PhnCDE involved in phosphonates, phosphate esters, phosphite and phosphate import. Responsible for energy coupling to the transport system
Gene Name:
phnC
Uniprot ID:
P16677
Molecular weight:
29430
Reactions
ATP + H(2)O + phosphonate(Out) = ADP + phosphate + phosphonate(In).