Inorganic phosphate (ECMDB21380) (M2MDB001776)

General function:

Involved in phosphorylase activity

Specific function:

Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties

Gene Name:

malP

Uniprot ID:

P00490

Molecular weight:

90522

Reactions

General function:

Involved in catalytic activity

Specific function:

A phosphate monoester + H(2)O = an alcohol + phosphate

Gene Name:

phoA

Uniprot ID:

P00634

Molecular weight:

49438

Reactions

General function:

Involved in phosphoenolpyruvate carboxylase activity

Specific function:

Through the carboxylation of phosphoenolpyruvate (PEP) it forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle

Gene Name:

ppc

Uniprot ID:

P00864

Molecular weight:

99062

Reactions

General function:

Involved in catalytic activity

Specific function:

Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)

Gene Name:

aroH

Uniprot ID:

P00887

Molecular weight:

38735

Reactions

General function:

Involved in catalytic activity

Specific function:

Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)

Gene Name:

aroF

Uniprot ID:

P00888

Molecular weight:

38804

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. To a lesser extent, is able to slowly catalyze the deamination of L-threonine into alpha-ketobutyrate and that of L- serine and 3-chloroalanine into pyruvate. Is also able to rapidly convert vinylglycine to threonine, which proves that the pyridoxal p-quinonoid of vinylglycine is an intermediate in the TS reaction

Gene Name:

thrC

Uniprot ID:

P00934

Molecular weight:

47113

Reactions

General function:

Involved in ATP binding

Specific function:

2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate

Gene Name:

carB

Uniprot ID:

P00968

Molecular weight:

117841

Reactions

General function:

Involved in potassium-transporting ATPase activity

Specific function:

One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions

Gene Name:

kdpA

Uniprot ID:

P03959

Molecular weight:

59189

Reactions

General function:

Involved in nucleotide binding

Specific function:

One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions

Gene Name:

kdpB

Uniprot ID:

P03960

Molecular weight:

72198

Reactions

General function:

Involved in potassium-transporting ATPase activity

Specific function:

One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex

Gene Name:

kdpC

Uniprot ID:

P03961

Molecular weight:

20267

Reactions

General function:

Involved in carboxyl- or carbamoyltransferase activity

Specific function:

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline

Gene Name:

argI

Uniprot ID:

P04391

Molecular weight:

36907

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione

Gene Name:

gshB

Uniprot ID:

P04425

Molecular weight:

35561

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex RbsABCD involved in ribose import. Responsible for energy coupling to the transport system

Gene Name:

rbsA

Uniprot ID:

P04983

Molecular weight:

55041

Reactions

General function:

Involved in RNA binding

Specific function:

Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction

Gene Name:

pnp

Uniprot ID:

P05055

Molecular weight:

77100

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system

Gene Name:

btuD

Uniprot ID:

P06611

Molecular weight:

27081

Reactions

General function:

Involved in carboxyl- or carbamoyltransferase activity

Specific function:

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline

Gene Name:

argF

Uniprot ID:

P06960

Molecular weight:

36827

Reactions

General function:

Involved in catalytic activity

Specific function:

D-erythro-1-(imidazol-4-yl)glycerol 3- phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O

Gene Name:

hisB

Uniprot ID:

P06987

Molecular weight:

40278

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

Gene Name:

proA

Uniprot ID:

P07004

Molecular weight:

44630

Reactions

General function:

Involved in hydrolase activity

Specific function:

Degradation of external UDP-glucose to uridine monophosphate and glucose-1-phosphate, which can then be used by the cell

Gene Name:

ushA

Uniprot ID:

P07024

Molecular weight:

60824

Reactions

General function:

Involved in acid phosphatase activity

Specific function:

A phosphate monoester + H(2)O = an alcohol + phosphate

Gene Name:

appA

Uniprot ID:

P07102

Molecular weight:

47056

Reactions

General function:

Involved in 3-dehydroquinate synthase activity

Specific function:

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate

Gene Name:

aroB

Uniprot ID:

P07639

Molecular weight:

38881

Reactions

General function:

Involved in transferase activity, transferring glycosyl groups

Specific function:

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis

Gene Name:

deoA

Uniprot ID:

P07650

Molecular weight:

47207

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Responsible for energy coupling to the transport system

Gene Name:

fhuC

Uniprot ID:

P07821

Molecular weight:

28886

Reactions

General function:

Involved in ATP binding

Specific function:

Cell wall formation

Gene Name:

ddlB

Uniprot ID:

P07862

Molecular weight:

32839

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + 2-(formamido)-N(1)-(5-phospho-D- ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D- ribosyl)imidazole

Gene Name:

purM

Uniprot ID:

P08178

Molecular weight:

36854

Reactions

General function:

Involved in tetrahydrofolylpolyglutamate synthase activity

Specific function:

Conversion of folates to polyglutamate derivatives

Gene Name:

folC

Uniprot ID:

P08192

Molecular weight:

45405

Reactions

General function:

Involved in hydrolase activity

Specific function:

This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2',3'- cyclic nucleotide to a 3'-nucleotide and then the 3'-nucleotide to the corresponding nucleoside and phosphate

Gene Name:

cpdB

Uniprot ID:

P08331

Molecular weight:

70832

Reactions

General function:

Involved in phosphoribosylaminoimidazole carboxylase activity

Specific function:

Possesses an ATPase activity that is dependent on the presence of AIR (aminoimidazole ribonucleotide). The association of purK and purE produces an enzyme complex capable of converting AIR to CAIR efficiently under physiological condition

Gene Name:

purK

Uniprot ID:

P09029

Molecular weight:

39461

Reactions

General function:

Involved in transferase activity, transferring alkyl or aryl (other than methyl) groups

Specific function:

Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate

Gene Name:

aroA

Uniprot ID:

P0A6D3

Molecular weight:

46095

Reactions

General function:

Involved in magnesium ion binding

Specific function:

ATP + 7,8-diaminononanoate + CO(2) = ADP + phosphate + dethiobiotin

Gene Name:

ynfK

Uniprot ID:

P0A6E9

Molecular weight:

24981

Reactions

General function:

Involved in glutamine catabolic process

Specific function:

2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate

Gene Name:

carA

Uniprot ID:

P0A6F1

Molecular weight:

41431

Reactions

General function:

Involved in ATP binding

Specific function:

Cell wall formation

Gene Name:

ddlA

Uniprot ID:

P0A6J8

Molecular weight:

39315

Reactions

General function:

Involved in glutamate-cysteine ligase activity

Specific function:

ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine

Gene Name:

gshA

Uniprot ID:

P0A6W9

Molecular weight:

58269

Reactions

General function:

Involved in catalytic activity

Specific function:

Synthesis of KDO 8-P which is required for lipid A maturation and cellular growth

Gene Name:

kdsA

Uniprot ID:

P0A715

Molecular weight:

30833

Reactions

General function:

Involved in methylglyoxal synthase activity

Specific function:

Glycerone phosphate = methylglyoxal + phosphate

Gene Name:

mgsA

Uniprot ID:

P0A731

Molecular weight:

16918

Reactions

General function:

Involved in transferase activity, transferring alkyl or aryl (other than methyl) groups

Specific function:

Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine. Target for the antibiotic phosphomycin

Gene Name:

murA

Uniprot ID:

P0A749

Molecular weight:

44817

Reactions

General function:

Involved in carboxyl- or carbamoyltransferase activity

Specific function:

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate

Gene Name:

pyrB

Uniprot ID:

P0A786

Molecular weight:

34427

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate

Gene Name:

pdxJ

Uniprot ID:

P0A794

Molecular weight:

26384

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Diphosphate + H(2)O = 2 phosphate

Gene Name:

ppa

Uniprot ID:

P0A7A9

Molecular weight:

19703

Reactions

General function:

Involved in adenylosuccinate synthase activity

Specific function:

Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP

Gene Name:

purA

Uniprot ID:

P0A7D4

Molecular weight:

47345

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate

Gene Name:

purC

Uniprot ID:

P0A7D7

Molecular weight:

26995

Reactions

General function:

Involved in CTP synthase activity

Specific function:

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

Gene Name:

pyrG

Uniprot ID:

P0A7E5

Molecular weight:

60374

Reactions

General function:

Involved in methionine adenosyltransferase activity

Specific function:

Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. Is essential for growth

Gene Name:

metK

Uniprot ID:

P0A817

Molecular weight:

41951

Reactions

General function:

Involved in catalytic activity

Specific function:

Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. Requires selenophosphate as the selenium-donor molecule

Gene Name:

selA

Uniprot ID:

P0A821

Molecular weight:

50607

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA

Gene Name:

sucC

Uniprot ID:

P0A836

Molecular weight:

41392

Reactions

General function:

Involved in hydrolase activity

Specific function:

Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'- monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain- length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. Also plays a significant physiological role in stress-response and is required for the survival of E.coli in stationary growth phase

Gene Name:

surE

Uniprot ID:

P0A840

Molecular weight:

26900

Reactions

General function:

Involved in catalytic activity

Specific function:

Nucleotidase that shows high phosphatase activity toward three nucleoside 5'-monophosphates, UMP, dUMP, and dTMP, and very low activity against TDP, IMP, UDP, GMP, dGMP, AMP, dAMP, and 6- phosphogluconate. Is strictly specific to substrates with 5'- phosphates and shows no activity against nucleoside 2'- or 3'- monophosphates. Might be involved in the pyrimidine nucleotide substrate cycles

Gene Name:

yjjG

Uniprot ID:

P0A8Y1

Molecular weight:

25300

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the dephosphorylation of the artificial chromogenic substrate p-nitrophenyl phosphate (pNPP) and of the natural substrates erythrose 4-phosphate and mannose 1-phosphate

Gene Name:

yidA

Uniprot ID:

P0A8Y5

Molecular weight:

29721

General function:

Involved in catalytic activity

Specific function:

Hydrolyzes phosphatidylglycerophosphate, phosphatidic acid, and lysophosphatidic acid; the pattern of activities varies according to subcellular location

Gene Name:

pgpB

Uniprot ID:

P0A924

Molecular weight:

29021

Reactions

General function:

Involved in phosphoric ester hydrolase activity

Specific function:

D-fructose 1,6-bisphosphate + H(2)O = D- fructose 6-phosphate + phosphate

Gene Name:

fbp

Uniprot ID:

P0A993

Molecular weight:

36834

Reactions

General function:

Involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

Specific function:

D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH

Gene Name:

gapA

Uniprot ID:

P0A9B2

Molecular weight:

35532

Reactions

General function:

Involved in glutamate-ammonia ligase activity

Specific function:

ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine

Gene Name:

glnA

Uniprot ID:

P0A9C5

Molecular weight:

51903

Reactions

General function:

Involved in glycerol metabolic process

Specific function:

D-fructose 1,6-bisphosphate + H(2)O = D- fructose 6-phosphate + phosphate

Gene Name:

glpX

Uniprot ID:

P0A9C9

Molecular weight:

35852

Reactions

General function:

Involved in phosphate acetyltransferase activity

Specific function:

Acetyl-CoA + phosphate = CoA + acetyl phosphate

Gene Name:

pta

Uniprot ID:

P0A9M8

Molecular weight:

77171

Reactions

General function:

Involved in acetyl-CoA carboxylase activity

Specific function:

Controls translation of mRNA for both itself and the alpha-subunit (accA) by binding to a probable hairpin in the 5' of the mRNA. Binding to mRNA inhibits translation; this is partially relieved by acetyl-CoA. Increasing amounts of mRNA also inhibit enzyme activity

Gene Name:

accD

Uniprot ID:

P0A9Q5

Molecular weight:

33322

Reactions

General function:

Involved in aspartate-semialdehyde dehydrogenase activity

Specific function:

L-aspartate 4-semialdehyde + phosphate + NADP(+) = L-4-aspartyl phosphate + NADPH

Gene Name:

asd

Uniprot ID:

P0A9Q9

Molecular weight:

40018

Reactions

General function:

Involved in protein tyrosine phosphatase activity

Specific function:

Dephosphorylates wzc. Required for the extracellular polysaccharide colanic acid synthesis. Probably involved in the export of colanic acid from the cell to medium

Gene Name:

wzb

Uniprot ID:

P0AAB2

Molecular weight:

16709

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex AraFGH involved in arabinose import. Responsible for energy coupling to the transport system (Probable)

Gene Name:

araG

Uniprot ID:

P0AAF3

Molecular weight:

55018

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system (Probable)

Gene Name:

mglA

Uniprot ID:

P0AAG8

Molecular weight:

56415

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex pstSACB involved in phosphate import. Responsible for energy coupling to the transport system

Gene Name:

pstB

Uniprot ID:

P0AAH0

Molecular weight:

29027

Reactions

General function:

Involved in acylphosphatase activity

Specific function:

An acylphosphate + H(2)O = a carboxylate + phosphate

Gene Name:

yccX

Uniprot ID:

P0AB65

Molecular weight:

10300

Reactions

General function:

Involved in catalytic activity

Specific function:

Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)

Gene Name:

aroG

Uniprot ID:

P0AB91

Molecular weight:

38009

Reactions

General function:

Involved in ATP binding

Specific function:

Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

Gene Name:

atpA

Uniprot ID:

P0ABB0

Molecular weight:

55222

Reactions

General function:

Involved in nucleotide binding

Specific function:

Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits

Gene Name:

atpD

Uniprot ID:

P0ABB4

Molecular weight:

50325

Reactions

General function:

Involved in hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

Specific function:

Mediates magnesium influx to the cytosol

Gene Name:

mgtA

Uniprot ID:

P0ABB8

Molecular weight:

99466

Reactions

General function:

Involved in acetyl-CoA carboxylase activity

Specific function:

Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA

Gene Name:

accA

Uniprot ID:

P0ABD5

Molecular weight:

35241

Reactions

General function:

Involved in purine-nucleoside phosphorylase activity

Specific function:

Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules

Gene Name:

deoD

Uniprot ID:

P0ABP8

Molecular weight:

25950

Reactions

General function:

Involved in 3-deoxy-manno-octulosonate-8-phosphatase activity

Specific function:

Catalyzes the hydrolysis of KDO 8-P to KDO and inorganic phosphate

Gene Name:

kdsC

Uniprot ID:

P0ABZ4

Molecular weight:

19997

Reactions

General function:

Involved in phosphorylase activity

Specific function:

Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties

Gene Name:

glgP

Uniprot ID:

P0AC86

Molecular weight:

93172

Reactions

General function:

Involved in protein tyrosine phosphatase activity

Specific function:

Dephosphorylates etk

Gene Name:

etp

Uniprot ID:

P0ACZ2

Molecular weight:

16386

Reactions

General function:

Involved in phosphatidylinositol phosphorylation

Specific function:

Myo-inositol phosphate + H(2)O = myo-inositol + phosphate

Gene Name:

suhB

Uniprot ID:

P0ADG4

Molecular weight:

29172

Reactions

General function:

Involved in acid phosphatase activity

Specific function:

Dephosphorylates several organic phosphomonoesters and catalyzes the transfer of low-energy phosphate groups from phosphomonoesters to hydroxyl groups of various organic compounds. Preferentially acts on aryl phosphoesters. Might function as a broad-spectrum dephosphorylating enzyme able to scavenge both 3'- and 5'-nucleotides and also additional organic phosphomonoesters

Gene Name:

aphA

Uniprot ID:

P0AE22

Molecular weight:

26103

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Catalyzes the formation of an amide bond between glutathione and spermidine coupled with hydrolysis of ATP; also catalyzes the hydrolysis of glutathionylspermidine to glutathione and spermidine

Gene Name:

gsp

Uniprot ID:

P0AES0

Molecular weight:

70531

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate of circa 500 residues long, while chains of circa 15 residues compete poorly with polyphosphate as substrate

Gene Name:

ppx

Uniprot ID:

P0AFL6

Molecular weight:

58136

Reactions

General function:

Involved in catalytic activity

Specific function:

O-phospho-L(or D)-serine + H(2)O = L(or D)- serine + phosphate

Gene Name:

serB

Uniprot ID:

P0AGB0

Molecular weight:

35042

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA

Gene Name:

sucD

Uniprot ID:

P0AGE9

Molecular weight:

29777

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system (Probable). Can also transport glycerophosphoryl diesters

Gene Name:

ugpC

Uniprot ID:

P10907

Molecular weight:

39524

Reactions

General function:

Involved in N-acetyl-gamma-glutamyl-phosphate reductase activity

Specific function:

N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = N-acetyl-5-glutamyl phosphate + NADPH

Gene Name:

argC

Uniprot ID:

P11446

Molecular weight:

35952

Reactions

General function:

Involved in quinolinate synthetase A activity

Specific function:

Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate

Gene Name:

nadA

Uniprot ID:

P11458

Molecular weight:

38240

Reactions

General function:

Involved in ATP binding

Specific function:

Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein

Gene Name:

murF

Uniprot ID:

P11880

Molecular weight:

47447

Reactions

General function:

Involved in chorismate synthase activity

Specific function:

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate

Gene Name:

aroC

Uniprot ID:

P12008

Molecular weight:

39137

Reactions

General function:

Involved in transferase activity, transferring pentosyl groups

Specific function:

Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis

Gene Name:

udp

Uniprot ID:

P12758

Molecular weight:

27159

Reactions

General function:

Involved in magnesium ion binding

Specific function:

ATP + 7,8-diaminononanoate + CO(2) = ADP + phosphate + dethiobiotin

Gene Name:

bioD

Uniprot ID:

P13000

Molecular weight:

24139

Reactions

General function:

Involved in ATP binding

Specific function:

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)

Gene Name:

murD

Uniprot ID:

P14900

Molecular weight:

46973

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + N(2)-formyl-N(1)-(5-phospho-D- ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2- (formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate

Gene Name:

purL

Uniprot ID:

P15254

Molecular weight:

141402

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide

Gene Name:

purD

Uniprot ID:

P15640

Molecular weight:

45940

Reactions

General function:

Involved in catalytic activity

Specific function:

Synthesizes selenophosphate from selenide and ATP

Gene Name:

selD

Uniprot ID:

P16456

Molecular weight:

36687

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system

Gene Name:

cysA

Uniprot ID:

P16676

Molecular weight:

41059

Reactions

General function:

Involved in ATP binding

Specific function:

Cell wall formation

Gene Name:

murC

Uniprot ID:

P17952

Molecular weight:

53626

Reactions

General function:

Involved in phosphatidylglycerophosphatase activity

Specific function:

One of the three phospholipid phosphatases, specifically hydrolyzes phosphatidylglycerophosphate

Gene Name:

pgpA

Uniprot ID:

P18200

Molecular weight:

19418

Reactions

General function:

Involved in acid phosphatase activity

Specific function:

Absolutely required for the growth of E.coli in a high- phosphate medium containing G-1-P as the sole carbon source

Gene Name:

agp

Uniprot ID:

P19926

Molecular weight:

45683

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the dephosphorylation of the artificial chromogenic substrate p-nitrophenyl phosphate (pNPP) and of the natural substrates pyridoxalphosphate and erythrose 4-phosphate

Gene Name:

ybhA

Uniprot ID:

P21829

Molecular weight:

30201

General function:

Involved in ATP binding

Specific function:

Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Is also able to use many meso-diaminopimelate analogs as substrates, although much less efficiently, but not L-lysine

Gene Name:

murE

Uniprot ID:

P22188

Molecular weight:

53343

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP. May also convert adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS). Has 10000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2)

Gene Name:

cysQ

Uniprot ID:

P22255

Molecular weight:

27176

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate

Gene Name:

ppsA

Uniprot ID:

P23538

Molecular weight:

87434

Reactions

General function:

Involved in ligase activity

Specific function:

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA

Gene Name:

accC

Uniprot ID:

P24182

Molecular weight:

49320

Reactions

General function:

Involved in guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity

Specific function:

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities

Gene Name:

gppA

Uniprot ID:

P25552

Molecular weight:

54871

Reactions

General function:

Involved in catalytic activity

Specific function:

Removes the phosphate from trehalose 6-phosphate to produce free trehalose

Gene Name:

otsB

Uniprot ID:

P31678

Molecular weight:

29175

Reactions

General function:

Involved in catalytic activity

Specific function:

Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress

Gene Name:

gph

Uniprot ID:

P32662

Molecular weight:

27389

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex AlsBAC involved in D-allose import. Probably responsible for energy coupling to the transport system

Gene Name:

alsA

Uniprot ID:

P32721

Molecular weight:

56744

Reactions

General function:

Involved in transferase activity, transferring selenium-containing groups

Specific function:

Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA

Gene Name:

selU

Uniprot ID:

P33667

Molecular weight:

41110

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system

Gene Name:

ccmA

Uniprot ID:

P33931

Molecular weight:

23053

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system

Gene Name:

fbpC

Uniprot ID:

P37009

Molecular weight:

39059

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex XylFGH involved in xylose import. Responsible for energy coupling to the transport system (Probable). The XylFGH system can also transport ribose in absence of xylose

Gene Name:

xylG

Uniprot ID:

P37388

Molecular weight:

56470

Reactions

General function:

Involved in nucleotide binding

Specific function:

Involved in export of lead, cadmium, zinc and mercury

Gene Name:

zntA

Uniprot ID:

P37617

Molecular weight:

76839

Reactions

General function:

Involved in catalytic activity

Specific function:

Converts N1-(5-phospho-alpha-D-ribosyl)-5,6- dimethylbenzimidazole into N1-alpha-D-ribosyl-5,6- dimethylbenzimidazole; involved in the assembly of the nucleotide loop of cobalamin

Gene Name:

cobC

Uniprot ID:

P52086

Molecular weight:

23308

Reactions

General function:

Involved in nucleotide binding

Specific function:

Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum. May be involved in a specialized protein export pathway that proceeds without signal peptide cleavage

Gene Name:

fliI

Uniprot ID:

P52612

Molecular weight:

49315

Reactions

General function:

Involved in hydrolase activity

Specific function:

Plays a key role in signaling protein misfolding via the cpxR/CPXA transducing system. It also modulates the phosphorylated status of many phosphoproteins in E.coli, some of which acting as major chaperones. Has been shown, in vitro, to act on Ser, Thr and Tyr-phosphorylated substrates

Gene Name:

pphA

Uniprot ID:

P55798

Molecular weight:

25274

Reactions

General function:

Involved in hydrolase activity

Specific function:

Has been shown, in vitro, to act on Ser, Thr and Tyr- phosphorylated substrates

Gene Name:

pphB

Uniprot ID:

P55799

Molecular weight:

25098

Reactions

General function:

Involved in undecaprenyl-diphosphatase activity

Specific function:

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin

Gene Name:

uppP

Uniprot ID:

P60932

Molecular weight:

29758

Reactions

General function:

Involved in riboflavin biosynthetic process

Specific function:

Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes the condensation of 5-amino-6-(1'-D)-ribityl-amino- 2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4- phosphate yielding 6,7-dimethyl-8-lumazine

Gene Name:

ribH

Uniprot ID:

P61714

Molecular weight:

16156

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Responsible for energy coupling to the transport system

Gene Name:

malK

Uniprot ID:

P68187

Molecular weight:

40990

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system

Gene Name:

potA

Uniprot ID:

P69874

Molecular weight:

43028

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the hydrolysis of sugar phosphate to sugar and inorganic phosphate. Has a wide substrate specificity catalyzing the hydrolysis of fructose-1-P most efficiently, but it remains uncertain if this is the real substrate in vivo

Gene Name:

supH

Uniprot ID:

P75792

Molecular weight:

30413

Reactions

General function:

Involved in catalytic activity

Specific function:

Overexpression leads to increased undecaprenyl diphosphatase activity and to increased resistance to bacitracin. May have a preferred substrate other than undecaprenyl diphosphate in vivo

Gene Name:

ybjG

Uniprot ID:

P75806

Molecular weight:

22398

Reactions

General function:

Involved in catalytic activity

Specific function:

Sucrose + phosphate = D-fructose + alpha-D- glucose 1-phosphate

Gene Name:

ycjM

Uniprot ID:

P76041

Molecular weight:

64185

Reactions

General function:

Involved in catalytic activity

Specific function:

2(alpha-D-mannosyl)-3-phosphoglycerate + H(2)O = 2(alpha-D-mannosyl)-D-glycerate + phosphate

Gene Name:

yedP

Uniprot ID:

P76329

Molecular weight:

30439

Reactions

General function:

Involved in catalytic activity

Specific function:

Nucleotidase that shows strict specificity toward deoxyribonucleoside 5'-monophosphates and does not dephosphorylate 5'-ribonucleotides or ribonucleoside 3'-monophosphates. Might be involved in the regulation of all dNTP pools in E.coli

Gene Name:

yfbR

Uniprot ID:

P76491

Molecular weight:

22708

Reactions

General function:

Involved in glutamate-ammonia ligase activity

Specific function:

Involved in the breakdown of putrescine via the biosynthesis of gamma-L-glutamylputrescine

Gene Name:

puuA

Uniprot ID:

P78061

Molecular weight:

53177

Reactions

General function:

Involved in nucleotide binding

Specific function:

Involved in copper export. May also be involved in silver export

Gene Name:

copA

Uniprot ID:

Q59385

Molecular weight:

87872

Reactions

General function:

Involved in phosphatase activity

Specific function:

Converts the D-glycero-beta-D-manno-heptose 1,7- bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1- phosphate by removing the phosphate group at the C-7 position

Gene Name:

gmhB

Uniprot ID:

P63228

Molecular weight:

21294

Reactions

General function:

Involved in catalytic activity

Specific function:

Specific function unknown

Gene Name:

yigL

Uniprot ID:

P27848

Molecular weight:

29708

Reactions

General function:

Involved in glycerol metabolic process

Specific function:

Specific function unknown

Gene Name:

yggF

Uniprot ID:

P21437

Molecular weight:

34323

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA

Gene Name:

plsX

Uniprot ID:

P27247

Molecular weight:

38214

Reactions

General function:

Involved in nucleoside-triphosphatase activity

Specific function:

Specific function unknown

Gene Name:

yjjX

Uniprot ID:

P39411

Molecular weight:

18213

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system

Gene Name:

nikD

Uniprot ID:

P33593

Molecular weight:

26820

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system

Gene Name:

nikE

Uniprot ID:

P33594

Molecular weight:

29721

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system

Gene Name:

tauB

Uniprot ID:

Q47538

Molecular weight:

28297

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system

Gene Name:

modC

Uniprot ID:

P09833

Molecular weight:

39102

Reactions

General function:

Involved in argininosuccinate synthase activity

Specific function:

Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))

Gene Name:

queC

Uniprot ID:

P77756

Molecular weight:

25514

Reactions

General function:

Not Available

Specific function:

Not Available

Gene Name:

yniC

Uniprot ID:

P77247

Molecular weight:

Not Available

General function:

Not Available

Specific function:

Not Available

Gene Name:

yfbT

Uniprot ID:

P77625

Molecular weight:

Not Available

General function:

Replication, recombination and repair

Specific function:

Has a helix-destabilizing activity, which is not coupled to the ATPase activity. Can unwind the 23S rRNA as well as 16S rRNA. Exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA. Could play a major role in ribosome assembly, specifically in the assembly process of the active center of 50S ribosomal subunits

Gene Name:

dbpA

Uniprot ID:

P21693

Molecular weight:

49187

Reactions

General function:

Replication, recombination and repair

Specific function:

Acts in 50S ribosomal subunit biogenesis at low temperatures, acting after srmB. Has a helix-destabilizing activity; however it is unclear whether it requires ATP:according to PubMed:8552679, it does not require ATP, while according to PubMed:15196029 and PubMed:15554978, it requires ATP. Requires a helicase substrate with a single-stranded overhang. Plays a key role in optimal cell growth at low temperature and is required for normal cell division. When overexpressed suppresses cold-sensitive mutants of the rpsB gene (ribosomal protein S2) and of the smbA2 cold-sensitive mutant (pyrH, uridylate kinase). Can replace rhlB, another ATP-dependent RNA helicase, in the RNA degradosome in vitro. Stimulates translation, probably at the level of initiation, of some mRNAs

Gene Name:

deaD

Uniprot ID:

P0A9P6

Molecular weight:

70546

Reactions

General function:

Transcription

Specific function:

Probable helicase involved in DNA repair and perhaps also replication

Gene Name:

dinG

Uniprot ID:

P27296

Molecular weight:

81439

Reactions

General function:

Replication, recombination and repair

Specific function:

Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with dnaC protein, primase, and other prepriming proteins

Gene Name:

dnaB

Uniprot ID:

P0ACB0

Molecular weight:

52390

Reactions

General function:

Replication, recombination and repair

Specific function:

Helicase IV catalyzes the unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand in a reaction that is dependent upon the hydrolysis of ATP

Gene Name:

helD

Uniprot ID:

P15038

Molecular weight:

77976

Reactions

General function:

Replication, recombination and repair

Specific function:

Not yet known

Gene Name:

hrpA

Uniprot ID:

P43329

Molecular weight:

149027

Reactions

General function:

Replication, recombination and repair

Specific function:

ATP + H(2)O = ADP + phosphate

Gene Name:

hrpB

Uniprot ID:

P37024

Molecular weight:

89147

Reactions

General function:

Carbohydrate transport and metabolism

Specific function:

Not Available

Gene Name:

yjeF

Uniprot ID:

P31806

Molecular weight:

54650

Reactions

General function:

Inorganic ion transport and metabolism

Specific function:

Part of the ABC transporter complex PhnCDE involved in phosphonates, phosphate esters, phosphite and phosphate import. Responsible for energy coupling to the transport system

Gene Name:

phnC

Uniprot ID:

P16677

Molecular weight:

29430

Reactions

General function:

Replication, recombination and repair

Specific function:

Critical role in recombination and DNA repair. Help process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3' to 5' polarity. recG unwind branched duplex DNA (Y-DNA). Has a role in constitutive stable DNA replication (csdR) and R-loop formation

Gene Name:

recG

Uniprot ID:

P24230

Molecular weight:

76430

Reactions

General function:

Replication, recombination and repair

Specific function:

Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase

Gene Name:

recQ

Uniprot ID:

P15043

Molecular weight:

68363

Reactions

General function:

Replication, recombination and repair

Specific function:

Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction

Gene Name:

rep

Uniprot ID:

P09980

Molecular weight:

77024

Reactions

General function:

Replication, recombination and repair

Specific function:

Can carry out ATP-dependent unwinding of double stranded RNA. Has a role in RNA decay. Involved in the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation

Gene Name:

rhlB

Uniprot ID:

P0A8J8

Molecular weight:

47125

Reactions

General function:

Replication, recombination and repair

Specific function:

Acts as an ATP-dependent RNA helicase, able to unwind ds-RNA

Gene Name:

rhlE

Uniprot ID:

P25888

Molecular weight:

49989

Reactions

General function:

Replication, recombination and repair

Specific function:

The ruvA-ruvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is an helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of ruvB. Binds both single- and double-stranded DNA (dsDNA). Binds preferentially to supercoiled rather than to relaxed dsDNA

Gene Name:

ruvA

Uniprot ID:

P0A809

Molecular weight:

22086

Reactions

General function:

Replication, recombination and repair

Specific function:

The ruvA-ruvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is an helicase that mediates the Holliday junction migration by localized denaturation and reannealing

Gene Name:

ruvB

Uniprot ID:

P0A812

Molecular weight:

37173

Reactions

General function:

Replication, recombination and repair

Specific function:

RNA-dependent ATPase activity. Acts in 50S ribosomal subunit biogenesis at low temperatures, acting before deaD/csdA. Suppressor of a mutant defective in 50S ribosomal subunit assembly. Probably interacts with 23S ribosomal RNA

Gene Name:

srmB

Uniprot ID:

P21507

Molecular weight:

49914

Reactions

General function:

Involved in tRNA binding

Specific function:

Not Available

Gene Name:

ypfI

Uniprot ID:

P76562

Molecular weight:

74892

Reactions

General function:

Replication, recombination and repair

Specific function:

Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair

Gene Name:

uvrD

Uniprot ID:

P03018

Molecular weight:

81989

Reactions

General function:

Translation, ribosomal structure and biogenesis

Specific function:

ATP + H(2)O = ADP + phosphate

Gene Name:

yoaA

Uniprot ID:

P76257

Molecular weight:

70377

Reactions