2.0 2012-07-30 14:55:25 -0600 2015-06-03 17:21:13 -0600 ECMDB21355 M2MDB001752 Selenite The selenite anion is a selenium oxoanion with the chemical formula SeO32−. A selenite (compound) is a compound that contains this ion. In slightly acid conditions, the hydrogenselenite ion, HSeO3−, is formed; in more acidic conditions selenous acid, H2SeO3, exists. Most selenite salts can be formed by heating the relevant metal oxide with selenium dioxide, e.g.:Na2O + SeO2 → Na2SeO3. Selenite is an inorganic form of selenium which may also be useful in cancer chemotherapy.(Wikipedia) Selenit Selenite Selenite (SeO32-) Selenite ion (SeO32-) Selenite ion(2-) Selenite(2-) Trioxidoselenate(2) Trioxidoselenic acid(2) Trioxoselenate(2) Trioxoselenate(4) Trioxoselenic acid(2) Trioxoselenic acid(4) [SeO3]2 O3Se 126.96 127.901265694 selenous acid selenious acid 14124-67-5 [O-][Se]([O-])=O InChI=1S/H2O3Se/c1-4(2)3/h(H2,1,2,3)/p-2 MCAHWIHFGHIESP-UHFFFAOYSA-L Solid Cytosol Extra-organism Periplasm logp -1.3 ChemAxon pka_strongest_acidic 1.2 ChemAxon iupac selenous acid ChemAxon average_mass 126.96 ChemAxon mono_mass 127.901265694 ChemAxon smiles [O-][Se]([O-])=O ChemAxon formula O3Se ChemAxon inchi InChI=1S/H2O3Se/c1-4(2)3/h(H2,1,2,3)/p-2 ChemAxon inchikey MCAHWIHFGHIESP-UHFFFAOYSA-L ChemAxon polar_surface_area 57.53 ChemAxon refractivity 19.69 ChemAxon polarizability 5.84 ChemAxon rotatable_bond_count 0 ChemAxon acceptor_count 4 ChemAxon donor_count 2 ChemAxon physiological_charge -2 ChemAxon formal_charge 0 ChemAxon Selenoamino acid metabolism ec00450 Selenium metabolism The selenium metabolism begins with the introduction of selenate and selenite to the cytosol through a sulphate permease system. Once in the cell, selenate can be reduced to selenite through nitrate reductases A and Z. Selenite then interacts with glutathione and 2 hydrogen ions resulting in the release of 2 water molecules, a hydroxide molecule, a glutathione disulfide and a selenodiglutathione. The latter compound then reacts with NADPH+H resulting in the release of a NADP, a glutathione and a glutathioselenol. Glutathiolselenol can then be oxidize resulting in a a glutathiolselenol ion which can then interact with a water molecule resulting in a release of glutathion and selenium Glutathiolselenol can also react with NADPH and hydrogen ion resulting in a release of glutathione, NADP, a hydroxide molecule and a hydrogen selenide. This compound can react in a reversible reaction by being oxidized resulting in a hydrogen selenide ion . This compound can then be phosphorylated by interacting with an ATP and releasing a AMP, a phosphate and a selenophosphate. PW001894 Metabolic inner membrane transport list of inner membrane transport complexes, transporting compounds from the periplasmic space to the cytosol This pathway should be updated regularly with the new inner membrae transports added PW000786 Metabolic Specdb::CMs 169794 Specdb::MsMs 63609 Specdb::MsMs 63610 Specdb::MsMs 63611 Specdb::MsMs 120576 Specdb::MsMs 120577 Specdb::MsMs 120578 Specdb::MsMs 2276202 Specdb::MsMs 2276203 Specdb::MsMs 2276204 Specdb::MsMs 3092293 Specdb::MsMs 3092294 Specdb::MsMs 3092295 HMDB11119 1090 1059 C05684 18212 SELENITE Selenite_(ion) Respiratory nitrate reductase 1 alpha chain P09152 NARG_ECOLI narG http://ecmdb.ca/proteins/P09152.xml Thioredoxin reductase P0A9P4 TRXB_ECOLI trxB http://ecmdb.ca/proteins/P0A9P4.xml Probable anaerobic dimethyl sulfoxide reductase chain ynfG P0AAJ1 YNFG_ECOLI ynfG http://ecmdb.ca/proteins/P0AAJ1.xml Respiratory nitrate reductase 2 gamma chain P0AF32 NARV_ECOLI narV http://ecmdb.ca/proteins/P0AF32.xml Respiratory nitrate reductase 1 beta chain P11349 NARH_ECOLI narH http://ecmdb.ca/proteins/P11349.xml Respiratory nitrate reductase 1 gamma chain P11350 NARI_ECOLI narI http://ecmdb.ca/proteins/P11350.xml Sulfate/thiosulfate import ATP-binding protein cysA P16676 CYSA_ECOLI cysA http://ecmdb.ca/proteins/P16676.xml Probable nitrate reductase molybdenum cofactor assembly chaperone NarW P19317 NARW_ECOLI narW http://ecmdb.ca/proteins/P19317.xml Respiratory nitrate reductase 2 beta chain P19318 NARY_ECOLI narY http://ecmdb.ca/proteins/P19318.xml Respiratory nitrate reductase 2 alpha chain P19319 NARZ_ECOLI narZ http://ecmdb.ca/proteins/P19319.xml Periplasmic nitrate reductase P33937 NAPA_ECOLI napA http://ecmdb.ca/proteins/P33937.xml Putative dimethyl sulfoxide reductase chain ynfE P77374 YNFE_ECOLI ynfE http://ecmdb.ca/proteins/P77374.xml Probable dimethyl sulfoxide reductase chain ynfF P77783 YNFF_ECOLI ynfF http://ecmdb.ca/proteins/P77783.xml Sulfate transport system permease protein cysW P0AEB0 CYSW_ECOLI cysW http://ecmdb.ca/proteins/P0AEB0.xml Sulfate transport system permease protein cysT P16701 CYST_ECOLI cysU http://ecmdb.ca/proteins/P16701.xml Thiosulfate-binding protein P16700 CYSP_ECOLI cysP http://ecmdb.ca/proteins/P16700.xml Diheme cytochrome c napB P0ABL3 NAPB_ECOLI napB http://ecmdb.ca/proteins/P0ABL3.xml Anaerobic dimethyl sulfoxide reductase chain ynfH P76173 YNFH_ECOLI ynfH http://ecmdb.ca/proteins/P76173.xml Nitrate reductase molybdenum cofactor assembly chaperone NarJ P0AF26 NARJ_ECOLI narJ http://ecmdb.ca/proteins/P0AF26.xml Sulfate/thiosulfate import ATP-binding protein cysA P16676 CYSA_ECOLI cysA http://ecmdb.ca/proteins/P16676.xml Sulfate transport system permease protein cysW P0AEB0 CYSW_ECOLI cysW http://ecmdb.ca/proteins/P0AEB0.xml Sulfate transport system permease protein cysT P16701 CYST_ECOLI cysU http://ecmdb.ca/proteins/P16701.xml Outer membrane protein N P77747 OMPN_ECOLI ompN http://ecmdb.ca/proteins/P77747.xml Thiosulfate-binding protein P16700 CYSP_ECOLI cysP http://ecmdb.ca/proteins/P16700.xml Outer membrane pore protein E P02932 PHOE_ECOLI phoE http://ecmdb.ca/proteins/P02932.xml Outer membrane protein F P02931 OMPF_ECOLI ompF http://ecmdb.ca/proteins/P02931.xml Outer membrane protein C P06996 OMPC_ECOLI ompC http://ecmdb.ca/proteins/P06996.xml Menaquinol 8 + Selenocystathionine > Water + Menaquinone 8 + Selenite Hydrogen selenide + 3 NADP + 3 Water <> Selenite +3 NADPH +5 Hydrogen ion R03596 Selenite + Glutathione + Hydrogen ion > Selenodiglutathione + Glutathione disulfide + Water RXN-12864 Selenite + Water + an oxidized electron acceptor < selenate + a reduced electron acceptor RXN0-2101 Selenite + Water + Adenosine triphosphate > Selenite + ADP + Phosphate + Hydrogen ion TRANS-RXN0-479 Selenite + Water + Adenosine triphosphate > Selenite + ADP + Phosphate + Hydrogen ion TRANS-RXN0-479 Selenite + Water + Acceptor <> Selenate + Reduced acceptor R07229 Selenate + 2 Hydrogen ion + 2 Electron > Selenite + Water PW_R005187 Hydrogen selenide + 3 NADP + 3 Water <> Selenite +3 NADPH