Cadmium (ECMDB21194) (M2MDB001603)

IdentificationTaxonomyPhysical PropertiesBiological PropertiesSpectraConcentrationsLinksReferencesEnzymes (1)Transporters (7)XML
Proteins (8)
Record Information
Version2.0
Creation Date2012-07-30 14:54:49 -0600
Update Date2015-09-13 12:56:14 -0600
Secondary Accession Numbers
  • ECMDB21194
Identification
Name:Cadmium
DescriptionCadmium is a chemical element with the symbol Cd and atomic number 48. Cadmium usually has an oxidation state of +2 in most of its compounds, but it also exists in the +1 state. (Wikipedia) Cadmium interacts with many E. coli enzymes in its 2+ cation form. For example, Cd2+ is an activator of threonine dehydrogenase, and an inhibitor of alpha-galactosidase. (EcoCyc)
Structure
Thumb
MOLSDFPDBSMILESInChI
Synonyms:
  • 48Cd
  • Cadmio
  • Cadmium
  • Cadmium atom
  • Cadmium elemental
  • Cadmium metallicum
  • Cd
  • Colloidal cadmium
  • Kadmium
Chemical Formula:Cd
Weight:Average: 112.411
Monoisotopic: 113.903358121
InChI Key:BDOSMKKIYDKNTQ-UHFFFAOYSA-N
InChI:InChI=1S/Cd
CAS number:7440-43-9
IUPAC Name:cadmium(2+) ion
Traditional IUPAC Name:cadmium(2+) ion
SMILES:[Cd]
Chemical Taxonomy
Description belongs to the class of inorganic compounds known as homogeneous transition metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a transition metal atom.
KingdomInorganic compounds
Super ClassHomogeneous metal compounds
ClassHomogeneous transition metal compounds
Sub ClassNot Available
Direct ParentHomogeneous transition metal compounds
Alternative ParentsNot Available
Substituents
  • Homogeneous transition metal
Molecular FrameworkNot Available
External Descriptors
Physical Properties
State:Solid
Charge:2
Melting point:321 °C
Experimental Properties:
PropertyValueSource
Predicted Properties
PropertyValueSource
logP-0.07ChemAxon
Physiological Charge2ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m³·mol⁻¹ChemAxon
Polarizability1.78 ųChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Biological Properties
Cellular Locations:Cytoplasm
Reactions:
Adenosine triphosphate + Cadmium + Water > ADP + Hydrogen ion + Phosphate + Cadmium
Adenosine triphosphate + Cadmium + Water > ADP + Hydrogen ion + Phosphate + Cadmium
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
EcoCyc Pathways:Not Available
Concentrations
Not Available
Spectra
Spectra:
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-03di-0900000000-f8713a66369086ec0ad5View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-03di-0900000000-f8713a66369086ec0ad5View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-03di-0900000000-f8713a66369086ec0ad5View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-03di-0900000000-c6c3e3d7e513c880c7f4View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-03di-0900000000-c6c3e3d7e513c880c7f4View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-03di-0900000000-c6c3e3d7e513c880c7f4View in MoNA
References
References:Not Available
Synthesis Reference:Not Available
Material Safety Data Sheet (MSDS)Download (PDF)
External Links:
ResourceLink
CHEBI ID22977
HMDB IDHMDB03638
Pubchem Compound ID23973
Kegg IDC01413
ChemSpider ID22410
WikipediaCadmium
BioCyc IDCD%2b2
EcoCyc IDCD%2b2

Enzymes

Protein Details
1. Lead, cadmium, zinc and mercury-transporting ATPase
General function:
Involved in nucleotide binding
Specific function:
Involved in export of lead, cadmium, zinc and mercury
Gene Name:
zntA
Uniprot ID:
P37617
Molecular weight:
76839
Reactions
ATP + H(2)O + Cd(2+)(In) = ADP + phosphate + Cd(2+)(Out).
ATP + H(2)O + Zn(2+)(In) = ADP + phosphate + Zn(2+)(Out).

Transporters

Protein Details
1. Zinc transporter zupT
General function:
Involved in metal ion transmembrane transporter activity
Specific function:
Mediates zinc uptake. May also transport other divalent cations such as copper and cadmium ions
Gene Name:
zupT
Uniprot ID:
P0A8H3
Molecular weight:
26484
Protein Details
2. Zinc transporter zitB
General function:
Involved in cation transmembrane transporter activity
Specific function:
Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc, whereas zntA is required for growth at more toxic concentrations
Gene Name:
zitB
Uniprot ID:
P75757
Molecular weight:
34678
Protein Details
3. Outer membrane protein N
General function:
Involved in transporter activity
Specific function:
Non-specific porin
Gene Name:
ompN
Uniprot ID:
P77747
Molecular weight:
41220
Protein Details
4. Ferrous-iron efflux pump fieF
General function:
Involved in cation transmembrane transporter activity
Specific function:
Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn(2+) in a proton- dependent manner
Gene Name:
fieF
Uniprot ID:
P69380
Molecular weight:
32927
Protein Details
5. Outer membrane pore protein E
General function:
Involved in transporter activity
Specific function:
Uptake of inorganic phosphate, phosphorylated compounds, and some other negatively charged solutes
Gene Name:
phoE
Uniprot ID:
P02932
Molecular weight:
38922
Protein Details
6. Outer membrane protein F
General function:
Involved in transporter activity
Specific function:
OmpF is a porin that forms passive diffusion pores which allow small molecular weight hydrophilic materials across the outer membrane. It is also a receptor for the bacteriophage T2
Gene Name:
ompF
Uniprot ID:
P02931
Molecular weight:
39333
Protein Details
7. Outer membrane protein C
General function:
Involved in transporter activity
Specific function:
Forms passive diffusion pores which allow small molecular weight hydrophilic materials across the outer membrane
Gene Name:
ompC
Uniprot ID:
P06996
Molecular weight:
40368