Ammonium (ECMDB21186) (M2MDB001595)

General function:

Involved in oxidoreductase activity

Specific function:

L-glutamate + H(2)O + NADP(+) = 2-oxoglutarate + NH(3) + NADPH

Gene Name:

gdhA

Uniprot ID:

P00370

Molecular weight:

48581

Reactions

General function:

Involved in asparaginase activity

Specific function:

L-asparagine + H(2)O = L-aspartate + NH(3)

Gene Name:

ansB

Uniprot ID:

P00805

Molecular weight:

36851

Reactions

General function:

Involved in cyanate hydratase activity

Specific function:

Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide

Gene Name:

cynS

Uniprot ID:

P00816

Molecular weight:

17049

Reactions

General function:

Involved in D-serine ammonia-lyase activity

Specific function:

D-serine = pyruvate + NH(3)

Gene Name:

dsdA

Uniprot ID:

P00926

Molecular weight:

47900

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP + L-aspartate + NH(3) = AMP + diphosphate + L-asparagine

Gene Name:

asnA

Uniprot ID:

P00963

Molecular weight:

36650

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia. Deaminates L-threonine, but also L-serine to a lesser extent

Gene Name:

ilvA

Uniprot ID:

P04968

Molecular weight:

56195

Reactions

General function:

Involved in biosynthetic process

Specific function:

Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine

Gene Name:

pabB

Uniprot ID:

P05041

Molecular weight:

50969

Reactions

General function:

Involved in pyridoxal phosphate binding

Specific function:

L-cystathionine + H(2)O = L-homocysteine + NH(3) + pyruvate

Gene Name:

metC

Uniprot ID:

P06721

Molecular weight:

43212

Reactions

General function:

Involved in hydroxymethylbilane synthase activity

Specific function:

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps

Gene Name:

hemC

Uniprot ID:

P06983

Molecular weight:

33851

Reactions

General function:

Involved in oxidation-reduction process

Specific function:

Ammonium hydroxide + 3 NAD(P)(+) + H(2)O = nitrite + 3 NAD(P)H

Gene Name:

nirB

Uniprot ID:

P08201

Molecular weight:

93121

Reactions

General function:

Involved in D-amino-acid dehydrogenase activity

Specific function:

Oxidative deamination of D-amino acids

Gene Name:

dadA

Uniprot ID:

P0A6J5

Molecular weight:

47607

Reactions

General function:

Involved in glutaminase activity

Specific function:

L-glutamine + H(2)O = L-glutamate + NH(3)

Gene Name:

glsA2

Uniprot ID:

P0A6W0

Molecular weight:

33515

Reactions

General function:

Involved in carbohydrate metabolic process

Specific function:

Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion

Gene Name:

nagB

Uniprot ID:

P0A759

Molecular weight:

29774

Reactions

General function:

Involved in lyase activity

Specific function:

L-tryptophan + H(2)O = indole + pyruvate + NH(3)

Gene Name:

tnaA

Uniprot ID:

P0A853

Molecular weight:

52773

Reactions

General function:

Involved in asparaginase activity

Specific function:

L-asparagine + H(2)O = L-aspartate + NH(3)

Gene Name:

ansA

Uniprot ID:

P0A962

Molecular weight:

37127

Reactions

General function:

Involved in glutamate-ammonia ligase activity

Specific function:

ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine

Gene Name:

glnA

Uniprot ID:

P0A9C5

Molecular weight:

51903

Reactions

General function:

Involved in nitrite reductase [NAD(P)H] activity

Specific function:

Required for activity of the reductase

Gene Name:

nirD

Uniprot ID:

P0A9I8

Molecular weight:

12284

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes

Gene Name:

lpdA

Uniprot ID:

P0A9P0

Molecular weight:

50688

Reactions

General function:

Involved in zinc ion binding

Specific function:

This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis

Gene Name:

cdd

Uniprot ID:

P0ABF6

Molecular weight:

31539

Reactions

General function:

Involved in nitrogen compound metabolic process

Specific function:

Plays a role in nitrite reduction

Gene Name:

nrfA

Uniprot ID:

P0ABK9

Molecular weight:

53703

Reactions

General function:

Involved in aspartate ammonia-lyase activity

Specific function:

L-aspartate = fumarate + NH(3)

Gene Name:

aspA

Uniprot ID:

P0AC38

Molecular weight:

52356

Reactions

General function:

Involved in catalytic activity

Specific function:

Ethanolamine = acetaldehyde + NH(3)

Gene Name:

eutB

Uniprot ID:

P0AEJ6

Molecular weight:

49403

Reactions

General function:

Involved in catalytic activity

Specific function:

Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase

Gene Name:

tdcB

Uniprot ID:

P0AGF6

Molecular weight:

35232

Reactions

General function:

Involved in L-serine ammonia-lyase activity

Specific function:

Deaminates also threonine, particularly when it is present in high concentration

Gene Name:

sdaA

Uniprot ID:

P16095

Molecular weight:

48906

Reactions

General function:

Involved in NAD+ synthase (glutamine-hydrolyzing) activity

Specific function:

Catalyzes a key step in NAD biosynthesis, transforming deamido-NAD into NAD by a two-step reaction

Gene Name:

nadE

Uniprot ID:

P18843

Molecular weight:

30637

Reactions

General function:

Involved in ethanolamine ammonia-lyase activity

Specific function:

Ethanolamine = acetaldehyde + NH(3)

Gene Name:

eutC

Uniprot ID:

P19636

Molecular weight:

31781

Reactions

General function:

Involved in catalytic activity

Specific function:

Nicotinamide + H(2)O = nicotinate + NH(3)

Gene Name:

pncA

Uniprot ID:

P21369

Molecular weight:

23362

Reactions

General function:

Involved in asparagine synthase (glutamine-hydrolyzing) activity

Specific function:

ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate

Gene Name:

asnB

Uniprot ID:

P22106

Molecular weight:

62659

Reactions

General function:

Involved in deaminase activity

Specific function:

Adenosine + H(2)O = inosine + NH(3)

Gene Name:

add

Uniprot ID:

P22333

Molecular weight:

36397

Reactions

General function:

Involved in transferase activity

Specific function:

Acts as a beta-cystathionase and as a repressor of the maltose regulon

Gene Name:

malY

Uniprot ID:

P23256

Molecular weight:

43641

Reactions

General function:

Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

Specific function:

Cytosine + H(2)O = uracil + NH(3)

Gene Name:

codA

Uniprot ID:

P25524

Molecular weight:

47591

Reactions

General function:

Involved in zinc ion binding

Specific function:

Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate

Gene Name:

ribD

Uniprot ID:

P25539

Molecular weight:

40338

Reactions

General function:

Involved in aminomethyltransferase activity

Specific function:

The glycine cleavage system catalyzes the degradation of glycine

Gene Name:

gcvT

Uniprot ID:

P27248

Molecular weight:

40146

Reactions

General function:

Involved in dCTP deaminase activity

Specific function:

dCTP + H(2)O = dUTP + NH(3)

Gene Name:

dcd

Uniprot ID:

P28248

Molecular weight:

21249

Reactions

General function:

Involved in L-serine ammonia-lyase activity

Specific function:

Deaminates also threonine, particularly when it is present in high concentration

Gene Name:

sdaB

Uniprot ID:

P30744

Molecular weight:

48753

Reactions

General function:

Involved in adenine deaminase activity

Specific function:

Adenine + H(2)O = hypoxanthine + NH(3)

Gene Name:

ade

Uniprot ID:

P31441

Molecular weight:

63739

Reactions

General function:

Involved in glycine dehydrogenase (decarboxylating) activity

Specific function:

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein

Gene Name:

gcvP

Uniprot ID:

P33195

Molecular weight:

104376

Reactions

General function:

Involved in cellular amino acid biosynthetic process

Specific function:

ATP + NH(3) + CO(2) = ADP + carbamoyl phosphate

Gene Name:

arcC

Uniprot ID:

P37306

Molecular weight:

31644

Reactions

General function:

Involved in hydrolase activity

Specific function:

May be involved in glutathione, and possibly other peptide, transport, although these results could also be due to polar effects of disruption

Gene Name:

iaaA

Uniprot ID:

P37595

Molecular weight:

33394

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Involved in the breakdown of putrescine via the oxidation of L-glutamylputrescine

Gene Name:

puuB

Uniprot ID:

P37906

Molecular weight:

47169

Reactions

General function:

Involved in L-serine ammonia-lyase activity

Specific function:

L-serine = pyruvate + NH(3)

Gene Name:

tdcG

Uniprot ID:

P42630

Molecular weight:

48521

Reactions

General function:

Involved in copper ion binding

Specific function:

The enzyme prefers aromatic over aliphatic amines

Gene Name:

tynA

Uniprot ID:

P46883

Molecular weight:

84378

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides

Gene Name:

guaC

Uniprot ID:

P60560

Molecular weight:

37383

Reactions

General function:

Involved in diaminopropionate ammonia-lyase activity

Specific function:

Catalyzes the alpha,beta-elimination reaction of both L- and D-alpha,beta-diaminopropionate, the most suitable substrates to form pyruvate and ammonia. The L- and D-isomers of serine are also degraded, though slowly; it is the only serine dehydratase which can eliminate an amino group at the beta-carbon position

Gene Name:

ygeX

Uniprot ID:

P66899

Molecular weight:

43327

Reactions

General function:

Involved in N-succinylarginine dihydrolase activity

Specific function:

Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2)

Gene Name:

astB

Uniprot ID:

P76216

Molecular weight:

49298

Reactions

General function:

Involved in D-cysteine desulfhydrase activity

Specific function:

Catalyzes the alpha,beta-elimination reaction of D- cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine. Can also catalyze the degradation of 3-chloro-D-alanine

Gene Name:

dcyD

Uniprot ID:

P76316

Molecular weight:

35153

Reactions

General function:

Involved in hydrolase activity

Specific function:

Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia

Gene Name:

guaD

Uniprot ID:

P76641

Molecular weight:

50244

Reactions

General function:

Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

Specific function:

Involved in the anaerobic utilization of allantoin. Converts allantoate to (S)-ureidoglycolate and ammonia

Gene Name:

allC

Uniprot ID:

P77425

Molecular weight:

45694

General function:

Involved in glutaminase activity

Specific function:

L-glutamine + H(2)O = L-glutamate + NH(3)

Gene Name:

glsA1

Uniprot ID:

P77454

Molecular weight:

32903

Reactions

General function:

Involved in cellular amino acid biosynthetic process

Specific function:

Specific function unknown

Gene Name:

yahI

Uniprot ID:

P77624

Molecular weight:

33931

General function:

Involved in ureidoglycolate hydrolase activity

Specific function:

Involved in the anaerobic utilization of allantoin. Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate

Gene Name:

allA

Uniprot ID:

P77731

Molecular weight:

18169

Reactions

General function:

Involved in glutamate-ammonia ligase activity

Specific function:

Involved in the breakdown of putrescine via the biosynthesis of gamma-L-glutamylputrescine

Gene Name:

puuA

Uniprot ID:

P78061

Molecular weight:

53177

Reactions

General function:

Involved in cellular amino acid biosynthetic process

Specific function:

Specific function unknown

Gene Name:

yqeA

Uniprot ID:

Q46807

Molecular weight:

33071

General function:

Inorganic ion transport and metabolism

Specific function:

Probably involved in the transfer of electrons from the quinone pool to the type-c cytochromes

Gene Name:

nrfD

Uniprot ID:

P32709

Molecular weight:

35042

General function:

Involved in electron carrier activity

Specific function:

Probably involved in the transfer of electrons from the quinone pool to the type-c cytochromes

Gene Name:

nrfC

Uniprot ID:

P0AAK7

Molecular weight:

24567

General function:

Involved in argininosuccinate synthase activity

Specific function:

Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))

Gene Name:

queC

Uniprot ID:

P77756

Molecular weight:

25514

Reactions

General function:

Involved in heme binding

Specific function:

Plays a role in nitrite reduction

Gene Name:

nrfB

Uniprot ID:

P0ABL1

Molecular weight:

20714

General function:

Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

Specific function:

Makes part of the rut operon, which is required for the utilization of pyrimidines as sole nitrogen source

Gene Name:

rutD

Uniprot ID:

P75895

Molecular weight:

28898

Reactions

General function:

Amino acid transport and metabolism

Specific function:

The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein

Gene Name:

gcvH

Uniprot ID:

P0A6T9

Molecular weight:

13811

General function:

Coenzyme transport and metabolism

Specific function:

Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

Gene Name:

pdxH

Uniprot ID:

P0AFI7

Molecular weight:

25545

Reactions

General function:

Not Available

Specific function:

Not Available

Gene Name:

ylbA

Uniprot ID:

P75713

Molecular weight:

Not Available

General function:

pyridine nucleotide biosynthetic process

Specific function:

Has nicotinamidemononucleotide (NMN) aminohydrolase activity, not active on other substrates.

Gene Name:

pncC

Uniprot ID:

P0A6G3

Molecular weight:

17581

Reactions