Ammonium (ECMDB21186) (M2MDB001595)
Enzymes
- General function:
- Involved in oxidoreductase activity
- Specific function:
- L-glutamate + H(2)O + NADP(+) = 2-oxoglutarate + NH(3) + NADPH
- Gene Name:
- gdhA
- Uniprot ID:
- P00370
- Molecular weight:
- 48581
Reactions
L-glutamate + H(2)O + NADP(+) = 2-oxoglutarate + NH(3) + NADPH. |
- General function:
- Involved in asparaginase activity
- Specific function:
- L-asparagine + H(2)O = L-aspartate + NH(3)
- Gene Name:
- ansB
- Uniprot ID:
- P00805
- Molecular weight:
- 36851
Reactions
L-asparagine + H(2)O = L-aspartate + NH(3). |
- General function:
- Involved in cyanate hydratase activity
- Specific function:
- Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
- Gene Name:
- cynS
- Uniprot ID:
- P00816
- Molecular weight:
- 17049
Reactions
Cyanate + HCO(3)(-) + 2 H(+) = NH(3) + 2 CO(2). |
- General function:
- Involved in D-serine ammonia-lyase activity
- Specific function:
- D-serine = pyruvate + NH(3)
- Gene Name:
- dsdA
- Uniprot ID:
- P00926
- Molecular weight:
- 47900
Reactions
D-serine = pyruvate + NH(3). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-aspartate + NH(3) = AMP + diphosphate + L-asparagine
- Gene Name:
- asnA
- Uniprot ID:
- P00963
- Molecular weight:
- 36650
Reactions
ATP + L-aspartate + NH(3) = AMP + diphosphate + L-asparagine. |
- General function:
- Involved in catalytic activity
- Specific function:
- Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia. Deaminates L-threonine, but also L-serine to a lesser extent
- Gene Name:
- ilvA
- Uniprot ID:
- P04968
- Molecular weight:
- 56195
Reactions
L-threonine = 2-oxobutanoate + NH(3). |
- General function:
- Involved in biosynthetic process
- Specific function:
- Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine
- Gene Name:
- pabB
- Uniprot ID:
- P05041
- Molecular weight:
- 50969
Reactions
Chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate. |
- General function:
- Involved in pyridoxal phosphate binding
- Specific function:
- L-cystathionine + H(2)O = L-homocysteine + NH(3) + pyruvate
- Gene Name:
- metC
- Uniprot ID:
- P06721
- Molecular weight:
- 43212
Reactions
L-cystathionine + H(2)O = L-homocysteine + NH(3) + pyruvate. |
- General function:
- Involved in hydroxymethylbilane synthase activity
- Specific function:
- Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
- Gene Name:
- hemC
- Uniprot ID:
- P06983
- Molecular weight:
- 33851
Reactions
4 porphobilinogen + H(2)O = hydroxymethylbilane + 4 NH(3). |
- General function:
- Involved in oxidation-reduction process
- Specific function:
- Ammonium hydroxide + 3 NAD(P)(+) + H(2)O = nitrite + 3 NAD(P)H
- Gene Name:
- nirB
- Uniprot ID:
- P08201
- Molecular weight:
- 93121
Reactions
Ammonium hydroxide + 3 NAD(P)(+) + H(2)O = nitrite + 3 NAD(P)H. |
- General function:
- Involved in D-amino-acid dehydrogenase activity
- Specific function:
- Oxidative deamination of D-amino acids
- Gene Name:
- dadA
- Uniprot ID:
- P0A6J5
- Molecular weight:
- 47607
Reactions
A D-amino acid + H(2)O + acceptor = a 2-oxo acid + NH(3) + reduced acceptor. |
- General function:
- Involved in glutaminase activity
- Specific function:
- L-glutamine + H(2)O = L-glutamate + NH(3)
- Gene Name:
- glsA2
- Uniprot ID:
- P0A6W0
- Molecular weight:
- 33515
Reactions
L-glutamine + H(2)O = L-glutamate + NH(3). |
- General function:
- Involved in carbohydrate metabolic process
- Specific function:
- Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
- Gene Name:
- nagB
- Uniprot ID:
- P0A759
- Molecular weight:
- 29774
Reactions
D-glucosamine 6-phosphate + H(2)O = D-fructose 6-phosphate + NH(3). |
- General function:
- Involved in lyase activity
- Specific function:
- L-tryptophan + H(2)O = indole + pyruvate + NH(3)
- Gene Name:
- tnaA
- Uniprot ID:
- P0A853
- Molecular weight:
- 52773
Reactions
L-tryptophan + H(2)O = indole + pyruvate + NH(3). |
- General function:
- Involved in asparaginase activity
- Specific function:
- L-asparagine + H(2)O = L-aspartate + NH(3)
- Gene Name:
- ansA
- Uniprot ID:
- P0A962
- Molecular weight:
- 37127
Reactions
L-asparagine + H(2)O = L-aspartate + NH(3). |
- General function:
- Involved in glutamate-ammonia ligase activity
- Specific function:
- ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine
- Gene Name:
- glnA
- Uniprot ID:
- P0A9C5
- Molecular weight:
- 51903
Reactions
ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine. |
- General function:
- Involved in nitrite reductase [NAD(P)H] activity
- Specific function:
- Required for activity of the reductase
- Gene Name:
- nirD
- Uniprot ID:
- P0A9I8
- Molecular weight:
- 12284
Reactions
Ammonium hydroxide + 3 NAD(P)(+) + H(2)O = nitrite + 3 NAD(P)H. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes
- Gene Name:
- lpdA
- Uniprot ID:
- P0A9P0
- Molecular weight:
- 50688
Reactions
Protein N(6)-(dihydrolipoyl)lysine + NAD(+) = protein N(6)-(lipoyl)lysine + NADH. |
- General function:
- Involved in zinc ion binding
- Specific function:
- This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
- Gene Name:
- cdd
- Uniprot ID:
- P0ABF6
- Molecular weight:
- 31539
Reactions
Cytidine + H(2)O = uridine + NH(3). |
- General function:
- Involved in nitrogen compound metabolic process
- Specific function:
- Plays a role in nitrite reduction
- Gene Name:
- nrfA
- Uniprot ID:
- P0ABK9
- Molecular weight:
- 53703
Reactions
NH(3) + 2 H(2)O + 6 ferricytochrome c = nitrite + 6 ferrocytochrome c + 7 H(+). |
- General function:
- Involved in aspartate ammonia-lyase activity
- Specific function:
- L-aspartate = fumarate + NH(3)
- Gene Name:
- aspA
- Uniprot ID:
- P0AC38
- Molecular weight:
- 52356
Reactions
L-aspartate = fumarate + NH(3). |
- General function:
- Involved in catalytic activity
- Specific function:
- Ethanolamine = acetaldehyde + NH(3)
- Gene Name:
- eutB
- Uniprot ID:
- P0AEJ6
- Molecular weight:
- 49403
Reactions
Ethanolamine = acetaldehyde + NH(3). |
- General function:
- Involved in catalytic activity
- Specific function:
- Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase
- Gene Name:
- tdcB
- Uniprot ID:
- P0AGF6
- Molecular weight:
- 35232
Reactions
L-threonine = 2-oxobutanoate + NH(3). |
L-serine = pyruvate + NH(3). |
- General function:
- Involved in L-serine ammonia-lyase activity
- Specific function:
- Deaminates also threonine, particularly when it is present in high concentration
- Gene Name:
- sdaA
- Uniprot ID:
- P16095
- Molecular weight:
- 48906
Reactions
L-serine = pyruvate + NH(3). |
- General function:
- Involved in NAD+ synthase (glutamine-hydrolyzing) activity
- Specific function:
- Catalyzes a key step in NAD biosynthesis, transforming deamido-NAD into NAD by a two-step reaction
- Gene Name:
- nadE
- Uniprot ID:
- P18843
- Molecular weight:
- 30637
Reactions
ATP + deamido-NAD(+) + NH(3) = AMP + diphosphate + NAD(+). |
- General function:
- Involved in ethanolamine ammonia-lyase activity
- Specific function:
- Ethanolamine = acetaldehyde + NH(3)
- Gene Name:
- eutC
- Uniprot ID:
- P19636
- Molecular weight:
- 31781
Reactions
Ethanolamine = acetaldehyde + NH(3). |
- General function:
- Involved in catalytic activity
- Specific function:
- Nicotinamide + H(2)O = nicotinate + NH(3)
- Gene Name:
- pncA
- Uniprot ID:
- P21369
- Molecular weight:
- 23362
Reactions
Nicotinamide + H(2)O = nicotinate + NH(3). |
- General function:
- Involved in asparagine synthase (glutamine-hydrolyzing) activity
- Specific function:
- ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate
- Gene Name:
- asnB
- Uniprot ID:
- P22106
- Molecular weight:
- 62659
Reactions
ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate. |
- General function:
- Involved in deaminase activity
- Specific function:
- Adenosine + H(2)O = inosine + NH(3)
- Gene Name:
- add
- Uniprot ID:
- P22333
- Molecular weight:
- 36397
Reactions
Adenosine + H(2)O = inosine + NH(3). |
- General function:
- Involved in transferase activity
- Specific function:
- Acts as a beta-cystathionase and as a repressor of the maltose regulon
- Gene Name:
- malY
- Uniprot ID:
- P23256
- Molecular weight:
- 43641
Reactions
L-cystathionine + H(2)O = L-homocysteine + NH(3) + pyruvate. |
- General function:
- Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
- Specific function:
- Cytosine + H(2)O = uracil + NH(3)
- Gene Name:
- codA
- Uniprot ID:
- P25524
- Molecular weight:
- 47591
Reactions
Cytosine + H(2)O = uracil + NH(3). |
- General function:
- Involved in zinc ion binding
- Specific function:
- Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
- Gene Name:
- ribD
- Uniprot ID:
- P25539
- Molecular weight:
- 40338
Reactions
2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + H(2)O = 5-amino-6-(5-phosphoribosylamino)uracil + NH(3). |
5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NADPH. |
- General function:
- Involved in aminomethyltransferase activity
- Specific function:
- The glycine cleavage system catalyzes the degradation of glycine
- Gene Name:
- gcvT
- Uniprot ID:
- P27248
- Molecular weight:
- 40146
Reactions
[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH(3). |
- General function:
- Involved in dCTP deaminase activity
- Specific function:
- dCTP + H(2)O = dUTP + NH(3)
- Gene Name:
- dcd
- Uniprot ID:
- P28248
- Molecular weight:
- 21249
Reactions
dCTP + H(2)O = dUTP + NH(3). |
- General function:
- Involved in L-serine ammonia-lyase activity
- Specific function:
- Deaminates also threonine, particularly when it is present in high concentration
- Gene Name:
- sdaB
- Uniprot ID:
- P30744
- Molecular weight:
- 48753
Reactions
L-serine = pyruvate + NH(3). |
- General function:
- Involved in adenine deaminase activity
- Specific function:
- Adenine + H(2)O = hypoxanthine + NH(3)
- Gene Name:
- ade
- Uniprot ID:
- P31441
- Molecular weight:
- 63739
Reactions
Adenine + H(2)O = hypoxanthine + NH(3). |
- General function:
- Involved in glycine dehydrogenase (decarboxylating) activity
- Specific function:
- The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein
- Gene Name:
- gcvP
- Uniprot ID:
- P33195
- Molecular weight:
- 104376
Reactions
Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO(2). |
- General function:
- Involved in cellular amino acid biosynthetic process
- Specific function:
- ATP + NH(3) + CO(2) = ADP + carbamoyl phosphate
- Gene Name:
- arcC
- Uniprot ID:
- P37306
- Molecular weight:
- 31644
Reactions
ATP + NH(3) + CO(2) = ADP + carbamoyl phosphate. |
- General function:
- Involved in hydrolase activity
- Specific function:
- May be involved in glutathione, and possibly other peptide, transport, although these results could also be due to polar effects of disruption
- Gene Name:
- iaaA
- Uniprot ID:
- P37595
- Molecular weight:
- 33394
Reactions
Cleavage of a beta-linked Asp residue from the N-terminus of a polypeptide. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Involved in the breakdown of putrescine via the oxidation of L-glutamylputrescine
- Gene Name:
- puuB
- Uniprot ID:
- P37906
- Molecular weight:
- 47169
Reactions
Gamma-glutamylputrescine + H(2)O + O(2) = Gamma-glutamyl-gamma-aminobutyraldehyde + NH(3) + H(2)O(2). |
- General function:
- Involved in L-serine ammonia-lyase activity
- Specific function:
- L-serine = pyruvate + NH(3)
- Gene Name:
- tdcG
- Uniprot ID:
- P42630
- Molecular weight:
- 48521
Reactions
L-serine = pyruvate + NH(3). |
- General function:
- Involved in copper ion binding
- Specific function:
- The enzyme prefers aromatic over aliphatic amines
- Gene Name:
- tynA
- Uniprot ID:
- P46883
- Molecular weight:
- 84378
Reactions
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2). |
2-phenylethylamine + H(2)O + O(2) = phenylacetaldehyde + NH(3) + H(2)O(2). |
- General function:
- Involved in catalytic activity
- Specific function:
- Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
- Gene Name:
- guaC
- Uniprot ID:
- P60560
- Molecular weight:
- 37383
Reactions
Inosine 5'-phosphate + NH(3) + NADP(+) = guanosine 5'-phosphate + NADPH. |
- General function:
- Involved in diaminopropionate ammonia-lyase activity
- Specific function:
- Catalyzes the alpha,beta-elimination reaction of both L- and D-alpha,beta-diaminopropionate, the most suitable substrates to form pyruvate and ammonia. The L- and D-isomers of serine are also degraded, though slowly; it is the only serine dehydratase which can eliminate an amino group at the beta-carbon position
- Gene Name:
- ygeX
- Uniprot ID:
- P66899
- Molecular weight:
- 43327
Reactions
2,3-diaminopropionate + H(2)O = pyruvate + 2 NH(3). |
- General function:
- Involved in N-succinylarginine dihydrolase activity
- Specific function:
- Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2)
- Gene Name:
- astB
- Uniprot ID:
- P76216
- Molecular weight:
- 49298
Reactions
N(2)-succinyl-L-arginine + 2 H(2)O = N(2)-succinyl-L-ornithine + 2 NH(3) + CO(2). |
- General function:
- Involved in D-cysteine desulfhydrase activity
- Specific function:
- Catalyzes the alpha,beta-elimination reaction of D- cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine. Can also catalyze the degradation of 3-chloro-D-alanine
- Gene Name:
- dcyD
- Uniprot ID:
- P76316
- Molecular weight:
- 35153
Reactions
D-cysteine + H(2)O = H(2)S + NH(3) + pyruvate. |
- General function:
- Involved in hydrolase activity
- Specific function:
- Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia
- Gene Name:
- guaD
- Uniprot ID:
- P76641
- Molecular weight:
- 50244
Reactions
Guanine + H(2)O = xanthine + NH(3). |
- General function:
- Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
- Specific function:
- Involved in the anaerobic utilization of allantoin. Converts allantoate to (S)-ureidoglycolate and ammonia
- Gene Name:
- allC
- Uniprot ID:
- P77425
- Molecular weight:
- 45694
- General function:
- Involved in glutaminase activity
- Specific function:
- L-glutamine + H(2)O = L-glutamate + NH(3)
- Gene Name:
- glsA1
- Uniprot ID:
- P77454
- Molecular weight:
- 32903
Reactions
L-glutamine + H(2)O = L-glutamate + NH(3). |
- General function:
- Involved in cellular amino acid biosynthetic process
- Specific function:
- Specific function unknown
- Gene Name:
- yahI
- Uniprot ID:
- P77624
- Molecular weight:
- 33931
- General function:
- Involved in ureidoglycolate hydrolase activity
- Specific function:
- Involved in the anaerobic utilization of allantoin. Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate
- Gene Name:
- allA
- Uniprot ID:
- P77731
- Molecular weight:
- 18169
Reactions
(S)-ureidoglycolate + H(2)O = glyoxylate + 2 NH(3) + CO(2). |
- General function:
- Involved in glutamate-ammonia ligase activity
- Specific function:
- Involved in the breakdown of putrescine via the biosynthesis of gamma-L-glutamylputrescine
- Gene Name:
- puuA
- Uniprot ID:
- P78061
- Molecular weight:
- 53177
Reactions
ATP + L-glutamate + putrescine = ADP + phosphate + gamma-L-glutamylputrescine. |
- General function:
- Involved in cellular amino acid biosynthetic process
- Specific function:
- Specific function unknown
- Gene Name:
- yqeA
- Uniprot ID:
- Q46807
- Molecular weight:
- 33071
- General function:
- Inorganic ion transport and metabolism
- Specific function:
- Probably involved in the transfer of electrons from the quinone pool to the type-c cytochromes
- Gene Name:
- nrfD
- Uniprot ID:
- P32709
- Molecular weight:
- 35042
- General function:
- Involved in electron carrier activity
- Specific function:
- Probably involved in the transfer of electrons from the quinone pool to the type-c cytochromes
- Gene Name:
- nrfC
- Uniprot ID:
- P0AAK7
- Molecular weight:
- 24567
- General function:
- Involved in argininosuccinate synthase activity
- Specific function:
- Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
- Gene Name:
- queC
- Uniprot ID:
- P77756
- Molecular weight:
- 25514
Reactions
7-carboxy-7-carbaguanine + NH(3) + ATP = 7-cyano-7-carbaguanine + ADP + phosphate + H(2)O. |
- General function:
- Involved in heme binding
- Specific function:
- Plays a role in nitrite reduction
- Gene Name:
- nrfB
- Uniprot ID:
- P0ABL1
- Molecular weight:
- 20714
- General function:
- Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
- Specific function:
- Makes part of the rut operon, which is required for the utilization of pyrimidines as sole nitrogen source
- Gene Name:
- rutD
- Uniprot ID:
- P75895
- Molecular weight:
- 28898
Reactions
(Z)-3-aminoacrylate + H(2)O = malonate semialdehyde + NH(3). |
- General function:
- Amino acid transport and metabolism
- Specific function:
- The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein
- Gene Name:
- gcvH
- Uniprot ID:
- P0A6T9
- Molecular weight:
- 13811
- General function:
- Coenzyme transport and metabolism
- Specific function:
- Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)
- Gene Name:
- pdxH
- Uniprot ID:
- P0AFI7
- Molecular weight:
- 25545
Reactions
Pyridoxamine 5'-phosphate + H(2)O + O(2) = pyridoxal 5'-phosphate + NH(3) + H(2)O(2). |
Pyridoxine 5'-phosphate + O(2) = pyridoxal 5'-phosphate + H(2)O(2). |
- General function:
- Not Available
- Specific function:
- Not Available
- Gene Name:
- ylbA
- Uniprot ID:
- P75713
- Molecular weight:
- Not Available
- General function:
- pyridine nucleotide biosynthetic process
- Specific function:
- Has nicotinamidemononucleotide (NMN) aminohydrolase activity, not active on other substrates.
- Gene Name:
- pncC
- Uniprot ID:
- P0A6G3
- Molecular weight:
- 17581
Reactions
Beta-nicotinamide D-ribonucleotide + H(2)O = beta-nicotinate D-ribonucleotide + NH(3) |
Transporters
- General function:
- Involved in ammonium transmembrane transporter activity
- Specific function:
- Involved in the uptake of ammonia
- Gene Name:
- amtB
- Uniprot ID:
- P69681
- Molecular weight:
- 44514
- General function:
- Involved in transporter activity
- Specific function:
- Non-specific porin
- Gene Name:
- ompN
- Uniprot ID:
- P77747
- Molecular weight:
- 41220
- General function:
- Involved in transporter activity
- Specific function:
- Uptake of inorganic phosphate, phosphorylated compounds, and some other negatively charged solutes
- Gene Name:
- phoE
- Uniprot ID:
- P02932
- Molecular weight:
- 38922
- General function:
- Involved in transporter activity
- Specific function:
- OmpF is a porin that forms passive diffusion pores which allow small molecular weight hydrophilic materials across the outer membrane. It is also a receptor for the bacteriophage T2
- Gene Name:
- ompF
- Uniprot ID:
- P02931
- Molecular weight:
- 39333
- General function:
- Involved in transporter activity
- Specific function:
- Forms passive diffusion pores which allow small molecular weight hydrophilic materials across the outer membrane
- Gene Name:
- ompC
- Uniprot ID:
- P06996
- Molecular weight:
- 40368