5'-Deoxyadenosine (ECMDB21174) (M2MDB001583)

General function:

Involved in catalytic activity

Specific function:

Activation of pyruvate formate-lyase 1 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine

Gene Name:

pflA

Uniprot ID:

P0A9N4

Molecular weight:

28204

Reactions

General function:

Involved in [formate-C-acetyltransferase]-activating enzyme activity

Specific function:

Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine

Gene Name:

nrdG

Uniprot ID:

P0A9N8

Molecular weight:

17446

General function:

Involved in adenosylhomocysteine nucleosidase activity

Specific function:

Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Can also use 5'-isobutylthioadenosine, 5'-n- butylthioadenosine, S-adenosyl-D-homocysteine, decarboxylated adenosylhomocysteine, deaminated adenosylhomocysteine and S-2-aza- adenosylhomocysteine as substrates

Gene Name:

mtnN

Uniprot ID:

P0AF12

Molecular weight:

24354

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism

Gene Name:

bioB

Uniprot ID:

P12996

Molecular weight:

38648

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes. Is also able to catalyze very poorly the transfer of lipoyl and octanoyl moiety from their acyl carrier protein

Gene Name:

lplA

Uniprot ID:

P32099

Molecular weight:

37926

Reactions

General function:

Involved in coproporphyrinogen oxidase activity

Specific function:

Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX

Gene Name:

hemN

Uniprot ID:

P32131

Molecular weight:

52729

Reactions

General function:

Involved in iron-sulfur cluster binding

Specific function:

Activation of pyruvate formate-lyase 2 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine

Gene Name:

pflC

Uniprot ID:

P32675

Molecular weight:

32429

Reactions

General function:

Involved in coproporphyrinogen oxidase activity

Specific function:

Not Available

Gene Name:

yggW

Uniprot ID:

P52062

Molecular weight:

42584

General function:

Involved in catalytic activity

Specific function:

Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. Free octanoate is not a substrate for lipA

Gene Name:

lipA

Uniprot ID:

P60716

Molecular weight:

36071

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Activation of pyruvate formate-lyase 2 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine

Gene Name:

ybiY

Uniprot ID:

P75794

Molecular weight:

33038

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S

Gene Name:

thiG

Uniprot ID:

P30139

Molecular weight:

26896

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the radical-mediated cleavage of tyrosine to dehydroglycine and p-cresol

Gene Name:

thiH

Uniprot ID:

P30140

Molecular weight:

43320

Reactions

General function:

Involved in thiamine biosynthetic process

Specific function:

Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction

Gene Name:

thiC

Uniprot ID:

P30136

Molecular weight:

70850

Reactions

General function:

Involved in 4 iron, 4 sulfur cluster binding

Specific function:

Specifically methylates position 2 of adenine 2503 in 23S rRNA

Gene Name:

rlmN

Uniprot ID:

P36979

Molecular weight:

43085

Reactions

General function:

tRNA methylthiolation

Specific function:

Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.

Gene Name:

miaB

Uniprot ID:

P0AEI1

Molecular weight:

53662

Reactions

General function:

RNA modification

Specific function:

Catalyzes the methylthiolation of the residue Asp-89 of ribosomal protein S12.

Gene Name:

rimO

Uniprot ID:

P0AEI4

Molecular weight:

49581

Reactions