2.0 2012-05-31 14:49:43 -0600 2015-09-18 09:17:43 -0600 ECMDB20540 M2MDB001347 D-Allulose-6-phosphate D-allulose-6-phosphate is a hexose phosphate. Hexoses are monosaccharides in which the sugar unit is a hexose. Allulose 6-phosphate Allulose 6-phosphoric acid D-Allulose 6-phosphate D-Allulose 6-phosphoric acid D-Allulose-6-P D-Allulose-6-phosphoric acid C6H11O9P 258.12 258.015166092 (3R,4R,5R)-1,3,4,5-tetrahydroxy-6-(phosphonatooxy)hexan-2-one D-allulose 6-phosphate [H][C@@](O)(COP([O-])([O-])=O)[C@@]([H])(O)[C@@]([H])(O)C(=O)CO InChI=1S/C6H13O9P/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14/h4-7,9-11H,1-2H2,(H2,12,13,14)/p-2/t4-,5+,6-/m1/s1 GSXOAOHZAIYLCY-NGJCXOISSA-L Cytosol logp -1.92 ALOGPS logs -0.72 ALOGPS solubility 5.63e+01 g/l ALOGPS logp -3.4 ChemAxon pka_strongest_acidic 1.49 ChemAxon pka_strongest_basic -3.3 ChemAxon iupac (3R,4R,5R)-1,3,4,5-tetrahydroxy-6-(phosphonatooxy)hexan-2-one ChemAxon average_mass 258.12 ChemAxon mono_mass 258.015166092 ChemAxon smiles [H][C@@](O)(COP([O-])([O-])=O)[C@@]([H])(O)[C@@]([H])(O)C(=O)CO ChemAxon formula C6H11O9P ChemAxon inchi InChI=1S/C6H13O9P/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14/h4-7,9-11H,1-2H2,(H2,12,13,14)/p-2/t4-,5+,6-/m1/s1 ChemAxon inchikey GSXOAOHZAIYLCY-NGJCXOISSA-L ChemAxon polar_surface_area 170.41 ChemAxon refractivity 46.19 ChemAxon polarizability 20.4 ChemAxon rotatable_bond_count 7 ChemAxon acceptor_count 8 ChemAxon donor_count 4 ChemAxon physiological_charge -2 ChemAxon formal_charge -2 ChemAxon D-allulose degradation E. coli can utilize D-allose as the sole source of carbon for growth. D-allose is transported into the cell in unphosphorylated form via the D-allose ABC transporter. AlsK, the D-allose kinase which phosphorylates D-allose, is not essential for this pathway. Allose-6-phosphate isomerase and allulose-6-phosphate 3-epimerase catalyze the remaining reactions resulting in D-allulose 6 phosphate and Beta-D-fructofuranose 6-phosphate respectively. Once Beta D fructofuranose 6-phosphate is synthesized, it goes into the glycolysis and pyruvatedehydrogenase pathway. PW000825 Metabolic D-allose degradation PWY0-44 Specdb::NmrOneD 248968 Specdb::NmrOneD 248969 Specdb::NmrOneD 248970 Specdb::NmrOneD 248971 Specdb::NmrOneD 248972 Specdb::NmrOneD 248973 Specdb::NmrOneD 248974 Specdb::NmrOneD 248975 Specdb::NmrOneD 248976 Specdb::NmrOneD 248977 Specdb::NmrOneD 248978 Specdb::NmrOneD 248979 Specdb::NmrOneD 248980 Specdb::NmrOneD 248981 Specdb::NmrOneD 248982 Specdb::NmrOneD 248983 Specdb::NmrOneD 248984 Specdb::NmrOneD 248985 Specdb::NmrOneD 248986 Specdb::NmrOneD 248987 21872891 10618776 D-ALLULOSE-6-PHOSPHATE Keseler, I. M., Collado-Vides, J., Santos-Zavaleta, A., Peralta-Gil, M., Gama-Castro, S., Muniz-Rascado, L., Bonavides-Martinez, C., Paley, S., Krummenacker, M., Altman, T., Kaipa, P., Spaulding, A., Pacheco, J., Latendresse, M., Fulcher, C., Sarker, M., Shearer, A. G., Mackie, A., Paulsen, I., Gunsalus, R. P., Karp, P. D. (2011). "EcoCyc: a comprehensive database of Escherichia coli biology." Nucleic Acids Res 39:D583-D590. 21097882 van der Werf, M. J., Overkamp, K. M., Muilwijk, B., Coulier, L., Hankemeier, T. (2007). "Microbial metabolomics: toward a platform with full metabolome coverage." Anal Biochem 370:17-25. 17765195 Winder, C. L., Dunn, W. B., Schuler, S., Broadhurst, D., Jarvis, R., Stephens, G. M., Goodacre, R. (2008). "Global metabolic profiling of Escherichia coli cultures: an evaluation of methods for quenching and extraction of intracellular metabolites." Anal Chem 80:2939-2948. 18331064 D-allulose-6-phosphate 3-epimerase P32719 ALSE_ECOLI alsE http://ecmdb.ca/proteins/P32719.xml Ribose-5-phosphate isomerase B P37351 RPIB_ECOLI rpiB http://ecmdb.ca/proteins/P37351.xml D-Allulose-6-phosphate <> Fructose 6-phosphate RXN0-304 D-Allose 6-phosphate <> D-Allulose-6-phosphate RXN0-303 D-Allulose-6-phosphate > Fructose 6-phosphate RXN0-304 D-Allose 6-phosphate > D-Allulose-6-phosphate aldehydo-D-allose 6-phosphate + aldehydo-D-allose 6-phosphate > D-allulose 6-phosphate + D-Allulose-6-phosphate PW_R002965 D-allulose 6-phosphate + D-Allulose-6-phosphate > D-tagatofuranose 6-phosphate PW_R002966