Undecaprenyl phosphate (ECMDB20208) (M2MDB001054)

General function:

Involved in phospho-N-acetylmuramoyl-pentapeptide-transferase activity

Specific function:

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan

Gene Name:

mraY

Uniprot ID:

P0A6W3

Molecular weight:

39875

Reactions

General function:

Involved in catalytic activity

Specific function:

Hydrolyzes phosphatidylglycerophosphate, phosphatidic acid, and lysophosphatidic acid; the pattern of activities varies according to subcellular location

Gene Name:

pgpB

Uniprot ID:

P0A924

Molecular weight:

29021

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55). It is the first lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis and an acceptor for the addition of subsequent sugars to complete the biosynthesis of O-antigen. The apparent affinity of WecA for the polyisoprenyl phosphate substrates increases with the polyisoprenyl chain length. WecA is unable to utilize dolichyl phosphate (Dol-P)

Gene Name:

wecA

Uniprot ID:

P0AC78

Molecular weight:

40957

Reactions

General function:

Involved in fucosyltransferase activity

Specific function:

Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis

Gene Name:

wecF

Uniprot ID:

P56258

Molecular weight:

40639

Reactions

General function:

Involved in undecaprenyl-diphosphatase activity

Specific function:

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin

Gene Name:

uppP

Uniprot ID:

P60932

Molecular weight:

29758

Reactions

General function:

Involved in catalytic activity

Specific function:

Overexpression leads to increased undecaprenyl diphosphatase activity and to increased resistance to bacitracin. May have a preferred substrate other than undecaprenyl diphosphate in vivo

Gene Name:

ybjG

Uniprot ID:

P75806

Molecular weight:

22398

Reactions

General function:

Involved in phosphotransferase activity, for other substituted phosphate groups

Specific function:

Catalyzes the transfer of 4-deoxy-4-formamido-L- arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides

Gene Name:

arnC

Uniprot ID:

P77757

Molecular weight:

36339

Reactions

General function:

Involved in transferase activity, transferring pentosyl groups

Specific function:

Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides

Gene Name:

arnT

Uniprot ID:

P76473

Molecular weight:

62542

Reactions

General function:

Involved in catalytic activity

Specific function:

Specific function unknown

Gene Name:

yeiU

Uniprot ID:

P76445

Molecular weight:

26759

General function:

Involved in transferase activity, transferring hexosyl groups

Specific function:

Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in ECA synthesis

Gene Name:

wecG

Uniprot ID:

P27836

Molecular weight:

27928

Reactions