2.0 2012-05-31 14:18:55 -0600 2015-12-09 12:07:30 -0700 ECMDB10573 M2MDB000793 PG(16:0/18:1(11Z)) PG(16:0/18:1(11Z)) is a phosphatidylglycerol. Phosphatidylglycerols consist of a glycerol 3-phosphate backbone esterified to either saturated or unsaturated fatty acids on carbons 1 and 2. As is the case with diacylglycerols, phosphatidylglycerols can have many different combinations of fatty acids of varying lengths and saturation attached to the C-1 and C-2 positions. PG(16:0/18:1(11Z)), in particular, consists of one hexadecanoyl chain to the C-1 atom, and one 11Z-octadecenoyl to the C-2 atom. In E. coli glycerophospholipid metabolism, phosphatidylglycerol is formed from phosphatidic acid (1,2-diacyl-sn-glycerol 3-phosphate) by a sequence of enzymatic reactions that proceeds via two intermediates, cytidine diphosphate diacylglycerol (CDP-diacylglycerol) and phosphatidylglycerophosphate (PGP, a phosphorylated phosphatidylglycerol). Phosphatidylglycerols, along with CDP-diacylglycerol, also serve as precursor molecules for the synthesis of cardiolipin, a phospholipid found in membranes. 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-glycero-3-phospho-(1'-glycerol) 1-hexadecanoyl-2-(11Z-octadecenoyl)-sn-glycero-3-phosphoglycerol 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-phosphoglycerol 1-phosphatidylglycerol 3(3-phosphatidyl-)glycerol 3-(3-<i>sn</i>-phosphatidyl)glycerol 3-(3-sn-Phosphatidyl)glycerol GPG(16:0/18:1) GPG(16:0/18:1n7) GPG(16:0/18:1w7) GPG(34:1) PG(16:0/18:1) PG(16:0/18:1n7) PG(16:0/18:1w7) PG(34:1) Phosphatidylglycerol Phosphatidylglycerol(16:0/18:1) Phosphatidylglycerol(16:0/18:1n7) Phosphatidylglycerol(16:0/18:1w7) Phosphatidylglycerol(34:1) C40H77O10P 749.0071 748.525435196 [(2S)-2,3-dihydroxypropoxy][(2R)-2-(hexadecanoyloxy)-3-[(11Z)-octadec-11-enoyloxy]propoxy]phosphinic acid (2S)-2,3-dihydroxypropoxy(2R)-2-(hexadecanoyloxy)-3-[(11Z)-octadec-11-enoyloxy]propoxyphosphinic acid [H][C@](O)(CO)COP(O)(=O)OC[C@@]([H])(COC(=O)CCCCCCCCC\C=C/CCCCCC)OC(=O)CCCCCCCCCCCCCCC InChI=1S/C40H77O10P/c1-3-5-7-9-11-13-15-17-18-20-21-23-25-27-29-31-39(43)47-35-38(36-49-51(45,46)48-34-37(42)33-41)50-40(44)32-30-28-26-24-22-19-16-14-12-10-8-6-4-2/h13,15,37-38,41-42H,3-12,14,16-36H2,1-2H3,(H,45,46)/b15-13-/t37-,38+/m0/s1 PYSDYMWMDIXQNB-GPJPVTGXSA-N Solid Inner membrane Membrane Outer membrane logp 8.15 ALOGPS logs -6.86 ALOGPS solubility 1.03e-04 g/l ALOGPS logp 11.46 ChemAxon pka_strongest_acidic 1.89 ChemAxon pka_strongest_basic -3 ChemAxon iupac [(2S)-2,3-dihydroxypropoxy][(2R)-2-(hexadecanoyloxy)-3-[(11Z)-octadec-11-enoyloxy]propoxy]phosphinic acid ChemAxon average_mass 749.0071 ChemAxon mono_mass 748.525435196 ChemAxon smiles [H][C@](O)(CO)COP(O)(=O)OC[C@@]([H])(COC(=O)CCCCCCCCC\C=C/CCCCCC)OC(=O)CCCCCCCCCCCCCCC ChemAxon formula C40H77O10P ChemAxon inchi InChI=1S/C40H77O10P/c1-3-5-7-9-11-13-15-17-18-20-21-23-25-27-29-31-39(43)47-35-38(36-49-51(45,46)48-34-37(42)33-41)50-40(44)32-30-28-26-24-22-19-16-14-12-10-8-6-4-2/h13,15,37-38,41-42H,3-12,14,16-36H2,1-2H3,(H,45,46)/b15-13-/t37-,38+/m0/s1 ChemAxon inchikey PYSDYMWMDIXQNB-GPJPVTGXSA-N ChemAxon polar_surface_area 148.82 ChemAxon refractivity 205.63 ChemAxon polarizability 90.84 ChemAxon rotatable_bond_count 41 ChemAxon acceptor_count 6 ChemAxon donor_count 3 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon Glycerophospholipid metabolism ec00564 phospholipid biosynthesis I PHOSLIPSYN-PWY Specdb::CMs 777451 Specdb::CMs 777452 Specdb::CMs 777453 Specdb::CMs 777454 Specdb::CMs 777455 Specdb::CMs 777456 Specdb::CMs 777457 Specdb::CMs 777458 Specdb::CMs 777459 Specdb::NmrOneD 332258 Specdb::NmrOneD 332259 Specdb::NmrOneD 332260 Specdb::NmrOneD 332261 Specdb::NmrOneD 332262 Specdb::NmrOneD 332263 Specdb::NmrOneD 332264 Specdb::NmrOneD 332265 Specdb::NmrOneD 332266 Specdb::NmrOneD 332267 Specdb::NmrOneD 332268 Specdb::NmrOneD 332269 Specdb::NmrOneD 332270 Specdb::NmrOneD 332271 Specdb::NmrOneD 332272 Specdb::NmrOneD 332273 Specdb::NmrOneD 332274 Specdb::NmrOneD 332275 Specdb::NmrOneD 332276 Specdb::NmrOneD 332277 Specdb::MsMs 25991 Specdb::MsMs 25992 Specdb::MsMs 25993 Specdb::MsMs 32549 Specdb::MsMs 32550 Specdb::MsMs 32551 Specdb::MsMs 2563251 Specdb::MsMs 2563252 Specdb::MsMs 2563253 HMDB10573 4451166 C00344 L-1-PHOSPHATIDYL-GLYCEROL PGV Keseler, I. M., Collado-Vides, J., Santos-Zavaleta, A., Peralta-Gil, M., Gama-Castro, S., Muniz-Rascado, L., Bonavides-Martinez, C., Paley, S., Krummenacker, M., Altman, T., Kaipa, P., Spaulding, A., Pacheco, J., Latendresse, M., Fulcher, C., Sarker, M., Shearer, A. G., Mackie, A., Paulsen, I., Gunsalus, R. P., Karp, P. D. (2011). "EcoCyc: a comprehensive database of Escherichia coli biology." Nucleic Acids Res 39:D583-D590. 21097882 Kanehisa, M., Goto, S., Sato, Y., Furumichi, M., Tanabe, M. (2012). "KEGG for integration and interpretation of large-scale molecular data sets." Nucleic Acids Res 40:D109-D114. 22080510 Uniprot Consortium (2012). "Reorganizing the protein space at the Universal Protein Resource (UniProt)." Nucleic Acids Res 40:D71-D75. 22102590 Yurtsever D. (2007). Fatty acid methyl ester profiling of Enterococcus and Esherichia coli for microbial source tracking. M.sc. Thesis. Villanova University: U.S.A Phosphatidylglycerophosphatase B P0A924 PGPB_ECOLI pgpB http://ecmdb.ca/proteins/P0A924.xml Phosphatidylglycerophosphatase A P18200 PGPA_ECOLI pgpA http://ecmdb.ca/proteins/P18200.xml Protein crcA P37001 CRCA_ECOLI crcA http://ecmdb.ca/proteins/P37001.xml Cardiolipin synthase P0A6H8 CLS_ECOLI cls http://ecmdb.ca/proteins/P0A6H8.xml Putative cardiolipin synthase ybhO P0AA84 YBHO_ECOLI ybhO http://ecmdb.ca/proteins/P0AA84.xml Probable phospholipid ABC transporter-binding protein mlaB P64602 MLAB_ECOLI mlaB http://ecmdb.ca/proteins/P64602.xml Probable phospholipid ABC transporter-binding protein mlaD P64604 MLAD_ECOLI mlaD http://ecmdb.ca/proteins/P64604.xml Probable phospholipid ABC transporter permease protein mlaE P64606 MLAE_ECOLI mlaE http://ecmdb.ca/proteins/P64606.xml Water + PGP(16:0/18:1(11Z)) > Phosphate + PG(16:0/18:1(11Z)) PW_R003612