Oxygen (ECMDB04124) (M2MDB000624)

General function:

Involved in superoxide dismutase activity

Specific function:

Destroys radicals which are normally produced within the cells and which are toxic to biological systems

Gene Name:

sodA

Uniprot ID:

P00448

Molecular weight:

23097

Reactions

General function:

Involved in transferase activity

Specific function:

An aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate

Gene Name:

tyrB

Uniprot ID:

P04693

Molecular weight:

43537

Reactions

General function:

Involved in iron ion binding

Specific function:

Part of the multicomponent 3-phenylpropionate dioxygenase. Converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively

Gene Name:

hcaE

Uniprot ID:

P0ABR5

Molecular weight:

51109

Reactions

General function:

Involved in iron ion binding

Specific function:

Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively

Gene Name:

mhpB

Uniprot ID:

P0ABR9

Molecular weight:

34196

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Part of the multicomponent 3-phenylpropionate dioxygenase, that converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP- dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively. This protein seems to be a 2Fe-2S ferredoxin

Gene Name:

hcaC

Uniprot ID:

P0ABW0

Molecular weight:

11329

General function:

Involved in FMN binding

Specific function:

Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. Does not use oxygen directly. Is coupled to the respiratory chain

Gene Name:

hemG

Uniprot ID:

P0ACB4

Molecular weight:

21226

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Can oxidize menadiol to menadione

Gene Name:

ygiN

Uniprot ID:

P0ADU2

Molecular weight:

11532

General function:

Involved in catalytic activity

Specific function:

Specific function unknown

Gene Name:

glcD

Uniprot ID:

P0AEP9

Molecular weight:

53811

General function:

Involved in superoxide metabolic process

Specific function:

Destroys radicals which are normally produced within the cells and which are toxic to biological systems

Gene Name:

sodC

Uniprot ID:

P0AGD1

Molecular weight:

17681

Reactions

General function:

Involved in superoxide dismutase activity

Specific function:

Destroys radicals which are normally produced within the cells and which are toxic to biological systems

Gene Name:

sodB

Uniprot ID:

P0AGD3

Molecular weight:

21266

Reactions

General function:

Involved in electron carrier activity

Specific function:

Catalyzes the oxidation of L-aspartate to iminoaspartate

Gene Name:

nadB

Uniprot ID:

P10902

Molecular weight:

60337

Reactions

General function:

Involved in catalase activity

Specific function:

Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity. Displays also NADH oxidase, INH lyase and isonicotinoyl-NAD synthase activity

Gene Name:

katG

Uniprot ID:

P13029

Molecular weight:

80023

Reactions

General function:

Involved in catalase activity

Specific function:

Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide

Gene Name:

katE

Uniprot ID:

P21179

Molecular weight:

84162

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Various electron acceptors are also reduced by HMP in vitro, including dihydropterine, ferrisiderophores, ferric citrate, cytochrome c, nitrite, S-nitrosoglutathione, and alkylhydroperoxides. However, it is unknown if these reactions are of any biological significance in vivo

Gene Name:

hmp

Uniprot ID:

P24232

Molecular weight:

43867

Reactions

General function:

Involved in adenine deaminase activity

Specific function:

Adenine + H(2)O = hypoxanthine + NH(3)

Gene Name:

ade

Uniprot ID:

P31441

Molecular weight:

63739

Reactions

General function:

Involved in malate dehydrogenase (quinone) activity

Specific function:

(S)-malate + a quinone = oxaloacetate + reduced quinone

Gene Name:

mqo

Uniprot ID:

P33940

Molecular weight:

60229

Reactions

General function:

Involved in coproporphyrinogen oxidase activity

Specific function:

Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III

Gene Name:

hemF

Uniprot ID:

P36553

Molecular weight:

34322

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Probably involved in periplasmic detoxification of copper by oxidizing Cu(+) to Cu(2+) and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm

Gene Name:

cueO

Uniprot ID:

P36649

Molecular weight:

56556

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the conversion of taurine and alpha ketoglutarate to sulfite, aminoacetaldehyde and succinate. Required for the utilization of taurine (2-aminoethanesulfonic acid) as an alternative sulfur source. Pentane-sulfonic acid, 3- (N-morpholino)propanesulfonic acid and 1,3-dioxo-2- isoindolineethanesulfonic acid are also substrates for this enzyme

Gene Name:

tauD

Uniprot ID:

P37610

Molecular weight:

32409

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Involved in the breakdown of putrescine via the oxidation of L-glutamylputrescine

Gene Name:

puuB

Uniprot ID:

P37906

Molecular weight:

47169

Reactions

General function:

Involved in copper ion binding

Specific function:

The enzyme prefers aromatic over aliphatic amines

Gene Name:

tynA

Uniprot ID:

P46883

Molecular weight:

84378

Reactions

General function:

Involved in iron-sulfur cluster binding

Specific function:

Specific function unknown

Gene Name:

glcF

Uniprot ID:

P52074

Molecular weight:

45110

General function:

Involved in oxidoreductase activity

Specific function:

Oxygenase that introduces the hydroxyl group at carbon five of 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol

Gene Name:

ubiF

Uniprot ID:

P75728

Molecular weight:

42953

General function:

Involved in electron carrier activity

Specific function:

May be part of a multicomponent oxygenase involved in phenylacetyl-CoA hydroxylation

Gene Name:

paaE

Uniprot ID:

P76081

Molecular weight:

39320

General function:

Involved in oxidoreductase activity

Specific function:

Part of the multicomponent 3-phenylpropionate dioxygenase, that converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP- dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively

Gene Name:

hcaD

Uniprot ID:

P77650

Molecular weight:

43978

Reactions

General function:

Involved in FMN reductase activity

Specific function:

Catalyzes an NAD(P)H-dependent reduction of FMN, but is also able to reduce FAD or riboflavin

Gene Name:

ssuE

Uniprot ID:

P80644

Molecular weight:

21253

Reactions

General function:

Involved in alkanesulfonate monooxygenase activity

Specific function:

Involved in desulfonation of aliphatic sulfonates. Catalyzes the conversion of pentanesulfonic acid to sulfite and pentaldehyde and is able to desulfonate a wide range of sulfonated substrates including C-2 to C-10 unsubstituted linear alkanesulfonates, substituted ethanesulfonic acids and sulfonated buffers

Gene Name:

ssuD

Uniprot ID:

P80645

Molecular weight:

41736

Reactions

General function:

Involved in 3-phenylpropionate dioxygenase activity

Specific function:

Part of the multicomponent 3-phenylpropionate dioxygenase. Converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively

Gene Name:

hcaF

Uniprot ID:

Q47140

Molecular weight:

20579

Reactions

General function:

Involved in cytochrome bo3 ubiquinol oxidase activity

Specific function:

Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration

Gene Name:

cyoA

Uniprot ID:

P0ABJ1

Molecular weight:

34911

Reactions

General function:

Involved in FMN binding

Specific function:

Makes part of the rut operon, which is required for the utilization of pyrimidines as sole nitrogen source

Gene Name:

rutF

Uniprot ID:

P75893

Molecular weight:

17749

Reactions

General function:

Secondary metabolites biosynthesis, transport and catabolism

Specific function:

May be part of a multicomponent oxygenase involved in phenylacetyl-CoA hydroxylation

Gene Name:

paaB

Uniprot ID:

P76078

Molecular weight:

10942

General function:

Involved in catalytic activity

Specific function:

Specific function unknown

Gene Name:

glcE

Uniprot ID:

P52073

Molecular weight:

38361

General function:

Involved in cytochrome o ubiquinol oxidase activity

Specific function:

Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration

Gene Name:

cyoD

Uniprot ID:

P0ABJ6

Molecular weight:

12029

General function:

Involved in oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

Specific function:

Part of the rut operon, which is required for the utilization of pyrimidines as sole nitrogen source

Gene Name:

rutA

Uniprot ID:

P75898

Molecular weight:

42219

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

May be part of a multicomponent oxygenase involved in phenylacetyl-CoA hydroxylation

Gene Name:

paaA

Uniprot ID:

P76077

Molecular weight:

35499

Reactions

General function:

Involved in oxidation-reduction process

Specific function:

Cytochrome oxidase subunit

Gene Name:

appB

Uniprot ID:

P26458

Molecular weight:

42423

General function:

Involved in oxidoreductase activity

Specific function:

Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone

Gene Name:

ubiH

Uniprot ID:

P25534

Molecular weight:

42288

General function:

Involved in transferase activity, transferring phosphorus-containing groups

Specific function:

Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis. Specific for aerobically grown log-phase cells

Gene Name:

ubiB

Uniprot ID:

P0A6A0

Molecular weight:

63202

General function:

Energy production and conversion

Specific function:

Cytochrome oxidase subunit

Gene Name:

appC

Uniprot ID:

P26459

Molecular weight:

57919

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the oxidative demethylation of N-methyl-L- tryptophan. Can also use other N-methyl amino acids, including sarcosine, which, however, is a poor substrate

Gene Name:

solA

Uniprot ID:

P40874

Molecular weight:

40902

Reactions

General function:

Not Available

Specific function:

May be part of a multicomponent oxygenase involved in phenylacetyl-CoA hydroxylation

Gene Name:

paaD

Uniprot ID:

P76080

Molecular weight:

18324

General function:

Involved in oxidation-reduction process

Specific function:

Cytochrome d terminal oxidase complex is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at low aeration

Gene Name:

cydB

Uniprot ID:

P0ABK2

Molecular weight:

42453

Reactions

General function:

Involved in cytochrome-c oxidase activity

Specific function:

Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. This ubiquinol oxidase shows proton pump activity across the membrane in addition to the electron transfer

Gene Name:

cyoB

Uniprot ID:

P0ABI8

Molecular weight:

74367

Reactions

General function:

Involved in 3-(3-hydroxyphenyl)propionate hydroxylase activity

Specific function:

Catalyzes the insertion of one atom of molecular oxygen into position 2 of the phenyl ring of 3-(3- hydroxyphenyl)propionate (3-HPP) and hydroxycinnamic acid (3HCI)

Gene Name:

mhpA

Uniprot ID:

P77397

Molecular weight:

62185

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

May be part of a multicomponent oxygenase involved in phenylacetyl-CoA hydroxylation

Gene Name:

paaC

Uniprot ID:

P76079

Molecular weight:

27877

General function:

Energy production and conversion

Specific function:

Cytochrome d terminal oxidase complex is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at low aeration

Gene Name:

cydA

Uniprot ID:

P0ABJ9

Molecular weight:

58205

Reactions

General function:

Coenzyme transport and metabolism

Specific function:

Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

Gene Name:

pdxH

Uniprot ID:

P0AFI7

Molecular weight:

25545

Reactions

General function:

Involved in heme-copper terminal oxidase activity

Specific function:

Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration

Gene Name:

cyoC

Uniprot ID:

P0ABJ3

Molecular weight:

22623

Reactions

General function:

Not Available

Specific function:

Not Available

Gene Name:

ftnA

Uniprot ID:

P0A998

Molecular weight:

Not Available

General function:

Not Available

Specific function:

Not Available

Gene Name:

yeaW

Uniprot ID:

P0ABR7

Molecular weight:

Not Available

General function:

Not Available

Specific function:

Dioxygenase that repairs alkylated DNA and RNA containing 3-methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents), but not to MMNG and MNU (SN1 agents). Dioxygenase that repairs alkylated DNA and RNA containing 3-methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents), but not to MMNG and MNU (SN1 agents).

Gene Name:

alkB

Uniprot ID:

P05050

Molecular weight:

Not Available

Reactions

General function:

Inorganic ion transport and metabolism

Specific function:

May perform analogous functions in iron detoxification and storage to that of animal ferritins

Gene Name:

bfr

Uniprot ID:

P0ABD3

Molecular weight:

18495

Reactions

General function:

oxidative phosphorylation

Specific function:

Required for correct functioning of cytochrome bd-I oxidase. This protein and AppX may have some functional overlap.

Gene Name:

cydX

Uniprot ID:

P56100

Molecular weight:

4041