Oxoglutaric acid (ECMDB04123) (M2MDB000623)

General function:

Involved in oxidoreductase activity

Specific function:

L-glutamate + H(2)O + NADP(+) = 2-oxoglutarate + NH(3) + NADPH

Gene Name:

gdhA

Uniprot ID:

P00370

Molecular weight:

48581

Reactions

General function:

Involved in transferase activity

Specific function:

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

Gene Name:

aspC

Uniprot ID:

P00509

Molecular weight:

43573

Reactions

General function:

Involved in transferase activity

Specific function:

An aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate

Gene Name:

tyrB

Uniprot ID:

P04693

Molecular weight:

43537

Reactions

General function:

Involved in transferase activity

Specific function:

L-histidinol phosphate + 2-oxoglutarate = 3- (imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate

Gene Name:

hisC

Uniprot ID:

P06986

Molecular weight:

39360

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH

Gene Name:

icd

Uniprot ID:

P08200

Molecular weight:

45756

Reactions

General function:

Involved in catalytic activity

Specific function:

2 L-glutamate + NADP(+) = L-glutamine + 2- oxoglutarate + NADPH

Gene Name:

gltB

Uniprot ID:

P09831

Molecular weight:

166708

Reactions

General function:

Involved in iron-sulfur cluster binding

Specific function:

2 L-glutamate + NADP(+) = L-glutamine + 2- oxoglutarate + NADPH

Gene Name:

gltD

Uniprot ID:

P09832

Molecular weight:

52015

Reactions

General function:

Involved in glutamate-ammonia ligase activity

Specific function:

ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine

Gene Name:

glnA

Uniprot ID:

P0A9C5

Molecular weight:

51903

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes

Gene Name:

lpdA

Uniprot ID:

P0A9P0

Molecular weight:

50688

Reactions

General function:

Involved in amino acid binding

Specific function:

3-phospho-D-glycerate + NAD(+) = 3- phosphonooxypyruvate + NADH

Gene Name:

serA

Uniprot ID:

P0A9T0

Molecular weight:

44175

Reactions

General function:

Involved in oxoglutarate dehydrogenase (succinyl-transferring) activity

Specific function:

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components:2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)

Gene Name:

sucA

Uniprot ID:

P0AFG3

Molecular weight:

105061

Reactions

General function:

Involved in transferase activity, transferring acyl groups

Specific function:

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components:2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)

Gene Name:

sucB

Uniprot ID:

P0AFG6

Molecular weight:

44011

Reactions

General function:

Involved in thiamine pyrophosphate binding

Specific function:

Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)

Gene Name:

menD

Uniprot ID:

P17109

Molecular weight:

61367

Reactions

General function:

Involved in transaminase activity

Specific function:

Involved in both the arginine and lysine biosynthetic pathways

Gene Name:

argD

Uniprot ID:

P18335

Molecular weight:

43767

Reactions

General function:

Involved in 4-aminobutyrate transaminase activity

Specific function:

4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate

Gene Name:

gabT

Uniprot ID:

P22256

Molecular weight:

45774

Reactions

General function:

Involved in metabolic process

Specific function:

Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. Is involved in both pyridoxine and serine biosynthesis

Gene Name:

serC

Uniprot ID:

P23721

Molecular weight:

39783

Reactions

General function:

Involved in zinc ion binding

Specific function:

Displays a broad specificity and can also deacylate substrates such as acetylarginine, acetylhistidine or acetylglutamate semialdehyde

Gene Name:

argE

Uniprot ID:

P23908

Molecular weight:

42347

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the conversion of taurine and alpha ketoglutarate to sulfite, aminoacetaldehyde and succinate. Required for the utilization of taurine (2-aminoethanesulfonic acid) as an alternative sulfur source. Pentane-sulfonic acid, 3- (N-morpholino)propanesulfonic acid and 1,3-dioxo-2- isoindolineethanesulfonic acid are also substrates for this enzyme

Gene Name:

tauD

Uniprot ID:

P37610

Molecular weight:

32409

Reactions

General function:

Involved in transaminase activity

Specific function:

Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. Is also able to transaminate cadaverine and, in lower extent, spermidine, but not ornithine. Alpha-ketobutyrate and pyruvate can also act as amino acceptors, although much less efficiently

Gene Name:

patA

Uniprot ID:

P42588

Molecular weight:

49661

Reactions

General function:

Involved in 4-aminobutyrate transaminase activity

Specific function:

Involved in the breakdown of putrescine via transamination of gamma-aminobutyrate

Gene Name:

puuE

Uniprot ID:

P50457

Molecular weight:

44729

Reactions

General function:

Involved in transaminase activity

Specific function:

Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act as an acetylornithine aminotransferase

Gene Name:

astC

Uniprot ID:

P77581

Molecular weight:

43665

Reactions

General function:

Involved in transaminase activity

Specific function:

Catalyzes the conversion of UDP-4-keto-arabinose (UDP- Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides

Gene Name:

arnB

Uniprot ID:

P77690

Molecular weight:

41649

Reactions

General function:

Involved in 1-aminocyclopropane-1-carboxylate synthase activity

Specific function:

Specific function unknown

Gene Name:

yfbQ

Uniprot ID:

P0A959

Molecular weight:

45517

Reactions

General function:

Involved in catalytic activity

Specific function:

Acts on leucine, isoleucine and valine

Gene Name:

ilvE

Uniprot ID:

P0AB80

Molecular weight:

34093

Reactions

General function:

Involved in catalytic activity

Specific function:

Involved in ECA elongation

Gene Name:

rffA

Uniprot ID:

P27833

Molecular weight:

41901

General function:

Amino acid transport and metabolism

Specific function:

Specific function unknown

Gene Name:

yfdZ

Uniprot ID:

P77434

Molecular weight:

46216

Reactions

General function:

Not Available

Specific function:

Dioxygenase that repairs alkylated DNA and RNA containing 3-methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents), but not to MMNG and MNU (SN1 agents). Dioxygenase that repairs alkylated DNA and RNA containing 3-methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents), but not to MMNG and MNU (SN1 agents).

Gene Name:

alkB

Uniprot ID:

P05050

Molecular weight:

Not Available

Reactions