<?xml version="1.0" encoding="UTF-8"?>
<compound>
  <version>2.0</version>
  <creation_date>2012-05-31 14:02:03 -0600</creation_date>
  <update_date>2015-06-03 15:54:37 -0600</update_date>
  <accession>ECMDB04011</accession>
  <m2m_id>M2MDB000556</m2m_id>
  <name>Galactose 1-phosphate</name>
  <description>Galactose 1-phosphate is an intermediate in the Galactose metabolism </description>
  <synonyms>
    <synonym>&amp;alpha;-D-Gal-1-P</synonym>
    <synonym>&amp;alpha;-D-galactopyranose 1-phosphate</synonym>
    <synonym>&amp;alpha;-D-galactopyranose 1-phosphoric acid</synonym>
    <synonym>1-(Dihydrogen phosphate) Galactitol</synonym>
    <synonym>1-(Dihydrogen phosphoric acid) galactitol</synonym>
    <synonym>1-phosphate a-D-Galactopyranose</synonym>
    <synonym>1-Phosphate alpha-D-Galactopyranose</synonym>
    <synonym>1-Phosphate α-D-galactopyranose</synonym>
    <synonym>1-Phosphoric acid a-D-galactopyranose</synonym>
    <synonym>1-Phosphoric acid alpha-D-galactopyranose</synonym>
    <synonym>1-Phosphoric acid α-D-galactopyranose</synonym>
    <synonym>A-D-1-(Dihydrogen phosphate) Galactopyranose</synonym>
    <synonym>a-D-1-(Dihydrogen phosphoric acid) galactopyranose</synonym>
    <synonym>a-D-Gal-1-P</synonym>
    <synonym>a-D-Galactopyranose 1-phosphate</synonym>
    <synonym>a-D-Galactopyranose 1-phosphoric acid</synonym>
    <synonym>A-D-Galactopyranosyl phosphate</synonym>
    <synonym>a-D-Galactopyranosyl phosphoric acid</synonym>
    <synonym>A-D-Galactose 1-phosphate</synonym>
    <synonym>a-D-Galactose 1-phosphoric acid</synonym>
    <synonym>A-D-Galactosyl phosphate</synonym>
    <synonym>a-D-Galactosyl phosphoric acid</synonym>
    <synonym>Alpha-D-1-(Dihydrogen phosphate) Galactopyranose</synonym>
    <synonym>alpha-D-1-(Dihydrogen phosphoric acid) galactopyranose</synonym>
    <synonym>Alpha-D-Gal-1-P</synonym>
    <synonym>Alpha-D-Galactopyranose 1-phosphate</synonym>
    <synonym>alpha-D-Galactopyranose 1-phosphoric acid</synonym>
    <synonym>Alpha-D-Galactopyranosyl phosphate</synonym>
    <synonym>alpha-D-Galactopyranosyl phosphoric acid</synonym>
    <synonym>Alpha-D-Galactose 1-phosphate</synonym>
    <synonym>alpha-D-Galactose 1-phosphoric acid</synonym>
    <synonym>Alpha-D-Galactosyl phosphate</synonym>
    <synonym>alpha-D-Galactosyl phosphoric acid</synonym>
    <synonym>D-Galactose 1-phosphate</synonym>
    <synonym>D-Galactose 1-phosphoric acid</synonym>
    <synonym>D-Galactose-1-phosphate</synonym>
    <synonym>D-Galactose-1-phosphoric acid</synonym>
    <synonym>Galactopyranose 1-phosphate</synonym>
    <synonym>Galactopyranose 1-phosphoric acid</synonym>
    <synonym>Galactose 1-phosphate</synonym>
    <synonym>Galactose 1-phosphoric acid</synonym>
    <synonym>Galactose-1-P</synonym>
    <synonym>α-D-1-(Dihydrogen phosphate) galactopyranose</synonym>
    <synonym>α-D-1-(Dihydrogen phosphoric acid) galactopyranose</synonym>
    <synonym>α-D-Gal-1-P</synonym>
    <synonym>α-D-Galactopyranose 1-phosphate</synonym>
    <synonym>α-D-Galactopyranose 1-phosphoric acid</synonym>
    <synonym>α-D-Galactopyranosyl phosphate</synonym>
    <synonym>α-D-Galactopyranosyl phosphoric acid</synonym>
    <synonym>α-D-Galactose 1-phosphate</synonym>
    <synonym>α-D-Galactose 1-phosphoric acid</synonym>
    <synonym>α-D-Galactosyl phosphate</synonym>
    <synonym>α-D-Galactosyl phosphoric acid</synonym>
  </synonyms>
  <chemical_formula>C6H13O9P</chemical_formula>
  <average_molecular_weight>260.1358</average_molecular_weight>
  <monisotopic_moleculate_weight>260.029718526</monisotopic_moleculate_weight>
  <iupac_name>{[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phosphonic acid</iupac_name>
  <traditional_iupac>galactose 1 phosphate</traditional_iupac>
  <cas_registry_number>2255-14-3</cas_registry_number>
  <smiles>OC[C@H]1O[C@H](OP(O)(O)=O)[C@H](O)[C@@H](O)[C@H]1O</smiles>
  <inchi>InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3+,4+,5-,6-/m1/s1</inchi>
  <inchikey>HXXFSFRBOHSIMQ-FPRJBGLDSA-N</inchikey>
  <state>Solid</state>
  <cellular_locations>
    <cellular_location>Cytosol</cellular_location>
    <cellular_location>Extra-organism</cellular_location>
    <cellular_location>Periplasm</cellular_location>
  </cellular_locations>
  <predicted_properties>
    <property>
      <kind>logp</kind>
      <value>-2.00</value>
      <source>ALOGPS</source>
    </property>
    <property>
      <kind>logs</kind>
      <value>-0.91</value>
      <source>ALOGPS</source>
    </property>
    <property>
      <kind>solubility</kind>
      <value>3.23e+01 g/l</value>
      <source>ALOGPS</source>
    </property>
  </predicted_properties>
  <experimental_properties>
  </experimental_properties>
  <property>
    <kind>logp</kind>
    <value>-3.1</value>
    <source>ChemAxon</source>
  </property>
  <property>
    <kind>pka_strongest_acidic</kind>
    <value>1.16</value>
    <source>ChemAxon</source>
  </property>
  <property>
    <kind>pka_strongest_basic</kind>
    <value>-3</value>
    <source>ChemAxon</source>
  </property>
  <property>
    <kind>iupac</kind>
    <value>{[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phosphonic acid</value>
    <source>ChemAxon</source>
  </property>
  <property>
    <kind>average_mass</kind>
    <value>260.1358</value>
    <source>ChemAxon</source>
  </property>
  <property>
    <kind>mono_mass</kind>
    <value>260.029718526</value>
    <source>ChemAxon</source>
  </property>
  <property>
    <kind>smiles</kind>
    <value>OC[C@H]1O[C@H](OP(O)(O)=O)[C@H](O)[C@@H](O)[C@H]1O</value>
    <source>ChemAxon</source>
  </property>
  <property>
    <kind>formula</kind>
    <value>C6H13O9P</value>
    <source>ChemAxon</source>
  </property>
  <property>
    <kind>inchi</kind>
    <value>InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3+,4+,5-,6-/m1/s1</value>
    <source>ChemAxon</source>
  </property>
  <property>
    <kind>inchikey</kind>
    <value>HXXFSFRBOHSIMQ-FPRJBGLDSA-N</value>
    <source>ChemAxon</source>
  </property>
  <property>
    <kind>polar_surface_area</kind>
    <value>156.91</value>
    <source>ChemAxon</source>
  </property>
  <property>
    <kind>refractivity</kind>
    <value>46.8</value>
    <source>ChemAxon</source>
  </property>
  <property>
    <kind>polarizability</kind>
    <value>20.62</value>
    <source>ChemAxon</source>
  </property>
  <property>
    <kind>rotatable_bond_count</kind>
    <value>3</value>
    <source>ChemAxon</source>
  </property>
  <property>
    <kind>acceptor_count</kind>
    <value>8</value>
    <source>ChemAxon</source>
  </property>
  <property>
    <kind>donor_count</kind>
    <value>6</value>
    <source>ChemAxon</source>
  </property>
  <property>
    <kind>physiological_charge</kind>
    <value>-2</value>
    <source>ChemAxon</source>
  </property>
  <property>
    <kind>formal_charge</kind>
    <value>0</value>
    <source>ChemAxon</source>
  </property>
  <pathways>
    <pathway>
      <name>Starch and sucrose metabolism</name>
      <description>The metabolism of starch and sucrose begins with D-fructose interacting with a D-glucose in a reversible reaction through a maltodextrin glucosidase resulting in a water molecule and a sucrose. D-fructose is phosphorylated through an ATP driven fructokinase resulting in the release of an ADP, a hydrogen ion and a Beta-D-fructofuranose 6-phosphate. This compound can also be introduced into the cytoplasm through either a mannose PTS permease or a hexose-6-phosphate:phosphate antiporter. 
The Beta-D-fructofuranose 6-phosphate is isomerized through a phosphoglucose isomerase resulting in a Beta-D-glucose 6-phosphate. This compound can also be incorporated by glucose PTS permease or a hexose-6-phosphate:phosphate antiporter. 
The beta-D-glucose 6 phosphate can also be produced by a D-glucose being phosphorylated by an ATP-driven glucokinase resulting in a ADP, a hydrogen ion and a Beta-D-glucose 6 phosphate. 

The beta-D-glucose can produce alpha-D-glucose-1-phosphate  by two methods:
1.-Beta-D-glucose is isomerized into an alpha-D-Glucose 6-phosphate and then interacts in a reversible reaction through a phosphoglucomutase-1 resulting in a alpha-D-glucose-1-phosphate.
2.-Beta-D-glucose interacts with a putative beta-phosphoglucomutase resulting in a Beta-D-glucose 1-phosphate.  Beta-D-glucose 1-phosphate can be incorporated into the cytoplasm through a 
glucose PTS permease. This compound is then isomerized into a Alpha-D-glucose-1-phosphate
The beta-D-glucose can cycle back into a D-fructose by first interacting with D-fructose in a reversible reaction through a Polypeptide: predicted glucosyltransferase resulting in the release of a phosphate and a sucrose. The sucrose then interacts in a reversible reaction with a water molecule through a maltodextrin glucosidase resulting in a D-glucose and a D-fructose. 

Alpha-D-glucose-1-phosphate can produce glycogen in by two different sets of reactions:
1.-Alpha-D-glucose-1-phosphate interacts with a hydrogen ion and an ATP through a glucose-1-phosphate adenylyltransferase resulting in a pyrophosphate and an ADP-glucose. The ADP-glucose then interacts with an amylose through a glycogen synthase resulting in the release of an ADP and an Amylose. The amylose then interacts with 1,4-α-glucan branching enzyme resulting in glycogen
2.- Alpha-D-glucose-1-phosphate interacts with amylose through a maltodextrin phosphorylase resulting in a phosphate and a glycogen.

Alpha-D-glucose-1-phosphate can also interacts with UDP-galactose through a galactose-1-phosphate uridylyltransferase resulting in a galactose 1-phosphate and a Uridine diphosphate glucose. The UDP-glucose then interacts with an alpha-D-glucose 6-phosphate through a trehalose-6-phosphate synthase resulting in a uridine 5'-diphosphate, a hydrogen ion and a Trehalose 6- phosphate. The latter compound can also be incorporated into the cytoplasm through a trehalose PTS permease. Trehalose interacts with a water molecule through a trehalose-6-phosphate phosphatase resulting in the release of a phosphate and an alpha,alpha-trehalose.The alpha,alpha-trehalose can also be obtained from glycogen being metabolized through a glycogen debranching enzyme resulting in a the alpha, alpha-trehalose. This compound ca then be hydrated through a cytoplasmic trehalase resulting in the release of an alpha-D-glucose and a beta-d-glucose.

Glycogen is then metabolized by reacting with a phosphate through a glycogen phosphorylase resulting in a alpha-D-glucose-1-phosphate and a dextrin. The dextrin is then hydrated through a glycogen phosphorylase-limit dextrin α-1,6-glucohydrolase resulting in the release of a debranched limit dextrin and a maltotetraose. This compound can also be incorporated into the cytoplasm through a 
maltose ABC transporter. The maltotetraose interacts with a phosphate through a maltodextrin phosphorylase releasing a alpha-D-glucose-1-phosphate and a maltotriose. The maltotriose can also be incorporated through a maltose ABC transporter. The maltotriose can then interact with water through a maltodextrin glucosidase resulting in a D-glucose and a D-maltose. D-maltose can also be incorporated through a 
maltose ABC transporter 

The D-maltose can then interact with a maltotriose through a amylomaltase resulting in a maltotetraose and a D-glucose. The D-glucose is then phosphorylated through an ATP driven glucokinase resulting in a hydrogen ion, an ADP and a Beta-D-glucose 6-phosphate</description>
      <pathwhiz_id>PW000941</pathwhiz_id>
      <kegg_map_id>ec00500</kegg_map_id>
      <subject>Metabolic</subject>
    </pathway>
    <pathway>
      <name>Galactose metabolism</name>
      <description>Galactose can be synthesized through two pathways: melibiose degradation involving an alpha galactosidase and lactose degradation involving a beta galactosidase. Melibiose is first transported inside the cell through the melibiose:Li+/Na+/H+ symporter. Once inside the cell, melibiose is degraded through alpha galactosidase  into an alpha-D-galactose and a beta-D-glucose. The beta-D-glucose is phosphorylated by a glucokinase to produce a beta-D-glucose-6-phosphate which can spontaneously be turned into a alpha D glucose 6 phosphate. This alpha D-glucose-6-phosphate is metabolized into a glucose -1-phosphate through a phosphoglucomutase-1. The glucose -1-phosphate is transformed into a uridine diphosphate glucose through UTP--glucose-1-phosphate uridylyltransferase. The product, uridine diphosphate glucose, can undergo a reversible reaction in which it can be turned into uridine diphosphategalactose through an UDP-glucose 4-epimerase.
Galactose can also be produced by lactose degradation involving a lactose permease to uptake lactose from the environment and a beta-galactosidase to turn lactose into Beta-D-galactose. 
Beta-D-galactose can also be uptaken from the environment through a galactose proton symporter.
Galactose is degraded through the following process:
Beta-D-galactose is introduced into the cytoplasm through a galactose proton symporter, or it can be synthesized from an alpha lactose that is introduced into the cytoplasm through a lactose permease. Alpha lactose interacts with water through a beta-galactosidase resulting in a beta-D-glucose and beta-D-galactose. Beta-D-galactose is isomerized into D-galactose. D-Galactose undergoes phosphorylation through a galactokinase, hence producing galactose 1 phosphate. On the other side of the pathway, a gluose-1-phosphate (product of the interaction of alpha-D-glucose 6-phosphate with a phosphoglucomutase resulting in a alpha-D-glucose-1-phosphate, an isomer of Glucose 1-phosphate, or an isomer of Beta-D-glucose 1-phosphate) interacts with UTP and a hydrogen ion in order to produce a uridine diphosphate glucose. This is followed by the interaction of galactose-1-phosphate with an established amount of uridine diphosphate glucose through a galactose-1-phosphate uridylyltransferase, which in turn output a glucose-1-phosphate and a uridine diphosphate galactose. The glucose -1-phosphate is transformed into a uridine diphosphate glucose through UTP--glucose-1-phosphate uridylyltransferase. The product, uridine diphosphate glucose, can undergo a reversible reaction in which it can be turned into uridine diphosphategalactose through an  UDP-glucose 4-epimerase, and so the cycle can keep going as long as more lactose or galactose is imported into the cell
</description>
      <pathwhiz_id>PW000821</pathwhiz_id>
      <kegg_map_id>ec00052</kegg_map_id>
      <subject>Metabolic</subject>
    </pathway>
    <pathway>
      <name>Amino sugar and nucleotide sugar metabolism</name>
      <description/>
      <pathwhiz_id/>
      <kegg_map_id>ec00520</kegg_map_id>
      <subject/>
    </pathway>
    <pathway>
      <name>Metabolic pathways</name>
      <description/>
      <pathwhiz_id/>
      <kegg_map_id>eco01100</kegg_map_id>
      <subject/>
    </pathway>
    <pathway>
      <name>Amino sugar and nucleotide sugar metabolism II</name>
      <description>The synthesis of amino sugars and nucleotide sugars  starts with the phosphorylation of N-Acetylmuramic acid (MurNac) through its transport from the periplasmic space to the cytoplasm. Once in the cytoplasm, MurNac and water undergo a reversible reaction through a N-acetylmuramic acid 6-phosphate etherase, producing a D-lactic acid and N-Acetyl-D-Glucosamine 6-phosphate. This latter compound can also be introduced into the cytoplasm through a phosphorylating PTS permase in the inner membrane that allows for the transport of N-Acetyl-D-glucosamine from the periplasmic space.  N-Acetyl-D-Glucosamine 6-phosphate can also be obtained from chitin dependent reactions. Chitin is hydrated through a bifunctional chitinase to produce chitobiose. This in turn gets hydrated by a beta-hexosaminidase to produce N-acetyl-D-glucosamine. The latter undergoes an atp dependent phosphorylation leading to the production of N-Acetyl-D-Glucosamine 6-phosphate.
 N-Acetyl-D-Glucosamine 6-phosphate is then be deacetylated in order to produce Glucosamine 6-phosphate through a N-acetylglucosamine-6-phosphate deacetylase. This compound is then deaminased into Beta-D-fructofuranose 6-phosphate through a glucosamine-6-phosphate deaminase. 
The beta-D-fructofuranose 6 -phosphate is isomerized in a reversible reaction into an alpha-D-mannose 6-phosphate. This compound can also be introduced into the cell from the periplasmic space through a mannose PTS permease that phosphorylates an alpha-D-mannose. Alpha-D-mannose 6-phosphate undergoes a reversible reaction through a phosphomannomutase to produce an alpha-D-mannose 1-phosphate. 
The  alpha-D-mannose 1-phosphate enters the nucleotide sugar metabolism through a reaction with GTP producing a GDP-mannose and releasing a pyrophosphate, all through a mannose-1-phosphate guanylyltransferase. GDP-mannose is then dehydrated to produce GDP-4-dehydro-6-deoxy-alpha-D-mannose through a GDP-mannose 4,6-dehydratase. This compound is then used to synthesize GDP-Beta-L-fucose through a NADPH dependent GDP-L-fucose synthase.

Alpha-D-glucose is introduced into the cytoplasm through a glucose PTS permease, which phosphorylates the compound in order to produce an alpha-D-glucose 6-phosphate. This compound is then modified through a phosphoglucomutase 1 to yield alpha-D-glucose 1-phosphate. This compound can either be adenylated to produce ADP-glucose or uridylylated to produce galactose 1-phosphate through glucose-1-phosphate adenyllyltransferase and galactose-1-phosphate uridylyltransferase respectively.</description>
      <pathwhiz_id>PW000887</pathwhiz_id>
      <kegg_map_id/>
      <subject>Metabolic</subject>
    </pathway>
    <pathway>
      <name>Amino sugar and nucleotide sugar metabolism III</name>
      <description>The synthesis of amino sugars and nucleotide sugars  starts with the phosphorylation of N-Acetylmuramic acid (MurNac) through its transport from the periplasmic space to the cytoplasm. Once in the cytoplasm, MurNac and water undergo a reversible reaction through a N-acetylmuramic acid 6-phosphate etherase, producing a D-lactic acid and N-Acetyl-D-Glucosamine 6-phosphate. This latter compound can also be introduced into the cytoplasm through a phosphorylating PTS permase in the inner membrane that allows for the transport of N-Acetyl-D-glucosamine from the periplasmic space.  N-Acetyl-D-Glucosamine 6-phosphate can also be obtained from chitin dependent reactions. Chitin is hydrated through a bifunctional chitinase to produce chitobiose. This in turn gets hydrated by a beta-hexosaminidase to produce N-acetyl-D-glucosamine. The latter undergoes an atp dependent phosphorylation leading to the production of N-Acetyl-D-Glucosamine 6-phosphate.
 N-Acetyl-D-Glucosamine 6-phosphate is then be deacetylated in order to produce Glucosamine 6-phosphate through a N-acetylglucosamine-6-phosphate deacetylase. This compound is then deaminased into Beta-D-fructofuranose 6-phosphate through a glucosamine-6-phosphate deaminase.
 Beta-D-fructofuranose 6-phosphate is isomerized into a beta-D-glucose 6-phosphate through a glucose-6-phosphate isomerase. The compound is then isomerized by a putative beta-phosphoglucomutase to produce a beta-D-glucose 1-phosphate. This compound enters the nucleotide sugar metabolism through uridylation resulting in a UDP-glucose. UDP-glucose is then dehydrated through a UDP-glucose 6-dehydrogenase to produce a UDP-glucuronic acid. This compound undergoes a NAD dependent reaction through a bifunctional polymyxin resistance protein to produce UDP-Beta-L-threo-pentapyranos-4-ulose. This compound then reacts with L-glutamic acid through a UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase to produce an oxoglutaric acid and UDP-4-amino-4-deoxy-beta-L-arabinopyranose
The latter compound interacts with a N10-formyl-tetrahydrofolate through a bifunctional polymyxin resistance protein ArnA, resulting in  a tetrahydrofolate, a hydrogen ion and a UDP-4-deoxy-4-formamido-beta-L-arabinopyranose, which in turn reacts with a product of the methylerythritol phosphate and polysoprenoid biosynthesis pathway, di-trans,octa-cis-undecaprenyl phosphate to produce a 4-deoxy-4-formamido-alpha-L-arabinopyranosyl ditrans, octacis-undecaprenyl phosphate.

Alpha-D-glucose is introduced into the cytoplasm through a glucose PTS permease, which phosphorylates the compound in order to produce an alpha-D-glucose 6-phosphate. This compound is then modified through a phosphoglucomutase 1 to yield alpha-D-glucose 1-phosphate. This compound can either be adenylated to produce ADP-glucose or uridylylated to produce galactose 1-phosphate through glucose-1-phosphate adenyllyltransferase and galactose-1-phosphate uridylyltransferase respectively.</description>
      <pathwhiz_id>PW000895</pathwhiz_id>
      <kegg_map_id/>
      <subject>Metabolic</subject>
    </pathway>
    <pathway>
      <name>Galactitol and galactonate degradation</name>
      <description>D-galactonate can serve as the sole source of carbon and energy for E. coli . The initial step, after the transport of galactonic acid into the cell is the degradation of D-galactonate is dehydration to 2-dehydro-3-deoxy-D-galactonate by D-galactonate dehydratase. Subsequent phosphorylation by 2-dehydro-3-deoxygalactonate kinase and aldol cleavage by 2-oxo-3-deoxygalactonate 6-phosphate aldolase produce pyruvate and D-glyceraldehyde-3-phosphate, which enter central metabolism.
Galactitol can also be utilized by E. coli K-12 as a total source of carbon and energy. Each enters the cell via a specific phosphotransferase system, so the first intracellular species is  D-galactitol-1-phosphate or D-galactitol-6-phosphate, which are identical. This sugar alcohol phosphate becomes the substrate for a dehydrogenase that oxidizes its 2-alcohol group to a keto group. Galactitol-1-phosphate, the product of the dehydrogenation is tagatose-6-phosphate, which becomes the substrate of a kinase and subsequently an aldolase (in a pair of reactions that parallel those of glycolysis) before it is converted into intermediates (D-glyceraldehde-3-phosphate and dihydroxy-acetone-phosphate) of glycolysis.</description>
      <pathwhiz_id>PW000820</pathwhiz_id>
      <kegg_map_id/>
      <subject>Metabolic</subject>
    </pathway>
    <pathway>
      <name>galactose degradation/Leloir Pathway</name>
      <description>The degradation of galactose, also known as Leloir pathway, requires 3 main enzymes once Beta-D-galactose has been converted to galactose through an Aldose-1-epimerase. These are:  galactokinase , galactose-1-phosphate uridylyltransferase and UDP-glucose 4-epimerase. Beta-D-galactose can be uptaken from the environment through a galactose proton symporter. It can also be produced by lactose degradation involving a lactose permease to uptake lactose from the environment and a beta-galactosidase to turn lactose into Beta-D-galactose. 
Galactose is degraded through the following process:
Beta-D-galactose is introduced into the cytoplasm through a galactose proton symporter, or it can be synthesized from an alpha lactose that is introduced into the cytoplasm through a lactose permease. Alpha lactose interacts with water through a beta-galactosidase resulting in a beta-D-glucose and beta-D-galactose. Beta-D-galactose is isomerized into D-galactose. D-Galactose undergoes phosphorylation through a galactokinase, hence producing galactose 1 phosphate. On the other side of the pathway, a gluose-1-phosphate (product of the interaction of alpha-D-glucose 6-phosphate with a phosphoglucomutase resulting in a alpha-D-glucose-1-phosphate, an isomer of Glucose 1-phosphate, or an isomer of Beta-D-glucose 1-phosphate) interacts with UTP and a hydrogen ion in order to produce a uridine diphosphate glucose. This is followed by the interaction of galactose-1-phosphate with an established amount of uridine diphosphate glucose through a galactose-1-phosphate uridylyltransferase, which in turn output a glucose-1-phosphate and a uridine diphosphate galactose. The glucose -1-phosphate is transformed into a uridine diphosphate glucose through UTP--glucose-1-phosphate uridylyltransferase. The product, uridine diphosphate glucose, can undergo a reversible reaction in which it can be turned into uridine diphosphategalactose through an  UDP-glucose 4-epimerase, and so the cycle can keep going as long as more lactose or galactose is imported into the cell.

</description>
      <pathwhiz_id>PW000884</pathwhiz_id>
      <kegg_map_id/>
      <subject>Metabolic</subject>
    </pathway>
    <pathway>
      <name>galactose degradation I (Leloir pathway)</name>
      <ecocyc_pathway_id>GALACTMETAB-PWY</ecocyc_pathway_id>
    </pathway>
    <pathway>
      <name>colanic acid building blocks biosynthesis</name>
      <ecocyc_pathway_id>COLANSYN-PWY</ecocyc_pathway_id>
    </pathway>
  </pathways>
  <spectra>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>2915</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>37670</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>134920</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>142654</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>1071142</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>1071144</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>1071146</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>1071148</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>1071150</spectrum_id>
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    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>1071151</spectrum_id>
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    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>1071153</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>1071155</spectrum_id>
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    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>1071157</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>1071159</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>1071161</spectrum_id>
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    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>1071163</spectrum_id>
    </spectrum>
    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>1071165</spectrum_id>
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    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>1071167</spectrum_id>
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    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>1071168</spectrum_id>
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    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>1071170</spectrum_id>
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    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>1071172</spectrum_id>
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    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>1071174</spectrum_id>
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    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>1071176</spectrum_id>
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    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>1071178</spectrum_id>
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    <spectrum>
      <type>Specdb::CMs</type>
      <spectrum_id>1071180</spectrum_id>
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    <spectrum>
      <type>Specdb::NmrOneD</type>
      <spectrum_id>4716</spectrum_id>
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    <spectrum>
      <type>Specdb::NmrOneD</type>
      <spectrum_id>4717</spectrum_id>
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    <spectrum>
      <type>Specdb::NmrOneD</type>
      <spectrum_id>144650</spectrum_id>
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    <spectrum>
      <type>Specdb::NmrOneD</type>
      <spectrum_id>144651</spectrum_id>
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    <spectrum>
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      <spectrum_id>144652</spectrum_id>
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    <spectrum>
      <type>Specdb::NmrOneD</type>
      <spectrum_id>144653</spectrum_id>
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      <type>Specdb::NmrOneD</type>
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      <type>Specdb::NmrOneD</type>
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      <spectrum_id>144668</spectrum_id>
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      <spectrum_id>144669</spectrum_id>
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      <spectrum_id>28337</spectrum_id>
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      <spectrum_id>28338</spectrum_id>
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      <spectrum_id>34895</spectrum_id>
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      <spectrum_id>34896</spectrum_id>
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      <spectrum_id>34897</spectrum_id>
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      <spectrum_id>439124</spectrum_id>
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      <spectrum_id>439278</spectrum_id>
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      <spectrum_id>440089</spectrum_id>
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      <spectrum_id>1473413</spectrum_id>
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      <spectrum_id>1473414</spectrum_id>
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      <spectrum_id>1475346</spectrum_id>
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      <spectrum_id>1475348</spectrum_id>
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      <spectrum_id>1475349</spectrum_id>
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      <spectrum_id>1475350</spectrum_id>
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      <spectrum_id>1475351</spectrum_id>
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      <type>Specdb::MsMs</type>
      <spectrum_id>1475352</spectrum_id>
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      <spectrum_id>1475353</spectrum_id>
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      <type>Specdb::MsMs</type>
      <spectrum_id>1475354</spectrum_id>
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      <type>Specdb::MsMs</type>
      <spectrum_id>1475355</spectrum_id>
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      <type>Specdb::MsMs</type>
      <spectrum_id>1475356</spectrum_id>
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      <type>Specdb::MsMs</type>
      <spectrum_id>1475357</spectrum_id>
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      <type>Specdb::MsMs</type>
      <spectrum_id>1475358</spectrum_id>
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    <spectrum>
      <type>Specdb::MsMs</type>
      <spectrum_id>1475359</spectrum_id>
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  </spectra>
  <hmdb_id>HMDB00645</hmdb_id>
  <pubchem_compound_id>439995</pubchem_compound_id>
  <chemspider_id>110443</chemspider_id>
  <kegg_id>C00446</kegg_id>
  <chebi_id/>
  <biocyc_id>GALACTOSE-1P</biocyc_id>
  <het_id>GL1</het_id>
  <wikipidia>Galactose 1-phosphate</wikipidia>
  <foodb_id/>
  <general_references>
    <reference>
      <reference_text>Keseler, I. M., Collado-Vides, J., Santos-Zavaleta, A., Peralta-Gil, M., Gama-Castro, S., Muniz-Rascado, L., Bonavides-Martinez, C., Paley, S., Krummenacker, M., Altman, T., Kaipa, P., Spaulding, A., Pacheco, J., Latendresse, M., Fulcher, C., Sarker, M., Shearer, A. G., Mackie, A., Paulsen, I., Gunsalus, R. P., Karp, P. D. (2011). "EcoCyc: a comprehensive database of Escherichia coli biology." Nucleic Acids Res 39:D583-D590.</reference_text>
      <pubmed_id>21097882</pubmed_id>
    </reference>
    <reference>
      <reference_text>Kanehisa, M., Goto, S., Sato, Y., Furumichi, M., Tanabe, M. (2012). "KEGG for integration and interpretation of large-scale molecular data sets." Nucleic Acids Res 40:D109-D114.</reference_text>
      <pubmed_id>22080510</pubmed_id>
    </reference>
    <reference>
      <reference_text>Ning C, Reynolds R, Chen J, Yager C, Berry GT, McNamara PD, Leslie N, Segal S: Galactose metabolism by the mouse with galactose-1-phosphate uridyltransferase deficiency. Pediatr Res. 2000 Aug;48(2):211-7.</reference_text>
      <pubmed_id>10926297</pubmed_id>
    </reference>
    <reference>
      <reference_text>Berry GT, Palmieri M, Gross KC, Acosta PB, Henstenburg JA, Mazur A, Reynolds R, Segal S: The effect of dietary fruits and vegetables on urinary galactitol excretion in galactose-1-phosphate uridyltransferase deficiency. J Inherit Metab Dis. 1993;16(1):91-100.</reference_text>
      <pubmed_id>8487507</pubmed_id>
    </reference>
    <reference>
      <reference_text>Ono H, Mawatari H, Mizoguchi N, Eguchi T, Sakura N, Hamakawa M: Transient galactosemia detected by neonatal mass screening.  Pediatr Int. 1999 Jun;41(3):281-4.</reference_text>
      <pubmed_id>10365579</pubmed_id>
    </reference>
    <reference>
      <reference_text>Endres W: Inherited metabolic diseases affecting the carrier.  J Inherit Metab Dis. 1997 Mar;20(1):9-20.</reference_text>
      <pubmed_id>9061562</pubmed_id>
    </reference>
    <reference>
      <reference_text>Guerrero NV, Singh RH, Manatunga A, Berry GT, Steiner RD, Elsas LJ 2nd: Risk factors for premature ovarian failure in females with galactosemia.  J Pediatr. 2000 Dec;137(6):833-41.</reference_text>
      <pubmed_id>11113841</pubmed_id>
    </reference>
    <reference>
      <reference_text>Schaub J, Remberger K, Endres W, Bremer HJ: Galactosemia with endogenous production of galactose-1-phosphate and with cystic fibrosis-like appearance at autopsy. Helv Paediatr Acta. 1976 Jun;31(1):67-76.</reference_text>
      <pubmed_id>939702</pubmed_id>
    </reference>
    <reference>
      <reference_text>Bozkowa K, Zbieg-Sendecka E, Grodzka Z, Cabalska B: [Clinical and biochemical diagnosis of galactosemia among our cases]  Probl Med Wieku Rozwoj. 1979;8:63-9.</reference_text>
      <pubmed_id>263527</pubmed_id>
    </reference>
    <reference>
      <reference_text>Dahlqvist A: A fluorometric method for the assay of galactose-1-phosphate in red blood cells. J Lab Clin Med. 1971 Dec;78(6):931-8.</reference_text>
      <pubmed_id>5131857</pubmed_id>
    </reference>
    <reference>
      <reference_text>Bozkowa K, Duchnowska A, Chojnacki T, Mankowski T: [New radioisotope method of quantitative determination of galactose-1-phosphate in red blood cells in galactosemia] Pol Tyg Lek. 1975 Dec 22;30(51):2123-6.</reference_text>
      <pubmed_id>1197109</pubmed_id>
    </reference>
    <reference>
      <reference_text>Wharton CH, Berry HK, Bofinger MK: Galactose-1-phosphate accumulation by a Duarte-transferase deficiency double heterozygote. Clin Genet. 1978 Feb;13(2):171-5.</reference_text>
      <pubmed_id>627109</pubmed_id>
    </reference>
    <reference>
      <reference_text>Gitzelmann R, Steinmann B, Mitchell B, Haigis E: Uridine diphosphate galactose 4'-epimerase deficiency. IV. Report of eight cases in three families. Helv Paediatr Acta. 1977 Apr;31(6):441-52.</reference_text>
      <pubmed_id>404274</pubmed_id>
    </reference>
    <reference>
      <reference_text>Barbouth D, Slepak T, Klapper H, Lai K, Elsas LJ: Prevention of a molecular misdiagnosis in galactosemia.  Genet Med. 2006 Mar;8(3):178-82.</reference_text>
      <pubmed_id>16540753</pubmed_id>
    </reference>
    <reference>
      <reference_text>Mankowski T, Radomyska B, Zbieg-Sendecka E: Preliminary results of UDP galactose pyrophosphorylase in the erythrocytes of healthy persons and in patients with galactosaemia. Mater Med Pol. 1990 Jul-Sep;22(3):191-3.</reference_text>
      <pubmed_id>2132425</pubmed_id>
    </reference>
    <reference>
      <reference_text>Moller HE, Ullrich K, Vermathen P, Schuierer G, Koch HG: In vivo study of brain metabolism in galactosemia by 1H and 31P magnetic resonance spectroscopy. Eur J Pediatr. 1995;154(7 Suppl 2):S8-13.</reference_text>
      <pubmed_id>7671972</pubmed_id>
    </reference>
    <reference>
      <reference_text>Barth CA, Kopra N: Oral intake of glucose plus galactose and erythrocyte galactose-1-phosphate. A nutritional evaluation of hydrolyzed lactose. Z Ernahrungswiss. 1986 Sep;25(3):171-9.</reference_text>
      <pubmed_id>3776241</pubmed_id>
    </reference>
    <reference>
      <reference_text>Pesce MA, Bodourian SH: Clinical significance of plasma galactose and erythrocyte galactose-1-phosphate measurements in transferase-deficient galactosemia and in individuals with below-normal transferase activity. Clin Chem. 1982 Feb;28(2):301-5.</reference_text>
      <pubmed_id>6276048</pubmed_id>
    </reference>
    <reference>
      <reference_text>Schadewaldt P, Kamalanathan L, Hammen HW, Wendel U: Age dependence of endogenous galactose formation in Q188R homozygous galactosemic patients. Mol Genet Metab. 2004 Jan;81(1):31-44.</reference_text>
      <pubmed_id>14728989</pubmed_id>
    </reference>
    <reference>
      <reference_text>Pesce MA, Bodourian SH, Nicholson JF: A new microfluorometric method for the measurement of galactose-1-phosphate in erythrocytes. Clin Chim Acta. 1982 Feb 5;118(2-3):177-89.</reference_text>
      <pubmed_id>7055979</pubmed_id>
    </reference>
  </general_references>
  <synthesis_reference>Chen Jie; Yager Claire; Reynolds Robert; Palmieri Michael; Segal Stanton  Erythrocyte galactose 1-phosphate quantified by isotope-dilution gas chromatography-mass spectrometry.    Clinical chemistry  (2002),  48(4),  604-12. </synthesis_reference>
  <msds_url/>
  <enzymes>
    <enzyme>
      <name>Protein ushA</name>
      <uniprot_id>P07024</uniprot_id>
      <uniprot_name>USHA_ECOLI</uniprot_name>
      <gene_name>ushA</gene_name>
      <protein_url>http://ecmdb.ca/proteins/P07024.xml</protein_url>
    </enzyme>
    <enzyme>
      <name>Galactose-1-phosphate uridylyltransferase</name>
      <uniprot_id>P09148</uniprot_id>
      <uniprot_name>GAL7_ECOLI</uniprot_name>
      <gene_name>galT</gene_name>
      <protein_url>http://ecmdb.ca/proteins/P09148.xml</protein_url>
    </enzyme>
    <enzyme>
      <name>Galactokinase</name>
      <uniprot_id>P0A6T3</uniprot_id>
      <uniprot_name>GAL1_ECOLI</uniprot_name>
      <gene_name>galK</gene_name>
      <protein_url>http://ecmdb.ca/proteins/P0A6T3.xml</protein_url>
    </enzyme>
    <enzyme>
      <name>Galactitol-1-phosphate 5-dehydrogenase</name>
      <uniprot_id>P0A9S3</uniprot_id>
      <uniprot_name>GATD_ECOLI</uniprot_name>
      <gene_name>gatD</gene_name>
      <protein_url>http://ecmdb.ca/proteins/P0A9S3.xml</protein_url>
    </enzyme>
    <enzyme>
      <name>Glucose-1-phosphatase</name>
      <uniprot_id>P19926</uniprot_id>
      <uniprot_name>AGP_ECOLI</uniprot_name>
      <gene_name>agp</gene_name>
      <protein_url>http://ecmdb.ca/proteins/P19926.xml</protein_url>
    </enzyme>
    <enzyme>
      <name>Galactitol-specific phosphotransferase enzyme IIB component</name>
      <uniprot_id>P37188</uniprot_id>
      <uniprot_name>PTKB_ECOLI</uniprot_name>
      <gene_name>gatB</gene_name>
      <protein_url>http://ecmdb.ca/proteins/P37188.xml</protein_url>
    </enzyme>
    <enzyme>
      <name>Galactitol-specific phosphotransferase enzyme IIA component</name>
      <uniprot_id>P69828</uniprot_id>
      <uniprot_name>PTKA_ECOLI</uniprot_name>
      <gene_name>gatA</gene_name>
      <protein_url>http://ecmdb.ca/proteins/P69828.xml</protein_url>
    </enzyme>
    <enzyme>
      <name>Galactitol permease IIC component</name>
      <uniprot_id>P69831</uniprot_id>
      <uniprot_name>PTKC_ECOLI</uniprot_name>
      <gene_name>gatC</gene_name>
      <protein_url>http://ecmdb.ca/proteins/P69831.xml</protein_url>
    </enzyme>
    <enzyme>
      <name>Colanic acid biosynthesis protein wcaK</name>
      <uniprot_id>P71242</uniprot_id>
      <uniprot_name>WCAK_ECOLI</uniprot_name>
      <gene_name>wcaK</gene_name>
      <protein_url>http://ecmdb.ca/proteins/P71242.xml</protein_url>
    </enzyme>
  </enzymes>
  <transporters>
    <enzyme>
      <name>Galactitol permease IIC component</name>
      <uniprot_id>P69831</uniprot_id>
      <uniprot_name>PTKC_ECOLI</uniprot_name>
      <gene_name>gatC</gene_name>
      <protein_url>http://ecmdb.ca/proteins/P69831.xml</protein_url>
    </enzyme>
    <enzyme>
      <name>Outer membrane protein N</name>
      <uniprot_id>P77747</uniprot_id>
      <uniprot_name>OMPN_ECOLI</uniprot_name>
      <gene_name>ompN</gene_name>
      <protein_url>http://ecmdb.ca/proteins/P77747.xml</protein_url>
    </enzyme>
    <enzyme>
      <name>Outer membrane pore protein E</name>
      <uniprot_id>P02932</uniprot_id>
      <uniprot_name>PHOE_ECOLI</uniprot_name>
      <gene_name>phoE</gene_name>
      <protein_url>http://ecmdb.ca/proteins/P02932.xml</protein_url>
    </enzyme>
    <enzyme>
      <name>Outer membrane protein F</name>
      <uniprot_id>P02931</uniprot_id>
      <uniprot_name>OMPF_ECOLI</uniprot_name>
      <gene_name>ompF</gene_name>
      <protein_url>http://ecmdb.ca/proteins/P02931.xml</protein_url>
    </enzyme>
    <enzyme>
      <name>Outer membrane protein C</name>
      <uniprot_id>P06996</uniprot_id>
      <uniprot_name>OMPC_ECOLI</uniprot_name>
      <gene_name>ompC</gene_name>
      <protein_url>http://ecmdb.ca/proteins/P06996.xml</protein_url>
    </enzyme>
  </transporters>
  <reactions>
    <reaction_text>Adenosine triphosphate + D-Galactose + Alpha-D-Galactose &lt;&gt; ADP + Galactose 1-phosphate + Hydrogen ion</reaction_text>
    <kegg_reaction_id>R01092</kegg_reaction_id>
    <ecocyc_id>GALACTOKIN-RXN</ecocyc_id>
    <pw_reaction_id/>
    <reaction_text>Water + Uridine diphosphategalactose &gt; Galactose 1-phosphate +2 Hydrogen ion + Uridine 5'-monophosphate</reaction_text>
    <kegg_reaction_id/>
    <ecocyc_id/>
    <pw_reaction_id/>
    <reaction_text>Galactose 1-phosphate + UDP-Glucose &lt;&gt; Glucose 1-phosphate + Uridine diphosphategalactose</reaction_text>
    <kegg_reaction_id>R00955</kegg_reaction_id>
    <ecocyc_id>GALACTURIDYLYLTRANS-RXN</ecocyc_id>
    <pw_reaction_id/>
    <reaction_text>Galactose 1-phosphate + Water &gt; D-Galactose + Phosphate</reaction_text>
    <kegg_reaction_id/>
    <ecocyc_id/>
    <pw_reaction_id/>
    <reaction_text>Adenosine triphosphate + D-Galactose &lt;&gt; ADP + Galactose 1-phosphate</reaction_text>
    <kegg_reaction_id>R01092</kegg_reaction_id>
    <ecocyc_id/>
    <pw_reaction_id/>
    <reaction_text>D-Galactose + Adenosine triphosphate &gt; Hydrogen ion + Galactose 1-phosphate + ADP</reaction_text>
    <kegg_reaction_id>R01092</kegg_reaction_id>
    <ecocyc_id>GALACTOKIN-RXN</ecocyc_id>
    <pw_reaction_id/>
    <reaction_text>Adenosine triphosphate + D-Galactose &gt; ADP + Galactose 1-phosphate</reaction_text>
    <kegg_reaction_id/>
    <ecocyc_id/>
    <pw_reaction_id/>
    <reaction_text>UDP-Glucose + Galactose 1-phosphate &gt; Alpha-D-glucose 1-phosphate + Uridine diphosphategalactose</reaction_text>
    <kegg_reaction_id/>
    <ecocyc_id/>
    <pw_reaction_id/>
    <reaction_text>Galactose 1-phosphate + NAD + Galactose 1-phosphate &gt; NADH + Hydrogen ion + D-tagatofuranose 6-phosphate</reaction_text>
    <kegg_reaction_id/>
    <ecocyc_id/>
    <pw_reaction_id>PW_R002943</pw_reaction_id>
    <reaction_text>Galactose 1-phosphate + Galactose 1-phosphate &gt; Glucose 1-phosphate</reaction_text>
    <kegg_reaction_id/>
    <ecocyc_id/>
    <pw_reaction_id>PW_R002949</pw_reaction_id>
    <reaction_text>Galactose 1-phosphate + UDP-Glucose + Galactose 1-phosphate &gt; Uridine diphosphategalactose + Glucose 1-phosphate + Uridine diphosphategalactose</reaction_text>
    <kegg_reaction_id/>
    <ecocyc_id/>
    <pw_reaction_id>PW_R003296</pw_reaction_id>
    <reaction_text>Alpha-D-glucose 1-phosphate + UDP-galactose &gt; UDP-Glucose + Galactose 1-phosphate + Galactose 1-phosphate</reaction_text>
    <kegg_reaction_id/>
    <ecocyc_id/>
    <pw_reaction_id>PW_R003354</pw_reaction_id>
    <reaction_text>Alpha-D-Galactose + Adenosine triphosphate &gt; Adenosine diphosphate + Hydrogen ion + Galactose 1-phosphate + ADP + Galactose 1-phosphate</reaction_text>
    <kegg_reaction_id/>
    <ecocyc_id/>
    <pw_reaction_id>PW_R002952</pw_reaction_id>
    <reaction_text>Galactitol + HPr - phosphorylated &gt; Galactose 1-phosphate + HPr + Galactose 1-phosphate</reaction_text>
    <kegg_reaction_id/>
    <ecocyc_id/>
    <pw_reaction_id>PW_RCT000113</pw_reaction_id>
  </reactions>
  <concentrations>
  </concentrations>
</compound>
