2.0 2012-05-31 14:01:37 -0600 2015-07-14 14:32:03 -0600 ECMDB03974 M2MDB000548 Oxalosuccinic acid Oxalosuccinate is a substrate for cytoplasmic Isocitrate dehydrogenase and mitochondiral Isocitrate dehydrogenase (mitochondrial). Oxalo-succ Oxalosuccinate Oxalosuccinic acid C6H6O7 190.1076 190.011352546 1-oxopropane-1,2,3-tricarboxylic acid oxalosuccinate 1948-82-9 OC(=O)CC(C(O)=O)C(=O)C(O)=O InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13) UFSCUAXLTRFIDC-UHFFFAOYSA-N Solid Cytoplasm Periplasm logp -0.55 ALOGPS logs -1.41 ALOGPS solubility 7.47e+00 g/l ALOGPS logp -0.37 ChemAxon pka_strongest_acidic 2.38 ChemAxon pka_strongest_basic -10 ChemAxon iupac 1-oxopropane-1,2,3-tricarboxylic acid ChemAxon average_mass 190.1076 ChemAxon mono_mass 190.011352546 ChemAxon smiles OC(=O)CC(C(O)=O)C(=O)C(O)=O ChemAxon formula C6H6O7 ChemAxon inchi InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13) ChemAxon inchikey UFSCUAXLTRFIDC-UHFFFAOYSA-N ChemAxon polar_surface_area 128.97 ChemAxon refractivity 35.17 ChemAxon polarizability 14.95 ChemAxon rotatable_bond_count 5 ChemAxon acceptor_count 7 ChemAxon donor_count 3 ChemAxon physiological_charge -3 ChemAxon formal_charge 0 ChemAxon Glutathione metabolism The biosynthesis of glutathione starts with the introduction of L-glutamic acid through either a glutamate:sodium symporter, glutamate / aspartate : H+ symporter GltP or a glutamate / aspartate ABC transporter. Once in the cytoplasm, L-glutamice acid reacts with L-cysteine through an ATP glutamate-cysteine ligase resulting in gamma-glutamylcysteine. This compound reacts which Glycine through an ATP driven glutathione synthetase thus catabolizing Glutathione. This compound is metabolized through a spontaneous reaction with an oxidized glutaredoxin resulting in a reduced glutaredoxin and an oxidized glutathione. This compound is reduced by a NADPH glutathione reductase resulting in a glutathione. PW000833 ec00480 Metabolic Citrate cycle (TCA cycle) ec00020 Reductive carboxylate cycle (CO2 fixation) ec00720 Microbial metabolism in diverse environments ec01120 Metabolic pathways eco01100 Specdb::CMs 3033 Specdb::CMs 38681 Specdb::NmrOneD 288635 Specdb::NmrOneD 288636 Specdb::NmrOneD 288637 Specdb::NmrOneD 288638 Specdb::NmrOneD 288639 Specdb::NmrOneD 288640 Specdb::NmrOneD 288641 Specdb::NmrOneD 288642 Specdb::NmrOneD 288643 Specdb::NmrOneD 288644 Specdb::NmrOneD 288645 Specdb::NmrOneD 288646 Specdb::NmrOneD 288647 Specdb::NmrOneD 288648 Specdb::NmrOneD 288649 Specdb::NmrOneD 288650 Specdb::NmrOneD 288651 Specdb::NmrOneD 288652 Specdb::NmrOneD 288653 Specdb::NmrOneD 288654 Specdb::MsMs 28100 Specdb::MsMs 28101 Specdb::MsMs 28102 Specdb::MsMs 34658 Specdb::MsMs 34659 Specdb::MsMs 34660 Specdb::MsMs 3608797 Specdb::MsMs 3608798 Specdb::MsMs 3608799 Specdb::MsMs 3608800 Specdb::MsMs 3608801 Specdb::MsMs 3608802 HMDB03974 972 C05379 OXALO-SUCCINATE Oxalosuccinic_acid Keseler, I. M., Collado-Vides, J., Santos-Zavaleta, A., Peralta-Gil, M., Gama-Castro, S., Muniz-Rascado, L., Bonavides-Martinez, C., Paley, S., Krummenacker, M., Altman, T., Kaipa, P., Spaulding, A., Pacheco, J., Latendresse, M., Fulcher, C., Sarker, M., Shearer, A. G., Mackie, A., Paulsen, I., Gunsalus, R. P., Karp, P. D. (2011). "EcoCyc: a comprehensive database of Escherichia coli biology." Nucleic Acids Res 39:D583-D590. 21097882 Kanehisa, M., Goto, S., Sato, Y., Furumichi, M., Tanabe, M. (2012). "KEGG for integration and interpretation of large-scale molecular data sets." Nucleic Acids Res 40:D109-D114. 22080510 Takeda, Isao; Iguchi, Takashi. Fermentative production of oxalosuccinic acid from hydrocarbons. Jpn. Tokkyo Koho (1972), 3 pp. Isocitrate dehydrogenase [NADP] P08200 IDH_ECOLI icd http://ecmdb.ca/proteins/P08200.xml Oxalosuccinic acid <> alpha-Ketoglutarate + Carbon dioxide R00268 Isocitric acid + NADP <> Oxalosuccinic acid + NADPH + Hydrogen ion R01899 Oxalosuccinic acid + Hydrogen ion > Oxoglutaric acid + Carbon dioxide RXN-8642 Isocitric acid + NADP > Oxalosuccinic acid + NADPH + Hydrogen ion R01899 RXN-9951 Isocitric acid + NADP + Oxalosuccinic acid <> alpha-Ketoglutarate + Carbon dioxide + NADPH + Hydrogen ion R00267