2.0 2012-05-31 14:00:23 -0600 2015-06-03 15:54:32 -0600 ECMDB03840 M2MDB000525 Phosphoroselenoic acid Phosphoroselenoic acid, H3SePO3, is the activated selenium donor compound required for the biosynthesis of selenocysteyl-tRNA, the precursor of specific selenocysteine residues in bacterial and mammalian selenoproteins. Selenocysteine is often called the 21st amino acid, because Sec has a specific tRNA and codon UGA, and shares a major stop codon UGA. A number of enzymes have selenocysteine, residues and in some cases at their active sites. Proteins containing the 21st amino acid, selenocysteine (Sec), have been described in all three domains of life. (PMID: 18156471) Monoselenophosphate Monoselenophosphorate Monoselenophosphoric acid Phosphoroselenoate Selenophosphate Selenophosphorate Selenophosphoric acid SePO3 Trihydroxidoselenidophosphorus [P(OH)3Se] H3O3PSe 160.96 161.898502302 hydroxy(selanylidene)phosphonous acid selenophosphoric acid 25758-66-1 OP(O)(O)=[Se] InChI=1S/H3O3PSe/c1-4(2,3)5/h(H3,1,2,3,5) JRPHGDYSKGJTKZ-UHFFFAOYSA-N Solid Cytosol logp -1.1 ChemAxon pka_strongest_acidic -6.3 ChemAxon iupac hydroxy(selanylidene)phosphonous acid ChemAxon average_mass 160.96 ChemAxon mono_mass 161.898502302 ChemAxon smiles OP(O)(O)=[Se] ChemAxon formula H3O3PSe ChemAxon inchi InChI=1S/H3O3PSe/c1-4(2,3)5/h(H3,1,2,3,5) ChemAxon inchikey JRPHGDYSKGJTKZ-UHFFFAOYSA-N ChemAxon polar_surface_area 60.69 ChemAxon refractivity 26.32 ChemAxon polarizability 7.23 ChemAxon rotatable_bond_count 0 ChemAxon acceptor_count 4 ChemAxon donor_count 3 ChemAxon physiological_charge -3 ChemAxon formal_charge 0 ChemAxon Selenoamino acid metabolism ec00450 Aminoacyl-tRNA biosynthesis ec00970 Metabolic pathways eco01100 Specdb::CMs 15002 Specdb::CMs 136167 Specdb::CMs 143901 Specdb::MsMs 23129 Specdb::MsMs 23130 Specdb::MsMs 23131 Specdb::MsMs 29927 Specdb::MsMs 29928 Specdb::MsMs 29929 Specdb::MsMs 2733900 Specdb::MsMs 2733901 Specdb::MsMs 2733902 Specdb::MsMs 2971608 Specdb::MsMs 2971609 Specdb::MsMs 2971610 HMDB03840 1092 1061 C05172 16144 Kanehisa, M., Goto, S., Sato, Y., Furumichi, M., Tanabe, M. (2012). "KEGG for integration and interpretation of large-scale molecular data sets." Nucleic Acids Res 40:D109-D114. 22080510 Lobanov, A. V., Hatfield, D. L., Gladyshev, V. N. (2008). "Selenoproteinless animals: selenophosphate synthetase SPS1 functions in a pathway unrelated to selenocysteine biosynthesis." Protein Sci 17:176-182. 18156471 Ephraim, F.; Majler, E. Selenophosphates. Berichte der Deutschen Chemischen Gesellschaft (1910), 43 277-85. L-seryl-tRNA(Sec) selenium transferase P0A821 SELA_ECOLI selA http://ecmdb.ca/proteins/P0A821.xml Selenide, water dikinase P16456 SELD_ECOLI selD http://ecmdb.ca/proteins/P16456.xml tRNA 2-selenouridine synthase P33667 SELU_ECOLI selU http://ecmdb.ca/proteins/P33667.xml Adenosine triphosphate + Water + Selenium > Adenosine monophosphate + Phosphate + Phosphoroselenoic acid Phosphoroselenoic acid > Hydrogen ion + Phosphate + L-Selenocysteinyl-tRNA(Sec) Adenosine triphosphate + Hydrogen selenide + Water <> Adenosine monophosphate + Phosphoroselenoic acid + Phosphate R03595 L-Seryl-tRNA(Sec) + Phosphoroselenoic acid + L-Seryl-tRNA(Sec) <> L-Selenocysteinyl-tRNA(Sec) + Phosphate + L-Selenocysteinyl-tRNA(Sec) R08219 L-seryl-tRNA(Sec) + Phosphoroselenoic acid > L-selenocysteinyl-tRNA(Sec) + Inorganic phosphate Adenosine triphosphate + Hydrogen selenide + Water > Adenosine monophosphate + Phosphoroselenoic acid + Inorganic phosphate 5-Methylaminomethyl-2-thiouridine + Phosphoroselenoic acid > 5-Methylaminomethyl-2-selenouridine + Inorganic phosphate Adenosine triphosphate + Hydrogen selenide + Water <> Adenosine monophosphate + Phosphoroselenoic acid + Phosphate L-Seryl-tRNA(Sec) + Phosphoroselenoic acid <> L-Selenocysteinyl-tRNA(Sec) + Phosphate