2.0 2012-05-31 13:58:31 -0600 2015-06-03 15:54:22 -0600 ECMDB03335 M2MDB000490 IDP IDP is an inosine nucleotide containing a pyrophosphate group esterified to the C5 of the sugar moiety. 5'-IDP IDP Inosine 5'-(trihydrogen diphosphate) Inosine 5'-(trihydrogen diphosphoric acid) Inosine 5'-(trihydrogen pyrophosphate) Inosine 5'-(trihydrogen pyrophosphoric acid) Inosine 5'-diphosphate Inosine 5'-diphosphoric acid Inosine 5'-pyrophosphate Inosine 5'-pyrophosphoric acid Inosine diphosphate Inosine diphosphoric acid Inosine pyrophosphate Inosine pyrophosphoric acid Riboxin Riboxine C10H14N4O11P2 428.1859 428.013430334 [({[(2R,3S,4R)-3,4-dihydroxy-5-(6-oxo-6,9-dihydro-3H-purin-9-yl)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid {[(2R,3S,4R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methoxy(hydroxy)phosphoryl}oxyphosphonic acid 86-04-4 O[C@@H]1[C@@H](COP(O)(=O)OP(O)(O)=O)OC([C@@H]1O)N1C=NC2=C1NC=NC2=O InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/t4-,6-,7-,10?/m1/s1 JPXZQMKKFWMMGK-VTHZCTBJSA-N Solid Cytosol logp -0.99 ALOGPS logs -2.00 ALOGPS solubility 4.26e+00 g/l ALOGPS logp -3.6 ChemAxon pka_strongest_acidic 2.65 ChemAxon pka_strongest_basic 1.73 ChemAxon iupac [({[(2R,3S,4R)-3,4-dihydroxy-5-(6-oxo-6,9-dihydro-3H-purin-9-yl)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid ChemAxon average_mass 428.1859 ChemAxon mono_mass 428.013430334 ChemAxon smiles O[C@@H]1[C@@H](COP(O)(=O)OP(O)(O)=O)OC([C@@H]1O)N1C=NC2=C1NC=NC2=O ChemAxon formula C10H14N4O11P2 ChemAxon inchi InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/t4-,6-,7-,10?/m1/s1 ChemAxon inchikey JPXZQMKKFWMMGK-VTHZCTBJSA-N ChemAxon polar_surface_area 222.26 ChemAxon refractivity 82.64 ChemAxon polarizability 33.75 ChemAxon rotatable_bond_count 6 ChemAxon acceptor_count 12 ChemAxon donor_count 6 ChemAxon physiological_charge -3 ChemAxon formal_charge 0 ChemAxon Purine metabolism ec00230 Specdb::CMs 12469 Specdb::CMs 38574 Specdb::CMs 152384 Specdb::NmrOneD 135610 Specdb::NmrOneD 135611 Specdb::NmrOneD 135612 Specdb::NmrOneD 135613 Specdb::NmrOneD 135614 Specdb::NmrOneD 135615 Specdb::NmrOneD 135616 Specdb::NmrOneD 135617 Specdb::NmrOneD 135618 Specdb::NmrOneD 135619 Specdb::NmrOneD 135620 Specdb::NmrOneD 135621 Specdb::NmrOneD 135622 Specdb::NmrOneD 135623 Specdb::NmrOneD 135624 Specdb::NmrOneD 135625 Specdb::NmrOneD 135626 Specdb::NmrOneD 135627 Specdb::NmrOneD 135628 Specdb::NmrOneD 135629 Specdb::MsMs 24977 Specdb::MsMs 24978 Specdb::MsMs 24979 Specdb::MsMs 31535 Specdb::MsMs 31536 Specdb::MsMs 31537 Specdb::MsMs 2294628 Specdb::MsMs 2294629 Specdb::MsMs 2294630 Specdb::MsMs 2641573 Specdb::MsMs 2641574 Specdb::MsMs 2641575 HMDB03335 644173 559208 C00104 17808 IDP IDP Keseler, I. M., Collado-Vides, J., Santos-Zavaleta, A., Peralta-Gil, M., Gama-Castro, S., Muniz-Rascado, L., Bonavides-Martinez, C., Paley, S., Krummenacker, M., Altman, T., Kaipa, P., Spaulding, A., Pacheco, J., Latendresse, M., Fulcher, C., Sarker, M., Shearer, A. G., Mackie, A., Paulsen, I., Gunsalus, R. P., Karp, P. D. (2011). "EcoCyc: a comprehensive database of Escherichia coli biology." Nucleic Acids Res 39:D583-D590. 21097882 Kanehisa, M., Goto, S., Sato, Y., Furumichi, M., Tanabe, M. (2012). "KEGG for integration and interpretation of large-scale molecular data sets." Nucleic Acids Res 40:D109-D114. 22080510 Bennett, B. D., Kimball, E. H., Gao, M., Osterhout, R., Van Dien, S. J., Rabinowitz, J. D. (2009). "Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli." Nat Chem Biol 5:593-599. 19561621 Ishii, N., Nakahigashi, K., Baba, T., Robert, M., Soga, T., Kanai, A., Hirasawa, T., Naba, M., Hirai, K., Hoque, A., Ho, P. Y., Kakazu, Y., Sugawara, K., Igarashi, S., Harada, S., Masuda, T., Sugiyama, N., Togashi, T., Hasegawa, M., Takai, Y., Yugi, K., Arakawa, K., Iwata, N., Toya, Y., Nakayama, Y., Nishioka, T., Shimizu, K., Mori, H., Tomita, M. (2007). "Multiple high-throughput analyses monitor the response of E. coli to perturbations." Science 316:593-597. 17379776 Hlushko LV, Makovets'ka TI, Neiko IeM: [The dynamics of the glycocholic acid content of the bile in patients with chronic inactive hepatitis] Lik Sprava. 1995 May-Jun;(5-6):152-4. 8630789 Takada, Masao; Kashiwa, Kenichi. Nucleoside 5'-pyrophosphates. Jpn. Tokkyo Koho (1971), 3 pp. CODEN: JAXXAD JP 46021587 19710618 Showa. CAN 75:130076 AN 1971:530076 CAPLUS 6-phosphofructokinase isozyme 2 P06999 K6PF2_ECOLI pfkB http://ecmdb.ca/proteins/P06999.xml Nucleoside diphosphate kinase P0A763 NDK_ECOLI ndk http://ecmdb.ca/proteins/P0A763.xml 6-phosphofructokinase isozyme 1 P0A796 K6PF1_ECOLI pfkA http://ecmdb.ca/proteins/P0A796.xml Uridine kinase P0A8F4 URK_ECOLI udk http://ecmdb.ca/proteins/P0A8F4.xml Putative ribosome biogenesis GTPase RsgA P39286 RSGA_ECOLI rsgA http://ecmdb.ca/proteins/P39286.xml Adenylate kinase P69441 KAD_ECOLI adk http://ecmdb.ca/proteins/P69441.xml UPF0244 protein yjjX P39411 YJJX_ECOLI yjjX http://ecmdb.ca/proteins/P39411.xml Nucleoside diphosphate kinase P0A763 NDK_ECOLI ndk http://ecmdb.ca/proteins/P0A763.xml Water + Inosine triphosphate > Hydrogen ion + IDP + Phosphate RXN0-5073 Adenosine monophosphate + Inosine triphosphate <> ADP + IDP Adenosine triphosphate + IDP <> ADP + Inosine triphosphate R00722 Inosine triphosphate + Cytidine <> IDP + Cytidine monophosphate R00962 Inosine triphosphate + Uridine <> IDP + Uridine 5'-monophosphate R00970 Inosine triphosphate + D-Tagatose 6-phosphate <> IDP + D-Tagatose 1,6-bisphosphate R03239 48 mM Na2HPO4, 22 mM KH2PO4, 10 mM NaCl, 45 mM (NH4)2SO4, supplemented with 1 mM MgSO4, 1 mg/l thiamine·HCl, 5.6 mg/l CaCl2, 8 mg/l FeCl3, 1 mg/l MnCl2·4H2O, 1.7 mg/l ZnCl2, 0.43 mg/l CuCl2·2H2O, 0.6 mg/l CoCl2·2H2O and 0.6 mg/l Na2MoO4·2H2O. 4 g/L Gluco Bioreactor, pH controlled, O2 and CO2 controlled, dilution rate: 0.2/h 74.7 uM 0.0 37 oC BW25113 Stationary Phase, glucose limited 298800 0 Ishii, N., Nakahigashi, K., Baba, T., Robert, M., Soga, T., Kanai, A., Hirasawa, T., Naba, M., Hirai, K., Hoque, A., Ho, P. Y., Kakazu, Y., Sugawara, K., Igarashi, S., Harada, S., Masuda, T., Sugiyama, N., Togashi, T., Hasegawa, M., Takai, Y., Yugi, K., Arakawa, K., Iwata, N., Toya, Y., Nakayama, Y., Nishioka, T., Shimizu, K., Mori, H., Tomita, M. (2007). "Multiple high-throughput analyses monitor the response of E. coli to perturbations." Science 316:593-597. 17379776 Gutnick minimal complete medium (4.7 g/L KH2PO4; 13.5 g/L K2HPO4; 1 g/L K2SO4; 0.1 g/L MgSO4-7H2O; 10 mM NH4Cl) with 4 g/L glucose Shake flask and filter culture 23.8 uM 0.0 37 oC K12 NCM3722 Mid-Log Phase 95200 0 Bennett, B. D., Kimball, E. H., Gao, M., Osterhout, R., Van Dien, S. J., Rabinowitz, J. D. (2009). "Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli." Nat Chem Biol 5:593-599. 19561621