Undecaprenyl diphosphate (ECMDB01469) (M2MDB000394)

General function:

Involved in catalytic activity

Specific function:

Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)

Gene Name:

mrcA

Uniprot ID:

P02918

Molecular weight:

93636

General function:

Involved in catalytic activity

Specific function:

Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)

Gene Name:

mrcB

Uniprot ID:

P02919

Molecular weight:

94292

Reactions

General function:

Involved in catalytic activity

Specific function:

Hydrolyzes phosphatidylglycerophosphate, phosphatidic acid, and lysophosphatidic acid; the pattern of activities varies according to subcellular location

Gene Name:

pgpB

Uniprot ID:

P0A924

Molecular weight:

29021

Reactions

General function:

Involved in penicillin binding

Specific function:

Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates

Gene Name:

ftsI

Uniprot ID:

P0AD68

Molecular weight:

63877

Reactions

General function:

Cell wall/membrane/envelope biogenesis

Specific function:

Adds the O-antigen on the glucose group of LPS

Gene Name:

rfaL

Uniprot ID:

P27243

Molecular weight:

46877

General function:

Involved in lipopolysaccharide biosynthetic process

Specific function:

May link the O-antigen tetrasaccharide units into long chains, giving rise to typical smooth LPS

Gene Name:

rfc

Uniprot ID:

P37748

Molecular weight:

44744

General function:

Involved in transferase activity, transferring alkyl or aryl (other than methyl) groups

Specific function:

Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

Gene Name:

uppS

Uniprot ID:

P60472

Molecular weight:

28444

Reactions

General function:

Involved in undecaprenyl-diphosphatase activity

Specific function:

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin

Gene Name:

uppP

Uniprot ID:

P60932

Molecular weight:

29758

Reactions

General function:

Involved in catalytic activity

Specific function:

Overexpression leads to increased undecaprenyl diphosphatase activity and to increased resistance to bacitracin. May have a preferred substrate other than undecaprenyl diphosphate in vivo

Gene Name:

ybjG

Uniprot ID:

P75806

Molecular weight:

22398

Reactions

General function:

Involved in lipopolysaccharide biosynthetic process

Specific function:

Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules

Gene Name:

wzzB

Uniprot ID:

P76372

Molecular weight:

36455

General function:

Involved in catalytic activity

Specific function:

Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional

Gene Name:

pbpC

Uniprot ID:

P76577

Molecular weight:

85066

General function:

Involved in lipid transporter activity

Specific function:

Specific function unknown

Gene Name:

mviN

Uniprot ID:

P0AF16

Molecular weight:

55267

General function:

Involved in lipopolysaccharide biosynthetic process

Specific function:

Specific function unknown

Gene Name:

wzzE

Uniprot ID:

P0AG00

Molecular weight:

39489

General function:

Involved in catalytic activity

Specific function:

Specific function unknown

Gene Name:

yeiU

Uniprot ID:

P76445

Molecular weight:

26759

General function:

Not Available

Specific function:

Could be involved in ECA polysaccharide chain elongation

Gene Name:

wzyE

Uniprot ID:

P27835

Molecular weight:

51517