dGTP (ECMDB01440) (M2MDB000389)

General function:

Involved in nucleic acid binding

Specific function:

In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity. It is able to utilize nicked circular duplex DNA as a template and can unwind the parental DNA strand from its template

Gene Name:

polA

Uniprot ID:

P00582

Molecular weight:

103117

Reactions

General function:

Involved in DNA binding

Specific function:

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease

Gene Name:

dnaQ

Uniprot ID:

P03007

Molecular weight:

27099

Reactions

General function:

Involved in nucleotide binding

Specific function:

The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA

Gene Name:

dnaX

Uniprot ID:

P06710

Molecular weight:

71137

Reactions

General function:

Involved in nucleoside diphosphate kinase activity

Specific function:

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

Gene Name:

ndk

Uniprot ID:

P0A763

Molecular weight:

15463

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + uridine = ADP + UMP

Gene Name:

udk

Uniprot ID:

P0A8F4

Molecular weight:

24353

Reactions

General function:

Involved in DNA binding

Specific function:

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA

Gene Name:

dnaN

Uniprot ID:

P0A988

Molecular weight:

40586

Reactions

General function:

Involved in [formate-C-acetyltransferase]-activating enzyme activity

Specific function:

Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine

Gene Name:

nrdG

Uniprot ID:

P0A9N8

Molecular weight:

17446

General function:

Involved in DNA binding

Specific function:

The exact function of the theta subunit is unknown

Gene Name:

holE

Uniprot ID:

P0ABS8

Molecular weight:

8846

Reactions

General function:

Involved in magnesium ion binding

Specific function:

ATP + pyruvate = ADP + phosphoenolpyruvate

Gene Name:

pykF

Uniprot ID:

P0AD61

Molecular weight:

50729

Reactions

General function:

Involved in nucleoside-triphosphate diphosphatase activity

Specific function:

Specific function unknown

Gene Name:

mazG

Uniprot ID:

P0AEY3

Molecular weight:

30412

Reactions

General function:

Involved in 3'-5' exonuclease activity

Specific function:

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase

Gene Name:

dnaE

Uniprot ID:

P10443

Molecular weight:

129903

Reactions

General function:

Involved in magnesium ion binding

Specific function:

dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs

Gene Name:

dgt

Uniprot ID:

P15723

Molecular weight:

59382

Reactions

General function:

Involved in magnesium ion binding

Specific function:

ATP + pyruvate = ADP + phosphoenolpyruvate

Gene Name:

pykA

Uniprot ID:

P21599

Molecular weight:

51357

Reactions

General function:

Involved in DNA binding

Specific function:

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA

Gene Name:

holA

Uniprot ID:

P28630

Molecular weight:

38703

Reactions

General function:

Involved in DNA binding

Specific function:

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity

Gene Name:

holB

Uniprot ID:

P28631

Molecular weight:

36936

Reactions

General function:

Involved in DNA-directed DNA polymerase activity

Specific function:

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown

Gene Name:

holD

Uniprot ID:

P28632

Molecular weight:

15174

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Transports electrons between flavodoxin or ferredoxin and NADPH. Involved in the reductive activation of cobalamin- independent methionine synthase, pyruvate formate lyase and anaerobic ribonucleotide reductase. Also protects against superoxide radicals due to methyl viologen in the presence of oxygen

Gene Name:

fpr

Uniprot ID:

P28861

Molecular weight:

27751

Reactions

General function:

Involved in catalytic activity

Specific function:

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H(2)O = ribonucleoside triphosphate + thioredoxin

Gene Name:

nrdD

Uniprot ID:

P28903

Molecular weight:

80022

Reactions

General function:

Involved in DNA binding

Specific function:

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity

Gene Name:

holC

Uniprot ID:

P28905

Molecular weight:

16633

Reactions

General function:

Involved in hydrolase activity

Specific function:

Hydrolyzes O6 atom-containing purine bases deoxyinosine triphosphate (dITP) and xanthosine triphosphate (XTP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) to nucleotide monophosphate and pyrophosphate. Probably excludes non- standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions

Gene Name:

rdgB

Uniprot ID:

P52061

Molecular weight:

21039

Reactions

General function:

Involved in ATP binding

Specific function:

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

Gene Name:

adk

Uniprot ID:

P69441

Molecular weight:

23586

Reactions

General function:

Involved in FMN binding

Specific function:

Low-potential electron donor to a number of redox enzymes (Potential)

Gene Name:

fldB

Uniprot ID:

P0ABY4

Molecular weight:

19700

General function:

Involved in FMN binding

Specific function:

Low-potential electron donor to a number of redox enzymes (Potential). Involved in the reactivation of inactive cob(II)alamin in methionine synthase

Gene Name:

fldA

Uniprot ID:

P61949

Molecular weight:

19737

General function:

Replication, recombination and repair

Specific function:

Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus leading to A.T to G.C transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate

Gene Name:

mutT

Uniprot ID:

P08337

Molecular weight:

14927

Reactions