Guanosine monophosphate (ECMDB01397) (M2MDB000369)

General function:

Involved in GMP synthase (glutamine-hydrolyzing) activity

Specific function:

Catalyzes the synthesis of GMP from XMP

Gene Name:

guaA

Uniprot ID:

P04079

Molecular weight:

58679

Reactions

General function:

Involved in hydrolase activity

Specific function:

Degradation of external UDP-glucose to uridine monophosphate and glucose-1-phosphate, which can then be used by the cell

Gene Name:

ushA

Uniprot ID:

P07024

Molecular weight:

60824

Reactions

General function:

Involved in hydrolase activity

Specific function:

Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'- monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain- length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. Also plays a significant physiological role in stress-response and is required for the survival of E.coli in stationary growth phase

Gene Name:

surE

Uniprot ID:

P0A840

Molecular weight:

26900

Reactions

General function:

Involved in catalytic activity

Specific function:

Nucleotidase that shows high phosphatase activity toward three nucleoside 5'-monophosphates, UMP, dUMP, and dTMP, and very low activity against TDP, IMP, UDP, GMP, dGMP, AMP, dAMP, and 6- phosphogluconate. Is strictly specific to substrates with 5'- phosphates and shows no activity against nucleoside 2'- or 3'- monophosphates. Might be involved in the pyrimidine nucleotide substrate cycles

Gene Name:

yjjG

Uniprot ID:

P0A8Y1

Molecular weight:

25300

Reactions

General function:

Involved in hypoxanthine phosphoribosyltransferase activity

Specific function:

This enzyme acts exclusively on hypoxanthine; it does not act on guanine

Gene Name:

hpt

Uniprot ID:

P0A9M2

Molecular weight:

20115

Reactions

General function:

Involved in nucleoside metabolic process

Specific function:

Acts on guanine, xanthine and to a lesser extent hypoxanthine

Gene Name:

gpt

Uniprot ID:

P0A9M5

Molecular weight:

16971

Reactions

General function:

Involved in acid phosphatase activity

Specific function:

Dephosphorylates several organic phosphomonoesters and catalyzes the transfer of low-energy phosphate groups from phosphomonoesters to hydroxyl groups of various organic compounds. Preferentially acts on aryl phosphoesters. Might function as a broad-spectrum dephosphorylating enzyme able to scavenge both 3'- and 5'-nucleotides and also additional organic phosphomonoesters

Gene Name:

aphA

Uniprot ID:

P0AE22

Molecular weight:

26103

Reactions

General function:

Involved in hydrolase activity

Specific function:

Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P), and hydrolysis of thiamine pyrophosphate (TPP) to thiamine monophosphate (TMP). Can hydrolyze other substrates such as MeO-HMP-PP, CF(3)-HMP-PP and MeO-TPP. Is also a non-specific nucleoside tri- and diphosphatase that releases inorganic orthophosphate

Gene Name:

nudJ

Uniprot ID:

P0AEI6

Molecular weight:

17433

General function:

Involved in phosphotransferase activity, alcohol group as acceptor

Specific function:

ATP + inosine = ADP + IMP

Gene Name:

gsk

Uniprot ID:

P0AEW6

Molecular weight:

48448

Reactions

General function:

Involved in nucleoside-triphosphate diphosphatase activity

Specific function:

Specific function unknown

Gene Name:

mazG

Uniprot ID:

P0AEY3

Molecular weight:

30412

Reactions

General function:

Involved in cobalamin 5'-phosphate synthase activity

Specific function:

Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin)

Gene Name:

cobS

Uniprot ID:

P36561

Molecular weight:

26385

Reactions

General function:

Involved in hydrolase activity

Specific function:

Hydrolyzes O6 atom-containing purine bases deoxyinosine triphosphate (dITP) and xanthosine triphosphate (XTP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) to nucleotide monophosphate and pyrophosphate. Probably excludes non- standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions

Gene Name:

rdgB

Uniprot ID:

P52061

Molecular weight:

21039

Reactions

General function:

Involved in protein binding

Specific function:

Essential for recycling GMP and indirectly, cGMP

Gene Name:

gmk

Uniprot ID:

P60546

Molecular weight:

23593

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides

Gene Name:

guaC

Uniprot ID:

P60560

Molecular weight:

37383

Reactions

General function:

Involved in adenine phosphoribosyltransferase activity

Specific function:

Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

Gene Name:

apt

Uniprot ID:

P69503

Molecular weight:

19859

Reactions

General function:

Involved in phosphorus-oxygen lyase activity

Specific function:

In association with DosC is involved in the production and removal of the second messenger c-di-GMP in response to changing O(2) levels. Has phosphodiesterase (PDE) activity with c- di-GMP (PubMed:15995192), very poor activity on cAMP (PubMed:15995192) but not with cGMP, bis(p-nitrophenyl) phosphate or p-nitrophenyl phosphate (PubMed:11970957). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria

Gene Name:

dosP

Uniprot ID:

P76129

Molecular weight:

90260

Reactions

General function:

Involved in catalytic activity

Specific function:

Nucleotidase that shows strict specificity toward deoxyribonucleoside 5'-monophosphates and does not dephosphorylate 5'-ribonucleotides or ribonucleoside 3'-monophosphates. Might be involved in the regulation of all dNTP pools in E.coli

Gene Name:

yfbR

Uniprot ID:

P76491

Molecular weight:

22708

Reactions

General function:

Involved in hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

Specific function:

Catalyzes the hydrolysis of GDP-mannose. Can also use other substrates, catalyzing the hydrolysis of the pyrophosphate bond, releasing a nucleoside monophosphate and a phosphorylated moiety, depending on the substrate

Gene Name:

nudK

Uniprot ID:

P37128

Molecular weight:

21749

Reactions

General function:

Replication, recombination and repair

Specific function:

Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus leading to A.T to G.C transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate

Gene Name:

mutT

Uniprot ID:

P08337

Molecular weight:

14927

Reactions