D-Alanine (ECMDB01310) (M2MDB000333)

General function:

Involved in catalytic activity

Specific function:

Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)

Gene Name:

mrcA

Uniprot ID:

P02918

Molecular weight:

93636

General function:

Involved in catalytic activity

Specific function:

Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)

Gene Name:

mrcB

Uniprot ID:

P02919

Molecular weight:

94292

Reactions

General function:

Involved in ATP binding

Specific function:

Cell wall formation

Gene Name:

ddlB

Uniprot ID:

P07862

Molecular weight:

32839

Reactions

General function:

Involved in alanine racemase activity

Specific function:

Provides the D-alanine required for cell wall biosynthesis

Gene Name:

alr

Uniprot ID:

P0A6B4

Molecular weight:

39153

Reactions

General function:

Involved in D-amino-acid dehydrogenase activity

Specific function:

Oxidative deamination of D-amino acids

Gene Name:

dadA

Uniprot ID:

P0A6J5

Molecular weight:

47607

Reactions

General function:

Involved in ATP binding

Specific function:

Cell wall formation

Gene Name:

ddlA

Uniprot ID:

P0A6J8

Molecular weight:

39315

Reactions

General function:

Involved in catalytic activity

Specific function:

Interconversion of serine and glycine

Gene Name:

glyA

Uniprot ID:

P0A825

Molecular weight:

45316

Reactions

General function:

Involved in penicillin binding

Specific function:

Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates

Gene Name:

ftsI

Uniprot ID:

P0AD68

Molecular weight:

63877

Reactions

General function:

Involved in alanine racemase activity

Specific function:

Isomerizes L-alanine to D-alanine which is then oxidized to pyruvate by dadA

Gene Name:

dadX

Uniprot ID:

P29012

Molecular weight:

38844

Reactions

General function:

Involved in lyase activity

Specific function:

Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. L-threo-phenylserine and L- erythro-phenylserine are also good substrates

Gene Name:

ltaE

Uniprot ID:

P75823

Molecular weight:

36494

Reactions

General function:

Defense mechanisms

Specific function:

Releases the terminal D-alanine residue from the cytoplasmic tetrapeptide recycling product L-Ala-gamma-D-Glu-meso- Dap-D-Ala. To a lesser extent, can also cleave D-Ala from murein derivatives containing the tetrapeptide, i.e. MurNAc-tetrapeptide, UDP-MurNAc-tetrapeptide, GlcNAc-MurNAc-tetrapeptide, and GlcNAc- anhMurNAc-tetrapeptide. Does not act on murein sacculi or cross- linked muropeptides. The tripeptides produced by the lcdA reaction can then be reused as peptidoglycan building blocks; lcdA is thereby involved in murein recycling. Is also essential for viability during stationary phase

Gene Name:

ldcA

Uniprot ID:

P76008

Molecular weight:

33567

Reactions

General function:

Involved in carboxypeptidase activity

Specific function:

Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors

Gene Name:

dacC

Uniprot ID:

P08506

Molecular weight:

43609

Reactions

General function:

Involved in carboxypeptidase activity

Specific function:

Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors

Gene Name:

dacD

Uniprot ID:

P33013

Molecular weight:

43346

Reactions

General function:

Involved in penicillin binding

Specific function:

Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates

Gene Name:

mrdA

Uniprot ID:

P0AD65

Molecular weight:

70856

General function:

Involved in carboxypeptidase activity

Specific function:

Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors

Gene Name:

dacA

Uniprot ID:

P0AEB2

Molecular weight:

44444

Reactions

General function:

Involved in metallopeptidase activity

Specific function:

Hydrolyzes D-Ala-D-Ala. May have a role in cell-wall turnover

Gene Name:

ddpX

Uniprot ID:

P77790

Molecular weight:

21213

Reactions

General function:

Involved in serine-type carboxypeptidase activity

Specific function:

Not involved in transpeptidation but exclusively catalyzes a DD-carboxypeptidase and DD-endopeptidase reaction

Gene Name:

dacB

Uniprot ID:

P24228

Molecular weight:

51798

Reactions