Guanosine triphosphate (ECMDB01273) (M2MDB000319)

General function:

Involved in adenylate cyclase activity

Specific function:

ATP = 3',5'-cyclic AMP + diphosphate

Gene Name:

cyaA

Uniprot ID:

P00936

Molecular weight:

97585

Reactions

General function:

Involved in acid phosphatase activity

Specific function:

A phosphate monoester + H(2)O = an alcohol + phosphate

Gene Name:

appA

Uniprot ID:

P07102

Molecular weight:

47056

Reactions

General function:

Involved in GTP cyclohydrolase I activity

Specific function:

GTP + H(2)O = formate + 2-amino-4-hydroxy-6- (erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate

Gene Name:

folE

Uniprot ID:

P0A6T5

Molecular weight:

24830

Reactions

General function:

Involved in nucleoside diphosphate kinase activity

Specific function:

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

Gene Name:

ndk

Uniprot ID:

P0A763

Molecular weight:

15463

Reactions

General function:

Involved in adenylosuccinate synthase activity

Specific function:

Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP

Gene Name:

purA

Uniprot ID:

P0A7D4

Molecular weight:

47345

Reactions

General function:

Involved in GTP cyclohydrolase II activity

Specific function:

Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate

Gene Name:

ribA

Uniprot ID:

P0A7I7

Molecular weight:

21836

Reactions

General function:

Involved in DNA-directed RNA polymerase activity

Specific function:

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit plays an important role in subunit assembly since its dimerization is the first step in the sequential assembly of subunits to form the holoenzyme

Gene Name:

rpoA

Uniprot ID:

P0A7Z4

Molecular weight:

36511

Reactions

General function:

Involved in DNA-directed RNA polymerase activity

Specific function:

Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits

Gene Name:

rpoZ

Uniprot ID:

P0A800

Molecular weight:

10237

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + uridine = ADP + UMP

Gene Name:

udk

Uniprot ID:

P0A8F4

Molecular weight:

24353

Reactions

General function:

Involved in DNA binding

Specific function:

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

Gene Name:

rpoC

Uniprot ID:

P0A8T7

Molecular weight:

155159

Reactions

General function:

Involved in DNA binding

Specific function:

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

Gene Name:

rpoB

Uniprot ID:

P0A8V2

Molecular weight:

150631

Reactions

General function:

Involved in [formate-C-acetyltransferase]-activating enzyme activity

Specific function:

Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine

Gene Name:

nrdG

Uniprot ID:

P0A9N8

Molecular weight:

17446

General function:

Involved in magnesium ion binding

Specific function:

ATP + pyruvate = ADP + phosphoenolpyruvate

Gene Name:

pykF

Uniprot ID:

P0AD61

Molecular weight:

50729

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP-dependent phosphorylation of adenosylcobinamide and adds GMP to adenosylcobinamide phosphate

Gene Name:

cobU

Uniprot ID:

P0AE76

Molecular weight:

20164

Reactions

General function:

Involved in nucleoside-triphosphate diphosphatase activity

Specific function:

Specific function unknown

Gene Name:

mazG

Uniprot ID:

P0AEY3

Molecular weight:

30412

Reactions

General function:

Involved in amino acid binding

Specific function:

In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp

Gene Name:

relA

Uniprot ID:

P0AG20

Molecular weight:

83875

Reactions

General function:

Involved in catalytic activity

Specific function:

In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes both the synthesis and degradation of ppGpp. The second messengers ppGpp and c-di-GMP together control biofilm formation in response to translational stress; ppGpp represses biofilm formation while c- di-GMP induces it

Gene Name:

spoT

Uniprot ID:

P0AG24

Molecular weight:

79342

Reactions

General function:

Involved in magnesium ion binding

Specific function:

dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs

Gene Name:

dgt

Uniprot ID:

P15723

Molecular weight:

59382

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + sulfate = diphosphate + adenylyl sulfate

Gene Name:

cysD

Uniprot ID:

P21156

Molecular weight:

35188

Reactions

General function:

Involved in magnesium ion binding

Specific function:

ATP + pyruvate = ADP + phosphoenolpyruvate

Gene Name:

pykA

Uniprot ID:

P21599

Molecular weight:

51357

Reactions

General function:

Involved in GTPase activity

Specific function:

May be the GTPase, regulating ATP sulfurylase activity

Gene Name:

cysN

Uniprot ID:

P23845

Molecular weight:

52558

Reactions

General function:

Involved in nucleotidyltransferase activity

Specific function:

Involved in the biosynthesis of the capsular polysaccharide colanic acid

Gene Name:

manC

Uniprot ID:

P24174

Molecular weight:

53016

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Transports electrons between flavodoxin or ferredoxin and NADPH. Involved in the reductive activation of cobalamin- independent methionine synthase, pyruvate formate lyase and anaerobic ribonucleotide reductase. Also protects against superoxide radicals due to methyl viologen in the presence of oxygen

Gene Name:

fpr

Uniprot ID:

P28861

Molecular weight:

27751

Reactions

General function:

Involved in catalytic activity

Specific function:

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H(2)O = ribonucleoside triphosphate + thioredoxin

Gene Name:

nrdD

Uniprot ID:

P28903

Molecular weight:

80022

Reactions

General function:

Involved in GTPase activity

Specific function:

May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover. Dispensible for viability, but important for overall fitness. The intrinsic GTPase activity is stimulated by the presence of 30S (160-fold increase in kcat) or 70S (96 fold increase in kcat) ribosomes (PubMed:14973029). The GTPase is inhibited by aminoglycoside antibiotics such as neomycin and paromycin (PubMed:15466596) streptomycin and spectinomycin (PubMed:15828870). This inhibition is not due to competition for binding sites on the 30S or 70S ribosome (PubMed:15828870)

Gene Name:

rsgA

Uniprot ID:

P39286

Molecular weight:

39193

General function:

Involved in hydrolase activity

Specific function:

Hydrolyzes O6 atom-containing purine bases deoxyinosine triphosphate (dITP) and xanthosine triphosphate (XTP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) to nucleotide monophosphate and pyrophosphate. Probably excludes non- standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions

Gene Name:

rdgB

Uniprot ID:

P52061

Molecular weight:

21039

Reactions

General function:

Involved in ATP binding

Specific function:

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

Gene Name:

adk

Uniprot ID:

P69441

Molecular weight:

23586

Reactions

General function:

Involved in catalytic activity

Specific function:

Links a guanosine 5'-phosphate to molydopterin (MPT) forming molybdopterin guanine dinucleotide (MGD)

Gene Name:

mobA

Uniprot ID:

P32173

Molecular weight:

21643

Reactions

General function:

Involved in GTP binding

Specific function:

May bind the guanine nucleotide required for the synthesis of molybdopterin guanine dinucleotide

Gene Name:

mobB

Uniprot ID:

P32125

Molecular weight:

19363

General function:

Involved in FMN binding

Specific function:

Low-potential electron donor to a number of redox enzymes (Potential)

Gene Name:

fldB

Uniprot ID:

P0ABY4

Molecular weight:

19700

General function:

Involved in catalytic activity

Specific function:

Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z

Gene Name:

moaA

Uniprot ID:

P30745

Molecular weight:

37346

General function:

Involved in FMN binding

Specific function:

Low-potential electron donor to a number of redox enzymes (Potential). Involved in the reactivation of inactive cob(II)alamin in methionine synthase

Gene Name:

fldA

Uniprot ID:

P61949

Molecular weight:

19737

General function:

Involved in Mo-molybdopterin cofactor biosynthetic process

Specific function:

Together with moaA, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z

Gene Name:

moaC

Uniprot ID:

P0A738

Molecular weight:

17467

General function:

Replication, recombination and repair

Specific function:

Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus leading to A.T to G.C transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate

Gene Name:

mutT

Uniprot ID:

P08337

Molecular weight:

14927

Reactions

General function:

Not Available

Specific function:

Not Available

Gene Name:

dosC

Uniprot ID:

P0AA89

Molecular weight:

Not Available

General function:

Not Available

Specific function:

Not Available

Gene Name:

yeaP

Uniprot ID:

P76245

Molecular weight:

Not Available

General function:

Signal transduction mechanisms

Specific function:

A probable diguanylate cyclase. The last member of a cascade of expressed proteins, its expression requires YdaM. AdrA production induces biosynthesis of cellulose in some E.coli isolates, but not in K12 strains. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria

Gene Name:

adrA

Uniprot ID:

P0AAP1

Molecular weight:

41537

Reactions