Guanosine triphosphate (ECMDB01273) (M2MDB000319)
Enzymes
- General function:
- Involved in adenylate cyclase activity
- Specific function:
- ATP = 3',5'-cyclic AMP + diphosphate
- Gene Name:
- cyaA
- Uniprot ID:
- P00936
- Molecular weight:
- 97585
Reactions
ATP = 3',5'-cyclic AMP + diphosphate. |
- General function:
- Involved in acid phosphatase activity
- Specific function:
- A phosphate monoester + H(2)O = an alcohol + phosphate
- Gene Name:
- appA
- Uniprot ID:
- P07102
- Molecular weight:
- 47056
Reactions
A phosphate monoester + H(2)O = an alcohol + phosphate. |
Myo-inositol hexakisphosphate + H(2)O = 1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate. |
- General function:
- Involved in GTP cyclohydrolase I activity
- Specific function:
- GTP + H(2)O = formate + 2-amino-4-hydroxy-6- (erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
- Gene Name:
- folE
- Uniprot ID:
- P0A6T5
- Molecular weight:
- 24830
Reactions
GTP + H(2)O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. |
- General function:
- Involved in nucleoside diphosphate kinase activity
- Specific function:
- Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
- Gene Name:
- ndk
- Uniprot ID:
- P0A763
- Molecular weight:
- 15463
Reactions
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. |
- General function:
- Involved in adenylosuccinate synthase activity
- Specific function:
- Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP
- Gene Name:
- purA
- Uniprot ID:
- P0A7D4
- Molecular weight:
- 47345
Reactions
GTP + IMP + L-aspartate = GDP + phosphate + N(6)-(1,2-dicarboxyethyl)-AMP. |
- General function:
- Involved in GTP cyclohydrolase II activity
- Specific function:
- Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate
- Gene Name:
- ribA
- Uniprot ID:
- P0A7I7
- Molecular weight:
- 21836
Reactions
GTP + 3 H(2)O = formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + diphosphate. |
- General function:
- Involved in DNA-directed RNA polymerase activity
- Specific function:
- DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit plays an important role in subunit assembly since its dimerization is the first step in the sequential assembly of subunits to form the holoenzyme
- Gene Name:
- rpoA
- Uniprot ID:
- P0A7Z4
- Molecular weight:
- 36511
Reactions
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). |
- General function:
- Involved in DNA-directed RNA polymerase activity
- Specific function:
- Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
- Gene Name:
- rpoZ
- Uniprot ID:
- P0A800
- Molecular weight:
- 10237
Reactions
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). |
- General function:
- Involved in ATP binding
- Specific function:
- ATP + uridine = ADP + UMP
- Gene Name:
- udk
- Uniprot ID:
- P0A8F4
- Molecular weight:
- 24353
Reactions
ATP + uridine = ADP + UMP. |
ATP + cytidine = ADP + CMP. |
- General function:
- Involved in DNA binding
- Specific function:
- DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
- Gene Name:
- rpoC
- Uniprot ID:
- P0A8T7
- Molecular weight:
- 155159
Reactions
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). |
- General function:
- Involved in DNA binding
- Specific function:
- DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
- Gene Name:
- rpoB
- Uniprot ID:
- P0A8V2
- Molecular weight:
- 150631
Reactions
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). |
- General function:
- Involved in [formate-C-acetyltransferase]-activating enzyme activity
- Specific function:
- Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
- Gene Name:
- nrdG
- Uniprot ID:
- P0A9N8
- Molecular weight:
- 17446
- General function:
- Involved in magnesium ion binding
- Specific function:
- ATP + pyruvate = ADP + phosphoenolpyruvate
- Gene Name:
- pykF
- Uniprot ID:
- P0AD61
- Molecular weight:
- 50729
Reactions
ATP + pyruvate = ADP + phosphoenolpyruvate. |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP-dependent phosphorylation of adenosylcobinamide and adds GMP to adenosylcobinamide phosphate
- Gene Name:
- cobU
- Uniprot ID:
- P0AE76
- Molecular weight:
- 20164
Reactions
ATP or GTP + adenosylcobinamide = adenosylcobinamide phosphate + ADP or GDP. |
GTP + adenosylcobinamide phosphate = diphosphate + adenosylcobinamide-GDP. |
- General function:
- Involved in nucleoside-triphosphate diphosphatase activity
- Specific function:
- Specific function unknown
- Gene Name:
- mazG
- Uniprot ID:
- P0AEY3
- Molecular weight:
- 30412
Reactions
ATP + H(2)O = AMP + diphosphate. |
- General function:
- Involved in amino acid binding
- Specific function:
- In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp
- Gene Name:
- relA
- Uniprot ID:
- P0AG20
- Molecular weight:
- 83875
Reactions
ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes both the synthesis and degradation of ppGpp. The second messengers ppGpp and c-di-GMP together control biofilm formation in response to translational stress; ppGpp represses biofilm formation while c- di-GMP induces it
- Gene Name:
- spoT
- Uniprot ID:
- P0AG24
- Molecular weight:
- 79342
Reactions
ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate. |
Guanosine 3',5'-bis(diphosphate) + H(2)O = guanosine 5'-diphosphate + diphosphate. |
- General function:
- Involved in magnesium ion binding
- Specific function:
- dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs
- Gene Name:
- dgt
- Uniprot ID:
- P15723
- Molecular weight:
- 59382
Reactions
dGTP + H(2)O = deoxyguanosine + triphosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- ATP + sulfate = diphosphate + adenylyl sulfate
- Gene Name:
- cysD
- Uniprot ID:
- P21156
- Molecular weight:
- 35188
Reactions
ATP + sulfate = diphosphate + adenylyl sulfate. |
- General function:
- Involved in magnesium ion binding
- Specific function:
- ATP + pyruvate = ADP + phosphoenolpyruvate
- Gene Name:
- pykA
- Uniprot ID:
- P21599
- Molecular weight:
- 51357
Reactions
ATP + pyruvate = ADP + phosphoenolpyruvate. |
- General function:
- Involved in GTPase activity
- Specific function:
- May be the GTPase, regulating ATP sulfurylase activity
- Gene Name:
- cysN
- Uniprot ID:
- P23845
- Molecular weight:
- 52558
Reactions
ATP + sulfate = diphosphate + adenylyl sulfate. |
- General function:
- Involved in nucleotidyltransferase activity
- Specific function:
- Involved in the biosynthesis of the capsular polysaccharide colanic acid
- Gene Name:
- manC
- Uniprot ID:
- P24174
- Molecular weight:
- 53016
Reactions
GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Transports electrons between flavodoxin or ferredoxin and NADPH. Involved in the reductive activation of cobalamin- independent methionine synthase, pyruvate formate lyase and anaerobic ribonucleotide reductase. Also protects against superoxide radicals due to methyl viologen in the presence of oxygen
- Gene Name:
- fpr
- Uniprot ID:
- P28861
- Molecular weight:
- 27751
Reactions
2 reduced ferredoxin + NADP(+) + H(+) = 2 oxidized ferredoxin + NADPH. |
- General function:
- Involved in catalytic activity
- Specific function:
- 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H(2)O = ribonucleoside triphosphate + thioredoxin
- Gene Name:
- nrdD
- Uniprot ID:
- P28903
- Molecular weight:
- 80022
Reactions
2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H(2)O = ribonucleoside triphosphate + thioredoxin. |
- General function:
- Involved in GTPase activity
- Specific function:
- May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover. Dispensible for viability, but important for overall fitness. The intrinsic GTPase activity is stimulated by the presence of 30S (160-fold increase in kcat) or 70S (96 fold increase in kcat) ribosomes (PubMed:14973029). The GTPase is inhibited by aminoglycoside antibiotics such as neomycin and paromycin (PubMed:15466596) streptomycin and spectinomycin (PubMed:15828870). This inhibition is not due to competition for binding sites on the 30S or 70S ribosome (PubMed:15828870)
- Gene Name:
- rsgA
- Uniprot ID:
- P39286
- Molecular weight:
- 39193
- General function:
- Involved in hydrolase activity
- Specific function:
- Hydrolyzes O6 atom-containing purine bases deoxyinosine triphosphate (dITP) and xanthosine triphosphate (XTP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) to nucleotide monophosphate and pyrophosphate. Probably excludes non- standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions
- Gene Name:
- rdgB
- Uniprot ID:
- P52061
- Molecular weight:
- 21039
Reactions
A nucleoside triphosphate + H(2)O = a nucleotide + diphosphate. |
- General function:
- Involved in ATP binding
- Specific function:
- Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth
- Gene Name:
- adk
- Uniprot ID:
- P69441
- Molecular weight:
- 23586
Reactions
ATP + AMP = 2 ADP. |
- General function:
- Involved in catalytic activity
- Specific function:
- Links a guanosine 5'-phosphate to molydopterin (MPT) forming molybdopterin guanine dinucleotide (MGD)
- Gene Name:
- mobA
- Uniprot ID:
- P32173
- Molecular weight:
- 21643
Reactions
GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor. |
- General function:
- Involved in GTP binding
- Specific function:
- May bind the guanine nucleotide required for the synthesis of molybdopterin guanine dinucleotide
- Gene Name:
- mobB
- Uniprot ID:
- P32125
- Molecular weight:
- 19363
- General function:
- Involved in FMN binding
- Specific function:
- Low-potential electron donor to a number of redox enzymes (Potential)
- Gene Name:
- fldB
- Uniprot ID:
- P0ABY4
- Molecular weight:
- 19700
- General function:
- Involved in catalytic activity
- Specific function:
- Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z
- Gene Name:
- moaA
- Uniprot ID:
- P30745
- Molecular weight:
- 37346
- General function:
- Involved in FMN binding
- Specific function:
- Low-potential electron donor to a number of redox enzymes (Potential). Involved in the reactivation of inactive cob(II)alamin in methionine synthase
- Gene Name:
- fldA
- Uniprot ID:
- P61949
- Molecular weight:
- 19737
- General function:
- Involved in Mo-molybdopterin cofactor biosynthetic process
- Specific function:
- Together with moaA, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z
- Gene Name:
- moaC
- Uniprot ID:
- P0A738
- Molecular weight:
- 17467
- General function:
- Replication, recombination and repair
- Specific function:
- Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus leading to A.T to G.C transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate
- Gene Name:
- mutT
- Uniprot ID:
- P08337
- Molecular weight:
- 14927
Reactions
8-oxo-dGTP + H(2)O = 8-oxo-dGMP + diphosphate. |
- General function:
- Not Available
- Specific function:
- Not Available
- Gene Name:
- dosC
- Uniprot ID:
- P0AA89
- Molecular weight:
- Not Available
- General function:
- Not Available
- Specific function:
- Not Available
- Gene Name:
- yeaP
- Uniprot ID:
- P76245
- Molecular weight:
- Not Available
- General function:
- Signal transduction mechanisms
- Specific function:
- A probable diguanylate cyclase. The last member of a cascade of expressed proteins, its expression requires YdaM. AdrA production induces biosynthesis of cellulose in some E.coli isolates, but not in K12 strains. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria
- Gene Name:
- adrA
- Uniprot ID:
- P0AAP1
- Molecular weight:
- 41537
Reactions
2 GTP = 2 diphosphate + cyclic di-3',5'-guanylate. |
Transporters
- General function:
- Involved in nucleoside diphosphate kinase activity
- Specific function:
- Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
- Gene Name:
- ndk
- Uniprot ID:
- P0A763
- Molecular weight:
- 15463
Reactions
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. |
- General function:
- Involved in transporter activity
- Specific function:
- Non-specific porin
- Gene Name:
- ompN
- Uniprot ID:
- P77747
- Molecular weight:
- 41220
- General function:
- Involved in transporter activity
- Specific function:
- Uptake of inorganic phosphate, phosphorylated compounds, and some other negatively charged solutes
- Gene Name:
- phoE
- Uniprot ID:
- P02932
- Molecular weight:
- 38922
- General function:
- Involved in transporter activity
- Specific function:
- OmpF is a porin that forms passive diffusion pores which allow small molecular weight hydrophilic materials across the outer membrane. It is also a receptor for the bacteriophage T2
- Gene Name:
- ompF
- Uniprot ID:
- P02931
- Molecular weight:
- 39333
- General function:
- Involved in transporter activity
- Specific function:
- Forms passive diffusion pores which allow small molecular weight hydrophilic materials across the outer membrane
- Gene Name:
- ompC
- Uniprot ID:
- P06996
- Molecular weight:
- 40368