FAD (ECMDB01248) (M2MDB000308)

General function:

Involved in electron carrier activity

Specific function:

Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth

Gene Name:

frdA

Uniprot ID:

P00363

Molecular weight:

65971

Reactions

General function:

Involved in electron carrier activity

Specific function:

Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth

Gene Name:

sdhB

Uniprot ID:

P07014

Molecular weight:

26770

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Oxidizes proline to glutamate for use as a carbon and nitrogen source and also function as a transcriptional repressor of the put operon

Gene Name:

putA

Uniprot ID:

P09546

Molecular weight:

143814

Reactions

General function:

Involved in metabolic process

Specific function:

Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for NAD, biotin and Fe-S cluster synthesis. Transfers sulfur on 'Cys-456' of thiI in a transpersulfidation reaction. Transfers sulfur on 'Cys-19' of tusA in a transpersulfidation reaction. Functions also as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate

Gene Name:

iscS

Uniprot ID:

P0A6B7

Molecular weight:

45089

Reactions

General function:

Involved in D-amino-acid dehydrogenase activity

Specific function:

Oxidative deamination of D-amino acids

Gene Name:

dadA

Uniprot ID:

P0A6J5

Molecular weight:

47607

Reactions

General function:

Energy production and conversion

Specific function:

Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane

Gene Name:

frdC

Uniprot ID:

P0A8Q0

Molecular weight:

15015

General function:

Involved in fumarate metabolic process

Specific function:

Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane

Gene Name:

frdD

Uniprot ID:

P0A8Q3

Molecular weight:

13107

General function:

Involved in iron-sulfur cluster binding

Specific function:

Electron transfer protein; may also function as the membrane anchor for the glpAB dimer

Gene Name:

glpC

Uniprot ID:

P0A996

Molecular weight:

44108

General function:

Involved in oxidoreductase activity

Specific function:

Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor

Gene Name:

glpA

Uniprot ID:

P0A9C0

Molecular weight:

58958

Reactions

General function:

Involved in electron carrier activity

Specific function:

Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth

Gene Name:

sdhA

Uniprot ID:

P0AC41

Molecular weight:

64421

Reactions

General function:

Involved in succinate dehydrogenase activity

Specific function:

Membrane-anchoring subunit of succinate dehydrogenase (SDH)

Gene Name:

sdhD

Uniprot ID:

P0AC44

Molecular weight:

12867

General function:

Involved in electron carrier activity

Specific function:

Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth

Gene Name:

frdB

Uniprot ID:

P0AC47

Molecular weight:

27123

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the reduction of soluble flavins by reduced pyridine nucleotides. Seems to reduces the complexed Fe(3+) iron of siderophores to Fe(2+), thus releasing it from the chelator

Gene Name:

fre

Uniprot ID:

P0AEN1

Molecular weight:

26242

Reactions

General function:

Involved in FMN adenylyltransferase activity

Specific function:

ATP + riboflavin = ADP + FMN

Gene Name:

ribF

Uniprot ID:

P0AG40

Molecular weight:

34734

Reactions

General function:

Involved in electron carrier activity

Specific function:

Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor

Gene Name:

glpB

Uniprot ID:

P13033

Molecular weight:

45357

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses molecular oxygen or nitrate as electron acceptor

Gene Name:

glpD

Uniprot ID:

P13035

Molecular weight:

56750

Reactions

General function:

Involved in sulfite reductase (NADPH) activity

Specific function:

Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate

Gene Name:

cysI

Uniprot ID:

P17846

Molecular weight:

63998

Reactions

General function:

Involved in malate dehydrogenase (quinone) activity

Specific function:

(S)-malate + a quinone = oxaloacetate + reduced quinone

Gene Name:

mqo

Uniprot ID:

P33940

Molecular weight:

60229

Reactions

General function:

Involved in sulfite reductase (NADPH) activity

Specific function:

Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component

Gene Name:

cysJ

Uniprot ID:

P38038

Molecular weight:

66269

Reactions

General function:

Involved in 2 iron, 2 sulfur cluster binding

Specific function:

Involved in the reduction of ferric iron in cytoplasmic ferrioxamine B

Gene Name:

fhuF

Uniprot ID:

P39405

Molecular weight:

30113

General function:

Involved in succinate dehydrogenase activity

Specific function:

Membrane-anchoring subunit of succinate dehydrogenase (SDH)

Gene Name:

sdhC

Uniprot ID:

P69054

Molecular weight:

14299

General function:

Involved in metabolic process

Specific function:

Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L-selenocysteine. Selenocysteine lyase activity is however unsure in vivo

Gene Name:

sufS

Uniprot ID:

P77444

Molecular weight:

44433

Reactions

General function:

Involved in acyl-CoA dehydrogenase activity

Specific function:

Catalyzes the dehydrogenation of acyl-CoA

Gene Name:

fadE

Uniprot ID:

Q47146

Molecular weight:

89224

Reactions

General function:

Involved in nucleotide binding

Specific function:

Has low ATPase activity. The sufBCD complex acts synergistically with sufE to stimulate the cysteine desulfurase activity of sufS. The sufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation

Gene Name:

sufC

Uniprot ID:

P77499

Molecular weight:

27582

General function:

Involved in iron-sulfur cluster assembly

Specific function:

The sufBCD complex acts synergistically with sufE to stimulate the cysteine desulfurase activity of sufS. The sufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation

Gene Name:

sufB

Uniprot ID:

P77522

Molecular weight:

54745

General function:

Inorganic ion transport and metabolism

Specific function:

Specific function unknown

Gene Name:

cyaY

Uniprot ID:

P27838

Molecular weight:

12231

General function:

Involved in iron ion binding

Specific function:

May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins (Potential)

Gene Name:

nifU

Uniprot ID:

P0ACD4

Molecular weight:

13848

General function:

Not Available

Specific function:

Participates in cysteine desulfuration mediated by sufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for sufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of sufS, an intermediate product of cysteine desulfuration process. Together with the sufBCD complex, it thereby enhances up to 50- fold, the cysteine desulfurase activity of sufS. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Does not affect the selenocysteine lyase activity of sufS

Gene Name:

sufE

Uniprot ID:

P76194

Molecular weight:

15800

General function:

Involved in iron-sulfur cluster assembly

Specific function:

The sufBCD complex acts synergistically with sufE to stimulate the cysteine desulfurase activity of sufS. The sufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation. Required for the stability of the fhuF protein

Gene Name:

sufD

Uniprot ID:

P77689

Molecular weight:

46822