Acetyl-CoA (ECMDB01206) (M2MDB000298)
Enzymes
- General function:
- Involved in transferase activity, transferring acyl groups
- Specific function:
- The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)
- Gene Name:
- aceF
- Uniprot ID:
- P06959
- Molecular weight:
- 66096
Reactions
Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine. |
- General function:
- Involved in transferase activity
- Specific function:
- May assist cellular detoxification by acetylating non- metabolizable pyranosides, thereby preventing their reentry into the cell
- Gene Name:
- lacA
- Uniprot ID:
- P07464
- Molecular weight:
- 22799
Reactions
Acetyl-CoA + a beta-D-galactoside = CoA + a 6-acetyl-beta-D-galactoside. |
- General function:
- Involved in catalytic activity
- Specific function:
- Acetyl-CoA + H(2)O + glyoxylate = (S)-malate + CoA
- Gene Name:
- aceB
- Uniprot ID:
- P08997
- Molecular weight:
- 60273
Reactions
Acetyl-CoA + H(2)O + glyoxylate = (S)-malate + CoA. |
- General function:
- Involved in 2-isopropylmalate synthase activity
- Specific function:
- Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
- Gene Name:
- leuA
- Uniprot ID:
- P09151
- Molecular weight:
- 57297
Reactions
Acetyl-CoA + 3-methyl-2-oxobutanoate + H(2)O = (2S)-2-isopropylmalate + CoA. |
- General function:
- Involved in formate C-acetyltransferase activity
- Specific function:
- Acetyl-CoA + formate = CoA + pyruvate
- Gene Name:
- pflB
- Uniprot ID:
- P09373
- Molecular weight:
- 85357
Reactions
Acetyl-CoA + formate = CoA + pyruvate. |
- General function:
- Involved in cellular amino acid biosynthetic process
- Specific function:
- Acetyl-CoA + L-glutamate = CoA + N-acetyl-L- glutamate
- Gene Name:
- argA
- Uniprot ID:
- P0A6C5
- Molecular weight:
- 49195
Reactions
Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate. |
- General function:
- Involved in 3-oxoacyl-[acyl-carrier-protein] synthase activity
- Specific function:
- Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Has some substrate specificity for acetyl-CoA. Its substrate specificity determines the biosynthesis of straight-chain of fatty acids instead of branched-chain
- Gene Name:
- fabH
- Uniprot ID:
- P0A6R0
- Molecular weight:
- 33515
Reactions
Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO(2). |
- General function:
- Involved in N-acetyltransferase activity
- Specific function:
- This enzyme acetylates the N-terminal alanine of ribosomal protein S18
- Gene Name:
- rimI
- Uniprot ID:
- P0A944
- Molecular weight:
- 16610
Reactions
Acetyl-CoA + ribosomal-protein L-alanine = CoA + ribosomal-protein N-acetyl-L-alanine. |
- General function:
- Involved in N-acetyltransferase activity
- Specific function:
- This enzyme acetylates the N-terminal alanine of ribosomal protein S5. Plays also a role in the temperature regulation of pap pilin transcription
- Gene Name:
- rimJ
- Uniprot ID:
- P0A948
- Molecular weight:
- 22688
Reactions
Acetyl-CoA + ribosomal-protein L-alanine = CoA + ribosomal-protein N-acetyl-L-alanine. |
- General function:
- Involved in N-acetyltransferase activity
- Specific function:
- Regulates polyamine concentration by their degradation. Acts on spermidine, forming N(1)- and N(8)-acetylspermidine
- Gene Name:
- speG
- Uniprot ID:
- P0A951
- Molecular weight:
- 21887
Reactions
Acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine. |
- General function:
- Involved in transferase activity
- Specific function:
- Acetyl-CoA + L-serine = CoA + O-acetyl-L- serine
- Gene Name:
- cysE
- Uniprot ID:
- P0A9D4
- Molecular weight:
- 29316
Reactions
Acetyl-CoA + L-serine = CoA + O-acetyl-L-serine. |
- General function:
- Involved in carbon-carbon lyase activity
- Specific function:
- Represents a citryl-ACP lyase
- Gene Name:
- citE
- Uniprot ID:
- P0A9I1
- Molecular weight:
- 33109
Reactions
Citrate = acetate + oxaloacetate. |
(3S)-citryl-CoA = acetyl-CoA + oxaloacetate. |
- General function:
- Involved in phosphate acetyltransferase activity
- Specific function:
- Acetyl-CoA + phosphate = CoA + acetyl phosphate
- Gene Name:
- pta
- Uniprot ID:
- P0A9M8
- Molecular weight:
- 77171
Reactions
Acetyl-CoA + phosphate = CoA + acetyl phosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- Activation of pyruvate formate-lyase 1 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
- Gene Name:
- pflA
- Uniprot ID:
- P0A9N4
- Molecular weight:
- 28204
Reactions
S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine = 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes
- Gene Name:
- lpdA
- Uniprot ID:
- P0A9P0
- Molecular weight:
- 50688
Reactions
Protein N(6)-(dihydrolipoyl)lysine + NAD(+) = protein N(6)-(lipoyl)lysine + NADH. |
- General function:
- Involved in acetyl-CoA carboxylase activity
- Specific function:
- Controls translation of mRNA for both itself and the alpha-subunit (accA) by binding to a probable hairpin in the 5' of the mRNA. Binding to mRNA inhibits translation; this is partially relieved by acetyl-CoA. Increasing amounts of mRNA also inhibit enzyme activity
- Gene Name:
- accD
- Uniprot ID:
- P0A9Q5
- Molecular weight:
- 33322
Reactions
ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- This enzyme has three activities:ADH, ACDH, and PFL- deactivase. In aerobic conditions it acts as a hydrogen peroxide scavenger. The PFL deactivase activity catalyzes the quenching of the pyruvate-formate-lyase catalyst in an iron, NAD, and CoA dependent reaction
- Gene Name:
- adhE
- Uniprot ID:
- P0A9Q7
- Molecular weight:
- 96126
Reactions
An alcohol + NAD(+) = an aldehyde or ketone + NADH. |
Acetaldehyde + CoA + NAD(+) = acetyl-CoA + NADH. |
- General function:
- Involved in glycine C-acetyltransferase activity
- Specific function:
- Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA
- Gene Name:
- kbl
- Uniprot ID:
- P0AB77
- Molecular weight:
- 43117
Reactions
Acetyl-CoA + glycine = CoA + 2-amino-3-oxobutanoate. |
- General function:
- Involved in acetyl-CoA carboxylase activity
- Specific function:
- Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
- Gene Name:
- accA
- Uniprot ID:
- P0ABD5
- Molecular weight:
- 35241
Reactions
ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA. |
- General function:
- Involved in acetyl-CoA carboxylase activity
- Specific function:
- This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
- Gene Name:
- accB
- Uniprot ID:
- P0ABD8
- Molecular weight:
- 16687
- General function:
- Involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
- Specific function:
- Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA
- Gene Name:
- gltA
- Uniprot ID:
- P0ABH7
- Molecular weight:
- 48015
Reactions
Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA. |
- General function:
- Involved in magnesium ion binding
- Specific function:
- Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc
- Gene Name:
- glmU
- Uniprot ID:
- P0ACC7
- Molecular weight:
- 49190
Reactions
Acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + N-acetyl-alpha-D-glucosamine 1-phosphate. |
UTP + N-acetyl-alpha-D-glucosamine 1-phosphate = diphosphate + UDP-N-acetyl-D-glucosamine. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)
- Gene Name:
- aceE
- Uniprot ID:
- P0AFG8
- Molecular weight:
- 99668
Reactions
Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2). |
- General function:
- Involved in transferase activity, transferring acyl groups other than amino-acyl groups
- Specific function:
- Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA
- Gene Name:
- paaJ
- Uniprot ID:
- P0C7L2
- Molecular weight:
- 42276
Reactions
Succinyl-CoA + acetyl-CoA = CoA + 3-oxoadipyl-CoA. |
2,3-dehydroadipyl-CoA + acetyl-CoA = CoA + 3-oxo-5,6-dehydrosuberyl-CoA. |
- General function:
- Involved in acetyl-CoA C-acyltransferase activity
- Specific function:
- Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. Involved in the aerobic and anaerobic degradation of long-chain fatty acids
- Gene Name:
- fadA
- Uniprot ID:
- P21151
- Molecular weight:
- 40876
Reactions
Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. |
- General function:
- Involved in ligase activity
- Specific function:
- This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
- Gene Name:
- accC
- Uniprot ID:
- P24182
- Molecular weight:
- 49320
Reactions
ATP + biotin-[carboxyl-carrier-protein] + CO(2) = ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein]. |
ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA. |
- General function:
- Involved in acetate-CoA ligase activity
- Specific function:
- Enables the cell to use acetate during aerobic growth to generate energy via the TCA cycle, and biosynthetic compounds via the glyoxylate shunt. Acetylates CheY, the response regulator involved in flagellar movement and chemotaxis
- Gene Name:
- acs
- Uniprot ID:
- P27550
- Molecular weight:
- 72093
Reactions
ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. |
- General function:
- Involved in catalytic activity
- Specific function:
- Acetyl-CoA + formate = CoA + pyruvate
- Gene Name:
- pflD
- Uniprot ID:
- P32674
- Molecular weight:
- 85959
Reactions
Acetyl-CoA + formate = CoA + pyruvate. |
- General function:
- Involved in iron-sulfur cluster binding
- Specific function:
- Activation of pyruvate formate-lyase 2 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
- Gene Name:
- pflC
- Uniprot ID:
- P32675
- Molecular weight:
- 32429
Reactions
S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine = 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical. |
- General function:
- Involved in catalytic activity
- Specific function:
- Accounts for almost the entire malate-synthesizing activity in cells metabolizing glyoxylate
- Gene Name:
- glcB
- Uniprot ID:
- P37330
- Molecular weight:
- 80488
Reactions
Acetyl-CoA + H(2)O + glyoxylate = (S)-malate + CoA. |
- General function:
- Involved in formate C-acetyltransferase activity
- Specific function:
- Specific function unknown
- Gene Name:
- tdcE
- Uniprot ID:
- P42632
- Molecular weight:
- 85935
Reactions
Propionyl-CoA + formate = CoA + 2-oxobutanoate. |
Acetyl-CoA + formate = CoA + pyruvate. |
- General function:
- Involved in electron carrier activity
- Specific function:
- Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (Potential)
- Gene Name:
- ydbK
- Uniprot ID:
- P52647
- Molecular weight:
- 128823
Reactions
Pyruvate + CoA + oxidized flavodoxin = acetyl-CoA + CO(2) + reduced flavodoxin. |
- General function:
- Involved in citrate CoA-transferase activity
- Specific function:
- Represents a citrate:acetyl-ACP transferase
- Gene Name:
- citF
- Uniprot ID:
- P75726
- Molecular weight:
- 55172
Reactions
Citrate = acetate + oxaloacetate. |
Acetyl-CoA + citrate = acetate + (3S)-citryl-CoA. |
- General function:
- Involved in catalytic activity
- Specific function:
- Acetyl-CoA + formate = CoA + pyruvate
- Gene Name:
- ybiW
- Uniprot ID:
- P75793
- Molecular weight:
- 90125
Reactions
Acetyl-CoA + formate = CoA + pyruvate. |
- General function:
- Involved in CoA-transferase activity
- Specific function:
- Acyl-CoA + acetate = a fatty acid anion + acetyl-CoA
- Gene Name:
- atoD
- Uniprot ID:
- P76458
- Molecular weight:
- 23526
Reactions
Acyl-CoA + acetate = a fatty acid anion + acetyl-CoA. |
- General function:
- Involved in CoA-transferase activity
- Specific function:
- Acyl-CoA + acetate = a fatty acid anion + acetyl-CoA
- Gene Name:
- atoA
- Uniprot ID:
- P76459
- Molecular weight:
- 22960
Reactions
Acyl-CoA + acetate = a fatty acid anion + acetyl-CoA. |
- General function:
- Involved in transferase activity, transferring acyl groups other than amino-acyl groups
- Specific function:
- 2 acetyl-CoA = CoA + acetoacetyl-CoA
- Gene Name:
- atoB
- Uniprot ID:
- P76461
- Molecular weight:
- 40352
Reactions
2 acetyl-CoA = CoA + acetoacetyl-CoA. |
- General function:
- Involved in transferase activity
- Specific function:
- Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. Strongly involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate and weakly involved in the aerobic degradation of long- chain fatty acids
- Gene Name:
- fadI
- Uniprot ID:
- P76503
- Molecular weight:
- 46530
Reactions
Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. |
- General function:
- Involved in catalytic activity
- Specific function:
- Could possibly oxidize fatty acids using specific components
- Gene Name:
- paaG
- Uniprot ID:
- P77467
- Molecular weight:
- 28404
Reactions
2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA = 2-oxepin-2(3H)-ylideneacetyl-CoA. |
- General function:
- Involved in acetyltransferase activity
- Specific function:
- Acetyl-CoA + an N-hydroxyarylamine = CoA + an N-acetoxyarylamine
- Gene Name:
- nhoA
- Uniprot ID:
- P77567
- Molecular weight:
- 32274
Reactions
Acetyl-CoA + an N-hydroxyarylamine = CoA + an N-acetoxyarylamine. |
- General function:
- Involved in acetaldehyde dehydrogenase (acetylating) activity
- Specific function:
- Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of 3-phenylpropanoate. Functions as a chaperone protein for folding of mhpE
- Gene Name:
- mhpF
- Uniprot ID:
- P77580
- Molecular weight:
- 33442
Reactions
Acetaldehyde + CoA + NAD(+) = acetyl-CoA + NADH. |
- General function:
- Involved in transferase activity
- Specific function:
- Acetylates maltose and other sugars
- Gene Name:
- maa
- Uniprot ID:
- P77791
- Molecular weight:
- 20096
Reactions
Acetyl-CoA + maltose = CoA + acetyl-maltose. |
- General function:
- Involved in transferase activity, transferring acyl groups other than amino-acyl groups
- Specific function:
- 2 acetyl-CoA = CoA + acetoacetyl-CoA
- Gene Name:
- yqeF
- Uniprot ID:
- Q46939
- Molecular weight:
- 41018
Reactions
2 acetyl-CoA = CoA + acetoacetyl-CoA. |
- General function:
- Involved in transferase activity
- Specific function:
- Putative O-acetyltransferase that transfers an O-acetyl group to the O antigen
- Gene Name:
- wbbJ
- Uniprot ID:
- P37750
- Molecular weight:
- 21675
- General function:
- Involved in protein binding
- Specific function:
- Transaminase converting thymidine diphosphate(TDP)-4- keto-6-deoxy-D-glucose to TDP-4-amino-4,6-dideoxy-D-galactose, the immediate precursor of the ECA sugar TDP-Fuc4NAc
- Gene Name:
- rffC
- Uniprot ID:
- P27832
- Molecular weight:
- 24220
- General function:
- Involved in FMN binding
- Specific function:
- Low-potential electron donor to a number of redox enzymes (Potential)
- Gene Name:
- fldB
- Uniprot ID:
- P0ABY4
- Molecular weight:
- 19700
- General function:
- Involved in FMN binding
- Specific function:
- Low-potential electron donor to a number of redox enzymes (Potential). Involved in the reactivation of inactive cob(II)alamin in methionine synthase
- Gene Name:
- fldA
- Uniprot ID:
- P61949
- Molecular weight:
- 19737
- General function:
- Involved in transferase activity, transferring acyl groups
- Specific function:
- Specific function unknown
- Gene Name:
- eutD
- Uniprot ID:
- P77218
- Molecular weight:
- 36066
- General function:
- Involved in catalytic activity
- Specific function:
- Acts as a radical domain for damaged PFL and possibly other radical proteins
- Gene Name:
- grcA
- Uniprot ID:
- P68066
- Molecular weight:
- 14284
- General function:
- Involved in fatty acid biosynthetic process
- Specific function:
- Carrier of the growing fatty acid chain in fatty acid biosynthesis
- Gene Name:
- acpP
- Uniprot ID:
- P0A6A8
- Molecular weight:
- 8640
- General function:
- Not Available
- Specific function:
- Not Available
- Gene Name:
- eutE
- Uniprot ID:
- P77445
- Molecular weight:
- Not Available
- General function:
- Not Available
- Specific function:
- Not Available
- Gene Name:
- yncA
- Uniprot ID:
- P76112
- Molecular weight:
- Not Available
- General function:
- Involved in tRNA binding
- Specific function:
- Not Available
- Gene Name:
- ypfI
- Uniprot ID:
- P76562
- Molecular weight:
- 74892
Reactions
(Elongator tRNA(Met))-cytidine(34) + ATP + acetyl-CoA = (elongator tRNA(Met))-N(4)-acetylcytidine(34) + ADP + phosphate + CoA. |