Acetyl-CoA (ECMDB01206) (M2MDB000298)

General function:

Involved in transferase activity, transferring acyl groups

Specific function:

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)

Gene Name:

aceF

Uniprot ID:

P06959

Molecular weight:

66096

Reactions

General function:

Involved in transferase activity

Specific function:

May assist cellular detoxification by acetylating non- metabolizable pyranosides, thereby preventing their reentry into the cell

Gene Name:

lacA

Uniprot ID:

P07464

Molecular weight:

22799

Reactions

General function:

Involved in catalytic activity

Specific function:

Acetyl-CoA + H(2)O + glyoxylate = (S)-malate + CoA

Gene Name:

aceB

Uniprot ID:

P08997

Molecular weight:

60273

Reactions

General function:

Involved in 2-isopropylmalate synthase activity

Specific function:

Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)

Gene Name:

leuA

Uniprot ID:

P09151

Molecular weight:

57297

Reactions

General function:

Involved in formate C-acetyltransferase activity

Specific function:

Acetyl-CoA + formate = CoA + pyruvate

Gene Name:

pflB

Uniprot ID:

P09373

Molecular weight:

85357

Reactions

General function:

Involved in cellular amino acid biosynthetic process

Specific function:

Acetyl-CoA + L-glutamate = CoA + N-acetyl-L- glutamate

Gene Name:

argA

Uniprot ID:

P0A6C5

Molecular weight:

49195

Reactions

General function:

Involved in 3-oxoacyl-[acyl-carrier-protein] synthase activity

Specific function:

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Has some substrate specificity for acetyl-CoA. Its substrate specificity determines the biosynthesis of straight-chain of fatty acids instead of branched-chain

Gene Name:

fabH

Uniprot ID:

P0A6R0

Molecular weight:

33515

Reactions

General function:

Involved in N-acetyltransferase activity

Specific function:

This enzyme acetylates the N-terminal alanine of ribosomal protein S18

Gene Name:

rimI

Uniprot ID:

P0A944

Molecular weight:

16610

Reactions

General function:

Involved in N-acetyltransferase activity

Specific function:

This enzyme acetylates the N-terminal alanine of ribosomal protein S5. Plays also a role in the temperature regulation of pap pilin transcription

Gene Name:

rimJ

Uniprot ID:

P0A948

Molecular weight:

22688

Reactions

General function:

Involved in N-acetyltransferase activity

Specific function:

Regulates polyamine concentration by their degradation. Acts on spermidine, forming N(1)- and N(8)-acetylspermidine

Gene Name:

speG

Uniprot ID:

P0A951

Molecular weight:

21887

Reactions

General function:

Involved in transferase activity

Specific function:

Acetyl-CoA + L-serine = CoA + O-acetyl-L- serine

Gene Name:

cysE

Uniprot ID:

P0A9D4

Molecular weight:

29316

Reactions

General function:

Involved in carbon-carbon lyase activity

Specific function:

Represents a citryl-ACP lyase

Gene Name:

citE

Uniprot ID:

P0A9I1

Molecular weight:

33109

Reactions

General function:

Involved in phosphate acetyltransferase activity

Specific function:

Acetyl-CoA + phosphate = CoA + acetyl phosphate

Gene Name:

pta

Uniprot ID:

P0A9M8

Molecular weight:

77171

Reactions

General function:

Involved in catalytic activity

Specific function:

Activation of pyruvate formate-lyase 1 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine

Gene Name:

pflA

Uniprot ID:

P0A9N4

Molecular weight:

28204

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes

Gene Name:

lpdA

Uniprot ID:

P0A9P0

Molecular weight:

50688

Reactions

General function:

Involved in acetyl-CoA carboxylase activity

Specific function:

Controls translation of mRNA for both itself and the alpha-subunit (accA) by binding to a probable hairpin in the 5' of the mRNA. Binding to mRNA inhibits translation; this is partially relieved by acetyl-CoA. Increasing amounts of mRNA also inhibit enzyme activity

Gene Name:

accD

Uniprot ID:

P0A9Q5

Molecular weight:

33322

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

This enzyme has three activities:ADH, ACDH, and PFL- deactivase. In aerobic conditions it acts as a hydrogen peroxide scavenger. The PFL deactivase activity catalyzes the quenching of the pyruvate-formate-lyase catalyst in an iron, NAD, and CoA dependent reaction

Gene Name:

adhE

Uniprot ID:

P0A9Q7

Molecular weight:

96126

Reactions

General function:

Involved in glycine C-acetyltransferase activity

Specific function:

Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA

Gene Name:

kbl

Uniprot ID:

P0AB77

Molecular weight:

43117

Reactions

General function:

Involved in acetyl-CoA carboxylase activity

Specific function:

Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA

Gene Name:

accA

Uniprot ID:

P0ABD5

Molecular weight:

35241

Reactions

General function:

Involved in acetyl-CoA carboxylase activity

Specific function:

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA

Gene Name:

accB

Uniprot ID:

P0ABD8

Molecular weight:

16687

General function:

Involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

Specific function:

Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA

Gene Name:

gltA

Uniprot ID:

P0ABH7

Molecular weight:

48015

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

Gene Name:

glmU

Uniprot ID:

P0ACC7

Molecular weight:

49190

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)

Gene Name:

aceE

Uniprot ID:

P0AFG8

Molecular weight:

99668

Reactions

General function:

Involved in transferase activity, transferring acyl groups other than amino-acyl groups

Specific function:

Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA

Gene Name:

paaJ

Uniprot ID:

P0C7L2

Molecular weight:

42276

Reactions

General function:

Involved in acetyl-CoA C-acyltransferase activity

Specific function:

Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. Involved in the aerobic and anaerobic degradation of long-chain fatty acids

Gene Name:

fadA

Uniprot ID:

P21151

Molecular weight:

40876

Reactions

General function:

Involved in ligase activity

Specific function:

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA

Gene Name:

accC

Uniprot ID:

P24182

Molecular weight:

49320

Reactions

General function:

Involved in acetate-CoA ligase activity

Specific function:

Enables the cell to use acetate during aerobic growth to generate energy via the TCA cycle, and biosynthetic compounds via the glyoxylate shunt. Acetylates CheY, the response regulator involved in flagellar movement and chemotaxis

Gene Name:

acs

Uniprot ID:

P27550

Molecular weight:

72093

Reactions

General function:

Involved in catalytic activity

Specific function:

Acetyl-CoA + formate = CoA + pyruvate

Gene Name:

pflD

Uniprot ID:

P32674

Molecular weight:

85959

Reactions

General function:

Involved in iron-sulfur cluster binding

Specific function:

Activation of pyruvate formate-lyase 2 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine

Gene Name:

pflC

Uniprot ID:

P32675

Molecular weight:

32429

Reactions

General function:

Involved in catalytic activity

Specific function:

Accounts for almost the entire malate-synthesizing activity in cells metabolizing glyoxylate

Gene Name:

glcB

Uniprot ID:

P37330

Molecular weight:

80488

Reactions

General function:

Involved in formate C-acetyltransferase activity

Specific function:

Specific function unknown

Gene Name:

tdcE

Uniprot ID:

P42632

Molecular weight:

85935

Reactions

General function:

Involved in electron carrier activity

Specific function:

Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (Potential)

Gene Name:

ydbK

Uniprot ID:

P52647

Molecular weight:

128823

Reactions

General function:

Involved in citrate CoA-transferase activity

Specific function:

Represents a citrate:acetyl-ACP transferase

Gene Name:

citF

Uniprot ID:

P75726

Molecular weight:

55172

Reactions

General function:

Involved in catalytic activity

Specific function:

Acetyl-CoA + formate = CoA + pyruvate

Gene Name:

ybiW

Uniprot ID:

P75793

Molecular weight:

90125

Reactions

General function:

Involved in CoA-transferase activity

Specific function:

Acyl-CoA + acetate = a fatty acid anion + acetyl-CoA

Gene Name:

atoD

Uniprot ID:

P76458

Molecular weight:

23526

Reactions

General function:

Involved in CoA-transferase activity

Specific function:

Acyl-CoA + acetate = a fatty acid anion + acetyl-CoA

Gene Name:

atoA

Uniprot ID:

P76459

Molecular weight:

22960

Reactions

General function:

Involved in transferase activity, transferring acyl groups other than amino-acyl groups

Specific function:

2 acetyl-CoA = CoA + acetoacetyl-CoA

Gene Name:

atoB

Uniprot ID:

P76461

Molecular weight:

40352

Reactions

General function:

Involved in transferase activity

Specific function:

Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. Strongly involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate and weakly involved in the aerobic degradation of long- chain fatty acids

Gene Name:

fadI

Uniprot ID:

P76503

Molecular weight:

46530

Reactions

General function:

Involved in catalytic activity

Specific function:

Could possibly oxidize fatty acids using specific components

Gene Name:

paaG

Uniprot ID:

P77467

Molecular weight:

28404

Reactions

General function:

Involved in acetyltransferase activity

Specific function:

Acetyl-CoA + an N-hydroxyarylamine = CoA + an N-acetoxyarylamine

Gene Name:

nhoA

Uniprot ID:

P77567

Molecular weight:

32274

Reactions

General function:

Involved in acetaldehyde dehydrogenase (acetylating) activity

Specific function:

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of 3-phenylpropanoate. Functions as a chaperone protein for folding of mhpE

Gene Name:

mhpF

Uniprot ID:

P77580

Molecular weight:

33442

Reactions

General function:

Involved in transferase activity

Specific function:

Acetylates maltose and other sugars

Gene Name:

maa

Uniprot ID:

P77791

Molecular weight:

20096

Reactions

General function:

Involved in transferase activity, transferring acyl groups other than amino-acyl groups

Specific function:

2 acetyl-CoA = CoA + acetoacetyl-CoA

Gene Name:

yqeF

Uniprot ID:

Q46939

Molecular weight:

41018

Reactions

General function:

Involved in transferase activity

Specific function:

Putative O-acetyltransferase that transfers an O-acetyl group to the O antigen

Gene Name:

wbbJ

Uniprot ID:

P37750

Molecular weight:

21675

General function:

Involved in protein binding

Specific function:

Transaminase converting thymidine diphosphate(TDP)-4- keto-6-deoxy-D-glucose to TDP-4-amino-4,6-dideoxy-D-galactose, the immediate precursor of the ECA sugar TDP-Fuc4NAc

Gene Name:

rffC

Uniprot ID:

P27832

Molecular weight:

24220

General function:

Involved in FMN binding

Specific function:

Low-potential electron donor to a number of redox enzymes (Potential)

Gene Name:

fldB

Uniprot ID:

P0ABY4

Molecular weight:

19700

General function:

Involved in FMN binding

Specific function:

Low-potential electron donor to a number of redox enzymes (Potential). Involved in the reactivation of inactive cob(II)alamin in methionine synthase

Gene Name:

fldA

Uniprot ID:

P61949

Molecular weight:

19737

General function:

Involved in transferase activity, transferring acyl groups

Specific function:

Specific function unknown

Gene Name:

eutD

Uniprot ID:

P77218

Molecular weight:

36066

General function:

Involved in catalytic activity

Specific function:

Acts as a radical domain for damaged PFL and possibly other radical proteins

Gene Name:

grcA

Uniprot ID:

P68066

Molecular weight:

14284

General function:

Involved in fatty acid biosynthetic process

Specific function:

Carrier of the growing fatty acid chain in fatty acid biosynthesis

Gene Name:

acpP

Uniprot ID:

P0A6A8

Molecular weight:

8640

General function:

Not Available

Specific function:

Not Available

Gene Name:

eutE

Uniprot ID:

P77445

Molecular weight:

Not Available

General function:

Not Available

Specific function:

Not Available

Gene Name:

yncA

Uniprot ID:

P76112

Molecular weight:

Not Available

General function:

Involved in tRNA binding

Specific function:

Not Available

Gene Name:

ypfI

Uniprot ID:

P76562

Molecular weight:

74892

Reactions