Pyruvaldehyde (ECMDB01167) (M2MDB000281)

General function:

Involved in methylglyoxal synthase activity

Specific function:

Glycerone phosphate = methylglyoxal + phosphate

Gene Name:

mgsA

Uniprot ID:

P0A731

Molecular weight:

16918

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the NAD-dependent oxidation of glycerol to dihydroxyacetone (glycerone). Allows microorganisms to utilize glycerol as a source of carbon under anaerobic conditions. In E.coli, an important role of gldA is also likely to regulate the intracellular level of dihydroxyacetone by catalyzing the reverse reaction, i.e. the conversion of dihydroxyacetone into glycerol. Possesses a broad substrate specificity, since it is also able to oxidize 1,2-propanediol and to reduce glycolaldehyde, methylglyoxal and hydroxyacetone into ethylene glycol, lactaldehyde and 1,2-propanediol, respectively

Gene Name:

gldA

Uniprot ID:

P0A9S5

Molecular weight:

38712

Reactions

General function:

Involved in lactoylglutathione lyase activity

Specific function:

Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione

Gene Name:

gloA

Uniprot ID:

P0AC81

Molecular weight:

14920

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Acts on lactaldehyde as well as other aldehydes

Gene Name:

aldA

Uniprot ID:

P25553

Molecular weight:

52272

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG)

Gene Name:

dkgB

Uniprot ID:

P30863

Molecular weight:

29437

Reactions

General function:

Involved in copper ion binding

Specific function:

The enzyme prefers aromatic over aliphatic amines

Gene Name:

tynA

Uniprot ID:

P46883

Molecular weight:

84378

Reactions

General function:

Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Specific function:

Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Inactive towards 2-oxo-D-gluconate, 2-oxoglutarate, oxaloacetate and pyruvate. Only D- and L-glycerate are involved in the oxidative activity with NADP. Activity with NAD is very low

Gene Name:

ghrA

Uniprot ID:

P75913

Molecular weight:

35343

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives

Gene Name:

dkgA

Uniprot ID:

Q46857

Molecular weight:

31109

Reactions

General function:

Energy production and conversion

Specific function:

Specific function unknown

Gene Name:

yghZ

Uniprot ID:

Q46851

Molecular weight:

38832

General function:

Involved in oxidoreductase activity

Specific function:

Specific function unknown

Gene Name:

yeaE

Uniprot ID:

P76234

Molecular weight:

30986

General function:

Not Available

Specific function:

Functions as a holding molecular chaperone (holdase) which stabilizes unfolding intermediates and rapidly releases them in an active form once stress has abated. Plays an important role in protecting cells from severe heat shock and starvation, as well as in acid resistance of stationary-phase cells. It uses temperature-induced exposure of structured hydrophobic domains to capture and stabilizes early unfolding and denatured protein intermediates under severe thermal stress. Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. It can also use phenylglyoxal as substrate. Glyoxalase activity protects cells against dicarbonyl stress. Displays an aminopeptidase activity that is specific against peptide substrates with alanine or basic amino acids (lysine, arginine) at N-terminus. Functions as a holding molecular chaperone (holdase) which stabilizes unfolding intermediates and rapidly releases them in an active form once stress has abated. Plays an important role in protecting cells from severe heat shock and starvation, as well as in acid resistance of stationary-phase cells. It uses temperature-induced exposure of structured hydrophobic domains to capture and stabilizes early unfolding and denatured protein intermediates under severe thermal stress. Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. It can also use phenylglyoxal as substrate. Glyoxalase activity protects cells against dicarbonyl stress. Displays an aminopeptidase activity that is specific against peptide substrates with alanine or basic amino acids (lysine, arginine) at N-terminus.

Gene Name:

hchA

Uniprot ID:

P31658

Molecular weight:

Not Available

Reactions