Iron (ECMDB00692) (M2MDB000172)

General function:

Involved in metabolic process

Specific function:

Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for NAD, biotin and Fe-S cluster synthesis. Transfers sulfur on 'Cys-456' of thiI in a transpersulfidation reaction. Transfers sulfur on 'Cys-19' of tusA in a transpersulfidation reaction. Functions also as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate

Gene Name:

iscS

Uniprot ID:

P0A6B7

Molecular weight:

45089

Reactions

General function:

Involved in methyltransferase activity

Specific function:

Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme

Gene Name:

cysG

Uniprot ID:

P0AEA8

Molecular weight:

49951

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the reduction of soluble flavins by reduced pyridine nucleotides. Seems to reduces the complexed Fe(3+) iron of siderophores to Fe(2+), thus releasing it from the chelator

Gene Name:

fre

Uniprot ID:

P0AEN1

Molecular weight:

26242

Reactions

General function:

Involved in ferrochelatase activity

Specific function:

Catalyzes the ferrous insertion into protoporphyrin IX

Gene Name:

hemH

Uniprot ID:

P23871

Molecular weight:

35884

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Probably involved in periplasmic detoxification of copper by oxidizing Cu(+) to Cu(2+) and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm

Gene Name:

cueO

Uniprot ID:

P36649

Molecular weight:

56556

General function:

Involved in 2 iron, 2 sulfur cluster binding

Specific function:

Involved in the reduction of ferric iron in cytoplasmic ferrioxamine B

Gene Name:

fhuF

Uniprot ID:

P39405

Molecular weight:

30113

General function:

Involved in catalytic activity

Specific function:

Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. Free octanoate is not a substrate for lipA

Gene Name:

lipA

Uniprot ID:

P60716

Molecular weight:

36071

Reactions

General function:

Involved in metabolic process

Specific function:

Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L-selenocysteine. Selenocysteine lyase activity is however unsure in vivo

Gene Name:

sufS

Uniprot ID:

P77444

Molecular weight:

44433

Reactions

General function:

Involved in nucleotide binding

Specific function:

Has low ATPase activity. The sufBCD complex acts synergistically with sufE to stimulate the cysteine desulfurase activity of sufS. The sufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation

Gene Name:

sufC

Uniprot ID:

P77499

Molecular weight:

27582

General function:

Involved in GTP binding

Specific function:

GTP-driven Fe(2+) uptake system

Gene Name:

feoB

Uniprot ID:

P33650

Molecular weight:

84473

General function:

Involved in iron-sulfur cluster assembly

Specific function:

The sufBCD complex acts synergistically with sufE to stimulate the cysteine desulfurase activity of sufS. The sufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation

Gene Name:

sufB

Uniprot ID:

P77522

Molecular weight:

54745

General function:

Inorganic ion transport and metabolism

Specific function:

Specific function unknown

Gene Name:

cyaY

Uniprot ID:

P27838

Molecular weight:

12231

General function:

Involved in iron ion binding

Specific function:

May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins (Potential)

Gene Name:

nifU

Uniprot ID:

P0ACD4

Molecular weight:

13848

General function:

Not Available

Specific function:

Participates in cysteine desulfuration mediated by sufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for sufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of sufS, an intermediate product of cysteine desulfuration process. Together with the sufBCD complex, it thereby enhances up to 50- fold, the cysteine desulfurase activity of sufS. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Does not affect the selenocysteine lyase activity of sufS

Gene Name:

sufE

Uniprot ID:

P76194

Molecular weight:

15800

General function:

Involved in iron-sulfur cluster assembly

Specific function:

The sufBCD complex acts synergistically with sufE to stimulate the cysteine desulfurase activity of sufS. The sufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation. Required for the stability of the fhuF protein

Gene Name:

sufD

Uniprot ID:

P77689

Molecular weight:

46822

General function:

Involved in response to stress

Specific function:

Involved in anaerobic NO protection

Gene Name:

ytfE

Uniprot ID:

P69506

Molecular weight:

24882

General function:

Not Available

Specific function:

Not Available

Gene Name:

ftnA

Uniprot ID:

P0A998

Molecular weight:

Not Available

General function:

Inorganic ion transport and metabolism

Specific function:

May perform analogous functions in iron detoxification and storage to that of animal ferritins

Gene Name:

bfr

Uniprot ID:

P0ABD3

Molecular weight:

18495

Reactions

General function:

Inorganic ion transport and metabolism

Specific function:

Not Available

Gene Name:

yqjH

Uniprot ID:

Q46871

Molecular weight:

28871

Reactions