Adenosine triphosphate (ECMDB00538) (M2MDB000148)

General function:

Involved in ATP binding

Specific function:

Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate. Is also able to phosphorylate the hydroxy group on gamma-carbon of L-homoserine analogs when the functional group at the alpha-position is a carboxyl, an ester, or even a hydroxymethyl group. Neither L- threonine nor L-serine are substrates of the enzyme

Gene Name:

thrB

Uniprot ID:

P00547

Molecular weight:

33623

Reactions

General function:

Involved in amino acid binding

Specific function:

L-homoserine + NAD(P)(+) = L-aspartate 4- semialdehyde + NAD(P)H

Gene Name:

thrA

Uniprot ID:

P00561

Molecular weight:

89119

Reactions

General function:

Involved in cellular amino acid biosynthetic process

Specific function:

L-homoserine + NAD(P)(+) = L-aspartate 4- semialdehyde + NAD(P)H

Gene Name:

metL

Uniprot ID:

P00562

Molecular weight:

88887

Reactions

General function:

Involved in adenylate cyclase activity

Specific function:

ATP = 3',5'-cyclic AMP + diphosphate

Gene Name:

cyaA

Uniprot ID:

P00936

Molecular weight:

97585

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp)

Gene Name:

trpS

Uniprot ID:

P00954

Molecular weight:

37438

Reactions

General function:

Involved in nucleotide binding

Specific function:

Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)

Gene Name:

ileS

Uniprot ID:

P00956

Molecular weight:

104296

Reactions

General function:

Involved in nucleotide binding

Specific function:

Edits incorrectly charged Ser-tRNA(Ala) and Gly- tRNA(Ala) but not incorrectly charged Ser-tRNA(Thr)

Gene Name:

alaS

Uniprot ID:

P00957

Molecular weight:

96032

Reactions

General function:

Involved in nucleotide binding

Specific function:

Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation

Gene Name:

metG

Uniprot ID:

P00959

Molecular weight:

76254

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)

Gene Name:

glyQ

Uniprot ID:

P00960

Molecular weight:

34774

Reactions

General function:

Involved in arginine-tRNA ligase activity

Specific function:

ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)

Gene Name:

glyS

Uniprot ID:

P00961

Molecular weight:

76812

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)

Gene Name:

glnS

Uniprot ID:

P00962

Molecular weight:

63477

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP + L-aspartate + NH(3) = AMP + diphosphate + L-asparagine

Gene Name:

asnA

Uniprot ID:

P00963

Molecular weight:

36650

Reactions

General function:

Involved in ATP binding

Specific function:

2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate

Gene Name:

carB

Uniprot ID:

P00968

Molecular weight:

117841

Reactions

General function:

Involved in potassium-transporting ATPase activity

Specific function:

One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions

Gene Name:

kdpA

Uniprot ID:

P03959

Molecular weight:

59189

Reactions

General function:

Involved in nucleotide binding

Specific function:

One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions

Gene Name:

kdpB

Uniprot ID:

P03960

Molecular weight:

72198

Reactions

General function:

Involved in potassium-transporting ATPase activity

Specific function:

One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex

Gene Name:

kdpC

Uniprot ID:

P03961

Molecular weight:

20267

Reactions

General function:

Involved in GMP synthase (glutamine-hydrolyzing) activity

Specific function:

Catalyzes the synthesis of GMP from XMP

Gene Name:

guaA

Uniprot ID:

P04079

Molecular weight:

58679

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione

Gene Name:

gshB

Uniprot ID:

P04425

Molecular weight:

35561

Reactions

General function:

Involved in nucleotide binding

Specific function:

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction:glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)

Gene Name:

gltX

Uniprot ID:

P04805

Molecular weight:

53815

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex RbsABCD involved in ribose import. Responsible for energy coupling to the transport system

Gene Name:

rbsA

Uniprot ID:

P04983

Molecular weight:

55041

Reactions

General function:

Involved in bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity

Specific function:

Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP

Gene Name:

apaH

Uniprot ID:

P05637

Molecular weight:

31296

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system

Gene Name:

btuD

Uniprot ID:

P06611

Molecular weight:

27081

Reactions

General function:

Involved in biotin-[acetyl-CoA-carboxylase] ligase activity

Specific function:

BirA acts both as a biotin-operon repressor and as the enzyme that synthesizes the corepressor, acetyl-CoA:carbon-dioxide ligase. This protein also activates biotin to form biotinyl-5'- adenylate and transfers the biotin moiety to biotin-accepting proteins

Gene Name:

birA

Uniprot ID:

P06709

Molecular weight:

35312

Reactions

General function:

Involved in RNA binding

Specific function:

Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows highest phosphatase activity in the presence of Ni(2+) and hydrolyzes pyrophosphate, canonical 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi. Displays a metal-independent phosphodiesterase activity toward 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP. Without metal or in the presence of Mg(2+), this protein hydrolyzes 2',3'-cyclic substrates with the formation of 2'-nucleotides, whereas in the presence of Ni(2+), it also produces some 3'-nucleotides. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases

Gene Name:

cca

Uniprot ID:

P06961

Molecular weight:

46467

Reactions

General function:

Involved in phosphotransferase activity, alcohol group as acceptor

Specific function:

ATP + D-fructose 6-phosphate = ADP + D- fructose 1,6-bisphosphate

Gene Name:

pfkB

Uniprot ID:

P06999

Molecular weight:

32456

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the binding-protein-dependent transport system for histidine. Probably responsible for energy coupling to the transport system

Gene Name:

hisP

Uniprot ID:

P07109

Molecular weight:

28653

General function:

Involved in nucleotide binding

Specific function:

Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a "posttransfer" editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner

Gene Name:

valS

Uniprot ID:

P07118

Molecular weight:

108192

Reactions

General function:

Involved in RNA binding

Specific function:

ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)

Gene Name:

pheT

Uniprot ID:

P07395

Molecular weight:

87377

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)

Gene Name:

leuS

Uniprot ID:

P07813

Molecular weight:

97233

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Responsible for energy coupling to the transport system

Gene Name:

fhuC

Uniprot ID:

P07821

Molecular weight:

28886

Reactions

General function:

Involved in ATP binding

Specific function:

Cell wall formation

Gene Name:

ddlB

Uniprot ID:

P07862

Molecular weight:

32839

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + 2-(formamido)-N(1)-(5-phospho-D- ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D- ribosyl)imidazole

Gene Name:

purM

Uniprot ID:

P08178

Molecular weight:

36854

Reactions

General function:

Involved in tetrahydrofolylpolyglutamate synthase activity

Specific function:

Conversion of folates to polyglutamate derivatives

Gene Name:

folC

Uniprot ID:

P08192

Molecular weight:

45405

Reactions

General function:

Involved in phosphotransferase activity, alcohol group as acceptor

Specific function:

ATP + L(or D)-ribulose = ADP + L(or D)- ribulose 5-phosphate

Gene Name:

araB

Uniprot ID:

P08204

Molecular weight:

61089

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)

Gene Name:

pheS

Uniprot ID:

P08312

Molecular weight:

36832

Reactions

General function:

Involved in amino acid binding

Specific function:

ATP + L-aspartate = ADP + 4-phospho-L- aspartate

Gene Name:

lysC

Uniprot ID:

P08660

Molecular weight:

48531

Reactions

General function:

Involved in phosphoribosylaminoimidazole carboxylase activity

Specific function:

Possesses an ATPase activity that is dependent on the presence of AIR (aminoimidazole ribonucleotide). The association of purK and purE produces an enzyme complex capable of converting AIR to CAIR efficiently under physiological condition

Gene Name:

purK

Uniprot ID:

P09029

Molecular weight:

39461

Reactions

General function:

Involved in phosphotransferase activity, alcohol group as acceptor

Specific function:

ATP + D-xylulose = ADP + D-xylulose 5- phosphate

Gene Name:

xylB

Uniprot ID:

P09099

Molecular weight:

52618

Reactions

General function:

Involved in kinase activity

Specific function:

Involved in the activation of acetate to acetyl CoA and the secretion of acetate. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically

Gene Name:

ackA

Uniprot ID:

P0A6A3

Molecular weight:

43290

Reactions

General function:

Involved in metabolic process

Specific function:

Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for NAD, biotin and Fe-S cluster synthesis. Transfers sulfur on 'Cys-456' of thiI in a transpersulfidation reaction. Transfers sulfur on 'Cys-19' of tusA in a transpersulfidation reaction. Functions also as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate

Gene Name:

iscS

Uniprot ID:

P0A6B7

Molecular weight:

45089

Reactions

General function:

Involved in acetylglutamate kinase activity

Specific function:

ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L- glutamate 5-phosphate

Gene Name:

argB

Uniprot ID:

P0A6C8

Molecular weight:

27159

Reactions

General function:

Involved in shikimate kinase activity

Specific function:

Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate

Gene Name:

aroK

Uniprot ID:

P0A6D7

Molecular weight:

19538

Reactions

General function:

Involved in shikimate kinase activity

Specific function:

Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate

Gene Name:

aroL

Uniprot ID:

P0A6E1

Molecular weight:

19151

Reactions

General function:

Involved in argininosuccinate synthase activity

Specific function:

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate

Gene Name:

argG

Uniprot ID:

P0A6E4

Molecular weight:

49898

Reactions

General function:

Involved in hydrogen ion transporting ATP synthase activity, rotational mechanism

Specific function:

Produces ATP from ADP in the presence of a proton gradient across the membrane

Gene Name:

atpC

Uniprot ID:

P0A6E6

Molecular weight:

15068

General function:

Involved in magnesium ion binding

Specific function:

ATP + 7,8-diaminononanoate + CO(2) = ADP + phosphate + dethiobiotin

Gene Name:

ynfK

Uniprot ID:

P0A6E9

Molecular weight:

24981

Reactions

General function:

Involved in glutamine catabolic process

Specific function:

2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate

Gene Name:

carA

Uniprot ID:

P0A6F1

Molecular weight:

41431

Reactions

General function:

Involved in phosphotransferase activity, alcohol group as acceptor

Specific function:

Key enzyme in the regulation of glycerol uptake and metabolism

Gene Name:

glpK

Uniprot ID:

P0A6F3

Molecular weight:

56230

Reactions

General function:

Involved in cytidylate kinase activity

Specific function:

ATP, dATP, and GTP are equally effective as phosphate donors. CMP and dCMP are the best phosphate acceptors

Gene Name:

cmk

Uniprot ID:

P0A6I0

Molecular weight:

24746

Reactions

General function:

Involved in pantothenate kinase activity

Specific function:

ATP + (R)-pantothenate = ADP + (R)-4'- phosphopantothenate

Gene Name:

coaA

Uniprot ID:

P0A6I3

Molecular weight:

36359

Reactions

General function:

Involved in catalytic activity

Specific function:

Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate

Gene Name:

coaD

Uniprot ID:

P0A6I6

Molecular weight:

17837

Reactions

General function:

Involved in dephospho-CoA kinase activity

Specific function:

Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

Gene Name:

coaE

Uniprot ID:

P0A6I9

Molecular weight:

22622

Reactions

General function:

Involved in adenylylsulfate kinase activity

Specific function:

Catalyzes the synthesis of activated sulfate

Gene Name:

cysC

Uniprot ID:

P0A6J1

Molecular weight:

22321

Reactions

General function:

Involved in ATP binding

Specific function:

Cell wall formation

Gene Name:

ddlA

Uniprot ID:

P0A6J8

Molecular weight:

39315

Reactions

General function:

Involved in galactokinase activity

Specific function:

ATP + D-galactose = ADP + alpha-D-galactose 1- phosphate

Gene Name:

galK

Uniprot ID:

P0A6T3

Molecular weight:

41442

Reactions

General function:

Involved in glycogen biosynthetic process

Specific function:

ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose

Gene Name:

glgC

Uniprot ID:

P0A6V1

Molecular weight:

48697

Reactions

General function:

Involved in glucokinase activity

Specific function:

Not highly important in E.coli as glucose is transported into the cell by the PTS system already as glucose 6-phosphate

Gene Name:

glk

Uniprot ID:

P0A6V8

Molecular weight:

34723

Reactions

General function:

Involved in glutamate-cysteine ligase activity

Specific function:

ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine

Gene Name:

gshA

Uniprot ID:

P0A6W9

Molecular weight:

58269

Reactions

General function:

Involved in magnesium ion binding

Specific function:

ATP + D-ribose 5-phosphate = AMP + 5-phospho- alpha-D-ribose 1-diphosphate

Gene Name:

prs

Uniprot ID:

P0A717

Molecular weight:

34218

Reactions

General function:

Involved in thymidylate kinase activity

Specific function:

Catalyzes the reversible phosphorylation of deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), using ATP as its preferred phosphoryl donor. Situated at the junction of both de novo and salvage pathways of deoxythymidine triphosphate (dTTP) synthesis, is essential for DNA synthesis and cellular growth

Gene Name:

tmk

Uniprot ID:

P0A720

Molecular weight:

23783

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)

Gene Name:

nadD

Uniprot ID:

P0A752

Molecular weight:

24528

Reactions

General function:

Involved in nucleoside diphosphate kinase activity

Specific function:

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

Gene Name:

ndk

Uniprot ID:

P0A763

Molecular weight:

15463

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + D-fructose 6-phosphate = ADP + D- fructose 1,6-bisphosphate

Gene Name:

pfkA

Uniprot ID:

P0A796

Molecular weight:

34842

Reactions

General function:

Involved in phosphoglycerate kinase activity

Specific function:

ATP + 3-phospho-D-glycerate = ADP + 3-phospho- D-glyceroyl phosphate

Gene Name:

pgk

Uniprot ID:

P0A799

Molecular weight:

41118

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Can form linear polymers of orthophosphate with chain lengths up to 1000 or more. Can also act in the reverse direction to form ATP in the presence of excess ADP. Can also use GTP instead of ATP; but the efficiency of GTP is 5% that of ATP

Gene Name:

ppk

Uniprot ID:

P0A7B1

Molecular weight:

80431

Reactions

General function:

Involved in NAD+ kinase activity

Specific function:

Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus

Gene Name:

ppnK

Uniprot ID:

P0A7B3

Molecular weight:

32566