2.0 2012-05-31 10:27:09 -0600 2015-09-13 15:15:19 -0600 ECMDB00516 M2MDB000145 b-D-Glucose B-D-glucose is a member of the chemical class known as Hexoses. These are monosaccharides in which the sugar unit is a hexose. Glucose (C6H12O6, also known as D-glucose, dextrose, or grape sugar) is a simple sugar (monosaccharide) and an important carbohydrate in biology. Cells use it as the primary source of energy and a metabolic intermediate. Glucose is one of the main products of photosynthesis and fuels for cellular respiration. Glucose exists in several different molecular structures, but all of these structures can be divided into two families of mirror-images (stereoisomers). Only one set of these isomers exists in nature, those derived from the right-handed form of glucose, denoted D-glucose. D-glucose is sometimes referred to as dextrose, although the use of this name is strongly discouraged. The term dextrose is derived from dextrorotatory glucose. This name is therefore confusing when applied to the enantiomer, which rotates light the opposite direction. Starch and cellulose are polymers derived from the dehydration of D-glucose. The other stereoisomer, called L-glucose, is hardly ever found in nature. (WikiPedia) &beta;-D-glucopyranose &beta;-glucose 6-(Hydroxymethyl)tetrahydropyran-2,3,4,5-tetraol B-D-Glucopyranose b-delta-Glucopyranose B-Dextrose B-Glucose b-δ-Glucopyranose Beta-D-Glucopyranose Beta-D-Glucose Beta-delta-Glucopyranose Beta-Dextrose Beta-Glucose D-glucose D-Glucose-ring Dextrose Glc Glc-ring Glucose Glucoside β-D-Glucopyranose β-D-Glucose β-Dextrose β-Glucose β-δ-Glucopyranose C6H12O6 180.1559 180.063388116 (2R,3R,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol glucoside 492-61-5 OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6-/m1/s1 WQZGKKKJIJFFOK-VFUOTHLCSA-N Solid Cytoplasm Periplasm logp -2.57 ALOGPS logs 0.64 ALOGPS solubility 7.82e+02 g/l ALOGPS logp -2.9 ChemAxon pka_strongest_acidic 11.3 ChemAxon pka_strongest_basic -3 ChemAxon iupac (2R,3R,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol ChemAxon average_mass 180.1559 ChemAxon mono_mass 180.063388116 ChemAxon smiles OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O ChemAxon formula C6H12O6 ChemAxon inchi InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6-/m1/s1 ChemAxon inchikey WQZGKKKJIJFFOK-VFUOTHLCSA-N ChemAxon polar_surface_area 110.38 ChemAxon refractivity 35.92 ChemAxon polarizability 16.35 ChemAxon rotatable_bond_count 1 ChemAxon acceptor_count 6 ChemAxon donor_count 5 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Pentose phosphate pathway ec00030 Starch and sucrose metabolism The metabolism of starch and sucrose begins with D-fructose interacting with a D-glucose in a reversible reaction through a maltodextrin glucosidase resulting in a water molecule and a sucrose. D-fructose is phosphorylated through an ATP driven fructokinase resulting in the release of an ADP, a hydrogen ion and a Beta-D-fructofuranose 6-phosphate. This compound can also be introduced into the cytoplasm through either a mannose PTS permease or a hexose-6-phosphate:phosphate antiporter. The Beta-D-fructofuranose 6-phosphate is isomerized through a phosphoglucose isomerase resulting in a Beta-D-glucose 6-phosphate. This compound can also be incorporated by glucose PTS permease or a hexose-6-phosphate:phosphate antiporter. The beta-D-glucose 6 phosphate can also be produced by a D-glucose being phosphorylated by an ATP-driven glucokinase resulting in a ADP, a hydrogen ion and a Beta-D-glucose 6 phosphate. The beta-D-glucose can produce alpha-D-glucose-1-phosphate by two methods: 1.-Beta-D-glucose is isomerized into an alpha-D-Glucose 6-phosphate and then interacts in a reversible reaction through a phosphoglucomutase-1 resulting in a alpha-D-glucose-1-phosphate. 2.-Beta-D-glucose interacts with a putative beta-phosphoglucomutase resulting in a Beta-D-glucose 1-phosphate. Beta-D-glucose 1-phosphate can be incorporated into the cytoplasm through a glucose PTS permease. This compound is then isomerized into a Alpha-D-glucose-1-phosphate The beta-D-glucose can cycle back into a D-fructose by first interacting with D-fructose in a reversible reaction through a Polypeptide: predicted glucosyltransferase resulting in the release of a phosphate and a sucrose. The sucrose then interacts in a reversible reaction with a water molecule through a maltodextrin glucosidase resulting in a D-glucose and a D-fructose. Alpha-D-glucose-1-phosphate can produce glycogen in by two different sets of reactions: 1.-Alpha-D-glucose-1-phosphate interacts with a hydrogen ion and an ATP through a glucose-1-phosphate adenylyltransferase resulting in a pyrophosphate and an ADP-glucose. The ADP-glucose then interacts with an amylose through a glycogen synthase resulting in the release of an ADP and an Amylose. The amylose then interacts with 1,4-α-glucan branching enzyme resulting in glycogen 2.- Alpha-D-glucose-1-phosphate interacts with amylose through a maltodextrin phosphorylase resulting in a phosphate and a glycogen. Alpha-D-glucose-1-phosphate can also interacts with UDP-galactose through a galactose-1-phosphate uridylyltransferase resulting in a galactose 1-phosphate and a Uridine diphosphate glucose. The UDP-glucose then interacts with an alpha-D-glucose 6-phosphate through a trehalose-6-phosphate synthase resulting in a uridine 5'-diphosphate, a hydrogen ion and a Trehalose 6- phosphate. The latter compound can also be incorporated into the cytoplasm through a trehalose PTS permease. Trehalose interacts with a water molecule through a trehalose-6-phosphate phosphatase resulting in the release of a phosphate and an alpha,alpha-trehalose.The alpha,alpha-trehalose can also be obtained from glycogen being metabolized through a glycogen debranching enzyme resulting in a the alpha, alpha-trehalose. This compound ca then be hydrated through a cytoplasmic trehalase resulting in the release of an alpha-D-glucose and a beta-d-glucose. Glycogen is then metabolized by reacting with a phosphate through a glycogen phosphorylase resulting in a alpha-D-glucose-1-phosphate and a dextrin. The dextrin is then hydrated through a glycogen phosphorylase-limit dextrin α-1,6-glucohydrolase resulting in the release of a debranched limit dextrin and a maltotetraose. This compound can also be incorporated into the cytoplasm through a maltose ABC transporter. The maltotetraose interacts with a phosphate through a maltodextrin phosphorylase releasing a alpha-D-glucose-1-phosphate and a maltotriose. The maltotriose can also be incorporated through a maltose ABC transporter. The maltotriose can then interact with water through a maltodextrin glucosidase resulting in a D-glucose and a D-maltose. D-maltose can also be incorporated through a maltose ABC transporter The D-maltose can then interact with a maltotriose through a amylomaltase resulting in a maltotetraose and a D-glucose. The D-glucose is then phosphorylated through an ATP driven glucokinase resulting in a hydrogen ion, an ADP and a Beta-D-glucose 6-phosphate PW000941 ec00500 Metabolic Glycolysis / Gluconeogenesis ec00010 Galactose metabolism Galactose can be synthesized through two pathways: melibiose degradation involving an alpha galactosidase and lactose degradation involving a beta galactosidase. Melibiose is first transported inside the cell through the melibiose:Li+/Na+/H+ symporter. Once inside the cell, melibiose is degraded through alpha galactosidase into an alpha-D-galactose and a beta-D-glucose. The beta-D-glucose is phosphorylated by a glucokinase to produce a beta-D-glucose-6-phosphate which can spontaneously be turned into a alpha D glucose 6 phosphate. This alpha D-glucose-6-phosphate is metabolized into a glucose -1-phosphate through a phosphoglucomutase-1. The glucose -1-phosphate is transformed into a uridine diphosphate glucose through UTP--glucose-1-phosphate uridylyltransferase. The product, uridine diphosphate glucose, can undergo a reversible reaction in which it can be turned into uridine diphosphategalactose through an UDP-glucose 4-epimerase. Galactose can also be produced by lactose degradation involving a lactose permease to uptake lactose from the environment and a beta-galactosidase to turn lactose into Beta-D-galactose. Beta-D-galactose can also be uptaken from the environment through a galactose proton symporter. Galactose is degraded through the following process: Beta-D-galactose is introduced into the cytoplasm through a galactose proton symporter, or it can be synthesized from an alpha lactose that is introduced into the cytoplasm through a lactose permease. Alpha lactose interacts with water through a beta-galactosidase resulting in a beta-D-glucose and beta-D-galactose. Beta-D-galactose is isomerized into D-galactose. D-Galactose undergoes phosphorylation through a galactokinase, hence producing galactose 1 phosphate. On the other side of the pathway, a gluose-1-phosphate (product of the interaction of alpha-D-glucose 6-phosphate with a phosphoglucomutase resulting in a alpha-D-glucose-1-phosphate, an isomer of Glucose 1-phosphate, or an isomer of Beta-D-glucose 1-phosphate) interacts with UTP and a hydrogen ion in order to produce a uridine diphosphate glucose. This is followed by the interaction of galactose-1-phosphate with an established amount of uridine diphosphate glucose through a galactose-1-phosphate uridylyltransferase, which in turn output a glucose-1-phosphate and a uridine diphosphate galactose. The glucose -1-phosphate is transformed into a uridine diphosphate glucose through UTP--glucose-1-phosphate uridylyltransferase. The product, uridine diphosphate glucose, can undergo a reversible reaction in which it can be turned into uridine diphosphategalactose through an UDP-glucose 4-epimerase, and so the cycle can keep going as long as more lactose or galactose is imported into the cell PW000821 ec00052 Metabolic Microbial metabolism in diverse environments ec01120 Metabolic pathways eco01100 Secondary metabolites: Trehalose Biosynthesis and Metabolism Threhalose biosynthesis begins with an Alpha-D-glucose-1-phosphate interacting with an ATP through a glucose-1-phosphate adenylyltransferase resulting in the release of a pyrophosphate and an ADP-glucose. The latter compound interacts in a reversible reaction with an amylose through a glycogen synthase resulting in the release of an ADP and an amylose. Amylose then interacts in a reversible reaction with 1,4-α-glucan branching enzyme resulting in a glycogen Glycogen can also be produced by a reversible reaction with Amylose through a maltodextrin phosphorylase, releasing a phosphate and a glycogen. Glycogen is then transformed into trehalose through a glycogen debranching enzyme. Trehalose then interacts with a water molecule through a cytoplasmic trehalase resulting in the release of a Beta-D-glucose and an Alpha-D-glucose. The beta-D-glucose is then phosphorylated by and ATP driven glucokinase resulting in a hydrogen ion, an ADP and a Beta-D-glucose 6-phosphate. PW000968 Metabolic colanic acid building blocks biosynthesis The colonic acid building blocks biosynthesis starts with a Beta-D-Glucose undergoing a transport reaction mediated by a glucose PTS permease. The permease phosphorylates the Beta-D-Glucose, producing a Beta-D-Glucose 6-phosphate. This compound can either change to an Alpha-D-Glucose 6-phosphate spontaneously or into a fructose 6-phosphate through a glucose-6-phosphate isomerase. The latter compound can also be present in E.coli through the interaction of D-fructose and a mannose PTS permease which phosphorylate the D-fructose. Fructose 6-phosphate interacts in a reversible reaction with mannose-6-phosphate isomerase in order to produce a Alpha-D-mannose 6-phosphate. This compound can also be present in E.coli through the interaction of Alpha-D-mannose and a mannose PTS permease which phosphorylates the alpha-D-mannose. Alpha-D-mannose 6-phosphate interacts in a reversible reaction with a phosphomannomutase to produce a alpha-D-mannose 1-phosphate. This compound in turn with a hydrogen ion and gtp undergoes a reaction with a mannose-1-phosphate guanylyltransferase, releasing a pyrophosphate and producing a guanosine diphosphate mannose. Guanosine diphosphate mannose interacts with gdp-mannose 4,6-dehydratase releasing a water, and gdp-4-dehydro-6-deoxy-D-mannose. This compound in turn with hydrogen ion and NADPH interact with GDP-L-fucose synthase releasing NADP and producing a GDP-L-fucose. The Alpha-D-Glucose 6-phosphate interacts in a reversible reaction with phosphoglucomutase-1 to produce a alpha-D-glucose 1-phosphate. This in turn with UTP and hydrogen ion interact with UTP--glucose-1-phosphate uridyleltransferase releasing a pyrophosphate and UDP-glucose. UDP-glucose can either interact with galactose-1-phosphate uridylyltransferase to produce a UDP-galactose or in turn with NAD and water interact with UDP-glucose 6-dehydrogenase releasing a NADH and a hydrogen ion and producing a UDP-glucuronate. GDP-L-fucose, UDP-glucose, UDP-galactose and UDP-glucuronate are sugars that need to be activated in the form of nucleotide sugar prior to their assembly into colanic acid, also known as M antigen. Colanic acid is an extracellular polysaccharide which has been linked to a cluster of 19 genes(wca). PW000951 Metabolic galactose degradation/Leloir Pathway The degradation of galactose, also known as Leloir pathway, requires 3 main enzymes once Beta-D-galactose has been converted to galactose through an Aldose-1-epimerase. These are: galactokinase , galactose-1-phosphate uridylyltransferase and UDP-glucose 4-epimerase. Beta-D-galactose can be uptaken from the environment through a galactose proton symporter. It can also be produced by lactose degradation involving a lactose permease to uptake lactose from the environment and a beta-galactosidase to turn lactose into Beta-D-galactose. Galactose is degraded through the following process: Beta-D-galactose is introduced into the cytoplasm through a galactose proton symporter, or it can be synthesized from an alpha lactose that is introduced into the cytoplasm through a lactose permease. Alpha lactose interacts with water through a beta-galactosidase resulting in a beta-D-glucose and beta-D-galactose. Beta-D-galactose is isomerized into D-galactose. D-Galactose undergoes phosphorylation through a galactokinase, hence producing galactose 1 phosphate. On the other side of the pathway, a gluose-1-phosphate (product of the interaction of alpha-D-glucose 6-phosphate with a phosphoglucomutase resulting in a alpha-D-glucose-1-phosphate, an isomer of Glucose 1-phosphate, or an isomer of Beta-D-glucose 1-phosphate) interacts with UTP and a hydrogen ion in order to produce a uridine diphosphate glucose. This is followed by the interaction of galactose-1-phosphate with an established amount of uridine diphosphate glucose through a galactose-1-phosphate uridylyltransferase, which in turn output a glucose-1-phosphate and a uridine diphosphate galactose. The glucose -1-phosphate is transformed into a uridine diphosphate glucose through UTP--glucose-1-phosphate uridylyltransferase. The product, uridine diphosphate glucose, can undergo a reversible reaction in which it can be turned into uridine diphosphategalactose through an UDP-glucose 4-epimerase, and so the cycle can keep going as long as more lactose or galactose is imported into the cell. PW000884 Metabolic melibiose degradation PWY0-1301 glycogen degradation I GLYCOCAT-PWY trehalose degradation II (trehalase) PWY0-1182 trehalose degradation VI (periplasmic) PWY0-1466 glucose and glucose-1-phosphate degradation GLUCOSE1PMETAB-PWY lactose degradation III BGALACT-PWY trehalose degradation I (low osmolarity) TREDEGLOW-PWY Specdb::CMs 3243 Specdb::CMs 30807 Specdb::CMs 30808 Specdb::CMs 37587 Specdb::CMs 99577 Specdb::CMs 99578 Specdb::CMs 136889 Specdb::CMs 144623 Specdb::CMs 1050439 Specdb::CMs 1050440 Specdb::CMs 1050442 Specdb::CMs 1050444 Specdb::CMs 1050446 Specdb::CMs 1050447 Specdb::CMs 1050449 Specdb::CMs 1050451 Specdb::CMs 1050453 Specdb::CMs 1050455 Specdb::CMs 1050457 Specdb::CMs 1050459 Specdb::CMs 1050460 Specdb::CMs 1050462 Specdb::CMs 1050464 Specdb::CMs 1050466 Specdb::CMs 1050468 Specdb::EiMs 1826 Specdb::NmrOneD 5259 Specdb::NmrOneD 5260 Specdb::NmrOneD 142310 Specdb::NmrOneD 142311 Specdb::NmrOneD 142312 Specdb::NmrOneD 142313 Specdb::NmrOneD 142314 Specdb::NmrOneD 142315 Specdb::NmrOneD 142316 Specdb::NmrOneD 142317 Specdb::NmrOneD 142318 Specdb::NmrOneD 142319 Specdb::NmrOneD 142320 Specdb::NmrOneD 142321 Specdb::NmrOneD 142322 Specdb::NmrOneD 142323 Specdb::NmrOneD 142324 Specdb::NmrOneD 142325 Specdb::NmrOneD 142326 Specdb::NmrOneD 142327 Specdb::NmrOneD 142328 Specdb::NmrOneD 142329 Specdb::NmrOneD 166522 Specdb::NmrOneD 166654 Specdb::NmrOneD 166667 Specdb::MsMs 25901 Specdb::MsMs 25902 Specdb::MsMs 25903 Specdb::MsMs 32459 Specdb::MsMs 32460 Specdb::MsMs 32461 Specdb::MsMs 1448592 Specdb::MsMs 1448593 Specdb::MsMs 1448594 Specdb::MsMs 1448595 Specdb::MsMs 1448596 Specdb::MsMs 1448597 Specdb::MsMs 1448598 Specdb::MsMs 1448599 Specdb::MsMs 1448600 Specdb::MsMs 1448601 Specdb::MsMs 1448602 Specdb::MsMs 1448603 Specdb::MsMs 1448604 Specdb::MsMs 1474236 Specdb::MsMs 1474237 Specdb::MsMs 1474238 Specdb::MsMs 1474239 Specdb::MsMs 1474240 Specdb::MsMs 1474241 Specdb::NmrTwoD 2074 HMDB00516 58238 C00221 GLC BGC Keseler, I. M., Collado-Vides, J., Santos-Zavaleta, A., Peralta-Gil, M., Gama-Castro, S., Muniz-Rascado, L., Bonavides-Martinez, C., Paley, S., Krummenacker, M., Altman, T., Kaipa, P., Spaulding, A., Pacheco, J., Latendresse, M., Fulcher, C., Sarker, M., Shearer, A. G., Mackie, A., Paulsen, I., Gunsalus, R. P., Karp, P. D. (2011). "EcoCyc: a comprehensive database of Escherichia coli biology." Nucleic Acids Res 39:D583-D590. 21097882 Kanehisa, M., Goto, S., Sato, Y., Furumichi, M., Tanabe, M. (2012). "KEGG for integration and interpretation of large-scale molecular data sets." Nucleic Acids Res 40:D109-D114. 22080510 van der Werf, M. J., Overkamp, K. M., Muilwijk, B., Coulier, L., Hankemeier, T. (2007). "Microbial metabolomics: toward a platform with full metabolome coverage." Anal Biochem 370:17-25. 17765195 Wenck, Helmut; Kinedt, Claudia; Bader, Hans Joachim. Production of b-D-glucose. Praxis der Naturwissenschaften, Chemie (1986), 35(4), 23. Beta-galactosidase P00722 BGAL_ECOLI lacZ http://ecmdb.ca/proteins/P00722.xml Alpha-galactosidase P06720 AGAL_ECOLI melA http://ecmdb.ca/proteins/P06720.xml PTS system beta-glucoside-specific EIIBCA component P08722 PTV3B_ECOLI bglF http://ecmdb.ca/proteins/P08722.xml Glucokinase P0A6V8 GLK_ECOLI glk http://ecmdb.ca/proteins/P0A6V8.xml Aldose 1-epimerase P0A9C3 GALM_ECOLI galM http://ecmdb.ca/proteins/P0A9C3.xml 6-phospho-beta-glucosidase BglB P11988 BGLB_ECOLI bglB http://ecmdb.ca/proteins/P11988.xml Periplasmic trehalase P13482 TREA_ECOLI treA http://ecmdb.ca/proteins/P13482.xml Quinoprotein glucose dehydrogenase P15877 DHG_ECOLI gcd http://ecmdb.ca/proteins/P15877.xml 4-alpha-glucanotransferase P15977 MALQ_ECOLI malQ http://ecmdb.ca/proteins/P15977.xml 6-phospho-beta-glucosidase P17411 CHBF_ECOLI chbF http://ecmdb.ca/proteins/P17411.xml PTS system maltose- and glucose-specific EIICB component P19642 PTOCB_ECOLI malX http://ecmdb.ca/proteins/P19642.xml 6-phospho-beta-glucosidase AscB P24240 ASCB_ECOLI ascB http://ecmdb.ca/proteins/P24240.xml Trehalose-6-phosphate hydrolase P28904 TREC_ECOLI treC http://ecmdb.ca/proteins/P28904.xml Periplasmic beta-glucosidase P33363 BGLX_ECOLI bglX http://ecmdb.ca/proteins/P33363.xml Cytoplasmic trehalase P62601 TREF_ECOLI treF http://ecmdb.ca/proteins/P62601.xml Glucose-specific phosphotransferase enzyme IIA component P69783 PTGA_ECOLI crr http://ecmdb.ca/proteins/P69783.xml PTS system glucose-specific EIICB component P69786 PTGCB_ECOLI ptsG http://ecmdb.ca/proteins/P69786.xml 6-phospho-beta-glucosidase BglA Q46829 BGLA_ECOLI bglA http://ecmdb.ca/proteins/Q46829.xml Beta-galactosidase G0ZKW2 G0ZKW2_ECOLI lacZ http://ecmdb.ca/proteins/G0ZKW2.xml PTS system beta-glucoside-specific EIIBCA component P08722 PTV3B_ECOLI bglF http://ecmdb.ca/proteins/P08722.xml PTS system maltose- and glucose-specific EIICB component P19642 PTOCB_ECOLI malX http://ecmdb.ca/proteins/P19642.xml PTS system glucose-specific EIICB component P69786 PTGCB_ECOLI ptsG http://ecmdb.ca/proteins/P69786.xml Sugar efflux transporter C P31436 SETC_ECOLI setC http://ecmdb.ca/proteins/P31436.xml Cellobiose + Water <>2 b-D-Glucose R00026 Adenosine triphosphate + b-D-Glucose <> ADP + beta-D-Glucose 6-phosphate R01600 alpha-D-Glucose <> b-D-Glucose R01602 Cellulose + Water <> Cellulose + b-D-Glucose R02887 3-Ketolactose + Water <> 3-Keto-beta-D-galactose + b-D-Glucose R04783 b-D-Glucose <> D-glucose RXN0-6418 Phosphoenolpyruvic acid + b-D-Glucose > Glucose 6-phosphate + Pyruvic acid TRANS-RXN-157 a &beta;-D glucoside + Water a non glucosylated glucose acceptor + b-D-Glucose 3.2.1.21-RXN Cellobiose-6-phosphate + Water > Glucose 6-phosphate + b-D-Glucose 6-PHOSPHO-BETA-GLUCOSIDASE-RXN D-Glucose <> b-D-Glucose ALDOSE-1-EPIMERASE-RXN Water + Melibiose > D-Galactose + b-D-Glucose ALPHAGALACTOSID-RXN Maltotriose + D-Maltose <> Maltotetraose + b-D-Glucose AMYLOMALT-RXN Water + alpha-Lactose > D-Galactose + b-D-Glucose BETAGALACTOSID-RXN GDP-&alpha;-D-glucose + Water > Hydrogen ion + b-D-Glucose + Guanosine diphosphate GDP-GLUCOSIDASE-RXN b-D-Glucose + a ubiquinone > Gluconolactone + a ubiquinol GLUCDEHYDROG-RXN b-D-Glucose + Adenosine triphosphate > Hydrogen ion + Glucose 6-phosphate + ADP GLUCOKIN-RXN isoprimeverose + Water b-D-Glucose + D-Xylose RXN-12402 Gluconolactone + Hydrogen ion <> b-D-Glucose RXN0-6372 Trehalose 6-phosphate + Water > Glucose 6-phosphate + b-D-Glucose TRE6PHYDRO-RXN Trehalose + Water > b-D-Glucose + D-Glucose TREHALA-RXN alpha-D-Glucose > b-D-Glucose R01602 Trehalose + Water > b-D-Glucose + alpha-D-Glucose Trehalose + Water <> b-D-Glucose + alpha-D-Glucose R00010 R06103 alpha-Lactose + Water > beta-D-Galactose + Beta-D-Glucose + b-D-Glucose PW_R002956 Beta-D-Glucose + Adenosine triphosphate + b-D-Glucose > Hydrogen ion + Adenosine diphosphate + beta-D-Glucose 6-phosphate + ADP PW_R003297 Melibiose + Water > Alpha-D-Galactose + Beta-D-Glucose + b-D-Glucose PW_R003298 α,α-trehalose + Water > alpha-D-Glucose + Beta-D-Glucose + b-D-Glucose PW_R003516 Beta-D-Glucose + HPr - phosphorylated + b-D-Glucose > beta-D-Glucose 6-phosphate + HPr PW_RCT000138 Cellobiose + Water <>2 b-D-Glucose Adenosine triphosphate + b-D-Glucose <> ADP + beta-D-Glucose 6-phosphate Adenosine triphosphate + b-D-Glucose <> ADP + beta-D-Glucose 6-phosphate