Uridine 5'-diphosphate (ECMDB00295) (M2MDB000123)

General function:

Involved in oxidation-reduction process

Specific function:

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. It also provides redox- active cysteines

Gene Name:

nrdA

Uniprot ID:

P00452

Molecular weight:

85774

Reactions

General function:

Involved in RNA binding

Specific function:

Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction

Gene Name:

pnp

Uniprot ID:

P05055

Molecular weight:

77100

Reactions

General function:

Involved in phosphotransferase activity, alcohol group as acceptor

Specific function:

ATP + D-fructose 6-phosphate = ADP + D- fructose 1,6-bisphosphate

Gene Name:

pfkB

Uniprot ID:

P06999

Molecular weight:

32456

Reactions

General function:

Involved in cytidylate kinase activity

Specific function:

ATP, dATP, and GTP are equally effective as phosphate donors. CMP and dCMP are the best phosphate acceptors

Gene Name:

cmk

Uniprot ID:

P0A6I0

Molecular weight:

24746

Reactions

General function:

Involved in nucleoside diphosphate kinase activity

Specific function:

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

Gene Name:

ndk

Uniprot ID:

P0A763

Molecular weight:

15463

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + D-fructose 6-phosphate = ADP + D- fructose 1,6-bisphosphate

Gene Name:

pfkA

Uniprot ID:

P0A796

Molecular weight:

34842

Reactions

General function:

Involved in cellular amino acid biosynthetic process

Specific function:

Catalyzes the reversible phosphorylation of UMP to UDP, with ATP as the most efficient phosphate donor

Gene Name:

pyrH

Uniprot ID:

P0A7E9

Molecular weight:

25970

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + uridine = ADP + UMP

Gene Name:

udk

Uniprot ID:

P0A8F4

Molecular weight:

24353

Reactions

General function:

Involved in electron carrier activity

Specific function:

Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin

Gene Name:

trxC

Uniprot ID:

P0AGG4

Molecular weight:

15555

Reactions

General function:

Involved in lipid-A-disaccharide synthase activity

Specific function:

Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

Gene Name:

lpxB

Uniprot ID:

P10441

Molecular weight:

42382

Reactions

General function:

Involved in undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity

Specific function:

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)

Gene Name:

murG

Uniprot ID:

P17443

Molecular weight:

37815

Reactions

General function:

Involved in transferase activity, transferring glycosyl groups

Specific function:

UDP-glucose + lipopolysaccharide = UDP + D- glucosyl-lipopolysaccharide

Gene Name:

rfaJ

Uniprot ID:

P27129

Molecular weight:

39040

Reactions

General function:

Involved in UDP-N-acetylglucosamine 2-epimerase activity

Specific function:

Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues. Also involved in bacteriophage N4 adsorption

Gene Name:

wecB

Uniprot ID:

P27828

Molecular weight:

42244

Reactions

General function:

Involved in catalytic activity

Specific function:

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H(2)O = ribonucleoside triphosphate + thioredoxin

Gene Name:

nrdD

Uniprot ID:

P28903

Molecular weight:

80022

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the transfer of glucose from UDP-glucose to glucose-6-phosphate to form alpha,alpha-1,1 trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor. Essential for viability of the cells at low temperatures and at elevated osmotic strength

Gene Name:

otsA

Uniprot ID:

P31677

Molecular weight:

53611

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2F contains the tyrosyl radical required for catalysis

Gene Name:

nrdF

Uniprot ID:

P37146

Molecular weight:

36443

Reactions

General function:

Involved in cellulose synthase activity

Specific function:

Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose, which is produced as an extracellular component for mechanical and chemical protection at the onset of the stationary phase, when the cells exhibit multicellular behavior (rdar morphotype). Coexpression of cellulose and thin aggregative fimbriae leads to a hydrophobic network with tightly packed cells embedded in a highly inert matrix

Gene Name:

bcsA

Uniprot ID:

P37653

Molecular weight:

99784

Reactions

General function:

Involved in oxidation-reduction process

Specific function:

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1E contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide

Gene Name:

nrdE

Uniprot ID:

P39452

Molecular weight:

80478

Reactions

General function:

Involved in ATP binding

Specific function:

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

Gene Name:

adk

Uniprot ID:

P69441

Molecular weight:

23586

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2 contains the tyrosyl radical required for catalysis

Gene Name:

nrdB

Uniprot ID:

P69924

Molecular weight:

43517

Reactions

General function:

Involved in phosphotransferase activity, for other substituted phosphate groups

Specific function:

Catalyzes the transfer of 4-deoxy-4-formamido-L- arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides

Gene Name:

arnC

Uniprot ID:

P77757

Molecular weight:

36339

Reactions

General function:

Involved in biosynthetic process

Specific function:

Involved in the addition of the first glucose residue to the lipopolysaccharide core

Gene Name:

rfaG

Uniprot ID:

P25740

Molecular weight:

42284

General function:

Involved in transferase activity, transferring glycosyl groups

Specific function:

Adds the terminal N-acetyl-D-glucosamine group on the glucose(II) group of LPS

Gene Name:

waaU

Uniprot ID:

P27242

Molecular weight:

41729

Reactions

General function:

Involved in biosynthetic process

Specific function:

Adds a galactose goup to a glucose group of LPS

Gene Name:

rfaB

Uniprot ID:

P27127

Molecular weight:

40826

General function:

Involved in biosynthetic process

Specific function:

May be a glycosyltransferase involved in the transfer of UDP-GalF and UDP-glucose

Gene Name:

yefI

Uniprot ID:

P37751

Molecular weight:

43188

General function:

Involved in electron carrier activity

Specific function:

Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (Probable)

Gene Name:

grxD

Uniprot ID:

P0AC69

Molecular weight:

12879

General function:

Involved in electron carrier activity

Specific function:

The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione reductase

Gene Name:

grxC

Uniprot ID:

P0AC62

Molecular weight:

9137

General function:

Involved in transferase activity, transferring hexosyl groups

Specific function:

Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in ECA synthesis

Gene Name:

wecG

Uniprot ID:

P27836

Molecular weight:

27928

Reactions

General function:

Involved in lipopolysaccharide-1,6-galactosyltransferas

Specific function:

May be a glycosyltransferase involved in the transfer of UDP-GalF to the lipopolysaccharide

Gene Name:

yefG

Uniprot ID:

P37749

Molecular weight:

37757

General function:

Involved in protein binding

Specific function:

Involved in reducing some disulfides in a coupled system with glutathione reductase. Does not act as hydrogen donor for ribonucleotide reductase

Gene Name:

grxB

Uniprot ID:

P0AC59

Molecular weight:

24350

General function:

Involved in electron carrier activity

Specific function:

The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione reductase

Gene Name:

grxA

Uniprot ID:

P68688

Molecular weight:

9685

General function:

Involved in electron carrier activity

Specific function:

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions

Gene Name:

trxA

Uniprot ID:

P0AA25

Molecular weight:

11807

General function:

Involved in transferase activity, transferring glycosyl groups

Specific function:

UDP-galactose + lipopolysaccharide = UDP + 3- alpha-D-galactosyl-[lipopolysaccharide glucose]

Gene Name:

rfaI

Uniprot ID:

P27128

Molecular weight:

39423

Reactions