Uridine triphosphate (ECMDB00285) (M2MDB000117)

General function:

Involved in phosphotransferase activity, alcohol group as acceptor

Specific function:

ATP + D-fructose 6-phosphate = ADP + D- fructose 1,6-bisphosphate

Gene Name:

pfkB

Uniprot ID:

P06999

Molecular weight:

32456

Reactions

General function:

Involved in nucleoside diphosphate kinase activity

Specific function:

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

Gene Name:

ndk

Uniprot ID:

P0A763

Molecular weight:

15463

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + D-fructose 6-phosphate = ADP + D- fructose 1,6-bisphosphate

Gene Name:

pfkA

Uniprot ID:

P0A796

Molecular weight:

34842

Reactions

General function:

Involved in CTP synthase activity

Specific function:

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

Gene Name:

pyrG

Uniprot ID:

P0A7E5

Molecular weight:

60374

Reactions

General function:

Involved in DNA-directed RNA polymerase activity

Specific function:

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit plays an important role in subunit assembly since its dimerization is the first step in the sequential assembly of subunits to form the holoenzyme

Gene Name:

rpoA

Uniprot ID:

P0A7Z4

Molecular weight:

36511

Reactions

General function:

Involved in DNA-directed RNA polymerase activity

Specific function:

Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits

Gene Name:

rpoZ

Uniprot ID:

P0A800

Molecular weight:

10237

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + uridine = ADP + UMP

Gene Name:

udk

Uniprot ID:

P0A8F4

Molecular weight:

24353

Reactions

General function:

Involved in DNA binding

Specific function:

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

Gene Name:

rpoC

Uniprot ID:

P0A8T7

Molecular weight:

155159

Reactions

General function:

Involved in DNA binding

Specific function:

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

Gene Name:

rpoB

Uniprot ID:

P0A8V2

Molecular weight:

150631

Reactions

General function:

Involved in [formate-C-acetyltransferase]-activating enzyme activity

Specific function:

Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine

Gene Name:

nrdG

Uniprot ID:

P0A9N8

Molecular weight:

17446

General function:

Involved in enzyme regulator activity

Specific function:

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose

Gene Name:

galF

Uniprot ID:

P0AAB6

Molecular weight:

32829

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

Gene Name:

glmU

Uniprot ID:

P0ACC7

Molecular weight:

49190

Reactions

General function:

Involved in UTP:glucose-1-phosphate uridylyltransferase activity

Specific function:

May play a role in stationary phase survival

Gene Name:

galU

Uniprot ID:

P0AEP3

Molecular weight:

32942

Reactions

General function:

Involved in nucleoside-triphosphate diphosphatase activity

Specific function:

Specific function unknown

Gene Name:

mazG

Uniprot ID:

P0AEY3

Molecular weight:

30412

Reactions

General function:

Involved in amino acid binding

Specific function:

Modifies, by uridylylation or deuridylylation the PII (glnB) regulatory protein

Gene Name:

glnD

Uniprot ID:

P27249

Molecular weight:

102389

Reactions

General function:

Involved in dCTP deaminase activity

Specific function:

dCTP + H(2)O = dUTP + NH(3)

Gene Name:

dcd

Uniprot ID:

P28248

Molecular weight:

21249

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Transports electrons between flavodoxin or ferredoxin and NADPH. Involved in the reductive activation of cobalamin- independent methionine synthase, pyruvate formate lyase and anaerobic ribonucleotide reductase. Also protects against superoxide radicals due to methyl viologen in the presence of oxygen

Gene Name:

fpr

Uniprot ID:

P28861

Molecular weight:

27751

Reactions

General function:

Involved in catalytic activity

Specific function:

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H(2)O = ribonucleoside triphosphate + thioredoxin

Gene Name:

nrdD

Uniprot ID:

P28903

Molecular weight:

80022

Reactions

General function:

Involved in hydrolase activity

Specific function:

Hydrolyzes O6 atom-containing purine bases deoxyinosine triphosphate (dITP) and xanthosine triphosphate (XTP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) to nucleotide monophosphate and pyrophosphate. Probably excludes non- standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions

Gene Name:

rdgB

Uniprot ID:

P52061

Molecular weight:

21039

Reactions

General function:

Involved in ATP binding

Specific function:

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

Gene Name:

adk

Uniprot ID:

P69441

Molecular weight:

23586

Reactions

General function:

Involved in FMN binding

Specific function:

Low-potential electron donor to a number of redox enzymes (Potential)

Gene Name:

fldB

Uniprot ID:

P0ABY4

Molecular weight:

19700

General function:

Involved in FMN binding

Specific function:

Low-potential electron donor to a number of redox enzymes (Potential). Involved in the reactivation of inactive cob(II)alamin in methionine synthase

Gene Name:

fldA

Uniprot ID:

P61949

Molecular weight:

19737