Thiosulfate (ECMDB00257) (M2MDB000108)

General function:

Involved in pyridoxal phosphate binding

Specific function:

O(4)-succinyl-L-homoserine + L-cysteine = L- cystathionine + succinate

Gene Name:

metB

Uniprot ID:

P00935

Molecular weight:

41550

Reactions

General function:

Involved in thiosulfate sulfurtransferase activity

Specific function:

Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide. The relatively low affinity of glpE for both thiosulfate and cyanide suggests that these compounds are not the physiological substrates. Thioredoxin 1 or related dithiol proteins could instead be the physiological sulfur-acceptor substrate. Possible association with the metabolism of glycerol-phosphate remains to be elucidated

Gene Name:

glpE

Uniprot ID:

P0A6V5

Molecular weight:

12082

Reactions

General function:

Involved in cysteine biosynthetic process from serine

Specific function:

O(3)-acetyl-L-serine + H(2)S = L-cysteine + acetate

Gene Name:

cysK

Uniprot ID:

P0ABK5

Molecular weight:

34489

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system

Gene Name:

cysA

Uniprot ID:

P16676

Molecular weight:

41059

Reactions

General function:

Involved in cysteine biosynthetic process from serine

Specific function:

Two cysteine synthase enzymes are found. Both catalyze the same reaction. Cysteine synthase B can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product

Gene Name:

cysM

Uniprot ID:

P16703

Molecular weight:

32664

Reactions

General function:

Involved in thiosulfate sulfurtransferase activity

Specific function:

Transfers a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity (130-fold lower). Its participation in detoxification of cyanide may be small. May be involved in the enhancement of serine sensitivity

Gene Name:

sseA

Uniprot ID:

P31142

Molecular weight:

30812

Reactions

General function:

Involved in thiosulfate sulfurtransferase activity

Specific function:

Thiosulfate + cyanide = sulfite + thiocyanate

Gene Name:

ynjE

Uniprot ID:

P78067

Molecular weight:

48228

Reactions

General function:

Involved in transporter activity

Specific function:

Part of the ABC transporter complex cysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane

Gene Name:

cysW

Uniprot ID:

P0AEB0

Molecular weight:

32537

General function:

Involved in transporter activity

Specific function:

Part of the ABC transporter complex cysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane

Gene Name:

cysU

Uniprot ID:

P16701

Molecular weight:

30292

General function:

Involved in transporter activity

Specific function:

This protein specifically binds sulfate and is involved in its transmembrane transport

Gene Name:

sbp

Uniprot ID:

P0AG78

Molecular weight:

36659

General function:

Involved in transporter activity

Specific function:

Part of the ABC transporter complex cysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. This protein specifically binds thiosulfate and is involved in its transmembrane transport

Gene Name:

cysP

Uniprot ID:

P16700

Molecular weight:

37614

General function:

Inorganic ion transport and metabolism

Specific function:

The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspE catalyzes the sulfur-transfer reaction from thiosulfate to cyanide, to form sulfite and thiocyanate. Also able to use dithiol (dithiothreitol) as an alternate sulfur acceptor. Also possesses a very low mercaptopyruvate sulfurtransferase activity

Gene Name:

pspE

Uniprot ID:

P23857

Molecular weight:

11475

Reactions