Thiosulfate (ECMDB00257) (M2MDB000108)
Record Information | |||||||||||||||||||||||||||||||||||||||||||||||||
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Version | 2.0 | ||||||||||||||||||||||||||||||||||||||||||||||||
Creation Date | 2012-05-31 10:25:02 -0600 | ||||||||||||||||||||||||||||||||||||||||||||||||
Update Date | 2015-09-17 15:41:02 -0600 | ||||||||||||||||||||||||||||||||||||||||||||||||
Secondary Accession Numbers |
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Identification | |||||||||||||||||||||||||||||||||||||||||||||||||
Name: | Thiosulfate | ||||||||||||||||||||||||||||||||||||||||||||||||
Description | Thiosulfate occurs naturally in hot springs and geysers, and is produced by certain biochemical processes. Thiosulfate is an intermediate in several biochemical pathways, including the synthesis of L-cysteine. Thiosulfate is manufactured by some cells by oxidation of elemental sulfur and by degradation of L-cysteine. | ||||||||||||||||||||||||||||||||||||||||||||||||
Structure | |||||||||||||||||||||||||||||||||||||||||||||||||
Synonyms: |
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Chemical Formula: | O3S2 | ||||||||||||||||||||||||||||||||||||||||||||||||
Weight: | Average: 112.128 Monoisotopic: 111.928885246 | ||||||||||||||||||||||||||||||||||||||||||||||||
InChI Key: | DHCDFWKWKRSZHF-UHFFFAOYSA-L | ||||||||||||||||||||||||||||||||||||||||||||||||
InChI: | InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 | ||||||||||||||||||||||||||||||||||||||||||||||||
CAS number: | 14383-50-7 | ||||||||||||||||||||||||||||||||||||||||||||||||
IUPAC Name: | sulfanesulfonic acid | ||||||||||||||||||||||||||||||||||||||||||||||||
Traditional IUPAC Name: | sulfurothioic S-acid | ||||||||||||||||||||||||||||||||||||||||||||||||
SMILES: | [O-]S([S-])(=O)=O | ||||||||||||||||||||||||||||||||||||||||||||||||
Chemical Taxonomy | |||||||||||||||||||||||||||||||||||||||||||||||||
Description | belongs to the class of inorganic compounds known as non-metal thiosulfates. These are inorganic non-metallic compounds containing a thiosulfate as its largest oxoanion. | ||||||||||||||||||||||||||||||||||||||||||||||||
Kingdom | Inorganic compounds | ||||||||||||||||||||||||||||||||||||||||||||||||
Super Class | Homogeneous non-metal compounds | ||||||||||||||||||||||||||||||||||||||||||||||||
Class | Non-metal oxoanionic compounds | ||||||||||||||||||||||||||||||||||||||||||||||||
Sub Class | Non-metal thiosulfates | ||||||||||||||||||||||||||||||||||||||||||||||||
Direct Parent | Non-metal thiosulfates | ||||||||||||||||||||||||||||||||||||||||||||||||
Alternative Parents | |||||||||||||||||||||||||||||||||||||||||||||||||
Substituents |
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Molecular Framework | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||
External Descriptors |
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Physical Properties | |||||||||||||||||||||||||||||||||||||||||||||||||
State: | Solid | ||||||||||||||||||||||||||||||||||||||||||||||||
Charge: | -1 | ||||||||||||||||||||||||||||||||||||||||||||||||
Melting point: | 48 °C | ||||||||||||||||||||||||||||||||||||||||||||||||
Experimental Properties: |
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Predicted Properties |
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Biological Properties | |||||||||||||||||||||||||||||||||||||||||||||||||
Cellular Locations: | Cytoplasm | ||||||||||||||||||||||||||||||||||||||||||||||||
Reactions: | Adenosine triphosphate + Water + Thiosulfate > ADP + Hydrogen ion + Phosphate + Thiosulfate Adenosine triphosphate + Water + Thiosulfate > ADP + Hydrogen ion + Phosphate + Thiosulfate Hydrogen cyanide + Thiosulfate > Hydrogen ion + Sulfite + Thiocyanate Thiosulfate + Cyanide <> Sulfite + Thiocyanate 3-Mercaptopyruvic acid + Sulfite <> Thiosulfate + Pyruvic acid O-Acetylserine + Thiosulfate <> Cysteine-S-sulfate + Acetic acid O-Acetylserine + Thiosulfate + Thioredoxin + Hydrogen ion <> L-Cysteine + Sulfite + Thioredoxin disulfide + Acetic acid Adenosine triphosphate + Thiosulfate + Water > ADP + Phosphate + Thiosulfate + Hydrogen ion Adenosine triphosphate + Thiosulfate + Water > ADP + Phosphate + Thiosulfate + Hydrogen ion Thiosulfate + Hydrogen cyanide > Sulfite + Thiocyanate Cyanide + Thiosulfate + Cyanide + Thiosulfate > Thiocyanate + Sulfite + Hydrogen ion + Thiocyanate + Sulfite O-Acetylserine + Thiosulfate + Thiosulfate > Cysteine-S-sulfate + Acetic acid Hydrogen cyanide + Thiosulfate > Thiocyanate + Sulfite +2 Hydrogen ion Thiosulfate + Adenosine triphosphate + Water > ADP + Phosphate + Hydrogen ion Thiosulfate + Cyanide <> Sulfite + Thiocyanate Thiosulfate + Cyanide <> Sulfite + Thiocyanate | ||||||||||||||||||||||||||||||||||||||||||||||||
SMPDB Pathways: |
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KEGG Pathways: | |||||||||||||||||||||||||||||||||||||||||||||||||
EcoCyc Pathways: |
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Concentrations | |||||||||||||||||||||||||||||||||||||||||||||||||
Not Available | |||||||||||||||||||||||||||||||||||||||||||||||||
Spectra | |||||||||||||||||||||||||||||||||||||||||||||||||
Spectra: | |||||||||||||||||||||||||||||||||||||||||||||||||
References | |||||||||||||||||||||||||||||||||||||||||||||||||
References: |
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Synthesis Reference: | Serikova, E. A.; Racheva, I. V. Method for producing sodium thiosulfate. U.S.S.R. (1986), CODEN: URXXAF SU 1279954 A1 19861230 Patent written in Russian. | ||||||||||||||||||||||||||||||||||||||||||||||||
Material Safety Data Sheet (MSDS) | Download (PDF) | ||||||||||||||||||||||||||||||||||||||||||||||||
Links | |||||||||||||||||||||||||||||||||||||||||||||||||
External Links: |
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Enzymes
- General function:
- Involved in pyridoxal phosphate binding
- Specific function:
- O(4)-succinyl-L-homoserine + L-cysteine = L- cystathionine + succinate
- Gene Name:
- metB
- Uniprot ID:
- P00935
- Molecular weight:
- 41550
Reactions
O(4)-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate. |
- General function:
- Involved in thiosulfate sulfurtransferase activity
- Specific function:
- Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide. The relatively low affinity of glpE for both thiosulfate and cyanide suggests that these compounds are not the physiological substrates. Thioredoxin 1 or related dithiol proteins could instead be the physiological sulfur-acceptor substrate. Possible association with the metabolism of glycerol-phosphate remains to be elucidated
- Gene Name:
- glpE
- Uniprot ID:
- P0A6V5
- Molecular weight:
- 12082
Reactions
Thiosulfate + cyanide = sulfite + thiocyanate. |
- General function:
- Involved in cysteine biosynthetic process from serine
- Specific function:
- O(3)-acetyl-L-serine + H(2)S = L-cysteine + acetate
- Gene Name:
- cysK
- Uniprot ID:
- P0ABK5
- Molecular weight:
- 34489
Reactions
O(3)-acetyl-L-serine + H(2)S = L-cysteine + acetate. |
3-chloro-L-alanine + thioglycolate = S-carboxymethyl-L-cysteine + chloride. |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system
- Gene Name:
- cysA
- Uniprot ID:
- P16676
- Molecular weight:
- 41059
Reactions
ATP + H(2)O + sulfate(Out) = ADP + phosphate + sulfate(In). |
- General function:
- Involved in cysteine biosynthetic process from serine
- Specific function:
- Two cysteine synthase enzymes are found. Both catalyze the same reaction. Cysteine synthase B can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product
- Gene Name:
- cysM
- Uniprot ID:
- P16703
- Molecular weight:
- 32664
Reactions
O(3)-acetyl-L-serine + H(2)S = L-cysteine + acetate. |
- General function:
- Involved in thiosulfate sulfurtransferase activity
- Specific function:
- Transfers a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity (130-fold lower). Its participation in detoxification of cyanide may be small. May be involved in the enhancement of serine sensitivity
- Gene Name:
- sseA
- Uniprot ID:
- P31142
- Molecular weight:
- 30812
Reactions
3-mercaptopyruvate + cyanide = pyruvate + thiocyanate. |
- General function:
- Involved in thiosulfate sulfurtransferase activity
- Specific function:
- Thiosulfate + cyanide = sulfite + thiocyanate
- Gene Name:
- ynjE
- Uniprot ID:
- P78067
- Molecular weight:
- 48228
Reactions
Thiosulfate + cyanide = sulfite + thiocyanate. |
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex cysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- cysW
- Uniprot ID:
- P0AEB0
- Molecular weight:
- 32537
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex cysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- cysU
- Uniprot ID:
- P16701
- Molecular weight:
- 30292
- General function:
- Involved in transporter activity
- Specific function:
- This protein specifically binds sulfate and is involved in its transmembrane transport
- Gene Name:
- sbp
- Uniprot ID:
- P0AG78
- Molecular weight:
- 36659
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex cysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. This protein specifically binds thiosulfate and is involved in its transmembrane transport
- Gene Name:
- cysP
- Uniprot ID:
- P16700
- Molecular weight:
- 37614
- General function:
- Inorganic ion transport and metabolism
- Specific function:
- The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspE catalyzes the sulfur-transfer reaction from thiosulfate to cyanide, to form sulfite and thiocyanate. Also able to use dithiol (dithiothreitol) as an alternate sulfur acceptor. Also possesses a very low mercaptopyruvate sulfurtransferase activity
- Gene Name:
- pspE
- Uniprot ID:
- P23857
- Molecular weight:
- 11475
Reactions
Thiosulfate + cyanide = sulfite + thiocyanate. |
Transporters
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system
- Gene Name:
- cysA
- Uniprot ID:
- P16676
- Molecular weight:
- 41059
Reactions
ATP + H(2)O + sulfate(Out) = ADP + phosphate + sulfate(In). |
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex cysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- cysW
- Uniprot ID:
- P0AEB0
- Molecular weight:
- 32537
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex cysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- cysU
- Uniprot ID:
- P16701
- Molecular weight:
- 30292
- General function:
- Involved in transporter activity
- Specific function:
- This protein specifically binds sulfate and is involved in its transmembrane transport
- Gene Name:
- sbp
- Uniprot ID:
- P0AG78
- Molecular weight:
- 36659
- General function:
- Involved in transporter activity
- Specific function:
- Non-specific porin
- Gene Name:
- ompN
- Uniprot ID:
- P77747
- Molecular weight:
- 41220
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex cysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. This protein specifically binds thiosulfate and is involved in its transmembrane transport
- Gene Name:
- cysP
- Uniprot ID:
- P16700
- Molecular weight:
- 37614
- General function:
- Involved in transporter activity
- Specific function:
- Uptake of inorganic phosphate, phosphorylated compounds, and some other negatively charged solutes
- Gene Name:
- phoE
- Uniprot ID:
- P02932
- Molecular weight:
- 38922
- General function:
- Involved in transporter activity
- Specific function:
- OmpF is a porin that forms passive diffusion pores which allow small molecular weight hydrophilic materials across the outer membrane. It is also a receptor for the bacteriophage T2
- Gene Name:
- ompF
- Uniprot ID:
- P02931
- Molecular weight:
- 39333
- General function:
- Involved in transporter activity
- Specific function:
- Forms passive diffusion pores which allow small molecular weight hydrophilic materials across the outer membrane
- Gene Name:
- ompC
- Uniprot ID:
- P06996
- Molecular weight:
- 40368
- General function:
- respiratory electron transport chain
- Specific function:
- Not Available
- Gene Name:
- ydhU
- Uniprot ID:
- P77409
- Molecular weight:
- 29582
Reactions
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