Succinic acid (ECMDB00254) (M2MDB000107)

General function:

Involved in electron carrier activity

Specific function:

Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth

Gene Name:

frdA

Uniprot ID:

P00363

Molecular weight:

65971

Reactions

General function:

Involved in pyridoxal phosphate binding

Specific function:

O(4)-succinyl-L-homoserine + L-cysteine = L- cystathionine + succinate

Gene Name:

metB

Uniprot ID:

P00935

Molecular weight:

41550

Reactions

General function:

Involved in electron carrier activity

Specific function:

Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth

Gene Name:

sdhB

Uniprot ID:

P07014

Molecular weight:

26770

Reactions

General function:

Involved in catalytic activity

Specific function:

(S)-dihydroorotate + a quinone = orotate + a quinol

Gene Name:

pyrD

Uniprot ID:

P0A7E1

Molecular weight:

36774

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA

Gene Name:

sucC

Uniprot ID:

P0A836

Molecular weight:

41392

Reactions

General function:

Energy production and conversion

Specific function:

Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane

Gene Name:

frdC

Uniprot ID:

P0A8Q0

Molecular weight:

15015

General function:

Involved in fumarate metabolic process

Specific function:

Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane

Gene Name:

frdD

Uniprot ID:

P0A8Q3

Molecular weight:

13107

General function:

Involved in isocitrate lyase activity

Specific function:

Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway

Gene Name:

aceA

Uniprot ID:

P0A9G6

Molecular weight:

47521

Reactions

General function:

Involved in electron carrier activity

Specific function:

Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth

Gene Name:

sdhA

Uniprot ID:

P0AC41

Molecular weight:

64421

Reactions

General function:

Involved in succinate dehydrogenase activity

Specific function:

Membrane-anchoring subunit of succinate dehydrogenase (SDH)

Gene Name:

sdhD

Uniprot ID:

P0AC44

Molecular weight:

12867

General function:

Involved in electron carrier activity

Specific function:

Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth

Gene Name:

frdB

Uniprot ID:

P0AC47

Molecular weight:

27123

Reactions

General function:

Involved in FMN binding

Specific function:

Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. Does not use oxygen directly. Is coupled to the respiratory chain

Gene Name:

hemG

Uniprot ID:

P0ACB4

Molecular weight:

21226

Reactions

General function:

Involved in metallopeptidase activity

Specific function:

Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls

Gene Name:

dapE

Uniprot ID:

P0AED7

Molecular weight:

41269

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA

Gene Name:

sucD

Uniprot ID:

P0AGE9

Molecular weight:

29777

Reactions

General function:

Involved in electron carrier activity

Specific function:

Catalyzes the oxidation of L-aspartate to iminoaspartate

Gene Name:

nadB

Uniprot ID:

P10902

Molecular weight:

60337

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Succinate semialdehyde + NAD(P)(+) + H(2)O = succinate + NAD(P)H

Gene Name:

gabD

Uniprot ID:

P25526

Molecular weight:

51720

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the conversion of taurine and alpha ketoglutarate to sulfite, aminoacetaldehyde and succinate. Required for the utilization of taurine (2-aminoethanesulfonic acid) as an alternative sulfur source. Pentane-sulfonic acid, 3- (N-morpholino)propanesulfonic acid and 1,3-dioxo-2- isoindolineethanesulfonic acid are also substrates for this enzyme

Gene Name:

tauD

Uniprot ID:

P37610

Molecular weight:

32409

Reactions

General function:

Involved in succinate dehydrogenase activity

Specific function:

Membrane-anchoring subunit of succinate dehydrogenase (SDH)

Gene Name:

sdhC

Uniprot ID:

P69054

Molecular weight:

14299

General function:

Involved in hydrolase activity, acting on ester bonds

Specific function:

Transforms N(2)-succinylglutamate into succinate and glutamate

Gene Name:

astE

Uniprot ID:

P76215

Molecular weight:

35800

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the cleavage of the C5-C6 bond of 2-hydroxy-6- oxononadienedioate and 2-hydroxy-6-oxononatrienedioate, a dienol ring fission product of the bacterial meta-cleavage pathway for degradation of phenylpropionic acid

Gene Name:

mhpC

Uniprot ID:

P77044

Molecular weight:

32585

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the formation of pyruvate and succinate from 2-methylisocitrate

Gene Name:

prpB

Uniprot ID:

P77541

Molecular weight:

32134

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Specific function unknown

Gene Name:

yneI

Uniprot ID:

P76149

Molecular weight:

49717

Reactions

General function:

Involved in catalytic activity

Specific function:

Specific function unknown

Gene Name:

ygfH

Uniprot ID:

P52043

Molecular weight:

53824

Reactions

General function:

Not Available

Specific function:

Dioxygenase that repairs alkylated DNA and RNA containing 3-methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents), but not to MMNG and MNU (SN1 agents). Dioxygenase that repairs alkylated DNA and RNA containing 3-methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents), but not to MMNG and MNU (SN1 agents).

Gene Name:

alkB

Uniprot ID:

P05050

Molecular weight:

Not Available

Reactions