Pyruvic acid (ECMDB00243) (M2MDB000102)

General function:

Involved in transporter activity

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in mannitol transport

Gene Name:

mtlA

Uniprot ID:

P00550

Molecular weight:

67972

Reactions

General function:

Involved in magnesium ion binding

Specific function:

2 pyruvate = 2-acetolactate + CO(2)

Gene Name:

ilvI

Uniprot ID:

P00893

Molecular weight:

62984

Reactions

General function:

Involved in acetolactate synthase activity

Specific function:

2 pyruvate = 2-acetolactate + CO(2)

Gene Name:

ilvH

Uniprot ID:

P00894

Molecular weight:

17977

Reactions

General function:

Involved in biosynthetic process

Specific function:

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate

Gene Name:

trpE

Uniprot ID:

P00895

Molecular weight:

57494

Reactions

General function:

Involved in anthranilate phosphoribosyltransferase activity

Specific function:

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate

Gene Name:

trpD

Uniprot ID:

P00904

Molecular weight:

56869

Reactions

General function:

Involved in D-serine ammonia-lyase activity

Specific function:

D-serine = pyruvate + NH(3)

Gene Name:

dsdA

Uniprot ID:

P00926

Molecular weight:

47900

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia. Deaminates L-threonine, but also L-serine to a lesser extent

Gene Name:

ilvA

Uniprot ID:

P04968

Molecular weight:

56195

Reactions

General function:

Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucitol/sorbitol transport

Gene Name:

srlB

Uniprot ID:

P05706

Molecular weight:

13304

Reactions

General function:

Involved in flavin adenine dinucleotide binding

Specific function:

First component of the membrane-bound D-lactate oxidase, which is believed to play an important role in the energization of the active transport of a variety of sugars and amino acids

Gene Name:

dld

Uniprot ID:

P06149

Molecular weight:

64612

Reactions

General function:

Involved in pyridoxal phosphate binding

Specific function:

L-cystathionine + H(2)O = L-homocysteine + NH(3) + pyruvate

Gene Name:

metC

Uniprot ID:

P06721

Molecular weight:

43212

Reactions

General function:

Involved in transferase activity, transferring acyl groups

Specific function:

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)

Gene Name:

aceF

Uniprot ID:

P06959

Molecular weight:

66096

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Pyruvate + ferricytochrome b1 + H(2)O = acetate + CO(2) + ferrocytochrome b1

Gene Name:

poxB

Uniprot ID:

P07003

Molecular weight:

62011

Reactions

General function:

Involved in magnesium ion binding

Specific function:

2 pyruvate = 2-acetolactate + CO(2)

Gene Name:

ilvB

Uniprot ID:

P08142

Molecular weight:

60440

Reactions

General function:

Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

Specific function:

Acts as both a kinase and a phosphatase on BglG

Gene Name:

bglF

Uniprot ID:

P08722

Molecular weight:

66482

Reactions

General function:

Involved in transferase activity, transferring phosphorus-containing groups

Specific function:

General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)

Gene Name:

ptsI

Uniprot ID:

P08839

Molecular weight:

63561

Reactions

General function:

Involved in transferase activity

Specific function:

L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine

Gene Name:

avtA

Uniprot ID:

P09053

Molecular weight:

46711

Reactions

General function:

Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylglucosamine transport

Gene Name:

nagE

Uniprot ID:

P09323

Molecular weight:

68346

Reactions

General function:

Involved in formate C-acetyltransferase activity

Specific function:

Acetyl-CoA + formate = CoA + pyruvate

Gene Name:

pflB

Uniprot ID:

P09373

Molecular weight:

85357

Reactions

General function:

Involved in D-amino-acid dehydrogenase activity

Specific function:

Oxidative deamination of D-amino acids

Gene Name:

dadA

Uniprot ID:

P0A6J5

Molecular weight:

47607

Reactions

General function:

Involved in catalytic activity

Specific function:

L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H(2)O

Gene Name:

dapA

Uniprot ID:

P0A6L2

Molecular weight:

31270

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate

Gene Name:

nanA

Uniprot ID:

P0A6L4

Molecular weight:

32593

Reactions

General function:

Involved in catalytic activity

Specific function:

Interconversion of serine and glycine

Gene Name:

glyA

Uniprot ID:

P0A825

Molecular weight:

45316

Reactions

General function:

Involved in lyase activity

Specific function:

L-tryptophan + H(2)O = indole + pyruvate + NH(3)

Gene Name:

tnaA

Uniprot ID:

P0A853

Molecular weight:

52773

Reactions

General function:

Involved in catalytic activity

Specific function:

4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate

Gene Name:

eda

Uniprot ID:

P0A955

Molecular weight:

22284

Reactions

General function:

Involved in catalytic activity

Specific function:

Activation of pyruvate formate-lyase 1 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine

Gene Name:

pflA

Uniprot ID:

P0A9N4

Molecular weight:

28204

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes

Gene Name:

lpdA

Uniprot ID:

P0A9P0

Molecular weight:

50688

Reactions

General function:

Involved in 3-hydroxyisobutyrate dehydrogenase activity

Specific function:

(R)-glycerate + NAD(P)(+) = 2-hydroxy-3- oxopropanoate + NAD(P)H

Gene Name:

garR

Uniprot ID:

P0ABQ2

Molecular weight:

30427

Reactions

General function:

Involved in magnesium ion binding

Specific function:

ATP + pyruvate = ADP + phosphoenolpyruvate

Gene Name:

pykF

Uniprot ID:

P0AD61

Molecular weight:

50729

Reactions

General function:

Involved in amino acid binding

Specific function:

2 pyruvate = 2-acetolactate + CO(2)

Gene Name:

ilvN

Uniprot ID:

P0ADF8

Molecular weight:

11106

Reactions

General function:

Involved in acetolactate synthase activity

Specific function:

2 pyruvate = 2-acetolactate + CO(2)

Gene Name:

ilvM

Uniprot ID:

P0ADG1

Molecular weight:

9703

Reactions

General function:

Involved in isochorismatase activity

Specific function:

Required for production of 2,3-DHB. Also serves as an aryl carrier protein and plays a role in enterobactin assembly

Gene Name:

entB

Uniprot ID:

P0ADI4

Molecular weight:

32554

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)

Gene Name:

aceE

Uniprot ID:

P0AFG8

Molecular weight:

99668

Reactions

General function:

Involved in catalytic activity

Specific function:

Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase

Gene Name:

tdcB

Uniprot ID:

P0AGF6

Molecular weight:

35232

Reactions

General function:

Involved in L-serine ammonia-lyase activity

Specific function:

Deaminates also threonine, particularly when it is present in high concentration

Gene Name:

sdaA

Uniprot ID:

P16095

Molecular weight:

48906

Reactions

General function:

Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

Specific function:

MalX encodes a phosphotransferase system enzyme II that can recognize glucose and maltose as substrates even though these sugars may not represent the natural substrates of the system

Gene Name:

malX

Uniprot ID:

P19642

Molecular weight:

56627

Reactions

General function:

Involved in sugar:hydrogen symporter activity

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in fructose transport

Gene Name:

fruA

Uniprot ID:

P20966

Molecular weight:

57519

Reactions

General function:

Involved in magnesium ion binding

Specific function:

ATP + pyruvate = ADP + phosphoenolpyruvate

Gene Name:

pykA

Uniprot ID:

P21599

Molecular weight:

51357

Reactions

General function:

Involved in transferase activity

Specific function:

Acts as a beta-cystathionase and as a repressor of the maltose regulon

Gene Name:

malY

Uniprot ID:

P23256

Molecular weight:

43641

Reactions

General function:

Involved in carbon-carbon lyase activity

Specific function:

Catalyzes the reversible retro-aldol cleavage of both 5- keto-4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde

Gene Name:

garL

Uniprot ID:

P23522

Molecular weight:

27384

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate

Gene Name:

ppsA

Uniprot ID:

P23538

Molecular weight:

87434

Reactions

General function:

Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in arbutin, cellobiose, and salicin transport

Gene Name:

ascF

Uniprot ID:

P24241

Molecular weight:

51025

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Acts on lactaldehyde as well as other aldehydes

Gene Name:

aldA

Uniprot ID:

P25553

Molecular weight:

52272

Reactions

General function:

Involved in chorismate lyase activity

Specific function:

Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway

Gene Name:

ubiC

Uniprot ID:

P26602

Molecular weight:

18777

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

(S)-malate + NAD(+) = pyruvate + CO(2) + NADH

Gene Name:

sfcA

Uniprot ID:

P26616

Molecular weight:

63197

Reactions

General function:

Involved in 4-amino-4-deoxychorismate lyase activity

Specific function:

Converts 4-amino-4-deoxychorismate into 4-aminobenzoate (PABA) and pyruvate

Gene Name:

pabC

Uniprot ID:

P28305

Molecular weight:

29715

Reactions

General function:

Involved in L-serine ammonia-lyase activity

Specific function:

Deaminates also threonine, particularly when it is present in high concentration

Gene Name:

sdaB

Uniprot ID:

P30744

Molecular weight:

48753

Reactions

General function:

Involved in thiosulfate sulfurtransferase activity

Specific function:

Transfers a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity (130-fold lower). Its participation in detoxification of cyanide may be small. May be involved in the enhancement of serine sensitivity

Gene Name:

sseA

Uniprot ID:

P31142

Molecular weight:

30812

Reactions

General function:

Involved in transferase activity, transferring phosphorus-containing groups

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane

Gene Name:

ptsA

Uniprot ID:

P32670

Molecular weight:

91773

Reactions

General function:

Involved in catalytic activity

Specific function:

Acetyl-CoA + formate = CoA + pyruvate

Gene Name:

pflD

Uniprot ID:

P32674

Molecular weight:

85959

Reactions

General function:

Involved in iron-sulfur cluster binding

Specific function:

Activation of pyruvate formate-lyase 2 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine

Gene Name:

pflC

Uniprot ID:

P32675

Molecular weight:

32429

Reactions

General function:

Involved in catalytic activity

Specific function:

(S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H(+)

Gene Name:

lldD

Uniprot ID:

P33232

Molecular weight:

42728

Reactions

General function:

Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in trehalose transport

Gene Name:

treB

Uniprot ID:

P36672

Molecular weight:

51080

Reactions

General function:

Involved in protein binding

Specific function:

Component of the phosphoenolpyruvate-dependent nitrogen- metabolic phosphotransferase system (nitrogen-metabolic PTS), that seems to be involved in regulating nitrogen metabolism. Enzyme I- Ntr transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (NPr). Could function in the transcriptional regulation of sigma-54 dependent operons in conjunction with the NPr (ptsO) and EIIA-Ntr (ptsN) proteins

Gene Name:

ptsP

Uniprot ID:

P37177

Molecular weight:

83715

Reactions

General function:

Involved in sugar:hydrogen symporter activity

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in galactitol transport

Gene Name:

gatB

Uniprot ID:

P37188

Molecular weight:

10222

Reactions

General function:

Involved in 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity

Specific function:

Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro

Gene Name:

menH

Uniprot ID:

P37355

Molecular weight:

27682

Reactions

General function:

Involved in catalytic activity

Specific function:

Specific function unknown

Gene Name:

yjhH

Uniprot ID:

P39359

Molecular weight:

32721

General function:

Involved in L-serine ammonia-lyase activity

Specific function:

L-serine = pyruvate + NH(3)

Gene Name:

tdcG

Uniprot ID:

P42630

Molecular weight:

48521

Reactions

General function:

Involved in formate C-acetyltransferase activity

Specific function:

Specific function unknown

Gene Name:

tdcE

Uniprot ID:

P42632

Molecular weight:

85935

Reactions

General function:

Involved in 4-hydroxy-2-oxovalerate aldolase activity

Specific function:

Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of 3-phenylpropanoate

Gene Name:

mhpE

Uniprot ID:

P51020

Molecular weight:

36470

Reactions

General function:

Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Specific function:

Fermentative lactate dehydrogenase

Gene Name:

ldhA

Uniprot ID:

P52643

Molecular weight:

36535

Reactions

General function:

Involved in electron carrier activity

Specific function:

Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (Potential)

Gene Name:

ydbK

Uniprot ID:

P52647

Molecular weight:

128823

Reactions

General function:

Involved in transporter activity

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane

Gene Name:

hrsA

Uniprot ID:

P54745

Molecular weight:

69667

Reactions

General function:

Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucitol/sorbitol transport

Gene Name:

srlE

Uniprot ID:

P56580

Molecular weight:

33332

Reactions

General function:

Involved in diaminopropionate ammonia-lyase activity

Specific function:

Catalyzes the alpha,beta-elimination reaction of both L- and D-alpha,beta-diaminopropionate, the most suitable substrates to form pyruvate and ammonia. The L- and D-isomers of serine are also degraded, though slowly; it is the only serine dehydratase which can eliminate an amino group at the beta-carbon position

Gene Name:

ygeX

Uniprot ID:

P66899

Molecular weight:

43327

Reactions

General function:

Involved in sugar:hydrogen symporter activity

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport

Gene Name:

crr

Uniprot ID:

P69783

Molecular weight:

18251

Reactions

General function:

Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport. This enzyme is also a chemoreceptor monitoring the environment for changes in sugar concentration

Gene Name:

ptsG

Uniprot ID:

P69786

Molecular weight:

50676

Reactions

General function:

Involved in phosphoenolpyruvate-dependent sugar phosphotransferase system

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in mannose transport

Gene Name:

manX

Uniprot ID:

P69797

Molecular weight:

35047

Reactions

General function:

Involved in transporter activity

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in fructose transport

Gene Name:

fruB

Uniprot ID:

P69811

Molecular weight:

39647

Reactions

General function:

Involved in transporter activity

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport

Gene Name:

ulaC

Uniprot ID:

P69820

Molecular weight:

17237

Reactions

General function:

Involved in sugar:hydrogen symporter activity

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport

Gene Name:

ulaB

Uniprot ID:

P69822

Molecular weight:

10896

Reactions

General function:

Involved in transporter activity

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in galactitol transport

Gene Name:

gatA

Uniprot ID:

P69828

Molecular weight:

16907

Reactions

General function:

Involved in catalytic activity

Specific function:

Unknown Function

Gene Name:

yagE

Uniprot ID:

P75682

Molecular weight:

33316

General function:

Involved in catalytic activity

Specific function:

Acetyl-CoA + formate = CoA + pyruvate

Gene Name:

ybiW

Uniprot ID:

P75793

Molecular weight:

90125

Reactions

General function:

Involved in lyase activity

Specific function:

Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. L-threo-phenylserine and L- erythro-phenylserine are also good substrates

Gene Name:

ltaE

Uniprot ID:

P75823

Molecular weight:

36494

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Catalyzes the NAD(+)-dependent oxidative decarboxylation of D-malate into pyruvate. Is essential for aerobic growth on D- malate as the sole carbon source. But is not required for anaerobic D-malate utilization, although DmlA is expressed and active in those conditions. Appears to be not able to use L- tartrate as a substrate for dehydrogenation instead of D-malate

Gene Name:

dmlA

Uniprot ID:

P76251

Molecular weight:

40315

Reactions

General function:

Involved in D-cysteine desulfhydrase activity

Specific function:

Catalyzes the alpha,beta-elimination reaction of D- cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine. Can also catalyze the degradation of 3-chloro-D-alanine

Gene Name:

dcyD

Uniprot ID:

P76316

Molecular weight:

35153

Reactions

General function:

Involved in carbon-carbon lyase activity

Specific function:

Catalyzes the reversible retro-aldol cleavage of 2-keto- 3-deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde. 2-keto-3- deoxy-L-mannonate, 2-keto-3-deoxy-L-lyxonate and 4-hydroxy-2- ketoheptane-1,7-dioate (HKHD) are also reasonably good substrates, although 2-keto-3-deoxy-L-rhamnonate is likely to be the physiological substrate

Gene Name:

rhmA

Uniprot ID:

P76469

Molecular weight:

28916

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

(S)-malate + NADP(+) = pyruvate + CO(2) + NADPH

Gene Name:

maeB

Uniprot ID:

P76558

Molecular weight:

82417

Reactions

General function:

Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is responsible for growth on MurNAc as the sole source of carbon and energy. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6- anhydro ring

Gene Name:

murP

Uniprot ID:

P77272

Molecular weight:

49801

Reactions

General function:

Involved in transferase activity, transferring phosphorus-containing groups

Specific function:

Multifunctional protein that includes general (non sugar-specific) and sugar-specific components of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). HPr transfers the phosphoryl group to the phosphoryl carrier EIIA, which then transfers it to EIIB

Gene Name:

fryA

Uniprot ID:

P77439

Molecular weight:

92129

Reactions

General function:

Involved in metabolic process

Specific function:

Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L-selenocysteine. Selenocysteine lyase activity is however unsure in vivo

Gene Name:

sufS

Uniprot ID:

P77444

Molecular weight:

44433

Reactions

General function:

Involved in 1-deoxy-D-xylulose-5-phosphate synthase activity

Specific function:

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

Gene Name:

dxs

Uniprot ID:

P77488

Molecular weight:

67616

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the formation of pyruvate and succinate from 2-methylisocitrate

Gene Name:

prpB

Uniprot ID:

P77541

Molecular weight:

32134

Reactions

General function:

Involved in thiosulfate sulfurtransferase activity

Specific function:

Thiosulfate + cyanide = sulfite + thiocyanate

Gene Name:

ynjE

Uniprot ID:

P78067

Molecular weight:

48228

Reactions

General function:

Involved in catalytic activity

Specific function:

2-dehydro-3-deoxy-D-galactonate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate

Gene Name:

dgoA

Uniprot ID:

Q6BF16

Molecular weight:

21390

Reactions

General function:

Involved in phosphoenolpyruvate-dependent sugar phosphotransferase system

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active- transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in ascorbate transport

Gene Name:

ulaA

Uniprot ID:

P39301

Molecular weight:

50737

General function:

Involved in phosphoenolpyruvate-dependent sugar phosphotransferase system

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in glucitol/sorbitol transport

Gene Name:

srlA

Uniprot ID:

P56579

Molecular weight:

20580

General function:

Involved in phosphoenolpyruvate-dependent sugar phosphotransferase system

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in mannose transport

Gene Name:

manY

Uniprot ID:

P69801

Molecular weight:

27636

General function:

Involved in phosphoenolpyruvate-dependent sugar phosphotransferase system

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in mannose transport

Gene Name:

manZ

Uniprot ID:

P69805

Molecular weight:

31303

General function:

Involved in phosphoenolpyruvate-dependent sugar phosphotransferase system

Specific function:

The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in galactitol transport

Gene Name:

gatC

Uniprot ID:

P69831

Molecular weight:

48365

General function:

Energy production and conversion

Specific function:

Specific function unknown

Gene Name:

ykgE

Uniprot ID:

P77252

Molecular weight:

26004

General function:

Involved in 1-aminocyclopropane-1-carboxylate synthase activity

Specific function:

Specific function unknown

Gene Name:

yfbQ

Uniprot ID:

P0A959

Molecular weight:

45517

Reactions

General function:

Involved in FMN binding

Specific function:

Low-potential electron donor to a number of redox enzymes (Potential)

Gene Name:

fldB

Uniprot ID:

P0ABY4

Molecular weight:

19700

General function:

Involved in FMN binding

Specific function:

Low-potential electron donor to a number of redox enzymes (Potential). Involved in the reactivation of inactive cob(II)alamin in methionine synthase

Gene Name:

fldA

Uniprot ID:

P61949

Molecular weight:

19737

General function:

Involved in glycerone kinase activity

Specific function:

Dihydroxyacetone binding subunit of the dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone. Binds covalently dihydroxyacetone in hemiaminal linkage. Acts also as a corepressor of dhaR by binding to its sensor domain, in the absence of dihydroxyacetone

Gene Name:

dhaK

Uniprot ID:

P76015

Molecular weight:

38215

General function:

Unknown function

Specific function:

Specific function unknown

Gene Name:

ykgG

Uniprot ID:

P77433

Molecular weight:

25212

General function:

Involved in lactate oxidation

Specific function:

Specific function unknown

Gene Name:

ykgF

Uniprot ID:

P77536

Molecular weight:

53052

General function:

Involved in glycerone kinase activity

Specific function:

ADP-binding subunit of the dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone. DhaL- ADP receives a phosphoryl group from dhaM and transmits it to dihydroxyacetone. DhaL-ADP acts also as a coactivator by binding to the sensor domain of dhaR. DhaL-ATP is inactive

Gene Name:

dhaL

Uniprot ID:

P76014

Molecular weight:

22632

General function:

Involved in transferase activity, transferring phosphorus-containing groups

Specific function:

Phosphotransferase subunit of the dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone. DhaM serves as the phosphoryl donor. It is phosphorylated by HPr, then it donates its phosphoryl group to dhaL-ADP, which eventually transmits it to dihydroxyacetone

Gene Name:

dhaM

Uniprot ID:

P37349

Molecular weight:

51448

Reactions

General function:

Involved in sugar:hydrogen symporter activity

Specific function:

General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the permease (enzymes II/III)

Gene Name:

ptsH

Uniprot ID:

P0AA04

Molecular weight:

9119

Reactions

General function:

Involved in catalytic activity

Specific function:

Acts as a radical domain for damaged PFL and possibly other radical proteins

Gene Name:

grcA

Uniprot ID:

P68066

Molecular weight:

14284

General function:

Amino acid transport and metabolism

Specific function:

Specific function unknown

Gene Name:

yfdZ

Uniprot ID:

P77434

Molecular weight:

46216

Reactions