Sulfite (ECMDB00240) (M2MDB000100)

General function:

Involved in thiosulfate sulfurtransferase activity

Specific function:

Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide. The relatively low affinity of glpE for both thiosulfate and cyanide suggests that these compounds are not the physiological substrates. Thioredoxin 1 or related dithiol proteins could instead be the physiological sulfur-acceptor substrate. Possible association with the metabolism of glycerol-phosphate remains to be elucidated

Gene Name:

glpE

Uniprot ID:

P0A6V5

Molecular weight:

12082

Reactions

General function:

Involved in cysteine biosynthetic process from serine

Specific function:

O(3)-acetyl-L-serine + H(2)S = L-cysteine + acetate

Gene Name:

cysK

Uniprot ID:

P0ABK5

Molecular weight:

34489

Reactions

General function:

Involved in electron carrier activity

Specific function:

Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin

Gene Name:

trxC

Uniprot ID:

P0AGG4

Molecular weight:

15555

Reactions

General function:

Involved in cysteine biosynthetic process from serine

Specific function:

Two cysteine synthase enzymes are found. Both catalyze the same reaction. Cysteine synthase B can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product

Gene Name:

cysM

Uniprot ID:

P16703

Molecular weight:

32664

Reactions

General function:

Involved in sulfite reductase (NADPH) activity

Specific function:

Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate

Gene Name:

cysI

Uniprot ID:

P17846

Molecular weight:

63998

Reactions

General function:

Involved in phosphoadenylyl-sulfate reductase (thioredoxin) activity

Specific function:

Reduction of activated sulfate into sulfite

Gene Name:

cysH

Uniprot ID:

P17854

Molecular weight:

27976

Reactions

General function:

Involved in thiosulfate sulfurtransferase activity

Specific function:

Transfers a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity (130-fold lower). Its participation in detoxification of cyanide may be small. May be involved in the enhancement of serine sensitivity

Gene Name:

sseA

Uniprot ID:

P31142

Molecular weight:

30812

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the conversion of taurine and alpha ketoglutarate to sulfite, aminoacetaldehyde and succinate. Required for the utilization of taurine (2-aminoethanesulfonic acid) as an alternative sulfur source. Pentane-sulfonic acid, 3- (N-morpholino)propanesulfonic acid and 1,3-dioxo-2- isoindolineethanesulfonic acid are also substrates for this enzyme

Gene Name:

tauD

Uniprot ID:

P37610

Molecular weight:

32409

Reactions

General function:

Involved in sulfite reductase (NADPH) activity

Specific function:

Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component

Gene Name:

cysJ

Uniprot ID:

P38038

Molecular weight:

66269

Reactions

General function:

Involved in thiosulfate sulfurtransferase activity

Specific function:

Thiosulfate + cyanide = sulfite + thiocyanate

Gene Name:

ynjE

Uniprot ID:

P78067

Molecular weight:

48228

Reactions

General function:

Involved in FMN reductase activity

Specific function:

Catalyzes an NAD(P)H-dependent reduction of FMN, but is also able to reduce FAD or riboflavin

Gene Name:

ssuE

Uniprot ID:

P80644

Molecular weight:

21253

Reactions

General function:

Involved in alkanesulfonate monooxygenase activity

Specific function:

Involved in desulfonation of aliphatic sulfonates. Catalyzes the conversion of pentanesulfonic acid to sulfite and pentaldehyde and is able to desulfonate a wide range of sulfonated substrates including C-2 to C-10 unsubstituted linear alkanesulfonates, substituted ethanesulfonic acids and sulfonated buffers

Gene Name:

ssuD

Uniprot ID:

P80645

Molecular weight:

41736

Reactions

General function:

Involved in transporter activity

Specific function:

Part of a binding-protein-dependent transport system for aliphatic sulfonates. Probably responsible for the translocation of the substrate across the membrane

Gene Name:

ssuC

Uniprot ID:

P75851

Molecular weight:

28925

General function:

Involved in electron carrier activity

Specific function:

Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (Probable)

Gene Name:

grxD

Uniprot ID:

P0AC69

Molecular weight:

12879

General function:

Inorganic ion transport and metabolism

Specific function:

The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspE catalyzes the sulfur-transfer reaction from thiosulfate to cyanide, to form sulfite and thiocyanate. Also able to use dithiol (dithiothreitol) as an alternate sulfur acceptor. Also possesses a very low mercaptopyruvate sulfurtransferase activity

Gene Name:

pspE

Uniprot ID:

P23857

Molecular weight:

11475

Reactions

General function:

Involved in electron carrier activity

Specific function:

The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione reductase

Gene Name:

grxC

Uniprot ID:

P0AC62

Molecular weight:

9137

General function:

Involved in protein binding

Specific function:

Involved in reducing some disulfides in a coupled system with glutathione reductase. Does not act as hydrogen donor for ribonucleotide reductase

Gene Name:

grxB

Uniprot ID:

P0AC59

Molecular weight:

24350

General function:

Involved in electron carrier activity

Specific function:

The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione reductase

Gene Name:

grxA

Uniprot ID:

P68688

Molecular weight:

9685

General function:

Involved in electron carrier activity

Specific function:

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions

Gene Name:

trxA

Uniprot ID:

P0AA25

Molecular weight:

11807