Inosine (ECMDB00195) (M2MDB000082)

General function:

Involved in hydrolase activity

Specific function:

Degradation of external UDP-glucose to uridine monophosphate and glucose-1-phosphate, which can then be used by the cell

Gene Name:

ushA

Uniprot ID:

P07024

Molecular weight:

60824

Reactions

General function:

Involved in hydrolase activity

Specific function:

Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'- monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain- length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. Also plays a significant physiological role in stress-response and is required for the survival of E.coli in stationary growth phase

Gene Name:

surE

Uniprot ID:

P0A840

Molecular weight:

26900

Reactions

General function:

Involved in catalytic activity

Specific function:

Nucleotidase that shows high phosphatase activity toward three nucleoside 5'-monophosphates, UMP, dUMP, and dTMP, and very low activity against TDP, IMP, UDP, GMP, dGMP, AMP, dAMP, and 6- phosphogluconate. Is strictly specific to substrates with 5'- phosphates and shows no activity against nucleoside 2'- or 3'- monophosphates. Might be involved in the pyrimidine nucleotide substrate cycles

Gene Name:

yjjG

Uniprot ID:

P0A8Y1

Molecular weight:

25300

Reactions

General function:

Involved in purine-nucleoside phosphorylase activity

Specific function:

Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules

Gene Name:

deoD

Uniprot ID:

P0ABP8

Molecular weight:

25950

Reactions

General function:

Involved in acid phosphatase activity

Specific function:

Dephosphorylates several organic phosphomonoesters and catalyzes the transfer of low-energy phosphate groups from phosphomonoesters to hydroxyl groups of various organic compounds. Preferentially acts on aryl phosphoesters. Might function as a broad-spectrum dephosphorylating enzyme able to scavenge both 3'- and 5'-nucleotides and also additional organic phosphomonoesters

Gene Name:

aphA

Uniprot ID:

P0AE22

Molecular weight:

26103

Reactions

General function:

Involved in phosphotransferase activity, alcohol group as acceptor

Specific function:

ATP + inosine = ADP + IMP

Gene Name:

gsk

Uniprot ID:

P0AEW6

Molecular weight:

48448

Reactions

General function:

Involved in deaminase activity

Specific function:

Adenosine + H(2)O = inosine + NH(3)

Gene Name:

add

Uniprot ID:

P22333

Molecular weight:

36397

Reactions

General function:

Involved in hydrolase activity, hydrolyzing N-glycosyl compounds

Specific function:

Hydrolyzes both purine and pyrimidine ribonucleosides with a broad-substrate specificity with decreasing activity in the order uridine, xanthosine, inosine, adenosine, cytidine, guanosine

Gene Name:

rihC

Uniprot ID:

P22564

Molecular weight:

32560

General function:

Involved in hydrolase activity, hydrolyzing N-glycosyl compounds

Specific function:

Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively. Has a clear preference for cytidine over uridine. Strictly specific for ribonucleosides. Has a low but significant activity for the purine nucleoside xanthosine

Gene Name:

rihB

Uniprot ID:

P33022

Molecular weight:

33748

Reactions

General function:

Involved in catalytic activity

Specific function:

Nucleotidase that shows strict specificity toward deoxyribonucleoside 5'-monophosphates and does not dephosphorylate 5'-ribonucleotides or ribonucleoside 3'-monophosphates. Might be involved in the regulation of all dNTP pools in E.coli

Gene Name:

yfbR

Uniprot ID:

P76491

Molecular weight:

22708

Reactions

General function:

Involved in purine-nucleoside phosphorylase activity

Specific function:

The nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the nucleoside molecule, with the formation of the corresponding free bases and pentose-1-phosphate. This protein can degrade all purine nucleosides except adenosine and deoxyadenosine

Gene Name:

xapA

Uniprot ID:

P45563

Molecular weight:

29834

General function:

Energy production and conversion

Specific function:

Deaminates adenosine-34 to inosine in tRNA-Arg2. Mutation in this protein makes E.coli resistant to the toxic proteins encoded by the gef gene family. Essential for cell viability

Gene Name:

tadA

Uniprot ID:

P68398

Molecular weight:

18717

Reactions