Hypoxanthine (ECMDB00157) (M2MDB000059)

General function:

Involved in hypoxanthine phosphoribosyltransferase activity

Specific function:

This enzyme acts exclusively on hypoxanthine; it does not act on guanine

Gene Name:

hpt

Uniprot ID:

P0A9M2

Molecular weight:

20115

Reactions

General function:

Involved in nucleoside metabolic process

Specific function:

Acts on guanine, xanthine and to a lesser extent hypoxanthine

Gene Name:

gpt

Uniprot ID:

P0A9M5

Molecular weight:

16971

Reactions

General function:

Involved in purine-nucleoside phosphorylase activity

Specific function:

Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules

Gene Name:

deoD

Uniprot ID:

P0ABP8

Molecular weight:

25950

Reactions

General function:

Involved in hydrolase activity, hydrolyzing N-glycosyl compounds

Specific function:

Hydrolyzes both purine and pyrimidine ribonucleosides with a broad-substrate specificity with decreasing activity in the order uridine, xanthosine, inosine, adenosine, cytidine, guanosine

Gene Name:

rihC

Uniprot ID:

P22564

Molecular weight:

32560

General function:

Involved in adenine deaminase activity

Specific function:

Adenine + H(2)O = hypoxanthine + NH(3)

Gene Name:

ade

Uniprot ID:

P31441

Molecular weight:

63739

Reactions

General function:

Involved in hydrolase activity, hydrolyzing N-glycosyl compounds

Specific function:

Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively. Has a clear preference for cytidine over uridine. Strictly specific for ribonucleosides. Has a low but significant activity for the purine nucleoside xanthosine

Gene Name:

rihB

Uniprot ID:

P33022

Molecular weight:

33748

Reactions

General function:

Involved in flavin adenine dinucleotide binding

Specific function:

Xanthine + NAD(+) + H(2)O = urate + NADH

Gene Name:

yagS

Uniprot ID:

P77324

Molecular weight:

33858

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Xanthine + NAD(+) + H(2)O = urate + NADH

Gene Name:

yagR

Uniprot ID:

P77489

Molecular weight:

78088

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism). Deletion results in increased adenine sensitivity, suggesting that this protein contributes to the conversion of adenine to guanine nucleotides during purine salvage

Gene Name:

xdhA

Uniprot ID:

Q46799

Molecular weight:

81320

Reactions

General function:

Involved in flavin adenine dinucleotide binding

Specific function:

Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism)

Gene Name:

xdhB

Uniprot ID:

Q46800

Molecular weight:

31557

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Iron-sulfur subunit of the xanthine dehydrogenase complex

Gene Name:

xdhC

Uniprot ID:

Q46801

Molecular weight:

16922

General function:

Involved in purine-nucleoside phosphorylase activity

Specific function:

The nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the nucleoside molecule, with the formation of the corresponding free bases and pentose-1-phosphate. This protein can degrade all purine nucleosides except adenosine and deoxyadenosine

Gene Name:

xapA

Uniprot ID:

P45563

Molecular weight:

29834

General function:

Not Available

Specific function:

Not Available

Gene Name:

paoA

Uniprot ID:

P77165

Molecular weight:

Not Available