L-Glutamate (ECMDB00148) (M2MDB000055)

General function:

Involved in oxidoreductase activity

Specific function:

L-glutamate + H(2)O + NADP(+) = 2-oxoglutarate + NH(3) + NADPH

Gene Name:

gdhA

Uniprot ID:

P00370

Molecular weight:

48581

Reactions

General function:

Involved in transferase activity

Specific function:

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

Gene Name:

aspC

Uniprot ID:

P00509

Molecular weight:

43573

Reactions

General function:

Involved in asparaginase activity

Specific function:

L-asparagine + H(2)O = L-aspartate + NH(3)

Gene Name:

ansB

Uniprot ID:

P00805

Molecular weight:

36851

Reactions

General function:

Involved in biosynthetic process

Specific function:

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate

Gene Name:

trpE

Uniprot ID:

P00895

Molecular weight:

57494

Reactions

General function:

Involved in metabolic process

Specific function:

Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine

Gene Name:

pabA

Uniprot ID:

P00903

Molecular weight:

20772

Reactions

General function:

Involved in anthranilate phosphoribosyltransferase activity

Specific function:

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate

Gene Name:

trpD

Uniprot ID:

P00904

Molecular weight:

56869

Reactions

General function:

Involved in ATP binding

Specific function:

2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate

Gene Name:

carB

Uniprot ID:

P00968

Molecular weight:

117841

Reactions

General function:

Involved in GMP synthase (glutamine-hydrolyzing) activity

Specific function:

Catalyzes the synthesis of GMP from XMP

Gene Name:

guaA

Uniprot ID:

P04079

Molecular weight:

58679

Reactions

General function:

Involved in transferase activity

Specific function:

An aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate

Gene Name:

tyrB

Uniprot ID:

P04693

Molecular weight:

43537

Reactions

General function:

Involved in nucleotide binding

Specific function:

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction:glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)

Gene Name:

gltX

Uniprot ID:

P04805

Molecular weight:

53815

Reactions

General function:

Involved in biosynthetic process

Specific function:

Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine

Gene Name:

pabB

Uniprot ID:

P05041

Molecular weight:

50969

Reactions

General function:

Involved in transferase activity

Specific function:

L-histidinol phosphate + 2-oxoglutarate = 3- (imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate

Gene Name:

hisC

Uniprot ID:

P06986

Molecular weight:

39360

Reactions

General function:

Involved in tetrahydrofolylpolyglutamate synthase activity

Specific function:

Conversion of folates to polyglutamate derivatives

Gene Name:

folC

Uniprot ID:

P08192

Molecular weight:

45405

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Oxidizes proline to glutamate for use as a carbon and nitrogen source and also function as a transcriptional repressor of the put operon

Gene Name:

putA

Uniprot ID:

P09546

Molecular weight:

143814

Reactions

General function:

Involved in catalytic activity

Specific function:

2 L-glutamate + NADP(+) = L-glutamine + 2- oxoglutarate + NADPH

Gene Name:

gltB

Uniprot ID:

P09831

Molecular weight:

166708

Reactions

General function:

Involved in iron-sulfur cluster binding

Specific function:

2 L-glutamate + NADP(+) = L-glutamine + 2- oxoglutarate + NADPH

Gene Name:

gltD

Uniprot ID:

P09832

Molecular weight:

52015

Reactions

General function:

Involved in cellular amino acid biosynthetic process

Specific function:

Acetyl-CoA + L-glutamate = CoA + N-acetyl-L- glutamate

Gene Name:

argA

Uniprot ID:

P0A6C5

Molecular weight:

49195

Reactions

General function:

Involved in glutamine catabolic process

Specific function:

2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate

Gene Name:

carA

Uniprot ID:

P0A6F1

Molecular weight:

41431

Reactions

General function:

Involved in glutaminase activity

Specific function:

L-glutamine + H(2)O = L-glutamate + NH(3)

Gene Name:

glsA2

Uniprot ID:

P0A6W0

Molecular weight:

33515

Reactions

General function:

Involved in glutamate-cysteine ligase activity

Specific function:

ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine

Gene Name:

gshA

Uniprot ID:

P0A6W9

Molecular weight:

58269

Reactions

General function:

Involved in cellular amino acid biosynthetic process

Specific function:

Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline

Gene Name:

proB

Uniprot ID:

P0A7B5

Molecular weight:

39056

Reactions

General function:

Involved in CTP synthase activity

Specific function:

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

Gene Name:

pyrG

Uniprot ID:

P0A7E5

Molecular weight:

60374

Reactions

General function:

Involved in glutamate-ammonia ligase activity

Specific function:

ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine

Gene Name:

glnA

Uniprot ID:

P0A9C5

Molecular weight:

51903

Reactions

General function:

Involved in amidophosphoribosyltransferase activity

Specific function:

5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H(2)O

Gene Name:

purF

Uniprot ID:

P0AG16

Molecular weight:

56488

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + N(2)-formyl-N(1)-(5-phospho-D- ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2- (formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate

Gene Name:

purL

Uniprot ID:

P15254

Molecular weight:

141402

Reactions

General function:

Involved in hydrolase activity

Specific function:

Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipeptide amides and formyl amino acids are hydrolyzed. Also shows cysteinylglycinase activity, which is sufficient for E.coli to utilize cysteinylglycine as a cysteine source

Gene Name:

pepD

Uniprot ID:

P15288

Molecular weight:

52915

Reactions

General function:

Involved in metabolic process

Specific function:

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source

Gene Name:

glmS

Uniprot ID:

P17169

Molecular weight:

66894

Reactions

General function:

Involved in transaminase activity

Specific function:

Involved in both the arginine and lysine biosynthetic pathways

Gene Name:

argD

Uniprot ID:

P18335

Molecular weight:

43767

Reactions

General function:

Involved in NAD+ synthase (glutamine-hydrolyzing) activity

Specific function:

Catalyzes a key step in NAD biosynthesis, transforming deamido-NAD into NAD by a two-step reaction

Gene Name:

nadE

Uniprot ID:

P18843

Molecular weight:

30637

Reactions

General function:

Involved in gamma-glutamyltransferase activity

Specific function:

(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid

Gene Name:

ggt

Uniprot ID:

P18956

Molecular weight:

61768

Reactions

General function:

Involved in asparagine synthase (glutamine-hydrolyzing) activity

Specific function:

ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate

Gene Name:

asnB

Uniprot ID:

P22106

Molecular weight:

62659

Reactions

General function:

Involved in 4-aminobutyrate transaminase activity

Specific function:

4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate

Gene Name:

gabT

Uniprot ID:

P22256

Molecular weight:

45774

Reactions

General function:

Involved in racemase and epimerase activity, acting on amino acids and derivatives

Specific function:

Provides the (R)-glutamate required for cell wall biosynthesis

Gene Name:

murI

Uniprot ID:

P22634

Molecular weight:

31002

Reactions

General function:

Involved in metabolic process

Specific function:

Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. Is involved in both pyridoxine and serine biosynthesis

Gene Name:

serC

Uniprot ID:

P23721

Molecular weight:

39783

Reactions

General function:

Involved in zinc ion binding

Specific function:

Displays a broad specificity and can also deacylate substrates such as acetylarginine, acetylhistidine or acetylglutamate semialdehyde

Gene Name:

argE

Uniprot ID:

P23908

Molecular weight:

42347

Reactions

General function:

Involved in transaminase activity

Specific function:

Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. Is also able to transaminate cadaverine and, in lower extent, spermidine, but not ornithine. Alpha-ketobutyrate and pyruvate can also act as amino acceptors, although much less efficiently

Gene Name:

patA

Uniprot ID:

P42588

Molecular weight:

49661

Reactions

General function:

Involved in 4-aminobutyrate transaminase activity

Specific function:

Involved in the breakdown of putrescine via transamination of gamma-aminobutyrate

Gene Name:

puuE

Uniprot ID:

P50457

Molecular weight:

44729

Reactions

General function:

Involved in glutamate decarboxylase activity

Specific function:

Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria

Gene Name:

gadA

Uniprot ID:

P69908

Molecular weight:

52685

Reactions

General function:

Involved in glutamate decarboxylase activity

Specific function:

Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria

Gene Name:

gadB

Uniprot ID:

P69910

Molecular weight:

52668

Reactions

General function:

Involved in hydrolase activity

Specific function:

Involved in the breakdown of putrescine via hydrolysis of the gamma-glutamyl linkage of gamma-glutamyl-gamma- aminobutyrate

Gene Name:

puuD

Uniprot ID:

P76038

Molecular weight:

28013

Reactions

General function:

Involved in hydrolase activity, acting on ester bonds

Specific function:

Transforms N(2)-succinylglutamate into succinate and glutamate

Gene Name:

astE

Uniprot ID:

P76215

Molecular weight:

35800

Reactions

General function:

Involved in glutaminase activity

Specific function:

L-glutamine + H(2)O = L-glutamate + NH(3)

Gene Name:

glsA1

Uniprot ID:

P77454

Molecular weight:

32903

Reactions

General function:

Involved in transaminase activity

Specific function:

Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act as an acetylornithine aminotransferase

Gene Name:

astC

Uniprot ID:

P77581

Molecular weight:

43665

Reactions

General function:

Involved in transaminase activity

Specific function:

Catalyzes the conversion of UDP-4-keto-arabinose (UDP- Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides

Gene Name:

arnB

Uniprot ID:

P77690

Molecular weight:

41649

Reactions

General function:

Involved in glutamate-ammonia ligase activity

Specific function:

Involved in the breakdown of putrescine via the biosynthesis of gamma-L-glutamylputrescine

Gene Name:

puuA

Uniprot ID:

P78061

Molecular weight:

53177

Reactions

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for aspartate/glutamate; probably responsible for the translocation of the substrate across the membrane

Gene Name:

gltJ

Uniprot ID:

P0AER3

Molecular weight:

27502

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for aspartate/glutamate; probably responsible for the translocation of the substrate across the membrane

Gene Name:

gltK

Uniprot ID:

P0AER5

Molecular weight:

24914

General function:

Involved in transferase activity, transferring pentosyl groups

Specific function:

IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The hisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to hisF for the synthesis of IGP and AICAR

Gene Name:

hisH

Uniprot ID:

P60595

Molecular weight:

21653

Reactions

General function:

Involved in 1-aminocyclopropane-1-carboxylate synthase activity

Specific function:

Specific function unknown

Gene Name:

yfbQ

Uniprot ID:

P0A959

Molecular weight:

45517

Reactions

General function:

Involved in catalytic activity

Specific function:

Acts on leucine, isoleucine and valine

Gene Name:

ilvE

Uniprot ID:

P0AB80

Molecular weight:

34093

Reactions

General function:

Involved in catalytic activity

Specific function:

Involved in ECA elongation

Gene Name:

rffA

Uniprot ID:

P27833

Molecular weight:

41901

General function:

Involved in catalytic activity

Specific function:

IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The hisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the hisH subunit

Gene Name:

hisF

Uniprot ID:

P60664

Molecular weight:

28454

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the binding-protein-dependent transport system for glutamate and aspartate. Probably responsible for energy coupling to the transport system

Gene Name:

gltL

Uniprot ID:

P0AAG3

Molecular weight:

26661

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for glutamate and aspartate. Binds to both aspartate and glutamate

Gene Name:

gltI

Uniprot ID:

P37902

Molecular weight:

33420

General function:

Amino acid transport and metabolism

Specific function:

Specific function unknown

Gene Name:

yfdZ

Uniprot ID:

P77434

Molecular weight:

46216

Reactions