Formic acid (ECMDB00142) (M2MDB000053)

General function:

Involved in formate dehydrogenase (NAD+) activity

Specific function:

Decomposes formic acid to hydrogen and carbon dioxide under anaerobic conditions in the absence of exogenous electron acceptors

Gene Name:

fdhF

Uniprot ID:

P07658

Molecular weight:

79373

Reactions

General function:

Involved in formate C-acetyltransferase activity

Specific function:

Acetyl-CoA + formate = CoA + pyruvate

Gene Name:

pflB

Uniprot ID:

P09373

Molecular weight:

85357

Reactions

General function:

Involved in iron ion binding

Specific function:

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions

Gene Name:

def

Uniprot ID:

P0A6K3

Molecular weight:

19328

Reactions

General function:

Involved in GTP cyclohydrolase I activity

Specific function:

GTP + H(2)O = formate + 2-amino-4-hydroxy-6- (erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate

Gene Name:

folE

Uniprot ID:

P0A6T5

Molecular weight:

24830

Reactions

General function:

Involved in GTP cyclohydrolase II activity

Specific function:

Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate

Gene Name:

ribA

Uniprot ID:

P0A7I7

Molecular weight:

21836

Reactions

General function:

Involved in 3,4-dihydroxy-2-butanone-4-phosphate synthase activity

Specific function:

Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate

Gene Name:

ribB

Uniprot ID:

P0A7J0

Molecular weight:

23353

Reactions

General function:

Involved in catalytic activity

Specific function:

Activation of pyruvate formate-lyase 1 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine

Gene Name:

pflA

Uniprot ID:

P0A9N4

Molecular weight:

28204

Reactions

General function:

Involved in electron carrier activity

Specific function:

Formate dehydrogenase allows E.coli to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit

Gene Name:

fdnH

Uniprot ID:

P0AAJ3

Molecular weight:

32239

General function:

Involved in electron carrier activity

Specific function:

Allows to use formate as major electron donor during aerobic respiration. The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron- sulfur centers. Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit

Gene Name:

fdoH

Uniprot ID:

P0AAJ5

Molecular weight:

33100

General function:

Involved in electron carrier activity

Specific function:

Probable electron transfer protein for hydrogenase 3

Gene Name:

hycB

Uniprot ID:

P0AAK1

Molecular weight:

21873

General function:

Involved in respiratory electron transport chain

Specific function:

Formate dehydrogenase allows E.coli to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. Subunit gamma is the cytochrome b556(FDN) component of the formate dehydrogenase

Gene Name:

fdnI

Uniprot ID:

P0AEK7

Molecular weight:

25368

General function:

Involved in respiratory electron transport chain

Specific function:

Allows to use formate as major electron donor during aerobic respiration. Subunit gamma is probably the cytochrome b556(FDO) component of the formate dehydrogenase

Gene Name:

fdoI

Uniprot ID:

P0AEL0

Molecular weight:

24606

General function:

Involved in oxidoreductase activity, acting on NADH or NADPH

Specific function:

Specific function unknown

Gene Name:

hycE

Uniprot ID:

P16431

Molecular weight:

64980

General function:

Involved in electron carrier activity

Specific function:

Probable electron transfer protein for hydrogenase 3

Gene Name:

hycF

Uniprot ID:

P16432

Molecular weight:

20309

General function:

Involved in NADH dehydrogenase (ubiquinone) activity

Specific function:

Specific function unknown

Gene Name:

hycG

Uniprot ID:

P16433

Molecular weight:

27999

General function:

Involved in formate dehydrogenase (NAD+) activity

Specific function:

Formate dehydrogenase allows E.coli to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. The alpha subunit forms the active site

Gene Name:

fdnG

Uniprot ID:

P24183

Molecular weight:

112963

Reactions

General function:

Involved in formate dehydrogenase (NAD+) activity

Specific function:

Allows to use formate as major electron donor during aerobic respiration. Subunit alpha possibly forms the active site

Gene Name:

fdoG

Uniprot ID:

P32176

Molecular weight:

112549

Reactions

General function:

Involved in catalytic activity

Specific function:

Acetyl-CoA + formate = CoA + pyruvate

Gene Name:

pflD

Uniprot ID:

P32674

Molecular weight:

85959

Reactions

General function:

Involved in iron-sulfur cluster binding

Specific function:

Activation of pyruvate formate-lyase 2 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine

Gene Name:

pflC

Uniprot ID:

P32675

Molecular weight:

32429

Reactions

General function:

Involved in carboxylesterase activity

Specific function:

Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate. Shows also esterase activity against alpha-naphthyl acetate, lactoylglutathione, palmitoyl-CoA and several pNP-esters of short chain fatty acids

Gene Name:

yeiG

Uniprot ID:

P33018

Molecular weight:

31259

Reactions

General function:

Involved in ATP binding

Specific function:

Catalyzes two reactions:the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR; the second, a side reaction, is the production of acetyl phosphate and ADP from acetate and ATP

Gene Name:

purT

Uniprot ID:

P33221

Molecular weight:

42433

Reactions

General function:

Involved in amino acid binding

Specific function:

Produces formate from formyl-tetrahydrofolate. Provides the major source of formate for the purT-dependent synthesis of 5'-phosphoribosyl-N-formylglycinamide (FGAR) during aerobic growth. Has a role in regulating the one-carbon pool

Gene Name:

purU

Uniprot ID:

P37051

Molecular weight:

31934

Reactions

General function:

Involved in formate C-acetyltransferase activity

Specific function:

Specific function unknown

Gene Name:

tdcE

Uniprot ID:

P42632

Molecular weight:

85935

Reactions

General function:

Involved in carboxylesterase activity

Specific function:

Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate. Shows also esterase activity against two pNP-esters (pNP- acetate and pNP-propionate), alpha-naphthyl acetate and lactoylglutathione

Gene Name:

frmB

Uniprot ID:

P51025

Molecular weight:

31424

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate

Gene Name:

frc

Uniprot ID:

P69902

Molecular weight:

45828

Reactions

General function:

Involved in catalytic activity

Specific function:

Acetyl-CoA + formate = CoA + pyruvate

Gene Name:

ybiW

Uniprot ID:

P75793

Molecular weight:

90125

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)

Gene Name:

ispD

Uniprot ID:

Q46893

Molecular weight:

25737

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Specific function unknown

Gene Name:

hyfJ

Uniprot ID:

P77453

Molecular weight:

15577

General function:

Involved in NADH dehydrogenase (ubiquinone) activity

Specific function:

Specific function unknown

Gene Name:

hyfD

Uniprot ID:

P77416

Molecular weight:

51754

General function:

Involved in oxidoreductase activity, acting on NADH or NADPH

Specific function:

Specific function unknown

Gene Name:

hyfG

Uniprot ID:

P77329

Molecular weight:

63383

General function:

Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

Specific function:

Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (Probable)

Gene Name:

arnD

Uniprot ID:

P76472

Molecular weight:

33112

Reactions

General function:

Involved in NADH dehydrogenase (ubiquinone) activity

Specific function:

Specific function unknown

Gene Name:

hyfF

Uniprot ID:

P77437

Molecular weight:

56766

General function:

Involved in oxidoreductase activity, acting on NADH or NADPH

Specific function:

Specific function unknown

Gene Name:

hyfE

Uniprot ID:

P0AEW1

Molecular weight:

23361

General function:

Involved in oxidation-reduction process

Specific function:

Specific function unknown

Gene Name:

hyfC

Uniprot ID:

P77858

Molecular weight:

34359

General function:

Involved in thiamine biosynthetic process

Specific function:

Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction

Gene Name:

thiC

Uniprot ID:

P30136

Molecular weight:

70850

Reactions

General function:

Involved in NADH dehydrogenase (ubiquinone) activity

Specific function:

Specific function unknown

Gene Name:

hyfI

Uniprot ID:

P77668

Molecular weight:

28101

General function:

Involved in NADH dehydrogenase (ubiquinone) activity

Specific function:

Specific function unknown

Gene Name:

hyfB

Uniprot ID:

P23482

Molecular weight:

72582

General function:

Involved in catalytic activity

Specific function:

Acts as a radical domain for damaged PFL and possibly other radical proteins

Gene Name:

grcA

Uniprot ID:

P68066

Molecular weight:

14284

General function:

Involved in NADH dehydrogenase (ubiquinone) activity

Specific function:

Specific function unknown

Gene Name:

hycC

Uniprot ID:

P16429

Molecular weight:

64076

General function:

Involved in electron carrier activity

Specific function:

Probable electron transfer protein for hydrogenase 4

Gene Name:

hyfH

Uniprot ID:

P77423

Molecular weight:

20159

General function:

Involved in electron carrier activity

Specific function:

Probable electron transfer protein for hydrogenase 4

Gene Name:

hyfA

Uniprot ID:

P23481

Molecular weight:

22154

General function:

Involved in oxidation-reduction process

Specific function:

Specific function unknown

Gene Name:

hycD

Uniprot ID:

P16430

Molecular weight:

33029