Glutathione (ECMDB00125) (M2MDB000048)

General function:

Involved in ATP binding

Specific function:

ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione

Gene Name:

gshB

Uniprot ID:

P04425

Molecular weight:

35561

Reactions

General function:

Involved in glutathione peroxidase activity

Specific function:

Not essential for B12 transport; however, it is an auxiliary component of the transport system

Gene Name:

btuE

Uniprot ID:

P06610

Molecular weight:

20469

General function:

Involved in oxidoreductase activity

Specific function:

Maintains high levels of reduced glutathione in the cytosol

Gene Name:

gor

Uniprot ID:

P06715

Molecular weight:

48772

Reactions

General function:

Involved in protein binding

Specific function:

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles

Gene Name:

gst

Uniprot ID:

P0A9D2

Molecular weight:

22868

Reactions

General function:

Involved in arsenate reductase (glutaredoxin) activity

Specific function:

Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance

Gene Name:

arsC

Uniprot ID:

P0AB96

Molecular weight:

15853

Reactions

General function:

Involved in lactoylglutathione lyase activity

Specific function:

Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione

Gene Name:

gloA

Uniprot ID:

P0AC81

Molecular weight:

14920

Reactions

General function:

Involved in hydrolase activity

Specific function:

Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid

Gene Name:

gloB

Uniprot ID:

P0AC84

Molecular weight:

28434

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Catalyzes the formation of an amide bond between glutathione and spermidine coupled with hydrolysis of ATP; also catalyzes the hydrolysis of glutathionylspermidine to glutathione and spermidine

Gene Name:

gsp

Uniprot ID:

P0AES0

Molecular weight:

70531

Reactions

General function:

Involved in gamma-glutamyltransferase activity

Specific function:

(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid

Gene Name:

ggt

Uniprot ID:

P18956

Molecular weight:

61768

Reactions

General function:

Involved in carboxylesterase activity

Specific function:

Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate. Shows also esterase activity against alpha-naphthyl acetate, lactoylglutathione, palmitoyl-CoA and several pNP-esters of short chain fatty acids

Gene Name:

yeiG

Uniprot ID:

P33018

Molecular weight:

31259

Reactions

General function:

Involved in carboxylesterase activity

Specific function:

Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate. Shows also esterase activity against two pNP-esters (pNP- acetate and pNP-propionate), alpha-naphthyl acetate and lactoylglutathione

Gene Name:

frmB

Uniprot ID:

P51025

Molecular weight:

31424

Reactions

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane

Gene Name:

oppB

Uniprot ID:

P0AFH2

Molecular weight:

33443

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane

Gene Name:

oppC

Uniprot ID:

P0AFH6

Molecular weight:

33022

General function:

Involved in nucleotide binding

Specific function:

Somehow involved in the cytochrome D branch of aerobic respiration. Seems to be a component of a transport system

Gene Name:

cydC

Uniprot ID:

P23886

Molecular weight:

62920

General function:

Involved in nucleotide binding

Specific function:

Somehow involved in the cytochrome D branch of aerobic respiration. Seems to be a component of a transport system

Gene Name:

cydD

Uniprot ID:

P29018

Molecular weight:

65055

General function:

Involved in transporter activity

Specific function:

Part of the ABC transporter complex gsiABCD involved in glutathione import. Probably responsible for the translocation of the substrate across the membrane (Probable)

Gene Name:

gsiC

Uniprot ID:

P75798

Molecular weight:

34066

General function:

Involved in transporter activity

Specific function:

Part of the ABC transporter complex gsiABCD involved in glutathione import. Probably responsible for the translocation of the substrate across the membrane (Probable)

Gene Name:

gsiD

Uniprot ID:

P75799

Molecular weight:

33238

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex gsiABCD involved in glutathione import. Responsible for energy coupling to the transport system

Gene Name:

gsiA

Uniprot ID:

P75796

Molecular weight:

69113

General function:

Posttranslational modification, protein turnover, chaperones

Specific function:

Involved in disulfide bond formation. DsbG and DsbC are part of a periplasmic reducing system that controls the level of cysteine sulfenylation, and provides reducing equivalents to rescue oxidatively damaged secreted proteins such as ErfK, YbiS and YnhG. Probably also functions as a disulfide isomerase with a narrower substrate specificity than DsbC. DsbG is maintained in a reduced state by DsbD. Displays chaperone activity in both redox states in vitro

Gene Name:

dsbG

Uniprot ID:

P77202

Molecular weight:

27495

General function:

Involved in electron carrier activity

Specific function:

Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (Probable)

Gene Name:

grxD

Uniprot ID:

P0AC69

Molecular weight:

12879

General function:

Involved in cell redox homeostasis

Specific function:

Acts as a disulfide isomerase, interacting with incorrectly folded proteins to correct non-native disulfide bonds. DsbG and DsbC are part of a periplasmic reducing system that controls the level of cysteine sulfenylation, and provides reducing equivalents to rescue oxidatively damaged secreted proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by DsbD

Gene Name:

dsbC

Uniprot ID:

P0AEG6

Molecular weight:

25622

General function:

Involved in electron carrier activity

Specific function:

The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione reductase

Gene Name:

grxC

Uniprot ID:

P0AC62

Molecular weight:

9137

General function:

Involved in protein binding

Specific function:

Involved in reducing some disulfides in a coupled system with glutathione reductase. Does not act as hydrogen donor for ribonucleotide reductase

Gene Name:

grxB

Uniprot ID:

P0AC59

Molecular weight:

24350

General function:

Involved in transporter activity

Specific function:

Part of the ABC transporter complex gsiABCD involved in glutathione import

Gene Name:

gsiB

Uniprot ID:

P75797

Molecular weight:

56470

General function:

Involved in electron carrier activity

Specific function:

The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione reductase

Gene Name:

grxA

Uniprot ID:

P68688

Molecular weight:

9685

General function:

Not Available

Specific function:

Not Available

Gene Name:

yfcG

Uniprot ID:

P77526

Molecular weight:

Not Available