Adenine (ECMDB00034) (M2MDB000010)

General function:

Involved in hypoxanthine phosphoribosyltransferase activity

Specific function:

This enzyme acts exclusively on hypoxanthine; it does not act on guanine

Gene Name:

hpt

Uniprot ID:

P0A9M2

Molecular weight:

20115

Reactions

General function:

Involved in purine-nucleoside phosphorylase activity

Specific function:

Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules

Gene Name:

deoD

Uniprot ID:

P0ABP8

Molecular weight:

25950

Reactions

General function:

Involved in catalytic activity

Specific function:

Involved in regulation of AMP concentrations

Gene Name:

amn

Uniprot ID:

P0AE12

Molecular weight:

53994

Reactions

General function:

Involved in adenosylhomocysteine nucleosidase activity

Specific function:

Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Can also use 5'-isobutylthioadenosine, 5'-n- butylthioadenosine, S-adenosyl-D-homocysteine, decarboxylated adenosylhomocysteine, deaminated adenosylhomocysteine and S-2-aza- adenosylhomocysteine as substrates

Gene Name:

mtnN

Uniprot ID:

P0AF12

Molecular weight:

24354

Reactions

General function:

Involved in riboflavin synthase activity

Specific function:

Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The alpha subunit catalyzes the dismutation of 6,7-dimethyl-8-lumazine to riboflavin and 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)- pyrimidinedione

Gene Name:

ribE

Uniprot ID:

P0AFU8

Molecular weight:

23445

Reactions

General function:

Involved in hydrolase activity, hydrolyzing N-glycosyl compounds

Specific function:

Hydrolyzes both purine and pyrimidine ribonucleosides with a broad-substrate specificity with decreasing activity in the order uridine, xanthosine, inosine, adenosine, cytidine, guanosine

Gene Name:

rihC

Uniprot ID:

P22564

Molecular weight:

32560

General function:

Involved in adenine deaminase activity

Specific function:

Adenine + H(2)O = hypoxanthine + NH(3)

Gene Name:

ade

Uniprot ID:

P31441

Molecular weight:

63739

Reactions

General function:

Involved in hydrolase activity, hydrolyzing N-glycosyl compounds

Specific function:

Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively. Has a clear preference for cytidine over uridine. Strictly specific for ribonucleosides. Has a low but significant activity for the purine nucleoside xanthosine

Gene Name:

rihB

Uniprot ID:

P33022

Molecular weight:

33748

Reactions

General function:

Involved in adenine phosphoribosyltransferase activity

Specific function:

Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

Gene Name:

apt

Uniprot ID:

P69503

Molecular weight:

19859

Reactions

General function:

Involved in ATP binding

Specific function:

Catalyzes the formation of 2-(5''-triphosphoribosyl)-3'- dephosphocoenzyme-A, the precursor of the prosthetic group of the holo-acyl carrier protein (gamma chain) of citrate lyase, from ATP and dephospho-CoA

Gene Name:

citG

Uniprot ID:

P77231

Molecular weight:

31644

Reactions

General function:

Not Available

Specific function:

Dioxygenase that repairs alkylated DNA and RNA containing 3-methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents), but not to MMNG and MNU (SN1 agents). Dioxygenase that repairs alkylated DNA and RNA containing 3-methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents), but not to MMNG and MNU (SN1 agents).

Gene Name:

alkB

Uniprot ID:

P05050

Molecular weight:

Not Available

Reactions

General function:

Translation, ribosomal structure and biogenesis

Specific function:

Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)

Gene Name:

queA

Uniprot ID:

P0A7F9

Molecular weight:

39430

Reactions

General function:

organic phosphonate catabolic process

Specific function:

Together with PhnG, PhnH and PhnI is required for the transfer of the ribose triphosphate moiety from ATP to methyl phosphonate.

Gene Name:

phnL

Uniprot ID:

P16679

Molecular weight:

24705

Reactions

General function:

organic phosphonate catabolic process

Specific function:

Together with PhnG, PhnH and PhnL is required for the transfer of the ribose triphosphate moiety from ATP to methyl phosphonate. PhnI alone has nucleosidase activity, catalyzing the hydrolysis of ATP or GTP forming alpha-D-ribose 5-triphosphate and adenine or guanine, respectively.

Gene Name:

phnI

Uniprot ID:

P16687

Molecular weight:

38852

Reactions

General function:

organic phosphonate catabolic process

Specific function:

Together with PhnG, PhnI and PhnL is required for the transfer of the ribose triphosphate moiety from ATP to methyl phosphonate.

Gene Name:

phnH

Uniprot ID:

P16686

Molecular weight:

21027

Reactions

General function:

organic phosphonate transport

Specific function:

Together with PhnH, PhnI and PhnL is required for the transfer of the ribose triphosphate moiety from ATP to methyl phosphonate.

Gene Name:

phnG

Uniprot ID:

P16685

Molecular weight:

16539

Reactions