Identification
Name:Mechanosensitive channel MscK
Synonyms:Not Available
Gene Name:mscK
Enzyme Class:Not Available
Biological Properties
General Function:transmembrane transport
Specific Function:Mechanosensitive channel that opens in response to membrane tension and specific ionic conditions. Requires high concentrations of external K(+), NH(4)(+), Rb(+) or Cs(+) to gate. May participate in the regulation of osmotic pressure changes within the cell, although it does not appear to have a major role in osmolarity regulation. Forms an ion channel of 1.0 nanosiemens conductance. The channel can remain active for between 30 seconds and over 3 minutes; it does not desensitize upon extended pressure. Its activity is masked in wild-type cells by the MscS channel.
Cellular Location:Not Available
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Metabolites:
ECMDB IDNameView
GO Classification:
Function
cellular response to osmotic stress
cellular water homeostasis
integral component of membrane
plasma membrane
potassium ion transport
transmembrane transport
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>3363
atgactatgttccagtattacaaacgatcacggcattttgttttttcagcatttattgct
tttgtttttgtcttgttatgccagaacacggcgtttgcgcgggcgtcatcgaatggtgat
ctgccgacaaaagcggacctgcaggcgcaacttgactcactaaataaacaaaaagatctt
tctgctcaggacaaactggtgcagcaggatctgacagatacattagccaccctcgataaa
atcgatcgcataaaagaagagacagttcagctacggcaaaaagtcgctgaagcgccggaa
aaaatgcgccaggcgaccgcggcgttaacagcacttagcgatgtcgataacgacgaagaa
acgcgcaaaattctgagcacgctgtcgttgcgccagctggaaactcgcgttgcccaggcg
ctggacgatttgcaaaacgcacaaaacgatctggcgtcttataacagccagctggtttcg
ttacagacgcagcccgaacgcgtgcaaaatgcgatgtataacgcttcgcagcagctgcaa
caaattcgcagtcgtctggatgggactgatgtcggcgagacagccttacgtcccagccag
aaagtgttaatgcaggcccagcaggcgttgctgaatgcggagattgaccagcagcgtaaa
agcctggaagggaacaccgtcttgcaggataccttgcaaaagcaacgtgattacgtgacg
gcgaacagcgctcgtctggagcaccagttacaactgttgcaagaagcggtaaacagcaag
cgcctgactttaaccgaaaaaacggcgcaggaagccgtctccccggatgaagccgcgcgt
attcaggctaatccgctggtgaagcaggaactggaaattaaccagcagttaagtcagcgt
ctgattaccgcgactgaaaacggtaatcagttgatgcagcaaaacattaaagtcaaaaac
tggctggagcgggcgctgcaatcggaacgcaatattaaagagcagattgccgtcctgaag
ggcagcctgctgttgtctcgtatcctttaccagcaacaacaaacgctgccctcggcggat
gaactggaaaacatgaccaaccgcatcgcggatttgcgtctcgaacagtttgaagttaac
cagcagcgtgatgcactcttccagagcgatgcgttcgtcaacaaactggaagaaggtcac
accaacgaagtcaacagcgaagttcacgatgcgttattgcaagtggttgatatgcgtcgc
gaattgctggatcaactcaacaaacagttgggtaaccagctgatgatggccattaacctg
caaatcaaccagcagcagttaatgagtgtgtcgaaaaacctgaaatccatcctgactcag
caaatcttttgggtgaacagtaaccgtccaatggactgggactggatcaaagcgttcccg
caaagcctgaaagatgaatttaagtcgatgaaaatcacggtgaactggcaaaaagcctgg
cccgccgtttttatcgctttcctcgctggtttgccgctgctgttgattgccgggctgatc
cactggcgtctgggctggctgaaagcgtatcaacaaaaactggcttccgctgtgggttcc
ctgcgtaacgacagccagctcaacacaccaaaagcgatccttatcgacctgatccgtgcg
ctgccggtgtgcctgattattctcgcggttggcctgattctgttgaccatgcagctcaac
atcagcgaactgctatggtcgttcagcaaaaaactggcgatattctggctggtgtttggc
ctgtgctggaaggtactggagaaaaacggcgttgccgtacgtcacttcggcatgccggaa
cagcagaccagccactggcgtcggcaaattgtccgcatcagtctcgcattgctgcctatc
catttctggtctgtggtggcagaactttccccgctgcatctgatggatgatgtgctgggg
caagcgatgattttcttcaacctgctgctgattgccttcctggtatggccgatgtgccgc
gaaagctggcgtgataaagagtcgcacaccatgcgactggtcaccattaccgtgctgtcg
ataatcccgattgcgctgatggtgctgactgctacaggctacttctacactacgctgcgt
ctggcaggacgctggattgaaaccgtttatctggtgatcatctggaacctgctgtaccag
acggtactgcgtggcttaagcgtagcggcgcggcgtatcgcctggcgtcgtgcgctggcg
cgtcggcagaatctggtgaaagagggcgcagaaggtgctgaaccgccggaagaacccacc
attgcactggagcaagttaaccagcagacgctgcgtattaccatgttgctgatgtttgcg
ctgttcggtgtcatgttctgggcaatttggtccgatttgatcaccgtgttcagctatctc
gacagcatcacgctctggcattacaacggcactgaagctggcgctgcggtggtgaaaaac
gtcaccatgggcagtctgttgtttgcgattatcgcctcaatggtggcctgggcgttgatt
cgcaacctgcctggtttactggaagtgctggtgctctcgcgactgaatatgcgccagggc
gcgtcgtatgccattactaccatccttaactacatcattattgctgttggtgcgatgacg
gtgttcggatcgctgggcgtctcttgggataaactccagtggctggccgcagcattatcc
gtaggtcttggttttggtttacaagaaattttcggtaacttcgtctccggtttgatcatt
ctattcgaacgtccggtgcgtattggcgatacggtaaccattggtagcttctcggggacg
gtaagtaagatccgtattcgtgcgacaacgattaccgatttcgatcgcaaagaagtgatc
atcccgaacaaagcgtttgttaccgagcgtctgatcaactggtcgttgactgacactact
acgcgtctggtgatccgtctcggcgtggcctatggctccgatctggaaaaagtgcgtaaa
gtgttactgaaggcggcgactgagcacccaagggtgatgcacgaaccaatgccggaagtc
ttctttacggcatttggtgccagcacgttggatcatgagctgcgtctgtatgtgcgtgaa
ctgcgtgaccgtagtcgtactgtcgatgagctgaaccgtactatcgatcagctgtgccgt
gaaaacgacatcaacattgcctttaaccagcttgaagtgcatctgcacaacgagaagggc
gatgaggtgacggaagtaaaacgcgactacaaaggcgatgacccgacgccagcggtaggg
taa
Protein Properties
Pfam Domain Function:Not Available
Protein Residues:1120
Protein Molecular Weight:127214
Protein Theoretical pI:Not Available
Signaling Regions:
  • 1-33
Transmembrane Regions:
  • 500-520
  • 561-581
  • 583-603
  • 635-655
  • 658-678
  • 693-713
  • 729-749
  • 797-817
  • 840-860
  • 887-907
  • 922-942
Protein Sequence:
>Mechanosensitive channel MscK
MTMFQYYKRSRHFVFSAFIAFVFVLLCQNTAFARASSNGDLPTKADLQAQLDSLNKQKDL
SAQDKLVQQDLTDTLATLDKIDRIKEETVQLRQKVAEAPEKMRQATAALTALSDVDNDEE
TRKILSTLSLRQLETRVAQALDDLQNAQNDLASYNSQLVSLQTQPERVQNAMYNASQQLQ
QIRSRLDGTDVGETALRPSQKVLMQAQQALLNAEIDQQRKSLEGNTVLQDTLQKQRDYVT
ANSARLEHQLQLLQEAVNSKRLTLTEKTAQEAVSPDEAARIQANPLVKQELEINQQLSQR
LITATENGNQLMQQNIKVKNWLERALQSERNIKEQIAVLKGSLLLSRILYQQQQTLPSAD
ELENMTNRIADLRLEQFEVNQQRDALFQSDAFVNKLEEGHTNEVNSEVHDALLQVVDMRR
ELLDQLNKQLGNQLMMAINLQINQQQLMSVSKNLKSILTQQIFWVNSNRPMDWDWIKAFP
QSLKDEFKSMKITVNWQKAWPAVFIAFLAGLPLLLIAGLIHWRLGWLKAYQQKLASAVGS
LRNDSQLNTPKAILIDLIRALPVCLIILAVGLILLTMQLNISELLWSFSKKLAIFWLVFG
LCWKVLEKNGVAVRHFGMPEQQTSHWRRQIVRISLALLPIHFWSVVAELSPLHLMDDVLG
QAMIFFNLLLIAFLVWPMCRESWRDKESHTMRLVTITVLSIIPIALMVLTATGYFYTTLR
LAGRWIETVYLVIIWNLLYQTVLRGLSVAARRIAWRRALARRQNLVKEGAEGAEPPEEPT
IALEQVNQQTLRITMLLMFALFGVMFWAIWSDLITVFSYLDSITLWHYNGTEAGAAVVKN
VTMGSLLFAIIASMVAWALIRNLPGLLEVLVLSRLNMRQGASYAITTILNYIIIAVGAMT
VFGSLGVSWDKLQWLAAALSVGLGFGLQEIFGNFVSGLIILFERPVRIGDTVTIGSFSGT
VSKIRIRATTITDFDRKEVIIPNKAFVTERLINWSLTDTTTRLVIRLGVAYGSDLEKVRK
VLLKAATEHPRVMHEPMPEVFFTAFGASTLDHELRLYVRELRDRSRTVDELNRTIDQLCR
ENDINIAFNQLEVHLHNEKGDEVTEVKRDYKGDDPTPAVG
References
External Links:
ResourceLink
Uniprot ID:P77338
Uniprot Name:MSCK_ECOLI
CCDB:MSCK_ECOLI
General Reference:Not Available