6-carboxy-5,6,7,8-tetrahydropterin synthase (P65870)

Identification
Name:6-carboxy-5,6,7,8-tetrahydropterin synthase
Synonyms:
  • CPH4 synthase
  • Queuosine biosynthesis protein queD
Gene Name:queD
Enzyme Class:
Biological Properties
General Function:Coenzyme transport and metabolism
Specific Function:Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde. Can also convert 6-pyruvoyltetrahydropterin (PPH4) and sepiapterin to CPH4; these 2 compounds are probably intermediates in the reaction from H2NTP
Cellular Location:Not Available
SMPDB Pathways:
KEGG Pathways:
KEGG Reactions:
1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Dihydroneopterin triphosphate ↔ 1.0Dyspropterin + 1.0Triphosphate
ReactionCard
SMPDB Reactions:
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Triphosphate+2.0Thumb+1.0Thumb+1.0Thumb
1.07,8-dihydroneopterin 3'-triphosphate + 1.0Water → 1.0Acetaldehyde + 1.0Triphosphate + 2.0Hydrogen ion + 1.06-Carboxy-5,6,7,8-tetrahydropterin + 1.0Triphosphate
ReactionCard
EcoCyc Reactions:
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb+1.0Thumb
1.0Dihydroneopterin triphosphate + 1.0Water → 1.0Acetaldehyde + 1.06-Carboxy-5,6,7,8-tetrahydropterin + 1.0Hydrogen ion + 1.0Triphosphate
ReactionCard
Complex Reactions:
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb
1.0Dihydroneopterin triphosphate + 1.0Water → 1.06-Carboxy-5,6,7,8-tetrahydropterin + 1.0Acetaldehyde + 1.0Triphosphate
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB211806-Carboxy-5,6,7,8-tetrahydropterinMetaboCard
ECMDB242457,8-dihydroneopterin 3'-triphosphateMetaboCard
ECMDB00990AcetaldehydeMetaboCard
ECMDB01144Dihydroneopterin triphosphateMetaboCard
ECMDB01195DyspropterinMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB03379TriphosphateMetaboCard
ECMDB00494WaterMetaboCard
GO Classification:
Function
6-pyruvoyltetrahydropterin synthase activity
binding
carbon-oxygen lyase activity
carbon-oxygen lyase activity, acting on phosphates
catalytic activity
cation binding
ion binding
lyase activity
metal ion binding
Process
biosynthetic process
cellular biosynthetic process
heterocycle biosynthetic process
metabolic process
pteridine and derivative biosynthetic process
tetrahydrobiopterin biosynthetic process
Gene Properties
Blattner:b2765
Gene OrientationClockwise
Centisome Percentage:62.29
Left Sequence End2890236
Right Sequence End2890601
Gene Sequence:
>366 bp
ATGATCAGCAGAGTGACAGAAGCTCTAAGCAAAGTTAAAGGATCGATGGGAAGCCACGAG
CGCCATGCATTGCCTGGTGTTATCGGTGACGATCTTTTGCGATTTGGGAAGCTGCCACTC
TGCCTGTTCATTTGCATTATTTTGACGGCGGTGACTGTGGTAACCACGGCGCACCATACC
CGTTTACTGACCGCTCAGCGCGAACAACTGGTGCTGGAGCGAGATGCTTTAGACATTGAA
TGGCGCAACCTGATCCTTGAAGAGAATGCGCTCGGCGACCATAGCCGGGTGGAAAGGATC
GCCACGGAAAAGCTGCAAATGCAGCATGTTGATCCGTCACAAGAAAATATCGTAGTGCAA
AAATAA
Protein Properties
Pfam Domain Function:
Protein Residues:121
Protein Molecular Weight:13773
Protein Theoretical pI:7
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>6-carboxy-5,6,7,8-tetrahydropterin synthase
MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKA
AFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG
E
References
External Links:
ResourceLink
Uniprot ID:P65870
Uniprot Name:QUED_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85674321
Ecogene ID:EG13120
Ecocyc:EG13120
ColiBase:b2765
Kegg Gene:b2765
EchoBASE ID:EB2921
CCDB:QUED_ECOLI
BacMap:16130672
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • McCarty, R. M., Somogyi, A., Bandarian, V. (2009). "Escherichia coli QueD is a 6-carboxy-5,6,7,8-tetrahydropterin synthase." Biochemistry 48:2301-2303. Pubmed: 19231875