N-acetylgalactosamine permease IID component (P42911)

Identification
Name:N-acetylgalactosamine permease IID component
Synonyms:
  • EIID-Aga
  • PTS system N-acetylgalactosamine-specific EIID component
Gene Name:agaD
Enzyme Class:Not Available
Biological Properties
General Function:Involved in phosphoenolpyruvate-dependent sugar phosphotransferase system
Specific Function:The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in N-acetylgalactosamine transport
Cellular Location:Cell inner membrane; Multi-pass membrane protein
SMPDB Pathways:
KEGG Pathways:
Transports:
Transport References:
  • Uniprot Consortium (2012). "Reorganizing the protein space at the Universal Protein Resource (UniProt)." Nucleic Acids Res 40:D71-D75. Pubmed: 22102590
KEGG Reactions:
1.0Thumb+1.0Protein N(pi)-phospho-L-histidine ↔ 1.0Thumb+1.0Protein histidine
1.0D-Galactosamine + 1.0Protein N(pi)-phospho-L-histidine ↔ 1.0D-Galactosamine 6-phosphate + 1.0Protein histidine
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB20142D-GalactosamineMetaboCard
ECMDB20141D-Galactosamine 6-phosphateMetaboCard
ECMDB00853N-Acetyl-b-D-galactosamineMetaboCard
GO Classification:
Component
cell part
integral to membrane
intrinsic to membrane
membrane part
Process
carbohydrate transport
establishment of localization
phosphoenolpyruvate-dependent sugar phosphotransferase system
transport
Gene Properties
Blattner:b3140
Gene OrientationClockwise
Centisome Percentage:70.77
Left Sequence End3283500
Right Sequence End3284291
Gene Sequence:
>792 bp
ATGGGATCTGAAATCAGTAAAAAAGATATCACCCGTCTGGGCTTTCGTTCGTCGCTGCTG
CAAGCGAGCTTTAACTACGAAAGGATGCAGGCGGGCGGTTTTACCTGGGCGATGTTGCCG
ATCCTGAAAAAGATTTATAAGGACGACAAACCGGGCTTAAGCGCGGCGATGAAAGATAAC
CTCGAATTTATTAATACCCACCCGAATCTGGTCGGATTCCTGATGGGGTTATTAATTTCG
ATGGAAGAAAAAGGAGAAAACCGCGACACCATTAAAGGCCTCAAAGTGGCACTGTTTGGC
CCAATCGCCGGGATTGGCGATGCGATTTTCTGGTTTACTTTGTTGCCGATTATGGCGGGA
ATTTGCTCATCATTTGCCAGCCAGGGAAACCTGCTGGGGCCGATTCTATTTTTCGCCGTT
TACCTGCTTATCTTTTTCCTGCGCGTCGGCTGGACCCACGTCGGTTATTCAGTCGGCGTG
AAGGCGATCGATAAAGTGCGAGAGAACTCGCAGATGATTGCCCGTTCGGCAACCATCCTC
GGGATCACGGTAATCGGCGGGCTGATCGCTTCGTATGTGCATATTAACGTGGTGACATCG
TTTGCCATCGACAATACCCACAGCGTTGCGCTGCAGCAGGATTTCTTCGATAAAGTCTTC
CCGAACATTTTACCGATGGCCTACACCCTGCTGATGTATTACTTCCTGCGGGTGAAAAAA
GCGCATCCGGTGCTGTTAATCGGCGTGACTTTTGTGCTCTCTATTGTTTGTTCCGCATTC
GGCATTTTGTAA
Protein Properties
Pfam Domain Function:
Protein Residues:263
Protein Molecular Weight:29001
Protein Theoretical pI:10
Signaling Regions:
  • None
Transmembrane Regions:
  • 61-81
  • 98-118
  • 131-151
  • 178-198
  • 215-235
  • 243-263
Protein Sequence:
>N-acetylgalactosamine permease IID component
MGSEISKKDITRLGFRSSLLQASFNYERMQAGGFTWAMLPILKKIYKDDKPGLSAAMKDN
LEFINTHPNLVGFLMGLLISMEEKGENRDTIKGLKVALFGPIAGIGDAIFWFTLLPIMAG
ICSSFASQGNLLGPILFFAVYLLIFFLRVGWTHVGYSVGVKAIDKVRENSQMIARSATIL
GITVIGGLIASYVHINVVTSFAIDNTHSVALQQDFFDKVFPNILPMAYTLLMYYFLRVKK
AHPVLLIGVTFVLSIVCSAFGIL
References
External Links:
ResourceLink
Uniprot ID:P42911
Uniprot Name:PTPD_ECOLI
GenBank Gene ID:AF228498
Genebank Protein ID:8895756
Ecogene ID:EG12771
Ecocyc:EG12771
ColiBase:b3140
Kegg Gene:b3140
EchoBASE ID:EB2624
CCDB:PTPD_ECOLI
BacMap:16131032
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Brinkkotter, A., Kloss, H., Alpert, C., Lengeler, J. W. (2000). "Pathways for the utilization of N-acetyl-galactosamine and galactosamine in Escherichia coli." Mol Microbiol 37:125-135. Pubmed: 10931310
  • Daley, D. O., Rapp, M., Granseth, E., Melen, K., Drew, D., von Heijne, G. (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308:1321-1323. Pubmed: 15919996
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Reizer, J., Ramseier, T. M., Reizer, A., Charbit, A., Saier, M. H. Jr (1996). "Novel phosphotransferase genes revealed by bacterial genome sequencing: a gene cluster encoding a putative N-acetylgalactosamine metabolic pathway in Escherichia coli." Microbiology 142 ( Pt 2):231-250. Pubmed: 8932697