Identification
Name:Alcohol dehydrogenase, propanol-preferring
Synonyms:Not Available
Gene Name:adhP
Enzyme Class:
Biological Properties
General Function:Involved in zinc ion binding
Specific Function:Preferred specificity is towards 1-propanol
Cellular Location:Not Available
SMPDB Pathways:
KEGG Pathways:
KEGG Reactions:
1.0Thumb+1.0Thumb1.0Thumb+1.0Thumb+1.0Thumb
1.0Primary alcohol+1.0Thumb1.0Aldehyde+1.0Thumb+1.0Thumb
1.0Primary alcohol + 1.0NAD ↔ 1.0Aldehyde + 1.0NADH + 1.0Hydrogen ion
ReactionCard
1.0Thumb+1.0Thumb1.0Thumb+1.0Thumb+1.0Thumb
1.0trans-3-Chloro-2-propene-1-ol+1.0Thumb1.0trans-3-Chloroallyl aldehyde+1.0Thumb+1.0Thumb
1.0trans-3-Chloro-2-propene-1-ol + 1.0NAD ↔ 1.0trans-3-Chloroallyl aldehyde + 1.0NADH + 1.0Hydrogen ion
ReactionCard
1.0cis-3-Chloro-2-propene-1-ol+1.0Thumb1.0cis-3-Chloroallyl aldehyde+1.0Thumb+1.0Thumb
1.0cis-3-Chloro-2-propene-1-ol + 1.0NAD ↔ 1.0cis-3-Chloroallyl aldehyde + 1.0NADH + 1.0Hydrogen ion
ReactionCard
1.0Thumb+1.0Thumb1.0Thumb+1.0Thumb+1.0Thumb
1.0Chloral hydrate+1.0Thumb+1.0Thumb1.0Trichloroethanol+1.0Thumb+1.0Thumb
1.0Chloral hydrate + 1.0NADH + 1.0Hydrogen ion ↔ 1.0Trichloroethanol + 1.0NAD + 1.0Water
ReactionCard
1.0Thumb+1.0Thumb1.0Thumb+1.0Thumb+1.0Thumb
1.0Thumb+1.0Thumb1.0Thumb+1.0Thumb+1.0Thumb
1.0Primary alcohol+1.0Thumb+1.0Thumb1.0Thumb+1.0Thumb+1.0Thumb+1.0Thumb
1.0Primary alcohol + 1.0NAD + 1.0Secondary alcohol ↔ 1.0Aldehyde + 1.0NADH + 1.0Hydrogen ion + 1.0Ketone
ReactionCard
SMPDB Reactions:
1.0Thumb+1.0Thumb1.0Thumb+1.0Thumb+1.0Thumb
EcoCyc Reactions:
1.0Thumb+1.0Thumb1.0Thumb+1.0Thumb+1.0Thumb
1.0a primary alcohol+1.0Thumb1.0an aldehyde+1.0Thumb+1.0Thumb
1.0a primary alcohol + 1.0NAD ↔ 1.0an aldehyde + 1.0NADH + 1.0Hydrogen ion
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB20007(2-Naphthyl)methanolMetaboCard
ECMDB200211-HydroxymethylnaphthaleneMetaboCard
ECMDB200472-NaphthaldehydeMetaboCard
ECMDB200482-Phenyl-1,3-propanediol monocarbamateMetaboCard
ECMDB003183,4-DihydroxyphenylglycolMetaboCard
ECMDB200653-Carbamoyl-2-phenylpropionaldehydeMetaboCard
ECMDB200914-Hydroxy-5-phenyltetrahydro-1,3-oxazin-2-oneMetaboCard
ECMDB201075-Phenyl-1,3-oxazinane-2,4-dioneMetaboCard
ECMDB00990AcetaldehydeMetaboCard
ECMDB21646AldehydeMetaboCard
ECMDB00108EthanolMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB00902NADMetaboCard
ECMDB01487NADHMetaboCard
ECMDB21659RetinalMetaboCard
ECMDB21660RetinolMetaboCard
ECMDB00494WaterMetaboCard
GO Classification:
Function
binding
catalytic activity
cation binding
ion binding
metal ion binding
oxidoreductase activity
transition metal ion binding
zinc ion binding
Process
metabolic process
oxidation reduction
Gene Properties
Blattner:b1478
Gene OrientationCounterclockwise
Centisome Percentage:33.43
Left Sequence End1550852
Right Sequence End1551862
Gene Sequence:
>1011 bp
ATGTACTACCCCTTCGTTCGTAAAGCCCTTTTCCAGCTCGATCCAGAGCGCGCTCATGAG
TTTACTTTTCAGCAATTACGCCGTATTACAGGAACGCCGTTTGAAGCACTGGTGCGGCAG
AAAGTGCCTGCGAAACCTGTTAACTGCATGGGCCTGACGTTTAAAAATCCGCTTGGTCTG
GCAGCCGGTCTTGATAAAGACGGGGAGTGCATTGACGCGTTAGGCGCGATGGGATTTGGA
TCGATCGAGATCGGTACCGTCACGCCACGTCCACAGCCAGGTAATGACAAGCCGCGTCTC
TTTCGTCTGGTAGATGCCGAAGGTTTGATCAACCGTATGGGCTTTAATAATCTTGGCGTT
GATAACCTCGTAGAGAACGTAAAAAAGGCCCATTATGACGGCGTCCTGGGTATTAACATC
GGCAAAAATAAAGATACGCCAGTGGAGCAGGGCAAAGATGACTATCTGATTTGTATGGAA
AAAATCTATGCCTATGCGGGATATATCGCCATCAATATTTCATCGCCGAATACCCCAGGA
TTACGCACGCTGCAATATGGTGAAGCGCTGGATGATCTCTTAACCGCGATTAAAAATAAG
CAAAATGATTTGCAAGCGATGCACCATAAATATGTGCCGATCGCAGTGAAGATCGCGCCG
GATCTTTCTGAAGAAGAATTGATCCAGGTTGCCGATAGTTTAGTTCGCCATAATATTGAT
GGCGTTATTGCAACCAATACCACACTCGATCGTTCTCTTGTTCAGGGAATGAAAAATTGC
GATCAAACCGGTGGCTTAAGTGGTCGTCCGCTTCAGTTAAAAAGCACCGAAATTATTCGC
CGCTTGTCACTGGAATTAAACGGTCGCTTACCGATCATCGGTGTTGGCGGCATCGACTCG
GTTATCGCTGCGCGTGAAAAGATTGCTGCGGGTGCCTCACTGGTGCAAATTTATTCTGGT
TTTATTTTTAAAGGTCCGCCGCTGATTAAAGAAATCGTTACCCATATCTAA
Protein Properties
Pfam Domain Function:
Protein Residues:336
Protein Molecular Weight:35379
Protein Theoretical pI:6
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Alcohol dehydrogenase, propanol-preferring
MKAAVVTKDHHVDVTYKTLRSLKHGEALLKMECCGVCHTDLHVKNGDFGDKTGVILGHEG
IGVVAEVGPGVTSLKPGDRASVAWFYEGCGHCEYCNSGNETLCRSVKNAGYSVDGGMAEE
CIVVADYAVKVPDGLDSAAASSITCAGVTTYKAVKLSKIRPGQWIAIYGLGGLGNLALQY
AKNVFNAKVIAIDVNDEQLKLATEMGADLAINSHTEDAAKIVQEKTGGAHAAVVTAVAKA
AFNSAVDAVRAGGRVVAVGLPPESMSLDIPRLVLDGIEVVGSLVGTRQDLTEAFQFAAEG
KVVPKVALRPLADINTIFTEMEEGKIRGRMVIDFRH
References
External Links:
ResourceLink
Uniprot ID:P39451
Uniprot Name:ADHP_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:1651460
Ecogene ID:EG12622
Ecocyc:EG12622
ColiBase:b1478
Kegg Gene:b1478
EchoBASE ID:EB2506
CCDB:ADHP_ECOLI
BacMap:90111280
General Reference:
  • Aiba, H., Baba, T., Hayashi, K., Inada, T., Isono, K., Itoh, T., Kasai, H., Kashimoto, K., Kimura, S., Kitakawa, M., Kitagawa, M., Makino, K., Miki, T., Mizobuchi, K., Mori, H., Mori, T., Motomura, K., Nakade, S., Nakamura, Y., Nashimoto, H., Nishio, Y., Oshima, T., Saito, N., Sampei, G., Horiuchi, T., et, a. l. .. (1996). "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map." DNA Res 3:363-377. Pubmed: 9097039
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Kubo, K. M., Craig, N. L. (1990). "Bacterial transposon Tn7 utilizes two different classes of target sites." J Bacteriol 172:2774-2778. Pubmed: 2158980