L-tartrate/succinate antiporter (P39414)

Identification
Name:L-tartrate/succinate antiporter
Synonyms:
  • Tartrate carrier
  • Tartrate transporter
Gene Name:ttdT
Enzyme Class:Not Available
Biological Properties
General Function:Involved in transporter activity
Specific Function:Catalyzes the uptake of tartrate in exchange for intracellular succinate. Essential for anaerobic L-tartrate fermentation
Cellular Location:Cell inner membrane; Multi-pass membrane protein
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Transports:
Transport References:
  • Orth, J. D., Conrad, T. M., Na, J., Lerman, J. A., Nam, H., Feist, A. M., Palsson, B. O. (2011). "A comprehensive genome-scale reconstruction of Escherichia coli metabolism--2011." Mol Syst Biol 7:535. Pubmed: 21988831
  • Uniprot Consortium (2012). "Reorganizing the protein space at the Universal Protein Resource (UniProt)." Nucleic Acids Res 40:D71-D75. Pubmed: 22102590
Metabolites:
ECMDB IDNameView
ECMDB00254Succinic acidMetaboCard
ECMDB00956Tartaric acidMetaboCard
GO Classification:
Component
cell part
membrane
Function
transporter activity
Process
cation transport
establishment of localization
ion transport
monovalent inorganic cation transport
sodium ion transport
transmembrane transport
transport
Gene Properties
Blattner:b3063
Gene OrientationClockwise
Centisome Percentage:69.10
Left Sequence End3206046
Right Sequence End3207509
Gene Sequence:
>1464 bp
ATGTTCAGGCAGTTGAAAAAAAACCTGGTTGCAACCCTCATTGCTGCTATGACCATTGGT
CAGGTAGCCCCGGCGTTTGCCGACAGCGCAGACACCTTGCCGGATATGGGAACCTCCGCA
GGAAGCACGCTTTCCATTGGTCAGGAAATGCAGATGGGCGACTATTATGTCCGCCAGCTA
CGCGGCAGCGCGCCGTTAATTAATGACCCGCTGTTAACGCAATATATTAATTCGCTGGGG
ATGCGTCTGGTTTCGCATGCCAATTCGGTTAAGACACCGTTTCATTTTTTTCTGATCAAC
AACGACGAAATTAACGCCTTTGCTTTCTTTGGCGGCAACGTGGTGCTGCACTCTGCCCTG
TTCCGTTATTCCGATAACGAAAGTCAACTGGCTTCAGTTATGGCGCACGAAATCTCCCAC
GTCACCCAACGTCACCTGGCGCGAGCGATGGAAGATCAGCAGCGCAGCGCGCCGCTGACC
TGGGTCGGCGCGTTAGGTTCTATTTTACTGGCGATGGCCAGTCCGCAGGCGGGGATGGCG
GCGCTGACCGGTACACTGGCGGGAACGCGTCAGGGGATGATCAGTTTCACCCAGCAAAAT
GAACAGGAAGCGGACCGCATTGGTATTCAGGTGCTGCAACGCTCGGGATTCGATCCGCAG
GCGATGCCAACCTTCCTCGAAAAATTACTCGATCAGGCGCGTTACTCCTCGCGCCCGCCG
GAAATTTTATTGACTCACCCGTTGCCGGAAAGTCGTCTGGCAGATGCCCGCAACCGTGCT
AATCAGATGCGCCCGATGGTGGTGCAGTCGTCGGAAGATTTCTATCTGGCGAAAGCGCGC
ACACTGGGGATGTATAATTCCGGACGTAACCAGCTCACCAGTGATTTGCTGGATGAATGG
GCGAAAGGAAACGTTCGTCAGCAACGAGCAGCACAATATGGTCGTGCTTTACAGGCGATG
GAAGCCAATAAATACGACGAGGCGCGTAAAACGCTGCAACCGTTACTGGCGGCAGAACCT
GGCAACGCATGGTATCTCGATCTGGCTACTGATATCGATCTTGGGCAAAACAAAGCCAAT
GAGGCGATCAATCGTCTGAAAAATGCCCGCGATTTACGCACCAATCCGGTGTTGCAGCTC
AACCTGGCGAACGCTTATTTGCAAGGCGGTCAACCACAAGAAGCGGCCAATATTCTGAAT
CGCTACACCTTTAATAATAAAGATGACAGCAACGGCTGGGATTTGCTGGCACAGGCGGAA
GCCGCGCTAAATAACCGCGATCAGGAGCTGGCTGCGCGAGCAGAAGGTTATGCGCTCGCC
GGACGACTCGATCAGGCCATTTCGCTGTTGAGTAGCGCCAGTTCGCAGGTGAAATTAGGC
AGCCTGCAACAAGCGCGTTACGATGCGCGCATCGACCAGTTGCGCCAGCTGCAGGAACGC
TTTAAGCCTTATACCAAGATGTAA
Protein Properties
Pfam Domain Function:
Protein Residues:487
Protein Molecular Weight:52906
Protein Theoretical pI:9
Signaling Regions:
  • None
Transmembrane Regions:
  • 10-30
  • 33-53
  • 54-74
  • 93-113
  • 137-157
  • 189-209
  • 236-256
  • 292-312
  • 313-333
  • 340-360
  • 370-390
  • 393-413
  • 418-438
  • 465-485
Protein Sequence:
>L-tartrate/succinate antiporter
MKPSTEWWRYLAPLAVIAIIALLPVPAGLENHTWLYFAVFTGVIVGLILEPVPGAVVAMV
GISIIAILSPWLLFSPEQLAQPGFKFTAKSLSWAVSGFSNSVIWLIFAAFMFGTGYEKTG
LGRRIALILVKKMGHRTLFLGYAVMFSELILAPVTPSNSARGAGIIYPIIRNLPPLYQSQ
PNDSSSRSIGSYIMWMGIVADCVTSAIFLTAMAPNLLLIGLMKSASHATLSWGDWFLGML
PLSILLVLLVPWLAYVLYPPVLKSGDQVPRWAETELQAMGPLCSREKRMLGLMVGALVLW
IFGGDYIDAAMVGYSVVALMLLLRIISWDDIVSNKAAWNVFFWLASLITLATGLNNTGFI
SWFGKLLAGSLSGYSPTMVMVALIVVFYLLRYFFASATAYTSALAPMMIAAALAMPEIPL
PVFCLMVGAAIGLGSILTPYATGPSPIYYGSGYLPTADYWRLGAIFGLIFLVLLVITGLL
WMPVVLL
References
External Links:
ResourceLink
Uniprot ID:P39414
Uniprot Name:TTDT_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85675425
Ecogene ID:EG12393
Ecocyc:EG12393
ColiBase:b3063
Kegg Gene:b3063
CCDB:TTDT_ECOLI
BacMap:16130959
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Borodovsky, M., Rudd, K. E., Koonin, E. V. (1994). "Intrinsic and extrinsic approaches for detecting genes in a bacterial genome." Nucleic Acids Res 22:4756-4767. Pubmed: 7984428
  • Daley, D. O., Rapp, M., Granseth, E., Melen, K., Drew, D., von Heijne, G. (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308:1321-1323. Pubmed: 15919996
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Kim, O. B., Unden, G. (2007). "The L-tartrate/succinate antiporter TtdT (YgjE) of L-tartrate fermentation in Escherichia coli." J Bacteriol 189:1597-1603. Pubmed: 17172328
  • Nesin, M., Lupski, J. R., Svec, P., Godson, G. N. (1987). "Possible new genes as revealed by molecular analysis of a 5-kb Escherichia coli chromosomal region 5' to the rpsU-dnaG-rpoD macromolecular-synthesis operon." Gene 51:149-161. Pubmed: 3297921
  • Oshima, T., Biville, F. (2006). "Functional identification of ygiP as a positive regulator of the ttdA-ttdB-ygjE operon." Microbiology 152:2129-2135. Pubmed: 16804186
  • Pos, K. M., Dimroth, P., Bott, M. (1998). "The Escherichia coli citrate carrier CitT: a member of a novel eubacterial transporter family related to the 2-oxoglutarate/malate translocator from spinach chloroplasts." J Bacteriol 180:4160-4165. Pubmed: 9696764